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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qzhX69Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qzhX69Cyclin-dependent kinase 22.7.11.221.000
3roy22ZCyclin-dependent kinase 22.7.11.220.619
3r1sX73Cyclin-dependent kinase 22.7.11.220.615
3r7vZ02Cyclin-dependent kinase 22.7.11.220.613
3qqfX07Cyclin-dependent kinase 22.7.11.220.594
3r73X87Cyclin-dependent kinase 22.7.11.220.590
3rm719ZCyclin-dependent kinase 22.7.11.220.590
3qu0X40Cyclin-dependent kinase 22.7.11.220.589
1ke6LS2Cyclin-dependent kinase 22.7.11.220.582
3qtzX42Cyclin-dependent kinase 22.7.11.220.580
3r28XA0Cyclin-dependent kinase 22.7.11.220.580
3r7yZ04Cyclin-dependent kinase 22.7.11.220.572
3rpv26ZCyclin-dependent kinase 22.7.11.220.572
2w06FRVCyclin-dependent kinase 22.7.11.220.568
3rpo24ZCyclin-dependent kinase 22.7.11.220.568
1ke7LS3Cyclin-dependent kinase 22.7.11.220.567
3qzgX67Cyclin-dependent kinase 22.7.11.220.566
3r8lZ30Cyclin-dependent kinase 22.7.11.220.563
3sqq99ZCyclin-dependent kinase 22.7.11.220.563
1di8DTQCyclin-dependent kinase 22.7.11.220.562
3r6xX84Cyclin-dependent kinase 22.7.11.220.562
3qxoX65Cyclin-dependent kinase 22.7.11.220.559
4fkr45KCyclin-dependent kinase 22.7.11.220.558
1ckpPVBCyclin-dependent kinase 22.7.11.220.556
2a4lRRCCyclin-dependent kinase 22.7.11.220.555
3lfnA27Cyclin-dependent kinase 22.7.11.220.555
3r9hZ67Cyclin-dependent kinase 22.7.11.220.555
4fki09KCyclin-dependent kinase 22.7.11.220.555
3r7uX96Cyclin-dependent kinase 22.7.11.220.554
4fkq42KCyclin-dependent kinase 22.7.11.220.553
2c6o4SPCyclin-dependent kinase 22.7.11.220.551
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.549
3qx2X63Cyclin-dependent kinase 22.7.11.220.548
3rm618ZCyclin-dependent kinase 22.7.11.220.548
2btrU73Cyclin-dependent kinase 22.7.11.220.547
3s1h56ZCyclin-dependent kinase 22.7.11.220.547
3r7eX88Cyclin-dependent kinase 22.7.11.220.545
3qtuX44Cyclin-dependent kinase 22.7.11.220.544
3rak03ZCyclin-dependent kinase 22.7.11.220.543
1v1k3FPCyclin-dependent kinase 22.7.11.220.542
3qwjX6ACyclin-dependent kinase 22.7.11.220.542
3r7iX9ICyclin-dependent kinase 22.7.11.220.541
3rk708ZCyclin-dependent kinase 22.7.11.220.541
1ke5LS1Cyclin-dependent kinase 22.7.11.220.540
2fvdLIACyclin-dependent kinase 22.7.11.220.540
3qqkX02Cyclin-dependent kinase 22.7.11.220.540
1oi9N20Cyclin-dependent kinase 22.7.11.220.539
2r64740Cyclin-dependent kinase 22.7.11.220.539
3r1yX76Cyclin-dependent kinase 22.7.11.220.539
2xmyCDKCyclin-dependent kinase 22.7.11.220.538
3rk507ZCyclin-dependent kinase 22.7.11.220.537
4ek610KCyclin-dependent kinase 22.7.11.220.537
1h0w207Cyclin-dependent kinase 22.7.11.220.536
4fkpLS5Cyclin-dependent kinase 22.7.11.220.536
1ke9LS5Cyclin-dependent kinase 22.7.11.220.535
1oiyN41Cyclin-dependent kinase 22.7.11.220.535
3ezvEZVCyclin-dependent kinase 22.7.11.220.535
3ql8X01Cyclin-dependent kinase 22.7.11.220.535
3unk0BYCyclin-dependent kinase 22.7.11.220.535
2btsU32Cyclin-dependent kinase 22.7.11.220.534
3r83Z14Cyclin-dependent kinase 22.7.11.220.533
1vyzN5BCyclin-dependent kinase 22.7.11.220.532
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.532
3qruX19Cyclin-dependent kinase 22.7.11.220.532
3s0o50ZCyclin-dependent kinase 22.7.11.220.532
3iggEFQCyclin-dependent kinase 22.7.11.220.530
3ti1B49Cyclin-dependent kinase 22.7.11.220.530
3unj0BXCyclin-dependent kinase 22.7.11.220.530
1w8cN69Cyclin-dependent kinase 22.7.11.220.529
2iw84SPCyclin-dependent kinase 22.7.11.220.529
2uzoC62Cyclin-dependent kinase 22.7.11.220.529
1ke8LS4Cyclin-dependent kinase 22.7.11.220.528
1ykr628Cyclin-dependent kinase 22.7.11.220.528
3ral04ZCyclin-dependent kinase 22.7.11.220.528
1vyw292Cyclin-dependent kinase 22.7.11.220.527
3sw418KCyclin-dependent kinase 22.7.11.220.527
3ddqRRCCyclin-dependent kinase 22.7.11.220.526
4fkj11KCyclin-dependent kinase 22.7.11.220.526
1oitHDTCyclin-dependent kinase 22.7.11.220.525
2b52D42Cyclin-dependent kinase 22.7.11.220.525
3ig7EFPCyclin-dependent kinase 22.7.11.220.524
3rmf20ZCyclin-dependent kinase 22.7.11.220.524
3rni21ZCyclin-dependent kinase 22.7.11.220.524
4fko20KCyclin-dependent kinase 22.7.11.220.524
3r1qX75Cyclin-dependent kinase 22.7.11.220.523
4fkt48KCyclin-dependent kinase 22.7.11.220.523
2r3lSCWCyclin-dependent kinase 22.7.11.220.522
1oiqHDUCyclin-dependent kinase 22.7.11.220.521
2w05FRTCyclin-dependent kinase 22.7.11.220.521
2c6iDT1Cyclin-dependent kinase 22.7.11.220.519
3r9dX6BCyclin-dependent kinase 22.7.11.220.519
1h0vUN4Cyclin-dependent kinase 22.7.11.220.518
1h1s4SPCyclin-dependent kinase 22.7.11.220.518
1oguST8Cyclin-dependent kinase 22.7.11.220.518
3raiX85Cyclin-dependent kinase 22.7.11.220.517
3s2pPMUCyclin-dependent kinase 22.7.11.220.517
5aniES4Cyclin-dependent kinase 22.7.11.220.517
1urwI1PCyclin-dependent kinase 22.7.11.220.516
1p2a5BNCyclin-dependent kinase 22.7.11.220.515
2iw94SPCyclin-dependent kinase 22.7.11.220.515
3rjc06ZCyclin-dependent kinase 22.7.11.220.515
4fkg4CKCyclin-dependent kinase 22.7.11.220.515
3py0SU9Cyclin-dependent kinase 22.7.11.220.514
4lyn1YGCyclin-dependent kinase 22.7.11.220.514
3fz1B98Cyclin-dependent kinase 22.7.11.220.513
3lfsA07Cyclin-dependent kinase 22.7.11.220.513
3qziX72Cyclin-dependent kinase 22.7.11.220.513
1h1r6CPCyclin-dependent kinase 22.7.11.220.512
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.512
2r3p3SCCyclin-dependent kinase 22.7.11.220.511
3ddpRC8Cyclin-dependent kinase 22.7.11.220.511
3qtxX43Cyclin-dependent kinase 22.7.11.220.511
3r71X86Cyclin-dependent kinase 22.7.11.220.511
4acm7YGCyclin-dependent kinase 22.7.11.220.511
1g5sI17Cyclin-dependent kinase 22.7.11.220.508
4ez30S0Cyclin-dependent kinase 22.7.11.220.508
2r3gSC9Cyclin-dependent kinase 22.7.11.220.506
3ezrEZRCyclin-dependent kinase 22.7.11.220.506
4qmpDKISerine/threonine-protein kinase 242.7.11.10.506
2b55D31Cyclin-dependent kinase 22.7.11.220.505
4ek816KCyclin-dependent kinase 22.7.11.220.505
3lfqA28Cyclin-dependent kinase 22.7.11.220.503
3rpy27ZCyclin-dependent kinase 22.7.11.220.503
4eor4SPCyclin-dependent kinase 22.7.11.220.503
2a0cCK9Cyclin-dependent kinase 22.7.11.220.502
4bgh3I6Cyclin-dependent kinase 22.7.11.220.502
4fks46KCyclin-dependent kinase 22.7.11.220.502
2r3iSCFCyclin-dependent kinase 22.7.11.220.501
3qxpX64Cyclin-dependent kinase 22.7.11.220.501
3qqlX03Cyclin-dependent kinase 22.7.11.220.500
3rahO1ZCyclin-dependent kinase 22.7.11.220.500
1b38ATPCyclin-dependent kinase 22.7.11.220.499
1e9hINRCyclin-dependent kinase 22.7.11.220.499
1gih1PUCyclin-dependent kinase 22.7.11.220.499
1pxkCK3Cyclin-dependent kinase 22.7.11.220.499
1pxmCK5Cyclin-dependent kinase 22.7.11.220.499
1r78FMDCyclin-dependent kinase 22.7.11.220.499
3rk909ZCyclin-dependent kinase 22.7.11.220.499
4nj32KDCyclin-dependent kinase 22.7.11.220.499
2bhhRYUCyclin-dependent kinase 22.7.11.220.498
4bcnT9NCyclin-dependent kinase 22.7.11.220.498
4bcpT3CCyclin-dependent kinase 22.7.11.220.498
2j9mPY8Cyclin-dependent kinase 22.7.11.220.497
2vthLZ2Cyclin-dependent kinase 22.7.11.220.497
1fvt106Cyclin-dependent kinase 22.7.11.220.496
3qqhX0ACyclin-dependent kinase 22.7.11.220.495
1pyePM1Cyclin-dependent kinase 22.7.11.220.494
2c4g514Cyclin-dependent kinase 22.7.11.220.494
2wpa889Cyclin-dependent kinase 22.7.11.220.494
2b54D05Cyclin-dependent kinase 22.7.11.220.493
3tiz3TICyclin-dependent kinase 22.7.11.220.493
4fkv61KCyclin-dependent kinase 22.7.11.220.493
2uznC96Cyclin-dependent kinase 22.7.11.220.492
2vtsLZCCyclin-dependent kinase 22.7.11.220.492
2r3fSC8Cyclin-dependent kinase 22.7.11.220.491
4bcmT7ZCyclin-dependent kinase 22.7.11.220.491
1pxoCK7Cyclin-dependent kinase 22.7.11.220.490
1y91CT9Cyclin-dependent kinase 22.7.11.220.490
3qx4X4BCyclin-dependent kinase 22.7.11.220.490
1b39ATPCyclin-dependent kinase 22.7.11.220.489
1w0xOLOCyclin-dependent kinase 22.7.11.220.488
3pj8404Cyclin-dependent kinase 22.7.11.220.488
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.487
2vu3LZECyclin-dependent kinase 22.7.11.220.487
3rkb12ZCyclin-dependent kinase 22.7.11.220.487
4eon1ROCyclin-dependent kinase 22.7.11.220.487
2w1hL0FCyclin-dependent kinase 22.7.11.220.486
3r8uZ31Cyclin-dependent kinase 22.7.11.220.486
4fx360KCyclin-dependent kinase 22.7.11.220.485
2c6mDT5Cyclin-dependent kinase 22.7.11.220.484
4eok4SPCyclin-dependent kinase 22.7.11.220.484
1oiuN76Cyclin-dependent kinase 22.7.11.220.483
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.483
3r8pZ46Cyclin-dependent kinase 22.7.11.220.483
1pxlCK4Cyclin-dependent kinase 22.7.11.220.482
2wihP48Cyclin-dependent kinase 22.7.11.220.482
3rpr25ZCyclin-dependent kinase 22.7.11.220.482
4fklCK2Cyclin-dependent kinase 22.7.11.220.482
3r8vZ62Cyclin-dependent kinase 22.7.11.220.481
2r3mSCXCyclin-dependent kinase 22.7.11.220.480
2r3o2SCCyclin-dependent kinase 22.7.11.220.480
3wblPDYCyclin-dependent kinase 22.7.11.220.480
4eos1ROCyclin-dependent kinase 22.7.11.220.479
1unlRRCCyclin-dependent-like kinase 52.7.11.10.478
3uli1N3Cyclin-dependent kinase 22.7.11.220.478
2r3kSCQCyclin-dependent kinase 22.7.11.220.476
3pxyJWSCyclin-dependent kinase 22.7.11.220.476
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.474
1gz8MBPCyclin-dependent kinase 22.7.11.220.473
4fkw62KCyclin-dependent kinase 22.7.11.220.472
1e1xNW1Cyclin-dependent kinase 22.7.11.220.471
1gii1PUCyclin-dependent kinase 22.7.11.220.471
1finATPCyclin-dependent kinase 22.7.11.220.470
2wxvWXVCyclin-dependent kinase 22.7.11.220.470
2vv9IM9Cyclin-dependent kinase 22.7.11.220.469
3r9nZ68Cyclin-dependent kinase 22.7.11.220.467
3s00Z60Cyclin-dependent kinase 22.7.11.220.467
4cfnJYMCyclin-dependent kinase 22.7.11.220.466
2c5nCK8Cyclin-dependent kinase 22.7.11.220.465
2duv371Cyclin-dependent kinase 22.7.11.220.465
3qtqX35Cyclin-dependent kinase 22.7.11.220.465
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.464
3sw719KCyclin-dependent kinase 22.7.11.220.464
1oirHDYCyclin-dependent kinase 22.7.11.220.463
3bhtMFRCyclin-dependent kinase 22.7.11.220.463
3qwkX62Cyclin-dependent kinase 22.7.11.220.463
2x1nX1NCyclin-dependent kinase 22.7.11.220.462
2i40BLZCyclin-dependent kinase 22.7.11.220.461
2vttLZDCyclin-dependent kinase 22.7.11.220.461
3qtrX36Cyclin-dependent kinase 22.7.11.220.461
2c6lDT4Cyclin-dependent kinase 22.7.11.220.460
3qzfX66Cyclin-dependent kinase 22.7.11.220.460
2wotZZGTGF-beta receptor type-12.7.11.300.459
3qrtX14Cyclin-dependent kinase 22.7.11.220.459
1h1q2A6Cyclin-dependent kinase 22.7.11.220.458
3rzb02ZCyclin-dependent kinase 22.7.11.220.458
3dogNNNCyclin-dependent kinase 22.7.11.220.457
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.457
1y8yCT7Cyclin-dependent kinase 22.7.11.220.456
2r3r6SCCyclin-dependent kinase 22.7.11.220.456
3tnwF18Cyclin-dependent kinase 22.7.11.220.456
2w17I19Cyclin-dependent kinase 22.7.11.220.455
3r8zZ63Cyclin-dependent kinase 22.7.11.220.455
1pkdUCNCyclin-dependent kinase 22.7.11.220.453
2bheBRYCyclin-dependent kinase 22.7.11.220.453
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2c69CT8Cyclin-dependent kinase 22.7.11.220.452
2cchATPCyclin-dependent kinase 22.7.11.220.452
4bcoT6QCyclin-dependent kinase 22.7.11.220.452
3ggfGVDSerine/threonine-protein kinase 26/0.451
3my5RFZCyclin-dependent kinase 22.7.11.220.451
2r3q5SCCyclin-dependent kinase 22.7.11.220.449
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.449
1dm2HMDCyclin-dependent kinase 22.7.11.220.448
1gij2PUCyclin-dependent kinase 22.7.11.220.448
2c5yMTWCyclin-dependent kinase 22.7.11.220.448
1h1pCMGCyclin-dependent kinase 22.7.11.220.446
3r9oZ71Cyclin-dependent kinase 22.7.11.220.446
2uzlC94Cyclin-dependent kinase 22.7.11.220.445
2vtqLZACyclin-dependent kinase 22.7.11.220.445
4eoi1ROCyclin-dependent kinase 22.7.11.220.445
3sheI85MAP kinase-activated protein kinase 32.7.11.10.444
1e1vCMGCyclin-dependent kinase 22.7.11.220.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1pxpCK8Cyclin-dependent kinase 22.7.11.220.442
1vjy460TGF-beta receptor type-12.7.11.300.442
4ii5ADPCyclin-dependent kinase 22.7.11.220.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
2uzdC85Cyclin-dependent kinase 22.7.11.220.441
4eol1ROCyclin-dependent kinase 22.7.11.220.440