sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fmo | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fmo | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 1.000 | |
| 2gbl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.519 | |
| 4o0m | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.513 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.500 | |
| 1t57 | FMN | Conserved protein | / | 0.499 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.495 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.493 | |
| 3ews | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 0.493 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.490 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.489 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.489 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.488 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.487 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.486 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.485 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.485 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.483 | |
| 3up0 | D7S | aceDAF-12 | / | 0.481 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.481 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.480 | |
| 3dvl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.480 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.480 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.479 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.478 | |
| 4a4z | ANP | Antiviral helicase SKI2 | 3.6.4.13 | 0.478 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.476 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.475 | |
| 2dvo | ITT | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.475 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.475 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.475 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.474 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.474 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.474 | |
| 1tf7 | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.473 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.473 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.473 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.472 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.472 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.471 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.470 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.470 | |
| 2v2v | V12 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.470 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.470 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 1u9i | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.469 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.469 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.469 | |
| 3lns | NAP | NAD(P)-dependent benzaldehyde dehydrogenase | 1.2.1.28 | 0.469 | |
| 4j49 | 1J1 | Uncharacterized protein | / | 0.469 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.469 | |
| 1hk4 | T44 | Serum albumin | / | 0.468 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.468 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.468 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.468 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.468 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.468 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.467 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.467 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.467 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.466 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.466 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.465 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.465 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.465 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.465 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.465 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.465 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.465 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.465 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.464 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.464 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.464 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.464 | |
| 1g6o | ADP | Cag alpha | / | 0.463 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.463 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 1yre | COA | Uncharacterized protein | / | 0.462 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.462 | |
| 3fbu | COA | Acetyltransferase, GNAT family | / | 0.462 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.462 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.462 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.462 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.461 | |
| 1ny5 | ADP | Transcriptional regulator (NtrC family) | / | 0.461 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.461 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.461 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.461 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.461 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.460 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.459 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3jzm | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.459 | |
| 3k0f | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.459 | |
| 3up3 | XCA | aceDAF-12 | / | 0.459 | |
| 3vqr | FAD | Putative oxidoreductase | / | 0.459 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.459 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.459 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.459 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.459 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.459 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.459 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.458 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.457 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.457 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.457 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.457 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2wvl | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.456 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.456 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.456 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4mk9 | 28R | Genome polyprotein | 2.7.7.48 | 0.456 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.455 | |
| 1nec | FMN | Oxygen-insensitive NAD(P)H nitroreductase | 1 | 0.455 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.455 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.455 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.455 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.455 | |
| 3uba | HC4 | Lactoperoxidase | 1.11.1.7 | 0.455 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.455 | |
| 4q03 | GDP | GTPase KRas | / | 0.455 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.454 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.454 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.454 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.454 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.453 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.453 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.453 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.453 | |
| 2wsi | FAD | FAD synthase | 2.7.7.2 | 0.453 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.453 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.453 | |
| 1wc3 | APC | Adenylate cyclase | / | 0.452 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.452 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.452 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.452 | |
| 4dem | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.452 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.452 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.452 | |
| 4l9k | EHF | Serum albumin | / | 0.452 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.452 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.452 | |
| 5mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.452 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.452 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.451 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.451 | |
| 2pid | YSA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.451 | |
| 2rtr | IMI | Streptavidin | / | 0.451 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.451 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.451 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.451 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.450 | |
| 1lce | TMF | Thymidylate synthase | / | 0.450 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 1oz0 | MS1 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.450 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.450 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.450 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 2quj | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.450 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.450 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.450 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.450 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.450 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.449 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 1swn | BTN | Streptavidin | / | 0.449 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.449 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.449 | |
| 3tlc | 7MD | Microcin C7 self-immunity protein MccF | / | 0.449 | |
| 3v1u | HXC | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.449 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.449 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 1s7n | COA | Acetyl transferase | / | 0.448 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.448 | |
| 2pda | TPP | Pyruvate synthase | / | 0.448 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.448 | |
| 3e6y | CW1 | 14-3-3-like protein C | / | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.448 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.448 | |
| 1ozp | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.447 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.447 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.447 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.447 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.447 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.447 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.447 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.447 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.446 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.446 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.446 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.446 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 2c7q | SAH | Modification methylase HhaI | 2.1.1.37 | 0.446 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.446 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.446 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.446 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.446 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4blr | UTP | NTPase P4 | / | 0.446 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.446 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1req | DCA | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.445 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.445 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3bxz | ADP | Protein translocase subunit SecA | / | 0.445 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4fx2 | FMN | Flavodoxin | / | 0.445 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.444 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.444 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.444 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.444 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.444 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.444 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.444 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.444 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.443 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.443 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.443 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 3coz | 54H | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3ql6 | NIM | Lactoperoxidase | 1.11.1.7 | 0.443 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.443 | |
| 4die | C5P | Cytidylate kinase | / | 0.443 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.443 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.443 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4y1b | NAP | AntE | / | 0.443 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.442 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.442 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.442 | |
| 2p0r | LEU_LEU_ACE_AR7 | Calpain-9 | / | 0.442 | |
| 2q0l | NAP | Thioredoxin reductase | 1.8.1.9 | 0.442 | |
| 2v1a | FMN | NPH1-1 | / | 0.442 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.442 | |
| 3l5b | BDO | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3qft | NAP | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 3vhh | VHH | Avidin | / | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.442 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.442 | |
| 4h5c | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.442 | |
| 4h80 | 04T | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.442 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.442 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.441 | |
| 1mfz | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.441 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.441 | |
| 1wc5 | APC | Adenylate cyclase | / | 0.441 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.441 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.441 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.441 | |
| 3kgc | LY7 | Glutamate receptor 2 | / | 0.441 | |
| 3px3 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.441 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.441 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.441 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.441 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4j7h | TRH | PCZA361.3 | / | 0.441 | |
| 4mka | 2AY | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.440 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.440 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.440 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.440 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.440 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.440 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.440 | |
| 3ete | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.440 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3lq4 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.440 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.440 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.440 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.440 | |
| 4jwp | ACO | GCN5-related N-acetyltransferase | / | 0.440 | |
| 4v12 | POG | MaoC like domain protein | / | 0.440 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 | |
| 5dbv | COA | Aldehyde Dehydrogenase | / | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 |