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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ylz FAD Phenylacetone monooxygenase 1.14.13.92

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ylz FADPhenylacetone monooxygenase 1.14.13.92 1.292
1w4x FADPhenylacetone monooxygenase 1.14.13.92 1.191
3gwf FADCyclohexanone monooxygenase / 0.958
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.890
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.889
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.883
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.881
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.879
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.859
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.858
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.857
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.825
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.820
4ap3 FADSteroid monooxygenase / 0.813
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.806
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.804
4aos FADSteroid monooxygenase / 0.796
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.795
2q7v FADThioredoxin reductase / 0.785
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.784
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.776
3dme FADPutative conserved exported protein / 0.767
4aox FADSteroid monooxygenase / 0.765
3gwd FADCyclohexanone monooxygenase / 0.762
4jq9 FADDihydrolipoyl dehydrogenase / 0.756
2eq8 FADDihydrolipoyl dehydrogenase / 0.751
4fwf FADLysine-specific histone demethylase 1B 1 0.751
3ish FADThioredoxin reductase 1.8.1.9 0.748
3urh FADDihydrolipoyl dehydrogenase / 0.746
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.743
3cty FADProbable thioredoxin reductase / 0.743
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.742
4gcm FADThioredoxin reductase 1.8.1.9 0.742
2gvc FADThiol-specific monooxygenase 1.14.13 0.738
2yg4 FADPutrescine oxidase / 0.738
2eq6 FADDihydrolipoyl dehydrogenase / 0.737
2gv8 FADThiol-specific monooxygenase 1.14.13 0.736
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.734
4ap1 FADSteroid monooxygenase / 0.734
2b9y FADPutative aminooxidase / 0.732
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.731
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.730
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.729
4gut FADLysine-specific histone demethylase 1B 1 0.728
3ict FADCoenzyme A disulfide reductase / 0.727
3kkj FADRenalase / 0.727
2bab FADPutative aminooxidase / 0.723
3mj4 FADUDP-galactopyranose mutase / 0.721
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.721
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.718
5hhf FDAUDP-galactopyranose mutase / 0.718
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.716
2b9w FADPutative aminooxidase / 0.716
2b9x FADPutative aminooxidase / 0.716
2bac FADPutative aminooxidase / 0.715
3lsh FADPyranose 2-oxidase / 0.714
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.711
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.710
4gus FADLysine-specific histone demethylase 1B 1 0.710
5br7 FADUDP-galactopyranose mutase / 0.710
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.709
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.708
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.708
4em4 FADCoenzyme A disulfide reductase / 0.708
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.706
3bg7 FADPyranose 2-oxidase / 0.706
3s5w FADL-ornithine N(5)-monooxygenase / 0.706
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.706
2ba9 FADPutative aminooxidase / 0.704
2r9z FADGlutathione amide reductase / 0.704
3qj4 FADRenalase / 0.704
4u8p FDAUDP-galactopyranose mutase / 0.703
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.702
4fwe FADLysine-specific histone demethylase 1B 1 0.702
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.701
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.701
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.701
2y48 FADLysine-specific histone demethylase 1A 1 0.700
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.700
1ges FADGlutathione reductase 1.8.1.7 0.699
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.698
2gr1 FADFerredoxin reductase / 0.698
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.698
1f8r FADL-amino-acid oxidase 1.4.3.2 0.697
1ojt FADDihydrolipoyl dehydrogenase / 0.697
4hsu FADLysine-specific histone demethylase 1B 1 0.697
3he3 FADUDP-galactopyranose mutase / 0.696
2yg6 FADPutrescine oxidase / 0.695
4fk1 FADPutative thioredoxin reductase / 0.695
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.694
1qo8 FADFumarate reductase flavoprotein subunit / 0.694
4mok FADPyranose 2-oxidase / 0.694
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.691
3rha FDAPutrescine oxidase / 0.691
4gdp FADPolyamine oxidase FMS1 / 0.691
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
4b64 FADL-ornithine N(5)-monooxygenase / 0.690
4ntd FADThioredoxin reductase / 0.690
4tm0 FADKtzI / 0.690
4u8k FDAUDP-galactopyranose mutase / 0.690
2yg7 FADPutrescine oxidase / 0.689
3lsi FADPyranose 2-oxidase / 0.689
2gr3 FADFerredoxin reductase / 0.688
2ign FADPyranose 2-oxidase / 0.687
2zbw FADFerredoxin--NADP reductase / 0.686
4opi FDAConserved Archaeal protein / 0.686
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.685
1tde FADThioredoxin reductase 1.8.1.9 0.685
2jb1 FADL-amino acid oxidase / 0.685
4c5o FADPutative monooxygenase / 0.685
1ger FADGlutathione reductase 1.8.1.7 0.684
2rab FADGlutathione amide reductase / 0.684
3nlc FADUncharacterized protein / 0.684
3b6d FAECholesterol oxidase 1.1.3.6 0.683
4eqw FADCoenzyme A disulfide reductase / 0.683
1mxt FAECholesterol oxidase 1.1.3.6 0.680
2gqw FADFerredoxin reductase / 0.680
2jae FADL-amino acid oxidase / 0.680
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
4cnk FADL-amino acid oxidase / 0.679
4opg FDAConserved Archaeal protein / 0.679
2xlp FADPutative flavin-containing monooxygenase / 0.678
4hb9 FADUncharacterized protein / 0.678
2yg5 FADPutrescine oxidase / 0.677
3f8p NADNADH oxidase/thioredoxin reductase / 0.677
4guu FA9Lysine-specific histone demethylase 1B 1 0.677
4yry FADGlutamate synthase, beta subunit / 0.677
3k30 ADPHistamine dehydrogenase / 0.676
4gde FDAUDP-galactopyranose mutase / 0.676
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.675
3uka FADUDP-galactopyranose mutase / 0.675
4usr FADMonooxygenase / 0.675
2yg3 FADPutrescine oxidase / 0.674
2yqu FADDihydrolipoyl dehydrogenase / 0.674
4j56 FADThioredoxin reductase 2 1.8.1.9 0.674
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.673
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.672
2xvi FADPutative flavin-containing monooxygenase / 0.672
4xbf FADLysine-specific histone demethylase 1A 1 0.672
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.672
1f8w FADNADH peroxidase 1.11.1.1 0.671
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
3atr FDAConserved Archaeal protein / 0.671
3k4c FADPyranose 2-oxidase / 0.671
3lsm SFDPyranose 2-oxidase / 0.671
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.670
2vqb FADPutative flavin-containing monooxygenase / 0.670
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.670
1zx9 FADMercuric reductase 1.16.1.1 0.669
3ukl FADUDP-galactopyranose mutase / 0.669
1nhr FADNADH peroxidase 1.11.1.1 0.668
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.668
2hqm FADGlutathione reductase 1.8.1.7 0.668
2q0l FADThioredoxin reductase 1.8.1.9 0.668
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.667
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.667
3ute FADUDP-galactopyranose mutase / 0.667
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.666
3cn8 FADPolyamine oxidase FMS1 / 0.666
1npx FADNADH peroxidase 1.11.1.1 0.665
1ryi FADGlycine oxidase 1.4.3.19 0.665
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.665
3ad9 NADSubunit alpha of sarocosine oxidase / 0.665
3pl8 FADPyranose 2-oxidase / 0.665
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.664
4b1b FADThioredoxin reductase 1.8.1.9 0.664
4mih FADPyranose 2-oxidase 1.1.3.10 0.664
1k0l FADp-hydroxybenzoate hydroxylase / 0.663
3cnt FADPolyamine oxidase FMS1 / 0.663
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.663
4nte FADDepH / 0.663
4xxg FADCholesterol oxidase 1.1.3.6 0.663
1nhp FADNADH peroxidase 1.11.1.1 0.661
2jk6 FADTrypanothione reductase / 0.661
2xvf FADPutative flavin-containing monooxygenase / 0.661
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.661
3bi2 FADPolyamine oxidase FMS1 / 0.660
3uth FDAUDP-galactopyranose mutase / 0.660
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.660
1c0k FADD-amino-acid oxidase 1.4.3.3 0.659
1cl0 FADThioredoxin reductase 1.8.1.9 0.659
1f3p FADFerredoxin reductase / 0.659
2wba FADTrypanothione reductase 1.8.1.12 0.659
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.658
3sz0 FADSulfide-quinone reductase / 0.658
4u8m FDAUDP-galactopyranose mutase / 0.658
1ng3 FADGlycine oxidase 1.4.3.19 0.657
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.657
2rgj FADFlavin-containing monooxygenase / 0.657
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.657
3jsk AHZThiamine thiazole synthase / 0.657
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.657
1get FADGlutathione reductase 1.8.1.7 0.656
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.656
1tdf FADThioredoxin reductase 1.8.1.9 0.656
2xve FADPutative flavin-containing monooxygenase / 0.656
5cku FADL-ornithine N(5)-monooxygenase / 0.656
1cf3 FADGlucose oxidase 1.1.3.4 0.655
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.655
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.655
1z6l FADPolyamine oxidase FMS1 / 0.655
2e1m FADL-glutamate oxidase / 0.654
4gdc FADUDP-galactopyranose mutase / 0.654
1cbo FADCholesterol oxidase 1.1.3.6 0.653
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
3cgc FADCoenzyme A disulfide reductase / 0.653
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
3f8r NAPNADH oxidase/thioredoxin reductase / 0.653
3utf FDAUDP-galactopyranose mutase / 0.653
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.652
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.651
4cnj FADL-amino acid oxidase / 0.651
4ntc FADThioredoxin reductase gliT / 0.651
4x4j FADPutative oxygenase / 0.651
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
1n1p FADCholesterol oxidase 1.1.3.6 0.650
1n4w FADCholesterol oxidase 1.1.3.6 0.650
1trb FADThioredoxin reductase 1.8.1.9 0.650
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.650
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.650