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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4o7lADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4o7lADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.61.000
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.600
4nyeADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.562
2z02ATPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.556
4o7nADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.546
3oquA8SAbscisic acid receptor PYL9/0.497
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.487
1dv2ATPBiotin carboxylase6.3.4.140.484
3gc9B45Mitogen-activated protein kinase 112.7.11.240.484
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.483
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.481
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.480
3njoP2MAbscisic acid receptor PYR1/0.479
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.476
3ns2PYVAbscisic acid receptor PYL2/0.475
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.475
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.473
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.472
3cgbCOACoenzyme A disulfide reductase/0.472
3lkiATPFructokinase/0.472
3w9rA8SAbscisic acid receptor PYL9/0.472
4mv4ACPBiotin carboxylase6.3.4.140.471
1pmn984Mitogen-activated protein kinase 102.7.11.240.470
3vthAPCCarbamoyltransferase/0.470
4gyiADPUncharacterized protein/0.470
4hjfC2EGGDEF family protein/0.470
2bbqPFGThymidylate synthase/0.469
3tfn2CJDehydrosqualene synthase/0.469
2oxtSAMGenome polyprotein/0.468
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.468
4enhFVXCholesterol 24-hydroxylase/0.468
5dldUD1UDP-N-Acetylglucosamine 2-epimerase/0.468
4ds8A8SAbscisic acid receptor PYL3/0.467
1kl2FONSerine hydroxymethyltransferase/0.466
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.466
4r7uUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.466
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.465
1u3cFADCryptochrome-1/0.465
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.465
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4o4eATPKinase/0.464
3r6pA8SAbscisic acid receptor PYL10/0.463
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.462
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.461
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.461
4bebATPType I restriction enzyme EcoR124II R protein3.1.21.30.461
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.461
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.460
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.460
3cgeCOACoenzyme A disulfide reductase/0.460
3mqe416Prostaglandin G/H synthase 21.14.99.10.460
3nj0PYVAbscisic acid receptor PYL2/0.460
3qu0X40Cyclin-dependent kinase 22.7.11.220.460
4fzvSAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.460
4o6mC5PUncharacterized protein/0.460
4u03GTPCyclic GMP-AMP synthase/0.460
4xiwAZMCarbonic anhydrase, alpha type/0.460
1f4fTP3Thymidylate synthase/0.459
1oc1ASVIsopenicillin N synthase1.21.3.10.459
1p7cT5AThymidine kinase/0.459
2btsU32Cyclin-dependent kinase 22.7.11.220.459
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
3e5aVX6Aurora kinase A2.7.11.10.459
3tm5SFGUncharacterized protein/0.459
3umoATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.459
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.459
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.458
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.458
3iodA6DPantothenate synthetase6.3.2.10.458
3njoPYVAbscisic acid receptor PYR1/0.458
3kdiA8SAbscisic acid receptor PYL2/0.457
3uwqU5POrotidine 5'-phosphate decarboxylase/0.457
4h9tHL4Phosphotriesterase/0.457
4ic7ANPMitogen-activated protein kinase 72.7.11.240.457
4ki8ADP60 kDa chaperonin/0.457
2c6dANPAurora kinase A2.7.11.10.456
2jjxATPUridylate kinase/0.456
3acy702Dehydrosqualene synthase/0.456
3u9eCOALmo1369 protein/0.456
4bchT7ZCyclin-dependent kinase 92.7.11.220.456
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.455
2j0lANPFocal adhesion kinase 12.7.10.20.455
2v7a627Tyrosine-protein kinase ABL12.7.10.20.455
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.455
3is9AC7Gag-Pol polyprotein2.7.7.490.455
3rusADPChaperonin/0.455
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4o4fATPKinase/0.455
1bxrANPCarbamoyl-phosphate synthase large chain/0.454
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.454
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.454
2pwlACPFibroblast growth factor receptor 2/0.454
3nr4PYVAbscisic acid receptor PYL2/0.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.454
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.454
4jubTPPBenzoylformate decarboxylase4.1.1.70.454
1f4gTP4Thymidylate synthase/0.453
3bheBZNGag-Pol polyprotein3.4.23.160.453
3nnuEDBMitogen-activated protein kinase 14/0.453
4x2dATPFic family protein putative filamentation induced by cAMP protein/0.453
2q6cHR13-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.452
3cgdCOACoenzyme A disulfide reductase/0.452
4en4ATPPyridoxal kinase2.7.1.350.452
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
1glbADPGlycerol kinase/0.451
2aazCB3Thymidylate synthase2.1.1.450.451
2ptfFMNUncharacterized protein MTH_863/0.451
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.451
2rl2UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.451
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.451
4fkpLS5Cyclin-dependent kinase 22.7.11.220.451
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.451
4iarERM5-hydroxytryptamine receptor 1B/0.451
4zolACPTubulin tyrosine ligase/0.451
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.450
1nzdUPGDNA beta-glucosyltransferase/0.450
3nmpPYVAbscisic acid receptor PYL2/0.450
3s7a684Dihydrofolate reductase1.5.1.30.450
4ea13RXDehydrosqualene synthase/0.450
4iirANPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.450
1w78PD8Dihydrofolate synthase/folylpolyglutamate synthase6.3.2.120.449
2az3CDPNucleoside diphosphate kinase/0.449
2g37FADProline dehydrogenase/0.449
2qe4JJ3Estrogen receptor/0.449
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.449
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.449
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3r9dX6BCyclin-dependent kinase 22.7.11.220.449
4lv7ADPInositol-pentakisphosphate 2-kinase2.7.1.1580.449
4qmySTUSerine/threonine-protein kinase 242.7.11.10.449
4tuvCPZCytochrome P450 1191.140.449
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.449
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.448
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4b12NHWGlycylpeptide N-tetradecanoyltransferase/0.448
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.448
4jbqVX6Aurora kinase A2.7.11.10.448
4jia1K3Tyrosine-protein kinase JAK2/0.448
4jrnANPRhoptry kinase family protein/0.448
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.448
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.448
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.448
1i5cADPChemotaxis protein CheA2.7.13.30.447
1j39UPGDNA beta-glucosyltransferase/0.447
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.447
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.447
3fhyATPPyridoxal kinase2.7.1.350.447
3gc8B45Mitogen-activated protein kinase 112.7.11.240.447
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
3rjc06ZCyclin-dependent kinase 22.7.11.220.447
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3vewADPnebramycin 5' synthase6.1.2.20.447
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4ia7BIVVitamin D3 receptor A/0.447
4j98ACPFibroblast growth factor receptor 2/0.447
1ckpPVBCyclin-dependent kinase 22.7.11.220.446
1i59ADPChemotaxis protein CheA2.7.13.30.446
1lolXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.446
1uymPU3Heat shock protein HSP 90-beta/0.446
2izrBRKCasein kinase I isoform gamma-32.7.11.10.446
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.446
3slkNDPPolyketide synthase extender module 2/0.446
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.446
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4o0uADNAurora kinase A2.7.11.10.446
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.446
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.446
5g3tFDAFlavin-dependent L-tryptophan oxidase VioA/0.446
5jqbIBPEnvelope glycoprotein/0.446
1lp6C5POrotidine 5'-phosphate decarboxylase4.1.1.230.445
1uydPU8Heat shock protein HSP 90-alpha/0.445
1wlvCOAPhenylacetic acid degradation protein PaaI/0.445
2eerNADNAD-dependent alcohol dehydrogenase1.1.1.10.445
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.445
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.445
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.445
3vf2ADPnebramycin 5' synthase6.1.2.20.445
4bewCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
4dscA8SAbscisic acid receptor PYL3/0.445
4ji91M3Tyrosine-protein kinase JAK2/0.445
4lyn1YGCyclin-dependent kinase 22.7.11.220.445
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.445
4qmlANPSerine/threonine-protein kinase 242.7.11.10.445
1bwfATFGlycerol kinase/0.444
1sn5T3Transthyretin/0.444
2e20B4PPropionate kinase/0.444
2hruADPPhosphoribosylformylglycinamidine synthase subunit PurL/0.444
2vu3LZECyclin-dependent kinase 22.7.11.220.444
2zdt46CMitogen-activated protein kinase 102.7.11.240.444
4at8ATPInterleukin enhancer-binding factor 2/0.444
4kxl6C62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.444
5l8lADPAurora kinase A2.7.11.10.444
1krv147Galactoside O-acetyltransferase2.3.1.180.443
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.443
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.443
2xclANPPhosphoribosylamine--glycine ligase/0.443
3cgcCOACoenzyme A disulfide reductase/0.443
3d0bSNXHeat shock protein HSP 90-alpha/0.443
3mdvCL6Cholesterol 24-hydroxylase/0.443
3w33W19Epidermal growth factor receptor2.7.10.10.443
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.443
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.443
4btjADPTau-tubulin kinase 12.7.11.10.443
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4l9kEHFSerum albumin/0.443
4riyADPEpidermal growth factor receptor2.7.10.10.443
4uofDATNucleoside diphosphate kinase/0.443
1kijNOVDNA gyrase subunit B/0.442
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3fgoCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3unj0BXCyclin-dependent kinase 22.7.11.220.442
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.442
3zkyWT4Isopenicillin N synthase1.21.3.10.442
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
1pxmCK5Cyclin-dependent kinase 22.7.11.220.441
2itqITQEpidermal growth factor receptor2.7.10.10.441
2wqeADPAurora kinase A2.7.11.10.441
2y9qANPMitogen-activated protein kinase 12.7.11.240.441
2zzaFOLDihydrofolate reductase/0.441
3issEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
3uvr06FMitogen-activated protein kinase 14/0.441
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.441
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4g3pUD1Bifunctional protein GlmU/0.441
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4k33ACPFibroblast growth factor receptor 32.7.10.10.441
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.441
1m17AQ4Epidermal growth factor receptor2.7.10.10.440
1qiqACCIsopenicillin N synthase1.21.3.10.440
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
2vcmM11Isopenicillin N synthase1.21.3.10.440
3lfsA07Cyclin-dependent kinase 22.7.11.220.440
3negPYVAbscisic acid receptor PYL1/0.440
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.440
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
3rhdNAPLactaldehyde dehydrogenase1.2.1.220.440
4becATPType I restriction enzyme EcoR124II R protein3.1.21.30.440
4c77N01Phenylacetone monooxygenase1.14.13.920.440
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.440
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.440
4ea0651Dehydrosqualene synthase/0.440
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.440
4s32ANPMitogen-activated protein kinase 12.7.11.240.440
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.440
5dbjFADFADH2-dependent halogenase PltA/0.440