Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4n3b12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4n3b12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/1.000
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.488
1fwkADPHomoserine kinase2.7.1.390.485
2qbnCAMCamphor 5-monooxygenase1.14.15.10.484
4kwi1TJReductase homolog/0.481
1qvnFRIInterleukin-2/0.479
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.478
1kkq471Peroxisome proliferator-activated receptor alpha/0.474
2givACOHistone acetyltransferase KAT8/0.474
2hcdBIVVitamin D3 receptor A/0.473
4er7AW3Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.472
5a3bAPRSIR2 family protein/0.472
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.470
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.469
4aoxFADSteroid monooxygenase/0.469
2c29NAPDihydroflavonol 4-reductase/0.468
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.468
3l0lHC3Nuclear receptor ROR-gamma/0.467
2r26CMCCitrate synthase2.3.3.160.466
3ln3NADAldo-keto reductase family 1 member C13/0.466
3t2zFADSulfide-quinone reductase/0.466
2hb7O1CVitamin D3 receptor/0.465
4ia3BIVVitamin D3 receptor A/0.465
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.465
2xgoZKDUncharacterized protein/0.464
2z3uCRRCytochrome P450/0.463
4a1zADPKinesin-like protein KIF11/0.463
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.463
4mihFADPyranose 2-oxidase1.1.3.100.463
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.462
3vt7VDXVitamin D3 receptor/0.462
3vt8YI3Vitamin D3 receptor/0.462
4gh5NADShort-chain dehydrogenase/reductase SDR/0.462
4y93746Tyrosine-protein kinase/0.462
2ou2ACOHistone acetyltransferase KAT5/0.461
3iaeD7KBenzaldehyde lyase/0.461
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.461
4g210VPVitamin D3 receptor A/0.461
4ktc1X3Genome polyprotein3.4.21.980.461
1qf5RPLAdenylosuccinate synthetase/0.460
3clsFADElectron transfer flavoprotein subunit alpha/0.460
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.460
4ejmNAPPutative zinc-binding dehydrogenase/0.460
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.460
4j54G52Gag-Pol polyprotein3.4.23.160.460
4xybNDPFormate dehydrogenase/0.460
1dz6CAMCamphor 5-monooxygenase1.14.15.10.459
1s5kCOAAminoglycoside N(6')-acetyltransferase type 1/0.459
1x2hLPALipoate-protein ligase A6.3.1.200.459
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.459
4f4qFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.459
4q72FADBifunctional protein PutA/0.459
1v35NAIEnoyl-ACP reductase/0.458
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.458
2gtmLIDMitogen-activated protein kinase 14/0.457
2rewREWPeroxisome proliferator-activated receptor alpha/0.457
3d7kD7KBenzaldehyde lyase/0.457
3oquA8SAbscisic acid receptor PYL9/0.457
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.457
4kwhNAPReductase homolog/0.457
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.457
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1iy8NADLevodione reductase/0.456
1pr9NAPL-xylulose reductase1.1.1.100.456
2jd1NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.456
3bi2FADPolyamine oxidase FMS1/0.456
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.456
4hxyNDPPlm1/0.456
4i02CMPcAMP-activated global transcriptional regulator CRP/0.456
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
2y0mACOHistone acetyltransferase KAT8/0.455
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.455
3pgpACOUncharacterized protein/0.455
4b8zNAPGDP-L-fucose synthase1.1.1.2710.455
4g95OAGDihydrofolate reductase1.5.1.30.455
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.455
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.454
1sn5T3Transthyretin/0.454
2cvjFADThioredoxin reductase related protein/0.454
2y05NAPProstaglandin reductase 1/0.454
3h2nB62Dihydropteroate synthase/0.454
3v0tATRPerakine reductase1.1.1.3170.454
1ng4FADGlycine oxidase1.4.3.190.453
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
2x7hPFNProstaglandin reductase 310.453
3u8w09JMitogen-activated protein kinase 14/0.453
3w0iO11Vitamin D3 receptor/0.453
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.453
4c717RD3-oxoacyl-ACP synthase/0.453
4l4xNDPAmphI/0.453
1nvtNAPShikimate dehydrogenase (NADP(+))/0.452
3nfaCBJGag-Pol polyprotein/0.452
4iaq2GM5-hydroxytryptamine receptor 1B/0.452
4ruoBIVVitamin D3 receptor A/0.452
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.452
5l3dFADLysine-specific histone demethylase 1A10.452
3fwgCAMCamphor 5-monooxygenase1.14.15.10.451
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.451
3nj0PYVAbscisic acid receptor PYL2/0.451
3nmpPYVAbscisic acid receptor PYL2/0.451
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.451
3stv3HOMethylketone synthase I/0.451
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
5fkkTDCTetracycline repressor protein class D/0.451
1mjaCOAHistone acetyltransferase ESA1/0.450
1ofgNDPGlucose--fructose oxidoreductase1.1.99.280.450
1rc0KT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.450
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.450
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.450
3atzFMNProstaglandin F2a synthase/0.450
3fwiCAMCamphor 5-monooxygenase1.14.15.10.450
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.450
4xg1LLPDiaminopimelate decarboxylase/0.450
5k2aZMAAdenosine receptor A2a/0.450
1fbmRTLCartilage oligomeric matrix protein/0.449
1rf7DHFDihydrofolate reductase1.5.1.30.449
1y4lSVRBasic phospholipase A2 homolog 2/0.449
2hkoFADLysine-specific histone demethylase 1A10.449
2qo9ANPEphrin type-A receptor 32.7.10.10.449
2rc4ACOHistone acetyltransferase KAT6A/0.449
2zuiCAMCamphor 5-monooxygenase1.14.15.10.449
3ds6A17Mitogen-activated protein kinase 14/0.449
3h6vNS6Glutamate receptor 2/0.449
3uleC69Actin-related protein 3/0.449
3vdqNAD3-hydroxybutyrate dehydrogenase/0.449
4g1z0VPVitamin D3 receptor A/0.449
4g2h0VQVitamin D3 receptor A/0.449
4ia1BIVVitamin D3 receptor A/0.449
4jnqFDAThioredoxin reductase/0.449
4q71FADBifunctional protein PutA/0.449
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.448
1mjbACOHistone acetyltransferase ESA1/0.448
3cukFADD-amino-acid oxidase1.4.3.30.448
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3hk1B64Fatty acid-binding protein, adipocyte/0.448
3och2MXDihydrofolate reductase1.5.1.30.448
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.448
3w5tLHPVitamin D3 receptor/0.448
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.448
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.448
4iarERM5-hydroxytryptamine receptor 1B/0.448
4ryvZEAProtein LlR18A/0.448
4y95746Tyrosine-protein kinase/0.448
4zcaADPKinesin-like protein KIF11/0.448
4zp1TPPPyruvate decarboxylase4.1.1.10.448
2jahNDPClavaldehyde dehydrogenase/0.447
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
2q59240Peroxisome proliferator-activated receptor gamma/0.447
2znq401Peroxisome proliferator-activated receptor delta/0.447
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.447
3h1vTK1Glucokinase2.7.1.20.447
3kpkFADSulfide-quinone reductase/0.447
3w0gW07Vitamin D3 receptor/0.447
3wrmCAMCamphor 5-monooxygenase1.14.15.10.447
4g1y0VOVitamin D3 receptor A/0.447
4xq9NADHomospermidine synthase2.5.1.440.447
1njfAGSDNA polymerase III subunit tau2.7.7.70.446
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.446
2p2xSAHDiphthine synthase/0.446
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.446
2vkeTACTetracycline repressor protein class D/0.446
3t4hMD5Alpha-ketoglutarate-dependent dioxygenase AlkB1.14.11.330.446
4a99FADTetX family tetracycline inactivation enzyme/0.446
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.446
4g2fC07Ephrin type-A receptor 32.7.10.10.446
5cvcPLPSerine racemase/0.446
1d4cFADFumarate reductase flavoprotein subunit1.3.5.40.445
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
1me8RVPInosine-5'-monophosphate dehydrogenase/0.445
1sdmADPKinesin heavy chain-like protein/0.445
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.445
2y3rTRKTamL/0.445
3em6017Gag-Pol polyprotein3.4.23.160.445
3fznD7KBenzoylformate decarboxylase4.1.1.70.445
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
4gt3ATPMitogen-activated protein kinase 12.7.11.240.445
4ih71ERGenome polyprotein2.7.7.480.445
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.445
5dp2NAPCurF/0.445
1dr3HBIDihydrofolate reductase1.5.1.30.444
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.444
1me6IVSPlasmepsin-23.4.23.390.444
1pzhNADLactate dehydrogenase/0.444
2igyA2TPlasmepsin 2/0.444
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.444
2x6o2TCTetracycline repressor protein class D/0.444
3cluFADElectron transfer flavoprotein subunit alpha/0.444
3grySAMProbable ribosomal RNA small subunit methyltransferase A/0.444
3lsmSFDPyranose 2-oxidase/0.444
3s7bNH5N-lysine methyltransferase SMYD2/0.444
3vt9YI4Vitamin D3 receptor/0.444
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.444
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.444
4rujVDXVitamin D3 receptor A/0.444
4tuvCPZCytochrome P450 1191.140.444
5cccDDFDihydrofolate reductase1.5.1.30.444
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.444
1dhiMTXDihydrofolate reductase1.5.1.30.443
1dz4CAMCamphor 5-monooxygenase1.14.15.10.443
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2feuCAMCamphor 5-monooxygenase1.14.15.10.443
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.443
2o0uC0MMitogen-activated protein kinase 102.7.11.240.443
2ym1FADPhenylacetone monooxygenase1.14.13.920.443
3cn8FADPolyamine oxidase FMS1/0.443
3d8xFADThioredoxin reductase 11.8.1.90.443
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4dh60KNBeta-secretase 13.4.23.460.443
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.443
4u2lSFDCholesterol oxidase1.1.3.60.443
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1pd9CO4Dihydrofolate reductase1.5.1.30.442
1xmsANPProtein RecA/0.442
1ykdCMPAdenylate cyclase/0.442
2a1nCAMCamphor 5-monooxygenase1.14.15.10.442
2g8yNADHydroxycarboxylate dehydrogenase B/0.442
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.442
2ykjYKJHeat shock protein HSP 90-alpha/0.442
3cic316Beta-secretase 13.4.23.460.442
3f1kNAPUncharacterized oxidoreductase YciK10.442
3w8eNAD3-hydroxybutyrate dehydrogenase/0.442
4dbzNDPPutative ketoacyl reductase1.3.10.442
4echFADPolyamine oxidase FMS1/0.442
4edz0O5Hematopoietic prostaglandin D synthase/0.442
4g9lNGHStromelysin-13.4.24.170.442
4q73FADBifunctional protein PutA/0.442
1vdcFADThioredoxin reductase 1, mitochondrial1.8.1.90.441
2iwuNP5ATP-dependent molecular chaperone HSP82/0.441
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.441
2qblCAMCamphor 5-monooxygenase1.14.15.10.441
2tscCB3Thymidylate synthase/0.441
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3p7nFMNLight-activated DNA-binding protein EL222/0.441
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3ukuC69Actin-related protein 3/0.441
3uteFADUDP-galactopyranose mutase/0.441
3vi2HMZOrotidine 5'-monophosphate decarboxylase/0.441
3zsh469Mitogen-activated protein kinase 14/0.441
4ez8DHFThymidylate synthase2.1.1.450.441
4xxvNAD3-isopropylmalate dehydrogenase/0.441
1cg1IMOAdenylosuccinate synthetase/0.440
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.440
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
1jpaANPEphrin type-B receptor 22.7.10.10.440
1nvmNADAcetaldehyde dehydrogenase1.2.1.100.440
1qf4RPDAdenylosuccinate synthetase/0.440
1rbzKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.440
1ryiFADGlycine oxidase1.4.3.190.440
2qboCAMCamphor 5-monooxygenase1.14.15.10.440
2ywwATPAspartate carbamoyltransferase regulatory chain/0.440
3drrR8EGag-Pol polyprotein2.7.7.490.440
3gtsD3MDdmC/0.440
3to6LYS_CMCHistone acetyltransferase ESA1/0.440
3vrwYS5Vitamin D3 receptor/0.440
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.440
5k2cZMAAdenosine receptor A2a/0.440