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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3r9oZ71Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3r9oZ71Cyclin-dependent kinase 22.7.11.221.000
3qtzX42Cyclin-dependent kinase 22.7.11.220.664
4fko20KCyclin-dependent kinase 22.7.11.220.626
3rak03ZCyclin-dependent kinase 22.7.11.220.609
3rmf20ZCyclin-dependent kinase 22.7.11.220.598
3s1h56ZCyclin-dependent kinase 22.7.11.220.595
3qu0X40Cyclin-dependent kinase 22.7.11.220.593
3rpv26ZCyclin-dependent kinase 22.7.11.220.593
4fkv61KCyclin-dependent kinase 22.7.11.220.593
4fkw62KCyclin-dependent kinase 22.7.11.220.585
1urwI1PCyclin-dependent kinase 22.7.11.220.581
3sw418KCyclin-dependent kinase 22.7.11.220.575
3r9dX6BCyclin-dependent kinase 22.7.11.220.571
3uli1N3Cyclin-dependent kinase 22.7.11.220.567
4fkr45KCyclin-dependent kinase 22.7.11.220.563
1y91CT9Cyclin-dependent kinase 22.7.11.220.561
3qtuX44Cyclin-dependent kinase 22.7.11.220.559
3r9hZ67Cyclin-dependent kinase 22.7.11.220.557
3rk708ZCyclin-dependent kinase 22.7.11.220.556
3ral04ZCyclin-dependent kinase 22.7.11.220.553
1di8DTQCyclin-dependent kinase 22.7.11.220.552
1gih1PUCyclin-dependent kinase 22.7.11.220.552
4acm7YGCyclin-dependent kinase 22.7.11.220.551
3rni21ZCyclin-dependent kinase 22.7.11.220.550
3sw719KCyclin-dependent kinase 22.7.11.220.550
2b52D42Cyclin-dependent kinase 22.7.11.220.546
1ke9LS5Cyclin-dependent kinase 22.7.11.220.544
3ti1B49Cyclin-dependent kinase 22.7.11.220.542
3unk0BYCyclin-dependent kinase 22.7.11.220.542
1g5sI17Cyclin-dependent kinase 22.7.11.220.541
2r3lSCWCyclin-dependent kinase 22.7.11.220.541
1ckpPVBCyclin-dependent kinase 22.7.11.220.539
1oitHDTCyclin-dependent kinase 22.7.11.220.539
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.539
2xmyCDKCyclin-dependent kinase 22.7.11.220.538
2iw94SPCyclin-dependent kinase 22.7.11.220.536
3rjc06ZCyclin-dependent kinase 22.7.11.220.536
3unj0BXCyclin-dependent kinase 22.7.11.220.535
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.533
3r8lZ30Cyclin-dependent kinase 22.7.11.220.533
1aq1STUCyclin-dependent kinase 22.7.11.220.532
2xnbY8LCyclin-dependent kinase 22.7.11.220.531
1ke6LS2Cyclin-dependent kinase 22.7.11.220.530
4fks46KCyclin-dependent kinase 22.7.11.220.530
3s2pPMUCyclin-dependent kinase 22.7.11.220.529
2w06FRVCyclin-dependent kinase 22.7.11.220.528
4ek816KCyclin-dependent kinase 22.7.11.220.528
2w1hL0FCyclin-dependent kinase 22.7.11.220.527
2btsU32Cyclin-dependent kinase 22.7.11.220.526
2c6o4SPCyclin-dependent kinase 22.7.11.220.526
3rpy27ZCyclin-dependent kinase 22.7.11.220.526
4fkq42KCyclin-dependent kinase 22.7.11.220.526
1oi9N20Cyclin-dependent kinase 22.7.11.220.524
1oiyN41Cyclin-dependent kinase 22.7.11.220.524
2vv9IM9Cyclin-dependent kinase 22.7.11.220.524
3qtxX43Cyclin-dependent kinase 22.7.11.220.524
3rk507ZCyclin-dependent kinase 22.7.11.220.524
3rk909ZCyclin-dependent kinase 22.7.11.220.524
2iw84SPCyclin-dependent kinase 22.7.11.220.523
4erwSTUCyclin-dependent kinase 22.7.11.220.523
2r64740Cyclin-dependent kinase 22.7.11.220.521
3lfnA27Cyclin-dependent kinase 22.7.11.220.521
1h1s4SPCyclin-dependent kinase 22.7.11.220.520
2bhhRYUCyclin-dependent kinase 22.7.11.220.520
1gij2PUCyclin-dependent kinase 22.7.11.220.518
2w17I19Cyclin-dependent kinase 22.7.11.220.518
3ezvEZVCyclin-dependent kinase 22.7.11.220.517
3py0SU9Cyclin-dependent kinase 22.7.11.220.517
1pxmCK5Cyclin-dependent kinase 22.7.11.220.516
3sqq99ZCyclin-dependent kinase 22.7.11.220.516
4bgh3I6Cyclin-dependent kinase 22.7.11.220.516
4fkt48KCyclin-dependent kinase 22.7.11.220.515
1p2a5BNCyclin-dependent kinase 22.7.11.220.514
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.514
1pyePM1Cyclin-dependent kinase 22.7.11.220.513
4ek610KCyclin-dependent kinase 22.7.11.220.513
1ke5LS1Cyclin-dependent kinase 22.7.11.220.511
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.511
3qtrX36Cyclin-dependent kinase 22.7.11.220.511
4fkg4CKCyclin-dependent kinase 22.7.11.220.511
1gii1PUCyclin-dependent kinase 22.7.11.220.510
3qxoX65Cyclin-dependent kinase 22.7.11.220.510
4fki09KCyclin-dependent kinase 22.7.11.220.510
3ddpRC8Cyclin-dependent kinase 22.7.11.220.509
3pxyJWSCyclin-dependent kinase 22.7.11.220.508
1pxoCK7Cyclin-dependent kinase 22.7.11.220.506
2pvnP63Casein kinase II subunit alpha2.7.11.10.506
3bhtMFRCyclin-dependent kinase 22.7.11.220.506
3tnwF18Cyclin-dependent kinase 22.7.11.220.506
2c6tDT5Cyclin-dependent kinase 22.7.11.220.505
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.505
2vthLZ2Cyclin-dependent kinase 22.7.11.220.504
2vttLZDCyclin-dependent kinase 22.7.11.220.504
4dgo0JWCasein kinase II subunit alpha2.7.11.10.504
4qmpDKISerine/threonine-protein kinase 242.7.11.10.502
2b55D31Cyclin-dependent kinase 22.7.11.220.501
3lfsA07Cyclin-dependent kinase 22.7.11.220.501
4fx360KCyclin-dependent kinase 22.7.11.220.500
1fvv107Cyclin-dependent kinase 22.7.11.220.499
2eufLQQCyclin-dependent kinase 62.7.11.220.499
2x1nX1NCyclin-dependent kinase 22.7.11.220.499
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.497
2uznC96Cyclin-dependent kinase 22.7.11.220.495
4fkpLS5Cyclin-dependent kinase 22.7.11.220.495
3qwkX62Cyclin-dependent kinase 22.7.11.220.494
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.494
1oguST8Cyclin-dependent kinase 22.7.11.220.493
1r78FMDCyclin-dependent kinase 22.7.11.220.493
3lfqA28Cyclin-dependent kinase 22.7.11.220.493
3r7uX96Cyclin-dependent kinase 22.7.11.220.493
1v1k3FPCyclin-dependent kinase 22.7.11.220.492
2a0cCK9Cyclin-dependent kinase 22.7.11.220.492
3r8vZ62Cyclin-dependent kinase 22.7.11.220.492
4dgnLU2Casein kinase II subunit alpha2.7.11.10.492
1h1r6CPCyclin-dependent kinase 22.7.11.220.491
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.491
3roy22ZCyclin-dependent kinase 22.7.11.220.491
2r3kSCQCyclin-dependent kinase 22.7.11.220.489
3qzgX67Cyclin-dependent kinase 22.7.11.220.489
1pxlCK4Cyclin-dependent kinase 22.7.11.220.488
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.487
1fvt106Cyclin-dependent kinase 22.7.11.220.486
2j9mPY8Cyclin-dependent kinase 22.7.11.220.486
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.486
3ddqRRCCyclin-dependent kinase 22.7.11.220.486
3pj8404Cyclin-dependent kinase 22.7.11.220.486
3r1sX73Cyclin-dependent kinase 22.7.11.220.486
1ke7LS3Cyclin-dependent kinase 22.7.11.220.485
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.485
2btrU73Cyclin-dependent kinase 22.7.11.220.485
2uzeC95Cyclin-dependent kinase 22.7.11.220.485
3r83Z14Cyclin-dependent kinase 22.7.11.220.485
4ez30S0Cyclin-dependent kinase 22.7.11.220.485
1vyw292Cyclin-dependent kinase 22.7.11.220.484
2c6iDT1Cyclin-dependent kinase 22.7.11.220.484
2uzdC85Cyclin-dependent kinase 22.7.11.220.484
3be9P04Casein kinase II subunit alpha2.7.11.10.484
3raiX85Cyclin-dependent kinase 22.7.11.220.484
3r8zZ63Cyclin-dependent kinase 22.7.11.220.483
3wblPDYCyclin-dependent kinase 22.7.11.220.483
3fz1B98Cyclin-dependent kinase 22.7.11.220.482
4jqeANPCasein kinase II subunit alpha2.7.11.10.482
3s0o50ZCyclin-dependent kinase 22.7.11.220.480
2bheBRYCyclin-dependent kinase 22.7.11.220.479
2c5nCK8Cyclin-dependent kinase 22.7.11.220.479
3qqkX02Cyclin-dependent kinase 22.7.11.220.479
3r7vZ02Cyclin-dependent kinase 22.7.11.220.479
4aua4AUCyclin-dependent kinase 62.7.11.220.479
4eok4SPCyclin-dependent kinase 22.7.11.220.478
4fkj11KCyclin-dependent kinase 22.7.11.220.478
4nj32KDCyclin-dependent kinase 22.7.11.220.478
1ke8LS4Cyclin-dependent kinase 22.7.11.220.477
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
1w0xOLOCyclin-dependent kinase 22.7.11.220.477
3r1yX76Cyclin-dependent kinase 22.7.11.220.477
3rm618ZCyclin-dependent kinase 22.7.11.220.477
2r3iSCFCyclin-dependent kinase 22.7.11.220.476
3iggEFQCyclin-dependent kinase 22.7.11.220.476
3rkb12ZCyclin-dependent kinase 22.7.11.220.476
4bcpT3CCyclin-dependent kinase 22.7.11.220.476
4eon1ROCyclin-dependent kinase 22.7.11.220.475
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.475
1oiuN76Cyclin-dependent kinase 22.7.11.220.474
3hmm855TGF-beta receptor type-12.7.11.300.474
1e9hINRCyclin-dependent kinase 22.7.11.220.473
2uzoC62Cyclin-dependent kinase 22.7.11.220.473
3gxlQIGTGF-beta receptor type-12.7.11.300.473
3le62BZCyclin-dependent kinase 22.7.11.220.473
3qzhX69Cyclin-dependent kinase 22.7.11.220.473
1pxpCK8Cyclin-dependent kinase 22.7.11.220.472
2wihP48Cyclin-dependent kinase 22.7.11.220.472
3r6xX84Cyclin-dependent kinase 22.7.11.220.472
3r7iX9ICyclin-dependent kinase 22.7.11.220.472
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.472
4bcmT7ZCyclin-dependent kinase 22.7.11.220.472
4dgmAGICasein kinase II subunit alpha2.7.11.10.472
4anmWULCasein kinase II subunit alpha2.7.11.10.471
4eomATPCyclin-dependent kinase 22.7.11.220.471
4eos1ROCyclin-dependent kinase 22.7.11.220.471
1oirHDYCyclin-dependent kinase 22.7.11.220.470
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.470
3ql8X01Cyclin-dependent kinase 22.7.11.220.470
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.468
4eor4SPCyclin-dependent kinase 22.7.11.220.468
1vyzN5BCyclin-dependent kinase 22.7.11.220.467
2duv371Cyclin-dependent kinase 22.7.11.220.467
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.467
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.467
1ykr628Cyclin-dependent kinase 22.7.11.220.466
2vtqLZACyclin-dependent kinase 22.7.11.220.466
4bcnT9NCyclin-dependent kinase 22.7.11.220.466
1m2pHNACasein kinase II subunit alpha2.7.11.10.465
2uzlC94Cyclin-dependent kinase 22.7.11.220.465
3r1qX75Cyclin-dependent kinase 22.7.11.220.465
1h1pCMGCyclin-dependent kinase 22.7.11.220.464
1om1IQACasein kinase II subunit alpha2.7.11.10.464
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.464
1qmzATPCyclin-dependent kinase 22.7.11.220.463
2c6lDT4Cyclin-dependent kinase 22.7.11.220.463
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.463
3ezrEZRCyclin-dependent kinase 22.7.11.220.463
2i40BLZCyclin-dependent kinase 22.7.11.220.462
2pvhP19Casein kinase II subunit alpha2.7.11.10.462
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.462
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.462
2b53D23Cyclin-dependent kinase 22.7.11.220.461
2xikJ60Serine/threonine-protein kinase 252.7.11.10.461
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.461
3r73X87Cyclin-dependent kinase 22.7.11.220.461
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.461
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.460
3zh8C58Protein kinase C iota type2.7.11.130.460
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.460
5e8wSTUTGF-beta receptor type-12.7.11.300.460
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.459
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.459
3qwjX6ACyclin-dependent kinase 22.7.11.220.459
3r71X86Cyclin-dependent kinase 22.7.11.220.459
3r8pZ46Cyclin-dependent kinase 22.7.11.220.459
4lfiGNPCasein kinase II subunit alpha2.7.11.10.459
1oiqHDUCyclin-dependent kinase 22.7.11.220.458
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.458
3qtwX3ACyclin-dependent kinase 22.7.11.220.458
4jr7GNPCasein kinase II subunit alpha2.7.11.10.458
1dawANPCasein kinase II subunit alpha2.7.11.10.457
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.457
3cgfJNFMitogen-activated protein kinase 102.7.11.240.456
3rm719ZCyclin-dependent kinase 22.7.11.220.456
1e1xNW1Cyclin-dependent kinase 22.7.11.220.455
2c6kDT2Cyclin-dependent kinase 22.7.11.220.455
2vtsLZCCyclin-dependent kinase 22.7.11.220.455
3qtqX35Cyclin-dependent kinase 22.7.11.220.454
3r7yZ04Cyclin-dependent kinase 22.7.11.220.454
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.454
4lyn1YGCyclin-dependent kinase 22.7.11.220.454
4ux9ANPMitogen-activated protein kinase 82.7.11.240.454
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
1vjy460TGF-beta receptor type-12.7.11.300.453
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.453
4fklCK2Cyclin-dependent kinase 22.7.11.220.453
4g3rCAMCamphor 5-monooxygenase1.14.15.10.453
4qmySTUSerine/threonine-protein kinase 242.7.11.10.453
2c5yMTWCyclin-dependent kinase 22.7.11.220.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.452
3nux3NVCyclin-dependent kinase 62.7.11.220.452
4grb0XGCasein kinase II subunit alpha2.7.11.10.452
1phgMYTCamphor 5-monooxygenase1.14.15.10.451
1pxkCK3Cyclin-dependent kinase 22.7.11.220.451
3dogNNNCyclin-dependent kinase 22.7.11.220.451
3qqhX0ACyclin-dependent kinase 22.7.11.220.451
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.451
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.451
4qmzB49Serine/threonine-protein kinase 242.7.11.10.451
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.450
2a4lRRCCyclin-dependent kinase 22.7.11.220.449
2cchATPCyclin-dependent kinase 22.7.11.220.449
3w33W19Epidermal growth factor receptor2.7.10.10.449
1rw8580TGF-beta receptor type-12.7.11.300.448
2r3p3SCCyclin-dependent kinase 22.7.11.220.448
2wpa889Cyclin-dependent kinase 22.7.11.220.448
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
3qqfX07Cyclin-dependent kinase 22.7.11.220.448
3qqlX03Cyclin-dependent kinase 22.7.11.220.448
3sheI85MAP kinase-activated protein kinase 32.7.11.10.448
4e4m0NHTyrosine-protein kinase JAK2/0.448
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.448
1xkkFMMEpidermal growth factor receptor2.7.10.10.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
3qrtX14Cyclin-dependent kinase 22.7.11.220.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
4bgg844Activin receptor type-12.7.11.300.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.447
4k8aK8AFocal adhesion kinase 12.7.10.20.447
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.447
3ggfGVDSerine/threonine-protein kinase 26/0.446
4a4qUX9Pol protein/0.446
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.446
4aqc88ATyrosine-protein kinase JAK2/0.446
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.446
4btjATPTau-tubulin kinase 12.7.11.10.446
4iwd1JCHepatocyte growth factor receptor2.7.10.10.446
5cvhADPCasein kinase II subunit alpha2.7.11.10.446
1iwiCAMCamphor 5-monooxygenase1.14.15.10.445
1lp4ANPCasein kinase II subunit alpha2.7.11.10.445
1y8yCT7Cyclin-dependent kinase 22.7.11.220.445
2fxdDR7Pol polyprotein/0.445
3kduNKSPeroxisome proliferator-activated receptor alpha/0.445
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.445
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.445
4gmy0X5Tyrosine-protein kinase JAK2/0.445
1h0w207Cyclin-dependent kinase 22.7.11.220.444
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.444
2uzbC75Cyclin-dependent kinase 22.7.11.220.444
3at4CCKCasein kinase II subunit alpha2.7.11.10.444
3fwiCAMCamphor 5-monooxygenase1.14.15.10.444
3zdu38RCyclin-dependent kinase-like 32.7.11.220.444
4jboWPHAurora kinase A2.7.11.10.444
1m2qMNXCasein kinase II subunit alpha2.7.11.10.443
1t86CAMCamphor 5-monooxygenase1.14.15.10.443
1v0oINRCell division control protein 2 homolog2.7.11.220.443
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
3nynSGVG protein-coupled receptor kinase 62.7.11.160.443
1xjdSTUProtein kinase C theta type2.7.11.130.442
3axwTIDCasein kinase II subunit alpha2.7.11.10.442
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.442
3mdvCL6Cholesterol 24-hydroxylase/0.442
4a6cQG9Gag-Pol polyprotein3.4.23.160.442
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.442
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.441
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
5dt3ATPAurora kinase A2.7.11.10.441
3iaeD7KBenzaldehyde lyase/0.440
4bchT7ZCyclin-dependent kinase 92.7.11.220.440
4uyf73BBromodomain-containing protein 2/0.440