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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yls FAD Phenylacetone monooxygenase 1.14.13.92

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yls FADPhenylacetone monooxygenase 1.14.13.92 1.446
2ylx FADPhenylacetone monooxygenase 1.14.13.92 1.383
4d04 FADPhenylacetone monooxygenase 1.14.13.92 1.383
4d03 FADPhenylacetone monooxygenase 1.14.13.92 1.374
2ylr FADPhenylacetone monooxygenase 1.14.13.92 1.341
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 1.323
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 1.314
2ylt FADPhenylacetone monooxygenase 1.14.13.92 1.311
2ylw FADPhenylacetone monooxygenase 1.14.13.92 1.104
3gwd FADCyclohexanone monooxygenase / 0.989
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.949
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.932
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.922
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.915
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.879
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.816
3gwf FADCyclohexanone monooxygenase / 0.814
2rgh FADAlpha-Glycerophosphate Oxidase / 0.810
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.805
2dw4 FADLysine-specific histone demethylase 1A 1 0.802
2xvh FADPutative flavin-containing monooxygenase / 0.776
2xls FADPutative flavin-containing monooxygenase / 0.768
2vqb FADPutative flavin-containing monooxygenase / 0.767
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.767
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.765
2gv8 FADThiol-specific monooxygenase 1.14.13 0.761
2gvc FADThiol-specific monooxygenase 1.14.13 0.754
4aos FADSteroid monooxygenase / 0.750
4ap1 FADSteroid monooxygenase / 0.750
4ap3 FADSteroid monooxygenase / 0.750
4z24 FADPutative GMC-type oxidoreductase R135 1 0.750
4b64 FADL-ornithine N(5)-monooxygenase / 0.747
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.746
2xvf FADPutative flavin-containing monooxygenase / 0.742
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.741
3qvp FADGlucose oxidase 1.1.3.4 0.736
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.736
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.732
2vq7 FADPutative flavin-containing monooxygenase / 0.732
3nlc FADUncharacterized protein / 0.731
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.729
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.726
2iw5 FADLysine-specific histone demethylase 1A 1 0.725
2xvi FADPutative flavin-containing monooxygenase / 0.724
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.723
4u2l SFDCholesterol oxidase 1.1.3.6 0.720
3qvr FADGlucose oxidase 1.1.3.4 0.718
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.717
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.716
3ukl FADUDP-galactopyranose mutase / 0.712
4xbf FADLysine-specific histone demethylase 1A 1 0.711
4z26 FADPutative GMC-type oxidoreductase R135 1 0.711
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.708
4b63 FADL-ornithine N(5)-monooxygenase / 0.708
2xlr FADPutative flavin-containing monooxygenase / 0.706
4b67 FADL-ornithine N(5)-monooxygenase / 0.706
4yry FADGlutamate synthase, beta subunit / 0.706
2rgo FADAlpha-Glycerophosphate Oxidase / 0.705
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.702
3ukk FDAUDP-galactopyranose mutase / 0.702
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.701
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.701
1ges FADGlutathione reductase 1.8.1.7 0.700
1d7y FADFerredoxin reductase / 0.699
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.698
4fwf FADLysine-specific histone demethylase 1B 1 0.698
4em3 FADCoenzyme A disulfide reductase / 0.697
4eqr FADCoenzyme A disulfide reductase / 0.696
4opt FDAConserved Archaeal protein / 0.696
3f8p NADNADH oxidase/thioredoxin reductase / 0.695
3s5w FADL-ornithine N(5)-monooxygenase / 0.695
1get FADGlutathione reductase 1.8.1.7 0.694
3cgc FADCoenzyme A disulfide reductase / 0.694
4b69 FADL-ornithine N(5)-monooxygenase / 0.694
4em4 FADCoenzyme A disulfide reductase / 0.694
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.693
4eqs FADCoenzyme A disulfide reductase / 0.693
3mj4 FADUDP-galactopyranose mutase / 0.692
4dsg FADUncharacterized protein / 0.691
4tm1 FDAKtzI / 0.691
1cf3 FADGlucose oxidase 1.1.3.4 0.689
4hb9 FADUncharacterized protein / 0.689
4jnq FDAThioredoxin reductase / 0.689
1yqz FADCoenzyme A disulfide reductase / 0.688
4wx1 FDAUDP-galactopyranose mutase / 0.688
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.687
2gr1 FADFerredoxin reductase / 0.687
2xlp FADPutative flavin-containing monooxygenase / 0.687
1h83 FADPolyamine oxidase 1.5.3.14 0.686
3f8d FADNADH oxidase/thioredoxin reductase / 0.686
3k30 ADPHistamine dehydrogenase / 0.685
4eqx FADCoenzyme A disulfide reductase / 0.684
2jb2 FADL-amino acid oxidase / 0.683
4aox FADSteroid monooxygenase / 0.683
4fwe FADLysine-specific histone demethylase 1B 1 0.683
3uka FADUDP-galactopyranose mutase / 0.682
1f3p FADFerredoxin reductase / 0.681
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
3f8r NAPNADH oxidase/thioredoxin reductase / 0.680
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.678
3t2y FADSulfide-quinone reductase / 0.678
3he3 FADUDP-galactopyranose mutase / 0.677
2bab FADPutative aminooxidase / 0.676
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.675
3kkj FADRenalase / 0.675
4c3x FAD3-ketosteroid dehydrogenase / 0.675
4tm3 FADKtzI / 0.675
5hhf FDAUDP-galactopyranose mutase / 0.675
2eq7 NADDihydrolipoyl dehydrogenase / 0.674
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.674
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.672
4gut FADLysine-specific histone demethylase 1B 1 0.672
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.671
3t37 FADPyridoxine 4-oxidase / 0.671
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.669
2yg7 FADPutrescine oxidase / 0.669
3icr FADCoenzyme A disulfide reductase / 0.669
3utf FDAUDP-galactopyranose mutase / 0.669
4qi5 FADCellobiose dehydrogenase / 0.669
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.668
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.668
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.667
3rha FDAPutrescine oxidase / 0.666
4tlz FADKtzI / 0.666
3gyj FADCholesterol oxidase 1.1.3.6 0.665
3vqr FADPutative oxidoreductase / 0.665
4fwj FADLysine-specific histone demethylase 1B 1 0.665
1f8r FADL-amino-acid oxidase 1.4.3.2 0.664
1h81 FADPolyamine oxidase 1.5.3.14 0.664
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
1rsg FADPolyamine oxidase FMS1 / 0.664
3jsk AHZThiamine thiazole synthase / 0.664
3qj4 FADRenalase / 0.664
4rek FADCholesterol oxidase 1.1.3.6 0.664
4mih FADPyranose 2-oxidase 1.1.3.10 0.663
1pdh FASp-hydroxybenzoate hydroxylase / 0.662
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.662
3ihg FADAklavinone 12-hydroxylase RdmE / 0.662
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.662
3pl8 FADPyranose 2-oxidase / 0.662
3ute FADUDP-galactopyranose mutase / 0.662
4u2t FADCholesterol oxidase 1.1.3.6 0.662
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.661
2q7v FADThioredoxin reductase / 0.661
2wba FADTrypanothione reductase 1.8.1.12 0.661
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.661
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.661
4u2s FDACholesterol oxidase 1.1.3.6 0.661
2yvf FADFerredoxin reductase / 0.660
1ng4 FADGlycine oxidase 1.4.3.19 0.659
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.659
2jae FADL-amino acid oxidase / 0.659
2jb1 FADL-amino acid oxidase / 0.659
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.659
3ada NADSubunit alpha of sarocosine oxidase / 0.659
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.659
4mo2 FDAUDP-galactopyranose mutase / 0.659
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.659
3ae4 FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.658
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.658
5cku FADL-ornithine N(5)-monooxygenase / 0.658
1b8s FADCholesterol oxidase 1.1.3.6 0.657
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.657
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.657
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.657
3gyi FADCholesterol oxidase 1.1.3.6 0.656
3ish FADThioredoxin reductase 1.8.1.9 0.656
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.655
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.655
4gdd FADUDP-galactopyranose mutase / 0.655
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
2igo FADPyranose 2-oxidase / 0.654
1nhr FADNADH peroxidase 1.11.1.1 0.653
3lad FADDihydrolipoyl dehydrogenase / 0.652
1zx9 FADMercuric reductase 1.16.1.1 0.651
2cvj FADThioredoxin reductase related protein / 0.651
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.651
4qi7 FADCellobiose dehydrogenase / 0.651
1cc2 FADCholesterol oxidase 1.1.3.6 0.650
1knr FADL-aspartate oxidase 1.4.3.16 0.650
3fpz AHZThiamine thiazole synthase / 0.650
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.650