sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 1.275 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 1.003 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 1.001 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 1.000 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.992 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.986 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.983 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.964 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.958 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.939 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.935 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.935 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.933 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.927 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.926 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.926 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.926 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.919 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.912 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.909 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.903 | |
| 4kwh | NAP | Reductase homolog | / | 0.901 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.897 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.896 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.896 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.895 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.891 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.889 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.889 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.889 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.888 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.880 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.873 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.872 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.867 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.866 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.865 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.865 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.865 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.865 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.863 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.862 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.858 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.857 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.857 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.855 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.854 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.851 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.851 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.850 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.848 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.848 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.845 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.845 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.843 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.842 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.841 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.841 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.839 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.838 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.837 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.834 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.834 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.833 | |
| 3sju | NDP | Keto reductase | / | 0.831 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.830 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.825 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.825 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.824 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.824 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.823 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.821 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.819 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.818 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.816 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.814 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.814 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.812 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.812 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.811 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.810 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.810 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.809 | |
| 1iy8 | NAD | Levodione reductase | / | 0.808 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.808 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.807 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.805 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.804 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.804 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.802 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.802 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.801 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.801 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.801 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.800 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.800 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.799 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.795 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.793 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.791 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.790 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.790 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.789 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.789 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.789 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.788 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.788 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.788 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.787 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.786 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.785 | |
| 4qed | NAP | ElxO | / | 0.785 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.784 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.784 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.783 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.782 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.782 | |
| 4qec | NAP | ElxO | / | 0.782 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.780 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.780 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.776 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.776 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.775 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.774 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.774 | |
| 3mje | NDP | AmphB | / | 0.774 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.773 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.773 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.772 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.772 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.771 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.769 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.768 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.768 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.767 | |
| 3bmo | NAP | Pteridine reductase | / | 0.767 | |
| 3uce | NDP | Dehydrogenase | / | 0.764 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.764 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.763 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.762 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.762 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.761 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.760 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.758 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.754 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.752 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.752 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.752 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.752 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.751 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.750 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.749 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.748 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.748 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.746 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.746 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.746 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.746 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.745 | |
| 4u7w | NDP | MxaA | / | 0.745 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.744 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.743 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.743 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.742 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.741 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.740 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.740 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.739 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.739 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.737 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.736 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.736 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.735 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.735 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.732 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.732 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.731 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.729 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.728 | |
| 4clo | NAP | Pteridine reductase | / | 0.728 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.725 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.725 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.724 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.723 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.722 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.721 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.720 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.720 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.719 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.719 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.719 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.718 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.716 | |
| 5d2e | NAP | MlnE | / | 0.716 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.715 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.715 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.714 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.713 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.712 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.711 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.710 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.710 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.710 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.707 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.706 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.705 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.705 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.704 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.704 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.704 | |
| 2hmv | ADP | Ktr system potassium uptake protein A | / | 0.702 | |
| 1sny | NAP | LD36273p | / | 0.699 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.697 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.696 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.696 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.696 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.696 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.695 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.695 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.694 | |
| 4hxy | NDP | Plm1 | / | 0.694 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.692 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.690 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.690 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.690 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.689 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.688 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.687 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.687 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.686 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.686 | |
| 10mh | SAH | Modification methylase HhaI | 2.1.1.37 | 0.685 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.683 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.683 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.683 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.683 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.683 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.683 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.682 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.681 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.681 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.681 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.681 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.680 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.679 | |
| 4gbe | SAH | DNA adenine methylase | 2.1.1.72 | 0.679 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.676 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.676 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.675 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.674 | |
| 5a04 | NDP | Glucose-fructose oxidoreductase | / | 0.674 | |
| 2g82 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.672 | |
| 2i9k | SAH | Modification methylase HhaI | 2.1.1.37 | 0.672 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.671 | |
| 3adp | NAI | Lambda-crystallin | 1.1.1.45 | 0.671 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.671 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.670 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.669 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.669 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.668 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.668 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.668 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.668 | |
| 3uj8 | SFG | Phosphoethanolamine N-methyltransferase | / | 0.666 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.665 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.665 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.664 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.664 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.664 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.663 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.663 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.661 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.661 | |
| 1evj | NAD | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.660 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.660 | |
| 3k30 | ADP | Histamine dehydrogenase | / | 0.660 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.660 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.659 | |
| 3qvx | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.658 | |
| 4okn | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.658 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.658 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.657 | |
| 1p1h | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.657 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.656 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.656 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.656 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.655 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.655 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.655 | |
| 1mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.654 | |
| 3ihg | FAD | Aklavinone 12-hydroxylase RdmE | / | 0.654 | |
| 5a06 | NDP | Glucose-fructose oxidoreductase | / | 0.654 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.653 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.653 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.653 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.653 | |
| 4y0k | NAP | AntE | / | 0.653 | |
| 1wy7 | SAH | Uncharacterized protein | / | 0.652 | |
| 2nyu | SAM | rRNA methyltransferase 2, mitochondrial | / | 0.652 | |
| 4e5k | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.652 | |
| 4y1b | NAP | AntE | / | 0.652 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.651 | |
| 3ou6 | SAM | SAM-dependent methyltransferase | / | 0.651 | |
| 4ihi | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.651 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.651 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.650 | |
| 3cox | FAD | Cholesterol oxidase | 1.1.3.6 | 0.650 | |
| 3iup | NDP | Possible NADH oxidoreductase | / | 0.650 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.650 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.650 | |
| 4j43 | NAD | Uncharacterized protein | / | 0.650 |