sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1kt6 | RTL | Retinol-binding protein 4 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1kt6 | RTL | Retinol-binding protein 4 | / | 1.000 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.692 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.683 | |
| 1kt4 | RTL | Retinol-binding protein 4 | / | 0.643 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.607 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.595 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.589 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.585 | |
| 1osv | CHC | Bile acid receptor | / | 0.517 | |
| 4pd6 | URI | Nucleoside permease | / | 0.517 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.513 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.512 | |
| 1kt5 | RTL | Retinol-binding protein 4 | / | 0.509 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.502 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.497 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.496 | |
| 5a3b | APR | SIR2 family protein | / | 0.494 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.492 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.491 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.491 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.488 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.487 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.486 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.485 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.483 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.483 | |
| 1eio | GCH | Gastrotropin | / | 0.481 | |
| 3h1j | SMA | Cytochrome b | / | 0.481 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.480 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.477 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.477 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.475 | |
| 5a3c | NAD | SIR2 family protein | / | 0.475 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.474 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.473 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.472 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.472 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.471 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.469 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.467 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.467 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.467 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.467 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.467 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.467 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.466 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.466 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.466 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.466 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.465 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.465 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.465 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.465 | |
| 2avi | BTN | Avidin | / | 0.464 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.464 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.464 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.464 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.463 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.463 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.463 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.462 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.462 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.462 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.462 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.461 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.461 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.460 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.460 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.460 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.460 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.459 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.459 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.459 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.459 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.459 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.459 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.459 | |
| 4b1f | KRH | Glutamate racemase | / | 0.459 | |
| 4iaw | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.459 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.459 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.458 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 4i3z | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4l8u | 9AZ | Serum albumin | / | 0.458 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.457 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.457 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.457 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.457 | |
| 3eq6 | BCO | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.457 | |
| 3uic | 09T | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.457 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.456 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.456 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.456 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.455 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.455 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.455 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.455 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.455 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.455 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.454 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.454 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.454 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.454 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.454 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.454 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.454 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 3wth | IM4 | Acetylcholine-binding protein | / | 0.454 | |
| 4a30 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.454 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.454 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4qec | NAP | ElxO | / | 0.454 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.454 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.454 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.454 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.453 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.453 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.453 | |
| 2acw | UPG | Glycosyltransferase | / | 0.453 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.453 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.453 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.453 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.453 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.453 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.452 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.452 | |
| 4hxy | NDP | Plm1 | / | 0.452 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.452 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.451 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.451 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.451 | |
| 3up0 | D7S | aceDAF-12 | / | 0.451 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.451 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.451 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.450 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2c4i | BTN | Avidin | / | 0.450 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.450 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.450 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.450 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.450 | |
| 4a32 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.450 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.449 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.449 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.449 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.449 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.449 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.449 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.449 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.449 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.449 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.448 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.448 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.448 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.448 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.448 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 3di6 | PDZ | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.448 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.447 | |
| 2wpx | ACO | Orf14 | / | 0.447 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.447 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.447 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4f9b | 0SY | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.447 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 4qoe | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.447 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.446 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.446 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.446 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.446 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.446 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.446 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4lb2 | DM5 | Serum albumin | / | 0.446 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.446 | |
| 1avd | BTN | Avidin | / | 0.445 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.445 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2q5q | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.445 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.445 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.445 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.445 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.445 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 4l4x | NDP | AmphI | / | 0.445 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.445 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.444 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.444 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.444 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.444 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4hzo | COA | Conserved hypthetical protein | / | 0.444 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.444 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.444 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.444 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.444 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.443 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.443 | |
| 1tys | TMP | Thymidylate synthase | / | 0.443 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.443 | |
| 2p15 | EZT | Estrogen receptor | / | 0.443 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.443 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3ute | FAD | UDP-galactopyranose mutase | / | 0.443 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.443 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.443 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.443 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1e7a | PFL | Serum albumin | / | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.442 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.442 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.442 | |
| 3bej | MUF | Bile acid receptor | / | 0.442 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.442 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.442 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.442 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.442 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.441 | |
| 1r2j | FAD | FkbI | / | 0.441 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.441 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.441 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.441 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.441 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3p9t | TCL | Repressor | / | 0.441 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.441 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.441 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ivh | COS | Isovaleryl-CoA dehydrogenase, mitochondrial | 1.3.8.4 | 0.440 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.440 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.440 | |
| 2xvv | 9DN | Serum albumin | / | 0.440 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.440 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.440 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.440 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.440 | |
| 4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.440 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.440 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.440 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.440 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.440 |