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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.261.000
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.613
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.602
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.602
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.600
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.598
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.596
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.586
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.580
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.562
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.561
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.557
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.553
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.552
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.551
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.549
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.547
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.541
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.534
3du8553Glycogen synthase kinase-3 beta2.7.11.260.529
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.529
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.528
4bchT7ZCyclin-dependent kinase 92.7.11.220.525
3i60E86Mitogen-activated protein kinase 12.7.11.240.520
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.519
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.511
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.510
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.510
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.507
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.506
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.504
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.503
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4aguD15Cyclin-dependent kinase-like 1/0.499
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.498
4jboWPHAurora kinase A2.7.11.10.497
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.496
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.495
2vu3LZECyclin-dependent kinase 22.7.11.220.495
2cchATPCyclin-dependent kinase 22.7.11.220.494
2ijmADPFocal adhesion kinase 12.7.10.20.494
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.493
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.491
3eb0DRKUncharacterized protein/0.491
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.490
4j95ACPFibroblast growth factor receptor 2/0.490
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.488
5e8ySTUTGF-beta receptor type-22.7.11.300.488
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.487
3w2sW2REpidermal growth factor receptor2.7.10.10.487
4ez50RSCyclin-dependent kinase 62.7.11.220.487
4qo9627Serine/threonine-protein kinase 242.7.11.10.487
4jrvKJVEpidermal growth factor receptor2.7.10.10.486
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.485
2fvdLIACyclin-dependent kinase 22.7.11.220.485
4bgg844Activin receptor type-12.7.11.300.485
4ic7ANPMitogen-activated protein kinase 72.7.11.240.485
2i0ePDSProtein kinase C beta type2.7.11.130.484
4dymIYZActivin receptor type-12.7.11.300.483
2ittAEEEpidermal growth factor receptor2.7.10.10.481
5cvfATPCasein kinase II subunit alpha2.7.11.10.481
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.480
3rak03ZCyclin-dependent kinase 22.7.11.220.480
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.480
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.479
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2w05FRTCyclin-dependent kinase 22.7.11.220.475
4fv6E57Mitogen-activated protein kinase 12.7.11.240.475
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.474
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.474
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.474
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.474
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.474
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.474
4qmySTUSerine/threonine-protein kinase 242.7.11.10.474
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.473
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.473
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.473
4jr3KJREpidermal growth factor receptor2.7.10.10.473
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.472
3be9P04Casein kinase II subunit alpha2.7.11.10.472
3sheI85MAP kinase-activated protein kinase 32.7.11.10.472
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.472
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.472
4jia1K3Tyrosine-protein kinase JAK2/0.472
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.472
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.471
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.471
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.471
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.471
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4fob0USALK tyrosine kinase receptor2.7.10.10.471
4ix6ADPUncharacterized protein/0.471
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.470
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.470
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.470
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.470
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.470
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.470
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.470
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.469
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.469
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.469
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.469
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.469
4jbpYPHAurora kinase A2.7.11.10.469
2hog710Serine/threonine-protein kinase Chk12.7.11.10.468
3zh8C58Protein kinase C iota type2.7.11.130.468
2ckeIQUDeath-associated protein kinase 2/0.467
2vd5BI8Myotonin-protein kinase2.7.11.10.467
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.467
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.467
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.467
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.466
4erwSTUCyclin-dependent kinase 22.7.11.220.466
5av2KMPDeath-associated protein kinase 12.7.11.10.466
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.465
4bgq38RCyclin-dependent kinase-like 52.7.11.220.465
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.465
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.465
4gk4L90Ephrin type-A receptor 32.7.10.10.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.465
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.464
2qocANPEphrin type-A receptor 32.7.10.10.464
3emg685Tyrosine-protein kinase SYK2.7.10.20.464
4bbe3O4Tyrosine-protein kinase JAK2/0.464
4qnyANPMitogen activated protein kinase, putative/0.464
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.464
5e8xSTUTGF-beta receptor type-12.7.11.300.464
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.463
3oom507Activin receptor type-12.7.11.300.463
4grb0XGCasein kinase II subunit alpha2.7.11.10.463
4h3qANPMitogen-activated protein kinase 12.7.11.240.463
5av3KMPDeath-associated protein kinase 12.7.11.10.463
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.462
2zjwREFCasein kinase II subunit alpha2.7.11.10.462
4bcqTJFCyclin-dependent kinase 22.7.11.220.462
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.462
4hvi19STyrosine-protein kinase JAK32.7.10.20.462
4jq8KJ8Epidermal growth factor receptor2.7.10.10.462
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.461
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.461
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.461
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.461
1m2pHNACasein kinase II subunit alpha2.7.11.10.460
2w17I19Cyclin-dependent kinase 22.7.11.220.460
1jklANPDeath-associated protein kinase 12.7.11.10.459
2xyuQ9GEphrin type-A receptor 42.7.10.10.459
3juhANPCasein kinase II subunit alpha2.7.11.10.459
3s1h56ZCyclin-dependent kinase 22.7.11.220.459
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.459
4c62XWWTyrosine-protein kinase JAK2/0.459
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.459
4j99ACPFibroblast growth factor receptor 2/0.459
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.458
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.458
3a62STURibosomal protein S6 kinase beta-12.7.11.10.458
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.458
3my5RFZCyclin-dependent kinase 22.7.11.220.458
3zdu38RCyclin-dependent kinase-like 32.7.11.220.458
4anmWULCasein kinase II subunit alpha2.7.11.10.458
4btjATPTau-tubulin kinase 12.7.11.10.458
4fmqANPMitogen-activated protein kinase 12.7.11.240.458
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.458
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.458
4l9i8PRRhodopsin kinase/0.458
1jstATPCyclin-dependent kinase 22.7.11.220.457
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.457
2uzdC85Cyclin-dependent kinase 22.7.11.220.457
3lltANPProtein serine/threonine kinase-1/0.457
1finATPCyclin-dependent kinase 22.7.11.220.456
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.456
2po7CHDFerrochelatase, mitochondrial4.99.1.10.456
3pe2E1BCasein kinase II subunit alpha2.7.11.10.456
3rkb12ZCyclin-dependent kinase 22.7.11.220.456
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.456
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.456
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.456
4wboANWRhodopsin kinase/0.456
4y93746Tyrosine-protein kinase/0.456
2itqITQEpidermal growth factor receptor2.7.10.10.455
2jedLG8Protein kinase C theta type2.7.11.130.455
2pvnP63Casein kinase II subunit alpha2.7.11.10.455
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.455
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.455
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.455
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.455
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.455
1fvv107Cyclin-dependent kinase 22.7.11.220.454
2itpAEEEpidermal growth factor receptor2.7.10.10.454
2j0m4STFocal adhesion kinase 12.7.10.20.454
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.454
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.454
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.454
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3kvxFMYMitogen-activated protein kinase 102.7.11.240.454
3u4uLNHCasein kinase II subunit alpha2.7.11.10.454
4dgnLU2Casein kinase II subunit alpha2.7.11.10.454
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.454
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.454
1h1r6CPCyclin-dependent kinase 22.7.11.220.453
2bujSTUSerine/threonine-protein kinase 16/0.453
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.453
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.453
3zep1NXTyrosine-protein kinase JAK32.7.10.20.453
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.453
4wsqKSAAP2-associated protein kinase 12.7.11.10.453
1fm4DXCMajor pollen allergen Bet v 1-L/0.452
2h96893Mitogen-activated protein kinase 82.7.11.240.452
2vv9IM9Cyclin-dependent kinase 22.7.11.220.452
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.452
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.452
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.452
1aq1STUCyclin-dependent kinase 22.7.11.220.451
1e3eNAIAlcohol dehydrogenase 41.1.1.10.451
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.451
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.451
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.451
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.451
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.451
3qrtX14Cyclin-dependent kinase 22.7.11.220.451
3tmz06XCytochrome P450 2B41.14.14.10.451
4bcmT7ZCyclin-dependent kinase 22.7.11.220.451
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.451
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.450
3c4xATPRhodopsin kinase/0.450
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.450
1zys199Serine/threonine-protein kinase Chk12.7.11.10.449
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3qxpX64Cyclin-dependent kinase 22.7.11.220.449
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.449
4c3pACPAurora kinase A2.7.11.10.449
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.449
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2q9fC3SCholesterol 24-hydroxylase/0.448
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.448
3d7tSTUTyrosine-protein kinase CSK/0.448
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4fz60VGTyrosine-protein kinase SYK2.7.10.20.448
4gk2L66Ephrin type-A receptor 32.7.10.10.448
4hge15VTyrosine-protein kinase JAK2/0.448
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
4r21STRCytochrome P450 family 17 polypeptide 2/0.448
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.447
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.447
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.447
3hx4ANPCalmodulin-domain protein kinase 1/0.447
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.447
4aqc88ATyrosine-protein kinase JAK2/0.447
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.447
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.446
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.446
3begANPSRSF protein kinase 12.7.11.10.446
3gu7ADPDeath-associated protein kinase 12.7.11.10.446
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.446
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.446
4ii5ADPCyclin-dependent kinase 22.7.11.220.446
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.446
1uymPU3Heat shock protein HSP 90-beta/0.445
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.445
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.445
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.445
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.445
4g2fC07Ephrin type-A receptor 32.7.10.10.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.444
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.444
2vzmNRBCytochrome P450 monooxygenase PikC/0.444
2yn8STUEphrin type-B receptor 42.7.10.10.444
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.444
4o0wADNAurora kinase A2.7.11.10.444
5dosATPAurora kinase A2.7.11.10.444
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.443
1zeoC01Peroxisome proliferator-activated receptor gamma/0.443
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.443
2ewpTXFEstrogen-related receptor gamma/0.443
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4b7dQLECytochrome P450 monooxygenase PikC/0.443
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.443
4qknJMSAlpha-ketoglutarate-dependent dioxygenase FTO/0.443
1me6IVSPlasmepsin-23.4.23.390.442
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.442
2wihP48Cyclin-dependent kinase 22.7.11.220.442
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.442
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.442
3blrCPBCyclin-dependent kinase 92.7.11.220.442
3lfqA28Cyclin-dependent kinase 22.7.11.220.442
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.442
4j97ACPFibroblast growth factor receptor 2/0.442
1oecAA2Fibroblast growth factor receptor 2/0.441
1xjdSTUProtein kinase C theta type2.7.11.130.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
1oi9N20Cyclin-dependent kinase 22.7.11.220.440
1pjkANPCasein kinase II subunit alpha2.7.11.10.440
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.440
2c7xNRBCytochrome P450 monooxygenase PikC/0.440
2chlDKICasein kinase I isoform gamma-32.7.11.10.440
2i40BLZCyclin-dependent kinase 22.7.11.220.440
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.440
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.440
4bcpT3CCyclin-dependent kinase 22.7.11.220.440
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.440
4fuxE75Mitogen-activated protein kinase 12.7.11.240.440
4q5hANPProtein kinase OspG2.70.440
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.440