sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 1.299 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.938 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.936 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.894 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.891 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.883 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.873 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.870 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.866 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.866 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.856 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.853 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.850 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.847 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.837 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.836 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.834 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.826 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.826 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.824 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.821 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.818 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.817 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.816 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.816 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.815 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.814 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.812 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.809 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.807 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.805 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.801 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.798 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.796 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.793 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.793 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.792 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.792 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.791 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.790 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.789 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.789 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.788 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.787 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.786 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.786 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.786 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.785 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.784 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.781 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.781 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.780 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.779 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.778 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.776 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.775 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.775 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.773 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.772 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.772 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.770 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.767 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.767 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.767 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.767 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.767 | |
| 4kwh | NAP | Reductase homolog | / | 0.767 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.766 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.765 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.765 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.764 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.762 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.760 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.760 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.759 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.759 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.759 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.759 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.759 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.758 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.758 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.756 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.756 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.756 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.756 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.755 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.754 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.754 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.753 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.753 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.749 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.748 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.747 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.747 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.746 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.746 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.745 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.745 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.743 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.743 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.742 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.738 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.738 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.736 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.735 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.735 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.733 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.733 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.733 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.732 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.731 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.731 | |
| 4qed | NAP | ElxO | / | 0.731 | |
| 4hxy | NDP | Plm1 | / | 0.730 | |
| 4u7w | NDP | MxaA | / | 0.730 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.729 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.729 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.729 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.728 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.728 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.727 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.727 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.726 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.726 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.725 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.725 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.725 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.724 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.724 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.721 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.721 | |
| 1iy8 | NAD | Levodione reductase | / | 0.719 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.718 | |
| 4qec | NAP | ElxO | / | 0.718 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.716 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.715 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.715 | |
| 2hmv | ADP | Ktr system potassium uptake protein A | / | 0.714 | |
| 1wy7 | SAH | Uncharacterized protein | / | 0.713 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.713 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.713 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.713 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.712 | |
| 3mje | NDP | AmphB | / | 0.712 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.712 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.712 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.712 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.710 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.707 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.707 | |
| 2o06 | MTA | Spermidine synthase | 2.5.1.16 | 0.707 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.706 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.705 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.705 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.704 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.704 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.704 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.703 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.702 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.702 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.701 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.701 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.701 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.700 | |
| 4o29 | SAH | Protein-L-isoaspartate O-methyltransferase | / | 0.699 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.698 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.697 | |
| 3uce | NDP | Dehydrogenase | / | 0.697 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.696 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.696 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.694 | |
| 4kwc | SAH | Methyltransferase domain family | / | 0.694 | |
| 2p35 | SAH | Trans-aconitate 2-methyltransferase | / | 0.693 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.693 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.692 | |
| 3adp | NAI | Lambda-crystallin | 1.1.1.45 | 0.691 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.690 | |
| 2ixb | NAD | Alpha-N-acetylgalactosaminidase | 3.2.1.49 | 0.690 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.690 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.689 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.689 | |
| 2bh2 | SAH | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | / | 0.689 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.689 | |
| 3sju | NDP | Keto reductase | / | 0.689 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.688 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.688 | |
| 4y9d | NAI | C alpha-dehydrogenase | / | 0.688 | |
| 5d2e | NAP | MlnE | / | 0.688 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.687 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.686 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.685 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.683 | |
| 1y9d | FAD | Pyruvate oxidase | 1.2.3.3 | 0.682 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.682 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.682 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.682 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.682 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.681 | |
| 2dt5 | NAD | Redox-sensing transcriptional repressor Rex | / | 0.681 | |
| 3ec7 | NAD | Inositol 2-dehydrogenase | / | 0.681 | |
| 3rw9 | DSH | Spermidine synthase | 2.5.1.16 | 0.681 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.681 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.681 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.680 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.680 | |
| 4fgz | SAH | Phosphoethanolamine N-methyltransferase | / | 0.680 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.679 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.679 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.678 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.678 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.678 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.678 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.677 | |
| 2pt6 | S4M | Spermidine synthase | / | 0.677 | |
| 5kcp | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.677 | |
| 1i9g | SAM | tRNA (adenine(58)-N(1))-methyltransferase TrmI | / | 0.676 | |
| 1o6z | NAD | Malate dehydrogenase | / | 0.676 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.676 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.676 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.675 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.675 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.674 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.674 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.673 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.673 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.672 | |
| 1uay | ADN | Oxidoreductase | / | 0.671 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.671 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.671 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.670 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.670 | |
| 1sny | NAP | LD36273p | / | 0.670 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.669 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.669 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.669 | |
| 2okc | SAM | Probable type I restriction enzyme BthVORF4518P M protein | 2.1.1.72 | 0.669 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.668 | |
| 4pyn | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.668 | |
| 1f0y | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.666 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.666 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.666 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.666 | |
| 3epp | SFG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.666 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.666 | |
| 4xcx | SAH | Small RNA 2'-O-methyltransferase | / | 0.666 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.665 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.665 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.665 | |
| 4kvz | SAH | PtnL protein | / | 0.665 | |
| 4nfh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.665 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.664 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.664 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.664 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.663 | |
| 5cdg | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.663 | |
| 1p1h | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.662 | |
| 5cds | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.661 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.661 | |
| 3cmc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.661 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.661 | |
| 5kjf | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.661 | |
| 1rjg | SAH | Leucine carboxyl methyltransferase 1 | 2.1.1.233 | 0.660 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.659 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.659 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.659 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.658 | |
| 1gd1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.658 | |
| 1jki | NAI | Inositol-3-phosphate synthase | 5.5.1.4 | 0.658 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.658 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.657 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.657 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.657 | |
| 2z6u | SAH | Modification methylase HhaI | 2.1.1.37 | 0.657 | |
| 3t7s | SAM | Uncharacterized protein | / | 0.657 | |
| 3zdn | FAD | Monoamine oxidase N | 1.4.3.4 | 0.657 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.656 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.656 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.656 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.655 | |
| 4pyo | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.655 | |
| 4yv0 | S4M | Spermidine synthase, putative | / | 0.655 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.655 | |
| 1sqf | SAM | Ribosomal RNA small subunit methyltransferase B | 2.1.1.176 | 0.654 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.654 | |
| 2ji7 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.654 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.654 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.654 | |
| 2cdu | ADP | NADH oxidase | / | 0.653 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.653 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.653 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.652 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.652 | |
| 1qyx | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.652 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.652 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.652 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.652 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.652 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.652 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.651 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.651 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.650 | |
| 3abi | NAD | Uncharacterized protein | / | 0.650 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.650 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.650 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.650 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.650 |