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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1urwI1PCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1urwI1PCyclin-dependent kinase 22.7.11.221.000
3qtzX42Cyclin-dependent kinase 22.7.11.220.612
1v1k3FPCyclin-dependent kinase 22.7.11.220.609
3rak03ZCyclin-dependent kinase 22.7.11.220.600
3s1h56ZCyclin-dependent kinase 22.7.11.220.598
3rmf20ZCyclin-dependent kinase 22.7.11.220.590
3rpv26ZCyclin-dependent kinase 22.7.11.220.588
3unj0BXCyclin-dependent kinase 22.7.11.220.585
1ke5LS1Cyclin-dependent kinase 22.7.11.220.583
1ke6LS2Cyclin-dependent kinase 22.7.11.220.583
3r9dX6BCyclin-dependent kinase 22.7.11.220.583
3rni21ZCyclin-dependent kinase 22.7.11.220.582
4bgh3I6Cyclin-dependent kinase 22.7.11.220.582
2w06FRVCyclin-dependent kinase 22.7.11.220.581
3unk0BYCyclin-dependent kinase 22.7.11.220.581
1di8DTQCyclin-dependent kinase 22.7.11.220.578
2b55D31Cyclin-dependent kinase 22.7.11.220.577
3ral04ZCyclin-dependent kinase 22.7.11.220.577
4acm7YGCyclin-dependent kinase 22.7.11.220.577
3sw418KCyclin-dependent kinase 22.7.11.220.576
1pxmCK5Cyclin-dependent kinase 22.7.11.220.574
3rjc06ZCyclin-dependent kinase 22.7.11.220.573
1oiqHDUCyclin-dependent kinase 22.7.11.220.571
1oitHDTCyclin-dependent kinase 22.7.11.220.570
4fko20KCyclin-dependent kinase 22.7.11.220.568
4fkr45KCyclin-dependent kinase 22.7.11.220.568
3sqq99ZCyclin-dependent kinase 22.7.11.220.567
3ezvEZVCyclin-dependent kinase 22.7.11.220.565
3qtuX44Cyclin-dependent kinase 22.7.11.220.565
1pxoCK7Cyclin-dependent kinase 22.7.11.220.563
3qtrX36Cyclin-dependent kinase 22.7.11.220.563
1gih1PUCyclin-dependent kinase 22.7.11.220.562
2a0cCK9Cyclin-dependent kinase 22.7.11.220.562
3r9oZ71Cyclin-dependent kinase 22.7.11.220.562
3lfnA27Cyclin-dependent kinase 22.7.11.220.559
3qu0X40Cyclin-dependent kinase 22.7.11.220.558
2btsU32Cyclin-dependent kinase 22.7.11.220.557
3sw719KCyclin-dependent kinase 22.7.11.220.557
1g5sI17Cyclin-dependent kinase 22.7.11.220.555
3rpy27ZCyclin-dependent kinase 22.7.11.220.555
1w0xOLOCyclin-dependent kinase 22.7.11.220.551
1ke9LS5Cyclin-dependent kinase 22.7.11.220.548
1oi9N20Cyclin-dependent kinase 22.7.11.220.548
1gii1PUCyclin-dependent kinase 22.7.11.220.547
1h1r6CPCyclin-dependent kinase 22.7.11.220.547
2xmyCDKCyclin-dependent kinase 22.7.11.220.547
3rk708ZCyclin-dependent kinase 22.7.11.220.547
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.546
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.545
1oiyN41Cyclin-dependent kinase 22.7.11.220.544
4ek610KCyclin-dependent kinase 22.7.11.220.544
3qtxX43Cyclin-dependent kinase 22.7.11.220.543
2vv9IM9Cyclin-dependent kinase 22.7.11.220.542
3qxoX65Cyclin-dependent kinase 22.7.11.220.542
3s0o50ZCyclin-dependent kinase 22.7.11.220.542
4fkq42KCyclin-dependent kinase 22.7.11.220.541
2r3lSCWCyclin-dependent kinase 22.7.11.220.540
3rk909ZCyclin-dependent kinase 22.7.11.220.540
4fkt48KCyclin-dependent kinase 22.7.11.220.540
3r9hZ67Cyclin-dependent kinase 22.7.11.220.539
4fkv61KCyclin-dependent kinase 22.7.11.220.539
2c6iDT1Cyclin-dependent kinase 22.7.11.220.537
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.537
3r1sX73Cyclin-dependent kinase 22.7.11.220.537
4fki09KCyclin-dependent kinase 22.7.11.220.537
2btrU73Cyclin-dependent kinase 22.7.11.220.536
3py0SU9Cyclin-dependent kinase 22.7.11.220.536
4erwSTUCyclin-dependent kinase 22.7.11.220.536
1r78FMDCyclin-dependent kinase 22.7.11.220.534
3qzgX67Cyclin-dependent kinase 22.7.11.220.532
1ke7LS3Cyclin-dependent kinase 22.7.11.220.531
1gij2PUCyclin-dependent kinase 22.7.11.220.530
1h1s4SPCyclin-dependent kinase 22.7.11.220.530
3qxpX64Cyclin-dependent kinase 22.7.11.220.530
3s2pPMUCyclin-dependent kinase 22.7.11.220.530
1oguST8Cyclin-dependent kinase 22.7.11.220.529
3ti1B49Cyclin-dependent kinase 22.7.11.220.529
2iw84SPCyclin-dependent kinase 22.7.11.220.527
3uli1N3Cyclin-dependent kinase 22.7.11.220.527
1vyzN5BCyclin-dependent kinase 22.7.11.220.526
2c6o4SPCyclin-dependent kinase 22.7.11.220.526
4fkw62KCyclin-dependent kinase 22.7.11.220.526
1aq1STUCyclin-dependent kinase 22.7.11.220.525
1pyePM1Cyclin-dependent kinase 22.7.11.220.525
2b52D42Cyclin-dependent kinase 22.7.11.220.525
3ezrEZRCyclin-dependent kinase 22.7.11.220.525
3rm719ZCyclin-dependent kinase 22.7.11.220.525
4eok4SPCyclin-dependent kinase 22.7.11.220.524
4fkj11KCyclin-dependent kinase 22.7.11.220.524
3rpo24ZCyclin-dependent kinase 22.7.11.220.523
2iw94SPCyclin-dependent kinase 22.7.11.220.522
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.521
3ddpRC8Cyclin-dependent kinase 22.7.11.220.521
3qqkX02Cyclin-dependent kinase 22.7.11.220.521
4ez30S0Cyclin-dependent kinase 22.7.11.220.521
3rk507ZCyclin-dependent kinase 22.7.11.220.520
3qzhX69Cyclin-dependent kinase 22.7.11.220.519
4ek816KCyclin-dependent kinase 22.7.11.220.519
3iggEFQCyclin-dependent kinase 22.7.11.220.518
3pj8404Cyclin-dependent kinase 22.7.11.220.518
2r64740Cyclin-dependent kinase 22.7.11.220.517
4fks46KCyclin-dependent kinase 22.7.11.220.517
1h0w207Cyclin-dependent kinase 22.7.11.220.516
4fkg4CKCyclin-dependent kinase 22.7.11.220.515
2fvdLIACyclin-dependent kinase 22.7.11.220.514
3r8lZ30Cyclin-dependent kinase 22.7.11.220.514
3rkb12ZCyclin-dependent kinase 22.7.11.220.513
4fkpLS5Cyclin-dependent kinase 22.7.11.220.513
3roy22ZCyclin-dependent kinase 22.7.11.220.512
4fx360KCyclin-dependent kinase 22.7.11.220.511
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.511
2vttLZDCyclin-dependent kinase 22.7.11.220.510
3tnwF18Cyclin-dependent kinase 22.7.11.220.510
1y91CT9Cyclin-dependent kinase 22.7.11.220.509
3r6xX84Cyclin-dependent kinase 22.7.11.220.509
3r73X87Cyclin-dependent kinase 22.7.11.220.509
3r8vZ62Cyclin-dependent kinase 22.7.11.220.509
2w17I19Cyclin-dependent kinase 22.7.11.220.507
3pxyJWSCyclin-dependent kinase 22.7.11.220.506
1oirHDYCyclin-dependent kinase 22.7.11.220.505
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.505
3r71X86Cyclin-dependent kinase 22.7.11.220.505
4fklCK2Cyclin-dependent kinase 22.7.11.220.505
1pkdUCNCyclin-dependent kinase 22.7.11.220.504
3qqfX07Cyclin-dependent kinase 22.7.11.220.504
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.504
1e9hINRCyclin-dependent kinase 22.7.11.220.503
1ykr628Cyclin-dependent kinase 22.7.11.220.503
2j9mPY8Cyclin-dependent kinase 22.7.11.220.503
2r3iSCFCyclin-dependent kinase 22.7.11.220.503
1ckpPVBCyclin-dependent kinase 22.7.11.220.502
2vthLZ2Cyclin-dependent kinase 22.7.11.220.502
3qruX19Cyclin-dependent kinase 22.7.11.220.501
3r1yX76Cyclin-dependent kinase 22.7.11.220.501
4eon1ROCyclin-dependent kinase 22.7.11.220.501
1ke8LS4Cyclin-dependent kinase 22.7.11.220.499
4qmpDKISerine/threonine-protein kinase 242.7.11.10.498
1p2a5BNCyclin-dependent kinase 22.7.11.220.497
2bheBRYCyclin-dependent kinase 22.7.11.220.497
3ddqRRCCyclin-dependent kinase 22.7.11.220.497
3r83Z14Cyclin-dependent kinase 22.7.11.220.496
4bcpT3CCyclin-dependent kinase 22.7.11.220.496
2r3kSCQCyclin-dependent kinase 22.7.11.220.495
4eor4SPCyclin-dependent kinase 22.7.11.220.495
3fz1B98Cyclin-dependent kinase 22.7.11.220.493
3ig7EFPCyclin-dependent kinase 22.7.11.220.493
3r7vZ02Cyclin-dependent kinase 22.7.11.220.493
3r8zZ63Cyclin-dependent kinase 22.7.11.220.493
1vyw292Cyclin-dependent kinase 22.7.11.220.492
3qwkX62Cyclin-dependent kinase 22.7.11.220.492
1h1pCMGCyclin-dependent kinase 22.7.11.220.491
2vtqLZACyclin-dependent kinase 22.7.11.220.491
4nj32KDCyclin-dependent kinase 22.7.11.220.491
3qqhX0ACyclin-dependent kinase 22.7.11.220.490
3rm618ZCyclin-dependent kinase 22.7.11.220.490
2duv371Cyclin-dependent kinase 22.7.11.220.489
2vtsLZCCyclin-dependent kinase 22.7.11.220.489
3r7uX96Cyclin-dependent kinase 22.7.11.220.488
1e1xNW1Cyclin-dependent kinase 22.7.11.220.487
4bcmT7ZCyclin-dependent kinase 22.7.11.220.487
2r3p3SCCyclin-dependent kinase 22.7.11.220.486
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.486
2i40BLZCyclin-dependent kinase 22.7.11.220.485
4eomATPCyclin-dependent kinase 22.7.11.220.485
2w1hL0FCyclin-dependent kinase 22.7.11.220.484
1fvv107Cyclin-dependent kinase 22.7.11.220.483
1qmzATPCyclin-dependent kinase 22.7.11.220.482
3qqlX03Cyclin-dependent kinase 22.7.11.220.482
1pxlCK4Cyclin-dependent kinase 22.7.11.220.481
2pvnP63Casein kinase II subunit alpha2.7.11.10.481
4eoi1ROCyclin-dependent kinase 22.7.11.220.481
3r1qX75Cyclin-dependent kinase 22.7.11.220.480
1oiuN76Cyclin-dependent kinase 22.7.11.220.479
2a4lRRCCyclin-dependent kinase 22.7.11.220.479
3lfqA28Cyclin-dependent kinase 22.7.11.220.479
3r28XA0Cyclin-dependent kinase 22.7.11.220.479
3r7yZ04Cyclin-dependent kinase 22.7.11.220.479
1w8cN69Cyclin-dependent kinase 22.7.11.220.478
2uznC96Cyclin-dependent kinase 22.7.11.220.478
3qwjX6ACyclin-dependent kinase 22.7.11.220.478
3r7iX9ICyclin-dependent kinase 22.7.11.220.477
2r3jSCJCyclin-dependent kinase 22.7.11.220.476
3dogNNNCyclin-dependent kinase 22.7.11.220.476
3qx2X63Cyclin-dependent kinase 22.7.11.220.476
4bcoT6QCyclin-dependent kinase 22.7.11.220.476
4eos1ROCyclin-dependent kinase 22.7.11.220.476
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.476
2eufLQQCyclin-dependent kinase 62.7.11.220.475
3qtqX35Cyclin-dependent kinase 22.7.11.220.475
2xnbY8LCyclin-dependent kinase 22.7.11.220.474
3lfsA07Cyclin-dependent kinase 22.7.11.220.474
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.474
2bhhRYUCyclin-dependent kinase 22.7.11.220.473
3bhtMFRCyclin-dependent kinase 22.7.11.220.472
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.471
4ez50RSCyclin-dependent kinase 62.7.11.220.471
4lyn1YGCyclin-dependent kinase 22.7.11.220.471
1fvt106Cyclin-dependent kinase 22.7.11.220.470
3r8uZ31Cyclin-dependent kinase 22.7.11.220.470
4dgnLU2Casein kinase II subunit alpha2.7.11.10.469
1pxpCK8Cyclin-dependent kinase 22.7.11.220.468
2r3mSCXCyclin-dependent kinase 22.7.11.220.468
3axwTIDCasein kinase II subunit alpha2.7.11.10.468
4kd11QKCyclin-dependent kinase 22.7.11.220.468
1pxkCK3Cyclin-dependent kinase 22.7.11.220.467
4anmWULCasein kinase II subunit alpha2.7.11.10.467
4bcnT9NCyclin-dependent kinase 22.7.11.220.467
2c69CT8Cyclin-dependent kinase 22.7.11.220.466
4dgo0JWCasein kinase II subunit alpha2.7.11.10.466
1dm2HMDCyclin-dependent kinase 22.7.11.220.464
2c5nCK8Cyclin-dependent kinase 22.7.11.220.464
3rzb02ZCyclin-dependent kinase 22.7.11.220.464
2c6tDT5Cyclin-dependent kinase 22.7.11.220.463
3wblPDYCyclin-dependent kinase 22.7.11.220.463
2c6kDT2Cyclin-dependent kinase 22.7.11.220.462
2x1nX1NCyclin-dependent kinase 22.7.11.220.462
3at4CCKCasein kinase II subunit alpha2.7.11.10.462
3ql8X01Cyclin-dependent kinase 22.7.11.220.462
3r7eX88Cyclin-dependent kinase 22.7.11.220.462
2vu3LZECyclin-dependent kinase 22.7.11.220.461
3qrtX14Cyclin-dependent kinase 22.7.11.220.461
1finATPCyclin-dependent kinase 22.7.11.220.460
3r8pZ46Cyclin-dependent kinase 22.7.11.220.459
1unlRRCCyclin-dependent-like kinase 52.7.11.10.458
2r3gSC9Cyclin-dependent kinase 22.7.11.220.458
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.458
3tiz3TICyclin-dependent kinase 22.7.11.220.458
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.458
3be9P04Casein kinase II subunit alpha2.7.11.10.457
3gubGUBDeath-associated protein kinase 12.7.11.10.457
4eol1ROCyclin-dependent kinase 22.7.11.220.456
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.455
1b38ATPCyclin-dependent kinase 22.7.11.220.454
1xjdSTUProtein kinase C theta type2.7.11.130.454
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.454
2uzdC85Cyclin-dependent kinase 22.7.11.220.453
3qtwX3ACyclin-dependent kinase 22.7.11.220.453
2uzeC95Cyclin-dependent kinase 22.7.11.220.452
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4bcqTJFCyclin-dependent kinase 22.7.11.220.452
2wotZZGTGF-beta receptor type-12.7.11.300.451
4eop1ROCyclin-dependent kinase 22.7.11.220.451
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.450
2c6lDT4Cyclin-dependent kinase 22.7.11.220.449
1h0vUN4Cyclin-dependent kinase 22.7.11.220.448
1m2pHNACasein kinase II subunit alpha2.7.11.10.448
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
3qziX72Cyclin-dependent kinase 22.7.11.220.448
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.448
2c4g514Cyclin-dependent kinase 22.7.11.220.447
3sheI85MAP kinase-activated protein kinase 32.7.11.10.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.447
2wihP48Cyclin-dependent kinase 22.7.11.220.446
3my5RFZCyclin-dependent kinase 22.7.11.220.446
4ii5ADPCyclin-dependent kinase 22.7.11.220.446
1b39ATPCyclin-dependent kinase 22.7.11.220.445
3wowANPCasein kinase II subunit alpha2.7.11.10.445
4jqeANPCasein kinase II subunit alpha2.7.11.10.445
2cchATPCyclin-dependent kinase 22.7.11.220.444
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.444
2pvlP55Casein kinase II subunit alpha2.7.11.10.444
3nga3NGCasein kinase II subunit alpha2.7.11.10.444
2c5yMTWCyclin-dependent kinase 22.7.11.220.443
3zewSTUEphrin type-B receptor 42.7.10.10.443
1h1q2A6Cyclin-dependent kinase 22.7.11.220.442
3raiX85Cyclin-dependent kinase 22.7.11.220.442
1xo2FSECyclin-dependent kinase 62.7.11.220.441
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3nynSGVG protein-coupled receptor kinase 62.7.11.160.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440