scPDB - Distribution of Binding site Similarity values of 3pyy entry / Site 4

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3pyy	3YY	Tyrosine-protein kinase ABL1	2.7.10.2

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3pyy	3YY	Tyrosine-protein kinase ABL1	2.7.10.2	1.000
1rby	KEU	Trifunctional purine biosynthetic protein adenosine-3	2.1.2.2	0.475
1j39	UPG	DNA beta-glucosyltransferase	/	0.466
4q71	FAD	Bifunctional protein PutA	/	0.465
1khr	VIR	Streptogramin A acetyltransferase	2.3.1	0.464
3il1	B5D	Glutamate receptor 2	/	0.464
1fml	RTL	Retinol dehydratase	/	0.463
2izr	BRK	Casein kinase I isoform gamma-3	2.7.11.1	0.463
2uxp	CLM	HTH-type transcriptional regulator TtgR	/	0.463
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.462
2clq	STU	Mitogen-activated protein kinase kinase kinase 5	2.7.11.25	0.462
2qd3	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.462
4jin	1L7	RIO-type serine/threonine-protein kinase Rio1	2.7.11.1	0.462
4ki8	ADP	60 kDa chaperonin	/	0.462
2el3	SAH	Diphthine synthase	/	0.461
2ele	SAH	Diphthine synthase	/	0.461
4q73	FAD	Bifunctional protein PutA	/	0.461
4fa6	0TA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.458
4xum	IMN	Peroxisome proliferator-activated receptor gamma	/	0.458
2v59	LZK	Biotin carboxylase	6.3.4.14	0.457
4b7s	QLE	Cytochrome P450 monooxygenase PikC	/	0.457
5c8y	ACP	Tubulin tyrosine ligase	/	0.457
2f4b	EHA	Peroxisome proliferator-activated receptor gamma	/	0.456
2iya	ZIO	Oleandomycin glycosyltransferase	/	0.456
2q61	SF1	Peroxisome proliferator-activated receptor gamma	/	0.456
2ejv	NAD	L-threonine 3-dehydrogenase	/	0.455
3nwx	KVS	Gag-Pol polyprotein	3.4.23.16	0.454
4fhk	0U0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.454
1q4t	4CO	4-hydroxybenzoyl-CoA thioesterase	3.1.2.23	0.453
2j9g	ANP	Biotin carboxylase	6.3.4.14	0.453
1e3e	NAI	Alcohol dehydrogenase 4	1.1.1.1	0.452
1k7f	IAV	Tryptophan synthase alpha chain	/	0.452
1nzf	UPG	DNA beta-glucosyltransferase	/	0.452
1zth	ADP	RIO-type serine/threonine-protein kinase Rio1	2.7.11.1	0.452
2q7v	FAD	Thioredoxin reductase	/	0.452
4jx1	CAH	Camphor 5-monooxygenase	1.14.15.1	0.452
1tj0	FAD	Bifunctional protein PutA	1.5.5.2	0.451
4xiw	AZM	Carbonic anhydrase, alpha type	/	0.451
1ee9	NAD	Methylenetetrahydrofolate dehydrogenase [NAD(+)]	1.5.1.15	0.450
5cwa	0GA	Anthranilate synthase component 1	4.1.3.27	0.450
1nzd	UPG	DNA beta-glucosyltransferase	/	0.449
2uuv	FAD	Alkyldihydroxyacetonephosphate synthase	2.5.1.26	0.449
2ww4	ADP	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	2.7.1.148	0.449
3qk0	QK0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.449
1uu9	BI3	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.448
2jcv	NDP	1-deoxy-D-xylulose 5-phosphate reductoisomerase	/	0.448
3t2z	FAD	Sulfide-quinone reductase	/	0.448
3uyt	0CK	Casein kinase I isoform delta	2.7.11.1	0.448
3zk5	Z18	Cytochrome P450 monooxygenase PikC	/	0.448
4mv8	ACP	Biotin carboxylase	6.3.4.14	0.448
4q72	FAD	Bifunctional protein PutA	/	0.448
2j5x	GSP	ADP-ribosylation factor 6	/	0.447
2owg	SAH	Diphthine synthase	/	0.447
2p20	PRX	Acetyl-coenzyme A synthetase	/	0.447
4gxs	0YS	Glutamate receptor 2	/	0.447
4h1m	0YJ	Protein-tyrosine kinase 2-beta	2.7.10.2	0.447
3cyl	VIT	Basic phospholipase A2 homolog piratoxin-2	/	0.446
3hk1	B64	Fatty acid-binding protein, adipocyte	/	0.446
3qpv	ADP	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	2.7.1.105	0.446
5dqr	FAD	7-hydroxymethyl chlorophyll a reductase, chloroplastic	1.17.7.2	0.446
5eyp	LOC	Tubulin beta chain	/	0.446
2dfv	NAD	L-threonine 3-dehydrogenase	/	0.445
2owk	SAH	Diphthine synthase	/	0.445
2p6d	SAH	Diphthine synthase	/	0.445
2wyv	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.445
3b6z	CO7	Enoyl reductase LovC	1	0.445
3ime	BZ2	Pantothenate synthetase	6.3.2.1	0.445
4ewq	MWL	Mitogen-activated protein kinase 14	/	0.445
4gb9	0WR	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.445
2eeq	SAH	Diphthine synthase	/	0.444
4qjq	OTR	Lactoperoxidase	/	0.444
1nhh	ANP	DNA mismatch repair protein MutL	/	0.443
1siq	FAD	Glutaryl-CoA dehydrogenase, mitochondrial	1.3.8.6	0.443
2vw5	BC6	ATP-dependent molecular chaperone HSP82	/	0.443
2znp	K55	Peroxisome proliferator-activated receptor delta	/	0.443
3vet	ADP	nebramycin 5' synthase	6.1.2.2	0.443
5ack	ATP	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.443
1a72	PAD	Alcohol dehydrogenase E chain	1.1.1.1	0.442
1jip	KTN	6-deoxyerythronolide B hydroxylase	/	0.442
2ejz	SAH	Diphthine synthase	/	0.442
3ioc	A5D	Pantothenate synthetase	6.3.2.1	0.442
3r35	4CO	4-hydroxybenzoyl-CoA thioesterase	3.1.2.23	0.442
1pjk	ANP	Casein kinase II subunit alpha	2.7.11.1	0.441
1zgy	BRL	Peroxisome proliferator-activated receptor gamma	/	0.441
2cd8	PXI	Cytochrome P450 monooxygenase PikC	/	0.441
2v5a	LZL	Biotin carboxylase	6.3.4.14	0.441
2y8q	ADP	5'-AMP-activated protein kinase subunit gamma-1	/	0.441
3ndr	NAD	Pyridoxal 4-dehydrogenase	1.1.1.107	0.441
3nug	NAD	Pyridoxal 4-dehydrogenase	1.1.1.107	0.441
1u7t	NAD	3-hydroxyacyl-CoA dehydrogenase type-2	1.1.1.35	0.440
2dwp	ACP	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	2.7.1.105	0.440
2giv	ACO	Histone acetyltransferase KAT8	/	0.440
2i1v	ADP	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	2.7.1.105	0.440
3mdv	CL6	Cholesterol 24-hydroxylase	/	0.440
4dym	IYZ	Activin receptor type-1	2.7.11.30	0.440
4xuh	SFI	Peroxisome proliferator-activated receptor gamma	/	0.440