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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pxxDIFProstaglandin G/H synthase 21.14.99.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pxxDIFProstaglandin G/H synthase 21.14.99.11.000
5ikqJMSProstaglandin G/H synthase 21.14.99.10.584
1ht5FL2Prostaglandin G/H synthase 11.14.99.10.580
5iktTLFProstaglandin G/H synthase 21.14.99.10.515
4rrxLURProstaglandin G/H synthase 21.14.99.10.507
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.503
6coxS58Prostaglandin G/H synthase 21.14.99.10.503
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.496
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.492
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.491
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.485
2p4yC03Peroxisome proliferator-activated receptor gamma/0.484
1bwsNDPGDP-L-fucose synthase/0.483
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.480
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.479
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.479
3mqe416Prostaglandin G/H synthase 21.14.99.10.478
4l8u9AZSerum albumin/0.478
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.476
2hcdBIVVitamin D3 receptor A/0.476
3jpuTY4Transcriptional activator protein LasR/0.476
2q59240Peroxisome proliferator-activated receptor gamma/0.474
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.474
3vt8YI3Vitamin D3 receptor/0.474
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.473
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.473
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
3r324CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.471
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.469
3vt7VDXVitamin D3 receptor/0.469
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.468
2znnS44Peroxisome proliferator-activated receptor alpha/0.468
1uyhPU0Heat shock protein HSP 90-alpha/0.467
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.467
4jazSTLPeroxisome proliferator-activated receptor gamma/0.467
1svlADPLarge T antigen3.6.40.466
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.466
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.466
2ovhAS0Progesterone receptor/0.466
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
2cy0NAPShikimate dehydrogenase (NADP(+))/0.465
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.465
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.464
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.464
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.463
4ocvANPAminoglycoside phosphotransferase/0.463
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
2wotZZGTGF-beta receptor type-12.7.11.300.462
3vrwYS5Vitamin D3 receptor/0.462
4fv7E94Mitogen-activated protein kinase 12.7.11.240.462
4awp99AHeat shock protein HSP 90-alpha/0.461
1m13HYFNuclear receptor subfamily 1 group I member 2/0.460
3hllI45Mitogen-activated protein kinase 14/0.460
1ay0TPPTransketolase 12.2.1.10.459
1cx2S58Prostaglandin G/H synthase 21.14.99.10.459
1qrpHH0Pepsin A-43.4.23.10.459
1xddAAYIntegrin alpha-L/0.459
2aylFLPProstaglandin G/H synthase 11.14.99.10.459
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.459
3d7kD7KBenzaldehyde lyase/0.459
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.459
1di8DTQCyclin-dependent kinase 22.7.11.220.458
2zbaZBATrichothecene 3-O-acetyltransferase/0.458
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.458
3oqkS52Renin3.4.23.150.458
2xvv9DNSerum albumin/0.457
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
1rx8NAPDihydrofolate reductase1.5.1.30.456
1umlFR4Adenosine deaminase3.5.4.40.456
2rhgIGPTryptophan synthase alpha chain/0.456
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.456
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.456
4olfHFGProline--tRNA ligase6.1.1.150.456
1h50FMNPentaerythritol tetranitrate reductase/0.455
1zrzBI1Protein kinase C iota type2.7.11.130.455
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2znq401Peroxisome proliferator-activated receptor delta/0.455
3dogNNNCyclin-dependent kinase 22.7.11.220.455
3v9y24LPeroxisome proliferator-activated receptor gamma/0.455
3vspEK8Peroxisome proliferator-activated receptor gamma/0.455
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.455
4c02TAKActivin receptor type-12.7.11.300.455
4g1z0VPVitamin D3 receptor A/0.455
4lxhC1EAlpha/beta hydrolase fold/0.455
4wa9AXITyrosine-protein kinase ABL12.7.10.20.455
1jioDEB6-deoxyerythronolide B hydroxylase/0.454
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.454
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1lf3EH5Plasmepsin-23.4.23.390.453
1zeoC01Peroxisome proliferator-activated receptor gamma/0.453
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.453
3gc9B45Mitogen-activated protein kinase 112.7.11.240.453
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.453
4jlj1NMDeoxycytidine kinase2.7.1.740.453
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.453
4rupH97Vitamin D3 receptor A/0.453
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.453
5k2cZMAAdenosine receptor A2a/0.453
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.452
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.452
3koo24DBifunctional epoxide hydrolase 23.3.2.100.452
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.452
3v3vMYUMitogen-activated protein kinase 82.7.11.240.452
3w32W32Epidermal growth factor receptor2.7.10.10.452
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.452
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.451
3cgeNDPCoenzyme A disulfide reductase/0.451
3zze6XPHepatocyte growth factor receptor2.7.10.10.451
4iah1DXAlr2278 protein/0.451
4ib4ERM5-hydroxytryptamine receptor 2B/0.451
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2b7aIZATyrosine-protein kinase JAK2/0.450
2bxmIMNSerum albumin/0.450
2i40BLZCyclin-dependent kinase 22.7.11.220.450
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2zjwREFCasein kinase II subunit alpha2.7.11.10.450
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.450
3r34COA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.450
3vf9477Tyrosine-protein kinase SYK2.7.10.20.450
3w0hW12Vitamin D3 receptor/0.450
3w5p4OAVitamin D3 receptor/0.450
4b4oNDPEpimerase family protein SDR39U1/0.450
1db1VDXVitamin D3 receptor/0.449
2yee2ECHeat shock protein HSP 90-alpha/0.449
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3vf80JETyrosine-protein kinase SYK2.7.10.20.449
4enhFVXCholesterol 24-hydroxylase/0.449
4l4cCAMCamphor 5-monooxygenase1.14.15.10.449
1ckpPVBCyclin-dependent kinase 22.7.11.220.448
1nzdUPGDNA beta-glucosyltransferase/0.448
1p0hACOMycothiol acetyltransferase2.3.1.1890.448
1phePIYCamphor 5-monooxygenase1.14.15.10.448
1r6g442Thyroid hormone receptor beta/0.448
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.448
2zaxCAMCamphor 5-monooxygenase1.14.15.10.448
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3f03FMNPentaerythritol tetranitrate reductase/0.448
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.448
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.448
4bfxZVXPantothenate kinase2.7.1.330.448
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.447
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.447
2jkkBI9Focal adhesion kinase 12.7.10.20.447
3l6jZ90Alr2278 protein/0.447
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.447
4kwi1TJReductase homolog/0.447
1s3vTQDDihydrofolate reductase1.5.1.30.446
1t86CAMCamphor 5-monooxygenase1.14.15.10.446
1uy7PU4Heat shock protein HSP 90-alpha/0.446
2abbFMNPentaerythritol tetranitrate reductase/0.446
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.446
4eetFMNPhototropin-22.7.11.10.446
4fhh0U3Vitamin D3 receptor A/0.446
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.446
1iyzNDPProbable quinone oxidoreductase/0.445
1txiTX5Vitamin D3 receptor/0.445
1zemNADXylitol dehydrogenase/0.445
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.445
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.445
3nga3NGCasein kinase II subunit alpha2.7.11.10.445
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3uzaT4GAdenosine receptor A2a/0.445
1d2sDHTSex hormone-binding globulin/0.444
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1eupASD6-deoxyerythronolide B hydroxylase/0.444
2acwUPGGlycosyltransferase/0.444
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.444
2xlsFADPutative flavin-containing monooxygenase/0.444
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.444
3vt5YI2Vitamin D3 receptor/0.444
3wowANPCasein kinase II subunit alpha2.7.11.10.444
3zoiM2WIsopenicillin N synthase1.21.3.10.444
4bcqTJFCyclin-dependent kinase 22.7.11.220.444
4bfsZVSPantothenate kinase2.7.1.330.444
4g210VPVitamin D3 receptor A/0.444
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.444
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.444
5cshATPCasein kinase II subunit alpha2.7.11.10.444
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.444
5k2aZMAAdenosine receptor A2a/0.444
3pwhZMAAdenosine receptor A2a/0.444
1fmlRTLRetinol dehydratase/0.443
1k7fIAVTryptophan synthase alpha chain/0.443
1unlRRCCyclin-dependent-like kinase 52.7.11.10.443
1vyw292Cyclin-dependent kinase 22.7.11.220.443
2c27ACOMycothiol acetyltransferase2.3.1.1890.443
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.443
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.443
2qboCAMCamphor 5-monooxygenase1.14.15.10.443
3at3ATKCasein kinase II subunit alpha2.7.11.10.443
3gu83GUDeath-associated protein kinase 12.7.11.10.443
3own3OWRenin3.4.23.150.443
3tz3B36Acetyl-CoA carboxylase/0.443
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.443
3vt9YI4Vitamin D3 receptor/0.443
4g1y0VOVitamin D3 receptor A/0.443
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
3uzcT4EAdenosine receptor A2a/0.443
1e3eNAIAlcohol dehydrogenase 41.1.1.10.442
1rf7DHFDihydrofolate reductase1.5.1.30.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2rcyNAPPyrroline-5-carboxylate reductase/0.442
2rh9IGPTryptophan synthase alpha chain/0.442
2uxoTACHTH-type transcriptional regulator TtgR/0.442
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.442
3pe2E1BCasein kinase II subunit alpha2.7.11.10.442
3sm2478Putative gag-pro-pol polyprotein/0.442
3vg9ZMAAdenosine receptor A2a/0.442
3zdu38RCyclin-dependent kinase-like 32.7.11.220.442
4c4jX21Dual specificity protein kinase TTK2.7.12.10.442
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.442
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.442
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.442
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.442
5a9sNAPPutative dehydrogenase/0.442
1kl2FONSerine hydroxymethyltransferase/0.441
1nytNAPShikimate dehydrogenase (NADP(+))/0.441
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2om9AJAPeroxisome proliferator-activated receptor gamma/0.441
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.441
3a4pDFQHepatocyte growth factor receptor2.7.10.10.441
3gfbNADL-threonine 3-dehydrogenase/0.441
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.441
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3orfNADDihydropteridine reductase1.5.1.340.441
3r3f4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.441
4fhi0S4Vitamin D3 receptor A/0.441
4gk2L66Ephrin type-A receptor 32.7.10.10.441
4oavACP2-5A-dependent ribonuclease3.1.260.441
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.441
1bygSTUTyrosine-protein kinase CSK/0.440
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1jpaANPEphrin type-B receptor 22.7.10.10.440
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1suoCPZCytochrome P450 2B41.14.14.10.440
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
2iw84SPCyclin-dependent kinase 22.7.11.220.440
2j9gANPBiotin carboxylase6.3.4.140.440
2q5qTPWIndole-3-pyruvate decarboxylase4.1.1.740.440
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.440
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.440
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.440
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.440
4iteTEYVitamin D3 receptor/0.440
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.440
4ure1PSCyclohexanol dehydrogenase/0.440
4xx0COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.440
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.440