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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.21.000
3vs3VSETyrosine-protein kinase HCK2.7.10.20.578
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.568
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.567
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.567
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.556
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.549
4j97ACPFibroblast growth factor receptor 2/0.543
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.535
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.533
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.533
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.532
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.529
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.529
4f640S8Fibroblast growth factor receptor 1/0.522
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.520
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.519
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.516
4nks2M2Fibroblast growth factor receptor 1/0.516
4gmy0X5Tyrosine-protein kinase JAK2/0.515
3w2sW2REpidermal growth factor receptor2.7.10.10.514
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.511
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.510
2henADPEphrin type-B receptor 22.7.10.10.508
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.508
4nka2K7Fibroblast growth factor receptor 1/0.508
2hk51BMTyrosine-protein kinase HCK2.7.10.20.507
2of4979Tyrosine-protein kinase Lck2.7.10.20.505
3vs1VSATyrosine-protein kinase HCK2.7.10.20.504
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.503
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.503
4k33ACPFibroblast growth factor receptor 32.7.10.10.502
2pwlACPFibroblast growth factor receptor 2/0.501
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.500
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.499
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.498
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.498
1m17AQ4Epidermal growth factor receptor2.7.10.10.495
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.495
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.494
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.494
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.494
2hog710Serine/threonine-protein kinase Chk12.7.11.10.493
2of2547Tyrosine-protein kinase Lck2.7.10.20.493
1u54ACPActivated CDC42 kinase 1/0.491
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.491
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.488
4gk3L87Ephrin type-A receptor 32.7.10.10.488
2itpAEEEpidermal growth factor receptor2.7.10.10.487
3poz03PEpidermal growth factor receptor2.7.10.10.487
4gk4L90Ephrin type-A receptor 32.7.10.10.487
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.486
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.486
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.485
2qo9ANPEphrin type-A receptor 32.7.10.10.484
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.484
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.484
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.483
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.483
2csnCKICasein kinase I homolog 12.7.11.10.482
2j0m4STFocal adhesion kinase 12.7.10.20.482
2wouZZFTGF-beta receptor type-12.7.11.300.482
2x6dX6DAurora kinase A2.7.11.10.482
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.482
1vjy460TGF-beta receptor type-12.7.11.300.481
2eb3ANPEpidermal growth factor receptor2.7.10.10.481
2itzIREEpidermal growth factor receptor2.7.10.10.481
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.481
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.481
4riyADPEpidermal growth factor receptor2.7.10.10.481
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.480
3vryB43Tyrosine-protein kinase HCK2.7.10.20.480
2pzpACPFibroblast growth factor receptor 2/0.479
3zewSTUEphrin type-B receptor 42.7.10.10.479
4btjATPTau-tubulin kinase 12.7.11.10.479
4jia1K3Tyrosine-protein kinase JAK2/0.479
2itqITQEpidermal growth factor receptor2.7.10.10.478
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.478
2j0lANPFocal adhesion kinase 12.7.10.20.477
2x9fX9FEphrin type-B receptor 42.7.10.10.477
3w33W19Epidermal growth factor receptor2.7.10.10.477
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.477
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.476
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.476
2qoqANPEphrin type-A receptor 32.7.10.10.475
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.475
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.474
2itnANPEpidermal growth factor receptor2.7.10.10.474
4i22IREEpidermal growth factor receptor2.7.10.10.474
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.473
2py3ACPFibroblast growth factor receptor 2/0.473
2xp2VGHALK tyrosine kinase receptor2.7.10.10.473
4c57FEFCyclin-G-associated kinase2.7.11.10.473
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.472
4id71G0Activated CDC42 kinase 1/0.472
3vjoANPEpidermal growth factor receptor2.7.10.10.471
4c62XWWTyrosine-protein kinase JAK2/0.471
4gu94GUFocal adhesion kinase 12.7.10.20.471
4hvh19RTyrosine-protein kinase JAK32.7.10.20.471
1wvxBD4Death-associated protein kinase 12.7.11.10.470
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.470
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
5eg3ACPFibroblast growth factor receptor 2/0.470
2ittAEEEpidermal growth factor receptor2.7.10.10.469
2vwu7X1Ephrin type-B receptor 42.7.10.10.469
3d7tSTUTyrosine-protein kinase CSK/0.469
4jq8KJ8Epidermal growth factor receptor2.7.10.10.469
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.469
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.469
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4bbe3O4Tyrosine-protein kinase JAK2/0.468
4c02TAKActivin receptor type-12.7.11.300.468
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.467
2xa4AZ5Tyrosine-protein kinase JAK2/0.467
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.467
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.467
3pxkPXKFocal adhesion kinase 12.7.10.20.467
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.466
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.466
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.466
4gk2L66Ephrin type-A receptor 32.7.10.10.465
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.465
4i231C9Epidermal growth factor receptor2.7.10.10.464
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.463
2fgiPD1Fibroblast growth factor receptor 1/0.463
2v7a627Tyrosine-protein kinase ABL12.7.10.20.463
2wotZZGTGF-beta receptor type-12.7.11.300.463
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.463
2c4g514Cyclin-dependent kinase 22.7.11.220.462
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.462
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.462
2pz5ACPFibroblast growth factor receptor 2/0.462
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.462
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.462
4wkqIREEpidermal growth factor receptor2.7.10.10.462
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
2pzrACPFibroblast growth factor receptor 2/0.461
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.461
3uvp048Mitogen-activated protein kinase 14/0.461
3zh8C58Protein kinase C iota type2.7.11.130.461
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.461
4g2fC07Ephrin type-A receptor 32.7.10.10.461
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.460
2qblCAMCamphor 5-monooxygenase1.14.15.10.460
3a7hATPSerine/threonine-protein kinase 242.7.11.10.460
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.460
4aguD15Cyclin-dependent kinase-like 1/0.460
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.460
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.460
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.459
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.459
4y95746Tyrosine-protein kinase/0.459
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.458
2yn8STUEphrin type-B receptor 42.7.10.10.458
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.458
4aotGW8Serine/threonine-protein kinase 102.7.11.10.458
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.458
4ic7ANPMitogen-activated protein kinase 72.7.11.240.458
2ckeIQUDeath-associated protein kinase 2/0.457
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.457
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.457
4fob0USALK tyrosine kinase receptor2.7.10.10.457
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.457
5e8wSTUTGF-beta receptor type-12.7.11.300.457
1jpaANPEphrin type-B receptor 22.7.10.10.456
1xkkFMMEpidermal growth factor receptor2.7.10.10.456
1zrzBI1Protein kinase C iota type2.7.11.130.456
2c6eHPMAurora kinase A2.7.11.10.456
2izrBRKCasein kinase I isoform gamma-32.7.11.10.456
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.456
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.456
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.456
3t8oATPRhodopsin kinase/0.455
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.455
4gyiADPUncharacterized protein/0.455
4jq7KJQEpidermal growth factor receptor2.7.10.10.455
5e8ySTUTGF-beta receptor type-22.7.11.300.455
1k6tXN1Gag-Pol polyprotein3.4.23.160.454
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.454
4btjADPTau-tubulin kinase 12.7.11.10.454
1k6pXN3Gag-Pol polyprotein3.4.23.160.453
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.453
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.453
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.453
4jrvKJVEpidermal growth factor receptor2.7.10.10.453
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.452
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.452
3bhy7CPDeath-associated protein kinase 3/0.452
3gxlQIGTGF-beta receptor type-12.7.11.300.452
3lpbNVBTyrosine-protein kinase JAK2/0.452
3qlrNDPDihydrofolate reductase1.5.1.30.452
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.452
5e8xSTUTGF-beta receptor type-12.7.11.300.452
1og5SWFCytochrome P450 2C9/0.451
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.451
1uyuCAMCamphor 5-monooxygenase1.14.15.10.451
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.451
2izuP01Casein kinase I isoform gamma-32.7.11.10.451
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.451
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.451
3gu6ADPDeath-associated protein kinase 12.7.11.10.451
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.451
4cd0AWJALK tyrosine kinase receptor2.7.10.10.451
4e4m0NHTyrosine-protein kinase JAK2/0.451
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.451
4y93746Tyrosine-protein kinase/0.451
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.450
3cgdNADCoenzyme A disulfide reductase/0.450
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.450
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.450
4anqVGHALK tyrosine kinase receptor2.7.10.10.450
5dt3ATPAurora kinase A2.7.11.10.450
2qo7ANPEphrin type-A receptor 32.7.10.10.449
2vwz7X6Ephrin type-B receptor 42.7.10.10.449
3i60E86Mitogen-activated protein kinase 12.7.11.240.449
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
4ckjADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.449
5auwQUEDeath-associated protein kinase 12.7.11.10.449
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
2xvdAS6Ephrin type-B receptor 42.7.10.10.448
3emg685Tyrosine-protein kinase SYK2.7.10.20.448
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.448
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.448
4iebANPCalmodulin-domain protein kinase 1/0.448
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.448
4qmlANPSerine/threonine-protein kinase 242.7.11.10.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.448
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.448
1mqbANPEphrin type-A receptor 22.7.10.10.447
2ghmLICMitogen-activated protein kinase 14/0.447
2itxANPEpidermal growth factor receptor2.7.10.10.447
2vwy7X5Ephrin type-B receptor 42.7.10.10.447
2wqeADPAurora kinase A2.7.11.10.447
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3gc9B45Mitogen-activated protein kinase 112.7.11.240.447
3zuxTCHTransporter/0.447
3wrmCAMCamphor 5-monooxygenase1.14.15.10.446
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.446
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.446
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.446
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.446
3bu5ATPInsulin receptor2.7.10.10.445
3iok1P6Tyrosine-protein kinase JAK2/0.445
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4c58824Cyclin-G-associated kinase2.7.11.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.445
4o0sADNAurora kinase A2.7.11.10.445
4xlvACPInsulin receptor2.7.10.10.445
5aaaVGHALK tyrosine kinase receptor2.7.10.10.445
6cp4CAMCamphor 5-monooxygenase1.14.15.10.445
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
2znq401Peroxisome proliferator-activated receptor delta/0.444
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.444
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.444
4tuvCPZCytochrome P450 1191.140.444
1dhjMTXDihydrofolate reductase1.5.1.30.443
1dz6CAMCamphor 5-monooxygenase1.14.15.10.443
1t86CAMCamphor 5-monooxygenase1.14.15.10.443
2ijmATPFocal adhesion kinase 12.7.10.20.443
2vwx7X4Ephrin type-B receptor 42.7.10.10.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4ewhT77Activated CDC42 kinase 1/0.443
4ez50RSCyclin-dependent kinase 62.7.11.220.443
4f630S7Fibroblast growth factor receptor 1/0.443
4hgs15GCasein kinase I isoform gamma-32.7.11.10.443
1jioDEB6-deoxyerythronolide B hydroxylase/0.442
1oiyN41Cyclin-dependent kinase 22.7.11.220.442
2qboCAMCamphor 5-monooxygenase1.14.15.10.442
2vx17X8Ephrin type-B receptor 42.7.10.10.442
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3nwq2NCGag-Pol polyprotein3.4.23.160.442
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4dfrMTXDihydrofolate reductase1.5.1.30.442
5e92ANPTGF-beta receptor type-22.7.11.300.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
2izsBRQCasein kinase I isoform gamma-32.7.11.10.441
3fwiCAMCamphor 5-monooxygenase1.14.15.10.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3uvqFS8Mitogen-activated protein kinase 14/0.441
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.441
4nk92K5Fibroblast growth factor receptor 1/0.441
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
1c70L75Protease/0.440
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2cig1DGDihydrofolate reductase1.5.1.30.440
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.440
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
2pvyACPFibroblast growth factor receptor 2/0.440
2xyuQ9GEphrin type-A receptor 42.7.10.10.440
3fwfCAMCamphor 5-monooxygenase1.14.15.10.440
3hx4ANPCalmodulin-domain protein kinase 1/0.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3nbwTR4Ketohexokinase/0.440
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.440
4fv9E71Mitogen-activated protein kinase 12.7.11.240.440
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.440