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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dtaADNAPH(2'')-Id

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dtaADNAPH(2'')-Id/1.000
4dt9GMPAPH(2'')-Id/0.607
4dt8ADNAPH(2'')-Id/0.564
4dtbGMPAPH(2'')-Id/0.523
4jia1K3Tyrosine-protein kinase JAK2/0.509
3igoANPCalmodulin-domain protein kinase 1, putative/0.505
4y93746Tyrosine-protein kinase/0.503
4n57ADPAPH(2'')-Id/0.501
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.500
4fob0USALK tyrosine kinase receptor2.7.10.10.493
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.490
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.488
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
3a62STURibosomal protein S6 kinase beta-12.7.11.10.481
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.480
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.480
4ix5ANPUncharacterized protein/0.480
4j95ACPFibroblast growth factor receptor 2/0.478
2pvmP29Casein kinase II subunit alpha2.7.11.10.477
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.476
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.475
4bcmT7ZCyclin-dependent kinase 22.7.11.220.475
4otiMI1Serine/threonine-protein kinase N1/0.475
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4hvi19STyrosine-protein kinase JAK32.7.10.20.474
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.473
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.473
4y95746Tyrosine-protein kinase/0.472
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.471
1fvv107Cyclin-dependent kinase 22.7.11.220.469
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.469
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.469
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
3pe2E1BCasein kinase II subunit alpha2.7.11.10.467
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.467
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.467
4ix6ADPUncharacterized protein/0.467
4q5hANPProtein kinase OspG2.70.467
1u3cFADCryptochrome-1/0.466
2zjwREFCasein kinase II subunit alpha2.7.11.10.466
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.466
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4nk92K5Fibroblast growth factor receptor 1/0.466
1pmn984Mitogen-activated protein kinase 102.7.11.240.465
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.465
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.465
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.465
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.465
1wvxBD4Death-associated protein kinase 12.7.11.10.464
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.464
3zh8C58Protein kinase C iota type2.7.11.130.463
4jqeANPCasein kinase II subunit alpha2.7.11.10.463
5av2KMPDeath-associated protein kinase 12.7.11.10.463
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.462
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.462
3ezrEZRCyclin-dependent kinase 22.7.11.220.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.462
4ic7ANPMitogen-activated protein kinase 72.7.11.240.462
2j0m4STFocal adhesion kinase 12.7.10.20.461
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.461
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.460
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
2j0lANPFocal adhesion kinase 12.7.10.20.460
3eb0DRKUncharacterized protein/0.460
3lf0ATPNitrogen regulatory protein P-II/0.460
3t8oATPRhodopsin kinase/0.460
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.460
1jioDEB6-deoxyerythronolide B hydroxylase/0.459
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.459
4f081RSTyrosine-protein kinase JAK2/0.459
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
1aq1STUCyclin-dependent kinase 22.7.11.220.458
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.458
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.457
2vu3LZECyclin-dependent kinase 22.7.11.220.457
3lltANPProtein serine/threonine kinase-1/0.457
4aqc88ATyrosine-protein kinase JAK2/0.457
4gub0Y4Casein kinase II subunit alpha2.7.11.10.457
4lrjANPUncharacterized protein/0.457
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.457
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.457
1oecAA2Fibroblast growth factor receptor 2/0.456
1zrzBI1Protein kinase C iota type2.7.11.130.456
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.456
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.455
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.455
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.455
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.455
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1yvj4STTyrosine-protein kinase JAK32.7.10.20.454
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.454
3gu6ADPDeath-associated protein kinase 12.7.11.10.454
4j98ACPFibroblast growth factor receptor 2/0.454
5dr9SKEAurora kinase A2.7.11.10.454
2xclANPPhosphoribosylamine--glycine ligase/0.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.452
2pvlP55Casein kinase II subunit alpha2.7.11.10.452
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.451
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2pwlACPFibroblast growth factor receptor 2/0.451
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3ezvEZVCyclin-dependent kinase 22.7.11.220.451
3lpbNVBTyrosine-protein kinase JAK2/0.451
3zewSTUEphrin type-B receptor 42.7.10.10.451
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.450
2c6lDT4Cyclin-dependent kinase 22.7.11.220.450
3bu5ATPInsulin receptor2.7.10.10.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.450
1v9aSAHUncharacterized protein/0.449
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.449
2yaaATPDeath-associated protein kinase 2/0.449
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.449
4hvh19RTyrosine-protein kinase JAK32.7.10.20.449
2ijmATPFocal adhesion kinase 12.7.10.20.448
2xngA0HAurora kinase A2.7.11.10.448
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.448
3be9P04Casein kinase II subunit alpha2.7.11.10.448
3dfcANPDeath-associated protein kinase 12.7.11.10.448
3ztxZTXAurora kinase B-A2.7.11.10.448
5dt0SKEAurora kinase A2.7.11.10.448
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.447
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.447
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.447
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.447
4o0sADNAurora kinase A2.7.11.10.447
2csnCKICasein kinase I homolog 12.7.11.10.446
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.446
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4tuvCPZCytochrome P450 1191.140.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.445
2vtqLZACyclin-dependent kinase 22.7.11.220.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4e6d0NUTyrosine-protein kinase JAK2/0.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.444
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3iok1P6Tyrosine-protein kinase JAK2/0.444
3pxkPXKFocal adhesion kinase 12.7.10.20.444
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.444
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.444
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2cciATPCyclin-dependent kinase 22.7.11.220.443
2ckeIQUDeath-associated protein kinase 2/0.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
3cgfJNFMitogen-activated protein kinase 102.7.11.240.443
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.443
3nszANPCasein kinase II subunit alpha2.7.11.10.443
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.443
3w2sW2REpidermal growth factor receptor2.7.10.10.443
4yuqKS1Calmodulin-like domain protein kinase/0.443
5av3KMPDeath-associated protein kinase 12.7.11.10.443
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.442
1u54ACPActivated CDC42 kinase 1/0.442
2bfyH1NAurora kinase B-A2.7.11.10.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.442
3nga3NGCasein kinase II subunit alpha2.7.11.10.442
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.442
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.442
4gu610NFocal adhesion kinase 12.7.10.20.442
4r21STRCytochrome P450 family 17 polypeptide 2/0.442
5dr6SKEAurora kinase A2.7.11.10.442
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1rbyKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.441
2olcADPMethylthioribose kinase2.7.1.1000.441
2vv9IM9Cyclin-dependent kinase 22.7.11.220.441
3sheI85MAP kinase-activated protein kinase 32.7.11.10.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4o4fATPKinase/0.441
1bygSTUTyrosine-protein kinase CSK/0.440
1eh4IC1Casein kinase I homolog 12.7.11.10.440
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.440
3bqr4RBDeath-associated protein kinase 3/0.440
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.440
3zxtACPDeath-associated protein kinase 12.7.11.10.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.440
4nks2M2Fibroblast growth factor receptor 1/0.440