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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4acg6LQGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4acg6LQGlycogen synthase kinase-3 beta2.7.11.261.000
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.603
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.601
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.580
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.577
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.576
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.567
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.562
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.556
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.555
3du8553Glycogen synthase kinase-3 beta2.7.11.260.548
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.537
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.522
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.522
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.518
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.517
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.515
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.515
4dymIYZActivin receptor type-12.7.11.300.511
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.507
3mtfA3FActivin receptor type-12.7.11.300.507
4bgg844Activin receptor type-12.7.11.300.507
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.506
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.505
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.500
2j4z626Aurora kinase A2.7.11.10.499
3eb0DRKUncharacterized protein/0.498
4bchT7ZCyclin-dependent kinase 92.7.11.220.498
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.496
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.494
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.494
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.491
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.489
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.489
2jedLG8Protein kinase C theta type2.7.11.130.489
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.488
3i60E86Mitogen-activated protein kinase 12.7.11.240.488
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.488
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.488
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.487
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.487
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.485
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.483
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.483
3oom507Activin receptor type-12.7.11.300.483
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.483
2pvnP63Casein kinase II subunit alpha2.7.11.10.482
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.482
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.481
2dwbANPAurora kinase A2.7.11.10.481
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.481
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.480
5dr9SKEAurora kinase A2.7.11.10.480
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.478
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.478
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.477
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.476
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.476
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.475
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.475
3iw4LW4Protein kinase C alpha type2.7.11.130.475
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.475
3e5aVX6Aurora kinase A2.7.11.10.474
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.474
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.474
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.474
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
5e8xSTUTGF-beta receptor type-12.7.11.300.474
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.473
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.472
4erwSTUCyclin-dependent kinase 22.7.11.220.471
1oguST8Cyclin-dependent kinase 22.7.11.220.470
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.470
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.470
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.470
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.470
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.470
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.470
2pvhP19Casein kinase II subunit alpha2.7.11.10.469
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.469
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.469
3be9P04Casein kinase II subunit alpha2.7.11.10.468
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.468
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.468
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.468
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.468
1dawANPCasein kinase II subunit alpha2.7.11.10.467
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.467
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.467
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.467
3r9dX6BCyclin-dependent kinase 22.7.11.220.467
1bygSTUTyrosine-protein kinase CSK/0.466
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.466
4jia1K3Tyrosine-protein kinase JAK2/0.466
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.465
3q9xEMOCasein kinase II subunit alpha2.7.11.10.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
4jq8KJ8Epidermal growth factor receptor2.7.10.10.465
2b52D42Cyclin-dependent kinase 22.7.11.220.464
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3zh8C58Protein kinase C iota type2.7.11.130.464
4aguD15Cyclin-dependent kinase-like 1/0.464
4i22IREEpidermal growth factor receptor2.7.10.10.464
4jboWPHAurora kinase A2.7.11.10.464
3sheI85MAP kinase-activated protein kinase 32.7.11.10.463
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.462
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.461
2uzlC94Cyclin-dependent kinase 22.7.11.220.461
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.461
1oiuN76Cyclin-dependent kinase 22.7.11.220.460
2cchATPCyclin-dependent kinase 22.7.11.220.460
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.460
4qmySTUSerine/threonine-protein kinase 242.7.11.10.460
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.459
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.459
3mdvCL6Cholesterol 24-hydroxylase/0.459
3zdu38RCyclin-dependent kinase-like 32.7.11.220.459
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.459
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.459
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.458
2ptfFMNUncharacterized protein MTH_863/0.458
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.458
5drdATPAurora kinase A2.7.11.10.458
5e8ySTUTGF-beta receptor type-22.7.11.300.458
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.457
1oi9N20Cyclin-dependent kinase 22.7.11.220.457
1y91CT9Cyclin-dependent kinase 22.7.11.220.457
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.457
3rak03ZCyclin-dependent kinase 22.7.11.220.457
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.457
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
2c5nCK8Cyclin-dependent kinase 22.7.11.220.456
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.456
2w1eL0EAurora kinase A2.7.11.10.456
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.456
3rni21ZCyclin-dependent kinase 22.7.11.220.456
4c02TAKActivin receptor type-12.7.11.300.456
4jbqVX6Aurora kinase A2.7.11.10.456
4jqeANPCasein kinase II subunit alpha2.7.11.10.456
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.456
1lp4ANPCasein kinase II subunit alpha2.7.11.10.455
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
3mdmFJZCholesterol 24-hydroxylase/0.455
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.455
4hvh19RTyrosine-protein kinase JAK32.7.10.20.455
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.455
4j97ACPFibroblast growth factor receptor 2/0.455
4jajXU1Aurora kinase A2.7.11.10.455
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
2wxvWXVCyclin-dependent kinase 22.7.11.220.454
4bbe3O4Tyrosine-protein kinase JAK2/0.454
4enhFVXCholesterol 24-hydroxylase/0.454
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.454
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.454
4wsqKSAAP2-associated protein kinase 12.7.11.10.454
1zeoC01Peroxisome proliferator-activated receptor gamma/0.453
2w05FRTCyclin-dependent kinase 22.7.11.220.453
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.453
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.453
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.453
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.453
3qu0X40Cyclin-dependent kinase 22.7.11.220.453
2iw84SPCyclin-dependent kinase 22.7.11.220.452
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.452
2w1fL0FAurora kinase A2.7.11.10.452
3rmf20ZCyclin-dependent kinase 22.7.11.220.452
3zep1NXTyrosine-protein kinase JAK32.7.10.20.452
4fkv61KCyclin-dependent kinase 22.7.11.220.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
4hvi19STyrosine-protein kinase JAK32.7.10.20.452
1di8DTQCyclin-dependent kinase 22.7.11.220.451
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.451
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.451
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.450
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.450
3t8oATPRhodopsin kinase/0.450
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
2v7a627Tyrosine-protein kinase ABL12.7.10.20.449
3efwAK8Aurora kinase A2.7.11.10.449
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.449
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.449
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.448
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.448
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.448
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.448
3gxlQIGTGF-beta receptor type-12.7.11.300.448
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3s1h56ZCyclin-dependent kinase 22.7.11.220.448
4anmWULCasein kinase II subunit alpha2.7.11.10.448
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.448
5dozNDPJamJ/0.448
5dr6SKEAurora kinase A2.7.11.10.448
1h1r6CPCyclin-dependent kinase 22.7.11.220.447
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.447
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.447
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.447
2eufLQQCyclin-dependent kinase 62.7.11.220.447
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.447
2vu3LZECyclin-dependent kinase 22.7.11.220.447
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
3hmm855TGF-beta receptor type-12.7.11.300.447
4c62XWWTyrosine-protein kinase JAK2/0.447
4fob0USALK tyrosine kinase receptor2.7.10.10.447
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.447
4gk2L66Ephrin type-A receptor 32.7.10.10.447
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.447
4lfiGNPCasein kinase II subunit alpha2.7.11.10.447
1oiyN41Cyclin-dependent kinase 22.7.11.220.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.446
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.446
2vv9IM9Cyclin-dependent kinase 22.7.11.220.446
3a60STURibosomal protein S6 kinase beta-12.7.11.10.446
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.446
1aq1STUCyclin-dependent kinase 22.7.11.220.445
1m2pHNACasein kinase II subunit alpha2.7.11.10.445
2h96893Mitogen-activated protein kinase 82.7.11.240.445
2i0ePDSProtein kinase C beta type2.7.11.130.445
3bu5ATPInsulin receptor2.7.10.10.445
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.445
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.445
5cvfATPCasein kinase II subunit alpha2.7.11.10.445
2bhhRYUCyclin-dependent kinase 22.7.11.220.444
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
3vf80JETyrosine-protein kinase SYK2.7.10.20.444
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.444
1h1s4SPCyclin-dependent kinase 22.7.11.220.443
2uxpCLMHTH-type transcriptional regulator TtgR/0.443
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.443
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4e4m0NHTyrosine-protein kinase JAK2/0.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
1e9hINRCyclin-dependent kinase 22.7.11.220.442
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.442
1pyePM1Cyclin-dependent kinase 22.7.11.220.442
2w17I19Cyclin-dependent kinase 22.7.11.220.442
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.442
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.442
3gbuATPUncharacterized sugar kinase PH14592.7.10.442
3k5uPFQAurora kinase A2.7.11.10.442
3r9oZ71Cyclin-dependent kinase 22.7.11.220.442
4ix6ADPUncharacterized protein/0.442
4jbpYPHAurora kinase A2.7.11.10.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
3ddpRC8Cyclin-dependent kinase 22.7.11.220.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.441
4gg70J8Hepatocyte growth factor receptor2.7.10.10.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441
4utdACPAurora kinase A2.7.11.10.441
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.440
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.440
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.440
2qo9ANPEphrin type-A receptor 32.7.10.10.440
2x6dX6DAurora kinase A2.7.11.10.440
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.440
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.440
3qtxX43Cyclin-dependent kinase 22.7.11.220.440
3r9hZ67Cyclin-dependent kinase 22.7.11.220.440
3rk708ZCyclin-dependent kinase 22.7.11.220.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.440
4o0wADNAurora kinase A2.7.11.10.440
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.440