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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fko20KCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fko20KCyclin-dependent kinase 22.7.11.221.000
3sw719KCyclin-dependent kinase 22.7.11.220.647
2xmyCDKCyclin-dependent kinase 22.7.11.220.637
3qtzX42Cyclin-dependent kinase 22.7.11.220.632
3unj0BXCyclin-dependent kinase 22.7.11.220.613
3sw418KCyclin-dependent kinase 22.7.11.220.607
4acm7YGCyclin-dependent kinase 22.7.11.220.603
3qtxX43Cyclin-dependent kinase 22.7.11.220.601
3rak03ZCyclin-dependent kinase 22.7.11.220.584
3r9oZ71Cyclin-dependent kinase 22.7.11.220.581
3rpv26ZCyclin-dependent kinase 22.7.11.220.581
4fkv61KCyclin-dependent kinase 22.7.11.220.579
3s1h56ZCyclin-dependent kinase 22.7.11.220.578
3unk0BYCyclin-dependent kinase 22.7.11.220.567
4ek816KCyclin-dependent kinase 22.7.11.220.563
1pxmCK5Cyclin-dependent kinase 22.7.11.220.561
2w1hL0FCyclin-dependent kinase 22.7.11.220.560
4fkq42KCyclin-dependent kinase 22.7.11.220.560
2w06FRVCyclin-dependent kinase 22.7.11.220.558
3qtuX44Cyclin-dependent kinase 22.7.11.220.557
3ral04ZCyclin-dependent kinase 22.7.11.220.557
3qxpX64Cyclin-dependent kinase 22.7.11.220.555
3r9dX6BCyclin-dependent kinase 22.7.11.220.555
2c6iDT1Cyclin-dependent kinase 22.7.11.220.554
4bgh3I6Cyclin-dependent kinase 22.7.11.220.553
4fkw62KCyclin-dependent kinase 22.7.11.220.552
1urwI1PCyclin-dependent kinase 22.7.11.220.551
3rmf20ZCyclin-dependent kinase 22.7.11.220.549
3r8lZ30Cyclin-dependent kinase 22.7.11.220.546
1y91CT9Cyclin-dependent kinase 22.7.11.220.544
2r3iSCFCyclin-dependent kinase 22.7.11.220.544
1ke6LS2Cyclin-dependent kinase 22.7.11.220.541
2xnbY8LCyclin-dependent kinase 22.7.11.220.541
2c6o4SPCyclin-dependent kinase 22.7.11.220.538
2vv9IM9Cyclin-dependent kinase 22.7.11.220.538
3py0SU9Cyclin-dependent kinase 22.7.11.220.538
3lfnA27Cyclin-dependent kinase 22.7.11.220.535
1pxpCK8Cyclin-dependent kinase 22.7.11.220.534
4fks46KCyclin-dependent kinase 22.7.11.220.533
3rk708ZCyclin-dependent kinase 22.7.11.220.532
3ti1B49Cyclin-dependent kinase 22.7.11.220.530
3s2pPMUCyclin-dependent kinase 22.7.11.220.529
1ke7LS3Cyclin-dependent kinase 22.7.11.220.528
2w17I19Cyclin-dependent kinase 22.7.11.220.528
3rk507ZCyclin-dependent kinase 22.7.11.220.527
1g5sI17Cyclin-dependent kinase 22.7.11.220.526
1y8yCT7Cyclin-dependent kinase 22.7.11.220.525
2r3jSCJCyclin-dependent kinase 22.7.11.220.524
2r3lSCWCyclin-dependent kinase 22.7.11.220.523
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.523
1oitHDTCyclin-dependent kinase 22.7.11.220.522
3qu0X40Cyclin-dependent kinase 22.7.11.220.521
3qtrX36Cyclin-dependent kinase 22.7.11.220.520
3rni21ZCyclin-dependent kinase 22.7.11.220.520
3qzhX69Cyclin-dependent kinase 22.7.11.220.519
1di8DTQCyclin-dependent kinase 22.7.11.220.518
2uzoC62Cyclin-dependent kinase 22.7.11.220.518
1gih1PUCyclin-dependent kinase 22.7.11.220.516
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.516
3ezvEZVCyclin-dependent kinase 22.7.11.220.515
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.513
3r9hZ67Cyclin-dependent kinase 22.7.11.220.512
3sqq99ZCyclin-dependent kinase 22.7.11.220.511
3r8zZ63Cyclin-dependent kinase 22.7.11.220.510
3uli1N3Cyclin-dependent kinase 22.7.11.220.510
3r8vZ62Cyclin-dependent kinase 22.7.11.220.509
2a0cCK9Cyclin-dependent kinase 22.7.11.220.508
2w05FRTCyclin-dependent kinase 22.7.11.220.508
1p2a5BNCyclin-dependent kinase 22.7.11.220.507
2iw84SPCyclin-dependent kinase 22.7.11.220.507
3pxyJWSCyclin-dependent kinase 22.7.11.220.507
4qmpDKISerine/threonine-protein kinase 242.7.11.10.506
3raiX85Cyclin-dependent kinase 22.7.11.220.505
4fkt48KCyclin-dependent kinase 22.7.11.220.504
3qqhX0ACyclin-dependent kinase 22.7.11.220.503
1oiyN41Cyclin-dependent kinase 22.7.11.220.500
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.500
2j9mPY8Cyclin-dependent kinase 22.7.11.220.499
1fvv107Cyclin-dependent kinase 22.7.11.220.498
1pxlCK4Cyclin-dependent kinase 22.7.11.220.497
2fvdLIACyclin-dependent kinase 22.7.11.220.497
2r64740Cyclin-dependent kinase 22.7.11.220.497
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.495
2r3o2SCCyclin-dependent kinase 22.7.11.220.495
2bheBRYCyclin-dependent kinase 22.7.11.220.494
3r71X86Cyclin-dependent kinase 22.7.11.220.494
3rjc06ZCyclin-dependent kinase 22.7.11.220.494
1ykr628Cyclin-dependent kinase 22.7.11.220.493
3r7vZ02Cyclin-dependent kinase 22.7.11.220.493
2vttLZDCyclin-dependent kinase 22.7.11.220.492
3r1sX73Cyclin-dependent kinase 22.7.11.220.492
1gii1PUCyclin-dependent kinase 22.7.11.220.491
1ke5LS1Cyclin-dependent kinase 22.7.11.220.491
3qruX19Cyclin-dependent kinase 22.7.11.220.491
4ez30S0Cyclin-dependent kinase 22.7.11.220.491
1h1s4SPCyclin-dependent kinase 22.7.11.220.490
2b52D42Cyclin-dependent kinase 22.7.11.220.490
4fkr45KCyclin-dependent kinase 22.7.11.220.490
1v1k3FPCyclin-dependent kinase 22.7.11.220.489
2iw94SPCyclin-dependent kinase 22.7.11.220.489
2c6lDT4Cyclin-dependent kinase 22.7.11.220.488
1ke9LS5Cyclin-dependent kinase 22.7.11.220.486
1w0xOLOCyclin-dependent kinase 22.7.11.220.486
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.486
1gij2PUCyclin-dependent kinase 22.7.11.220.485
1w8cN69Cyclin-dependent kinase 22.7.11.220.485
3rpy27ZCyclin-dependent kinase 22.7.11.220.485
1h1r6CPCyclin-dependent kinase 22.7.11.220.483
2eufLQQCyclin-dependent kinase 62.7.11.220.482
2r3kSCQCyclin-dependent kinase 22.7.11.220.482
4fkpLS5Cyclin-dependent kinase 22.7.11.220.482
1h0w207Cyclin-dependent kinase 22.7.11.220.481
2r3p3SCCyclin-dependent kinase 22.7.11.220.481
3s0o50ZCyclin-dependent kinase 22.7.11.220.481
1e1xNW1Cyclin-dependent kinase 22.7.11.220.480
1oguST8Cyclin-dependent kinase 22.7.11.220.480
4erwSTUCyclin-dependent kinase 22.7.11.220.479
3lfsA07Cyclin-dependent kinase 22.7.11.220.478
3r73X87Cyclin-dependent kinase 22.7.11.220.478
4fx360KCyclin-dependent kinase 22.7.11.220.478
1pxkCK3Cyclin-dependent kinase 22.7.11.220.477
2c5yMTWCyclin-dependent kinase 22.7.11.220.477
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.477
1oirHDYCyclin-dependent kinase 22.7.11.220.476
1ckpPVBCyclin-dependent kinase 22.7.11.220.475
3qxoX65Cyclin-dependent kinase 22.7.11.220.475
2btsU32Cyclin-dependent kinase 22.7.11.220.474
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.474
2uznC96Cyclin-dependent kinase 22.7.11.220.474
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.474
2a4lRRCCyclin-dependent kinase 22.7.11.220.473
2r3r6SCCyclin-dependent kinase 22.7.11.220.473
2bhhRYUCyclin-dependent kinase 22.7.11.220.472
3qzgX67Cyclin-dependent kinase 22.7.11.220.472
3rpo24ZCyclin-dependent kinase 22.7.11.220.472
3rm719ZCyclin-dependent kinase 22.7.11.220.471
4ek610KCyclin-dependent kinase 22.7.11.220.471
2r3fSC8Cyclin-dependent kinase 22.7.11.220.470
3qtqX35Cyclin-dependent kinase 22.7.11.220.470
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.470
3gxlQIGTGF-beta receptor type-12.7.11.300.469
3le62BZCyclin-dependent kinase 22.7.11.220.469
2b55D31Cyclin-dependent kinase 22.7.11.220.467
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.467
3iggEFQCyclin-dependent kinase 22.7.11.220.467
3r7yZ04Cyclin-dependent kinase 22.7.11.220.467
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.467
4kd11QKCyclin-dependent kinase 22.7.11.220.467
2vu3LZECyclin-dependent kinase 22.7.11.220.466
3dogNNNCyclin-dependent kinase 22.7.11.220.464
3iok1P6Tyrosine-protein kinase JAK2/0.464
3pj8404Cyclin-dependent kinase 22.7.11.220.463
3r6xX84Cyclin-dependent kinase 22.7.11.220.463
4aqc88ATyrosine-protein kinase JAK2/0.463
2vtsLZCCyclin-dependent kinase 22.7.11.220.462
3r1yX76Cyclin-dependent kinase 22.7.11.220.462
2b53D23Cyclin-dependent kinase 22.7.11.220.461
2c6kDT2Cyclin-dependent kinase 22.7.11.220.461
3qqkX02Cyclin-dependent kinase 22.7.11.220.461
3qzfX66Cyclin-dependent kinase 22.7.11.220.460
2btrU73Cyclin-dependent kinase 22.7.11.220.459
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.459
3r9nZ68Cyclin-dependent kinase 22.7.11.220.459
3rkb12ZCyclin-dependent kinase 22.7.11.220.459
3qtsX46Cyclin-dependent kinase 22.7.11.220.458
3rahO1ZCyclin-dependent kinase 22.7.11.220.458
1oi9N20Cyclin-dependent kinase 22.7.11.220.457
3r83Z14Cyclin-dependent kinase 22.7.11.220.457
4hge15VTyrosine-protein kinase JAK2/0.457
3wblPDYCyclin-dependent kinase 22.7.11.220.456
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.456
2vthLZ2Cyclin-dependent kinase 22.7.11.220.455
3fz1B98Cyclin-dependent kinase 22.7.11.220.455
3qwkX62Cyclin-dependent kinase 22.7.11.220.455
1ke8LS4Cyclin-dependent kinase 22.7.11.220.454
2p83MR0Beta-secretase 13.4.23.460.454
2r3q5SCCyclin-dependent kinase 22.7.11.220.454
3be9P04Casein kinase II subunit alpha2.7.11.10.454
3lfqA28Cyclin-dependent kinase 22.7.11.220.454
3qqfX07Cyclin-dependent kinase 22.7.11.220.454
3r7uX96Cyclin-dependent kinase 22.7.11.220.454
3roy22ZCyclin-dependent kinase 22.7.11.220.454
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
3ddpRC8Cyclin-dependent kinase 22.7.11.220.453
3r7eX88Cyclin-dependent kinase 22.7.11.220.453
1dm2HMDCyclin-dependent kinase 22.7.11.220.452
3qx2X63Cyclin-dependent kinase 22.7.11.220.451
3sheI85MAP kinase-activated protein kinase 32.7.11.10.451
4eok4SPCyclin-dependent kinase 22.7.11.220.451
1aq1STUCyclin-dependent kinase 22.7.11.220.450
2b54D05Cyclin-dependent kinase 22.7.11.220.450
3qtwX3ACyclin-dependent kinase 22.7.11.220.450
3tiz3TICyclin-dependent kinase 22.7.11.220.450
2wihP48Cyclin-dependent kinase 22.7.11.220.449
3qwjX6ACyclin-dependent kinase 22.7.11.220.449
3rk909ZCyclin-dependent kinase 22.7.11.220.449
4bbfO19Tyrosine-protein kinase JAK2/0.449
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.449
1eh4IC1Casein kinase I homolog 12.7.11.10.447
1pxoCK7Cyclin-dependent kinase 22.7.11.220.447
2i40BLZCyclin-dependent kinase 22.7.11.220.447
3w32W32Epidermal growth factor receptor2.7.10.10.447
2r3gSC9Cyclin-dependent kinase 22.7.11.220.446
3cic316Beta-secretase 13.4.23.460.446
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.446
4bgg844Activin receptor type-12.7.11.300.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.445
1pyePM1Cyclin-dependent kinase 22.7.11.220.445
2c69CT8Cyclin-dependent kinase 22.7.11.220.445
2uzlC94Cyclin-dependent kinase 22.7.11.220.445
3r7iX9ICyclin-dependent kinase 22.7.11.220.445
3r28XA0Cyclin-dependent kinase 22.7.11.220.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.443
3cid318Beta-secretase 13.4.23.460.443
3ddqRRCCyclin-dependent kinase 22.7.11.220.443
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.443
3nwxKVSGag-Pol polyprotein3.4.23.160.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1fvt106Cyclin-dependent kinase 22.7.11.220.442
1r78FMDCyclin-dependent kinase 22.7.11.220.442
2b7aIZATyrosine-protein kinase JAK2/0.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
3ezrEZRCyclin-dependent kinase 22.7.11.220.442
3qziX72Cyclin-dependent kinase 22.7.11.220.442
3rpr25ZCyclin-dependent kinase 22.7.11.220.442
4lyn1YGCyclin-dependent kinase 22.7.11.220.442
1ec3MS3Gag-Pol polyprotein3.4.23.160.441
2x1nX1NCyclin-dependent kinase 22.7.11.220.441
3mdmFJZCholesterol 24-hydroxylase/0.441
4a4qUX9Pol protein/0.441
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.440
1vyzN5BCyclin-dependent kinase 22.7.11.220.440
3nga3NGCasein kinase II subunit alpha2.7.11.10.440
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.440
3qqlX03Cyclin-dependent kinase 22.7.11.220.440
3rm618ZCyclin-dependent kinase 22.7.11.220.440
4uuxAPRCinA-like protein/0.440