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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wqeADPAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wqeADPAurora kinase A2.7.11.11.000
5l8lADPAurora kinase A2.7.11.10.630
4o0uADNAurora kinase A2.7.11.10.624
4c3pACPAurora kinase A2.7.11.10.603
4jbpYPHAurora kinase A2.7.11.10.574
3k5uPFQAurora kinase A2.7.11.10.570
2ijmATPFocal adhesion kinase 12.7.10.20.561
2bmcMPYAurora kinase A2.7.11.10.556
4c3rACPAurora kinase A2.7.11.10.545
4deeADPAurora kinase A2.7.11.10.543
4qmlANPSerine/threonine-protein kinase 242.7.11.10.535
2w1fL0FAurora kinase A2.7.11.10.534
4jboWPHAurora kinase A2.7.11.10.532
3c4xATPRhodopsin kinase/0.525
2c6eHPMAurora kinase A2.7.11.10.524
3w18N13Aurora kinase A2.7.11.10.524
3t8oATPRhodopsin kinase/0.520
5dt3ATPAurora kinase A2.7.11.10.515
2j0lANPFocal adhesion kinase 12.7.10.20.514
2qoqANPEphrin type-A receptor 32.7.10.10.509
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.509
1i44ACPInsulin receptor2.7.10.10.508
2henADPEphrin type-B receptor 22.7.10.10.508
2qo7ANPEphrin type-A receptor 32.7.10.10.508
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.505
4l9i8PRRhodopsin kinase/0.505
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.505
5dosATPAurora kinase A2.7.11.10.504
1ol5ADPAurora kinase A2.7.11.10.503
2w1gL0GAurora kinase A2.7.11.10.500
3c4wATPRhodopsin kinase/0.500
3c4zADPRhodopsin kinase/0.500
5dnrATPAurora kinase A2.7.11.10.500
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.497
4jbqVX6Aurora kinase A2.7.11.10.496
3cgfJNFMitogen-activated protein kinase 102.7.11.240.495
3qc9ADPRhodopsin kinase/0.494
1pmn984Mitogen-activated protein kinase 102.7.11.240.493
4j99ACPFibroblast growth factor receptor 2/0.491
2p33J07Mitogen-activated protein kinase 102.7.11.240.490
2xvdAS6Ephrin type-B receptor 42.7.10.10.489
4b0gVEKAurora kinase A2.7.11.10.489
5awmANPStress-activated protein kinase JNK2.7.11.240.489
4jia1K3Tyrosine-protein kinase JAK2/0.487
2w1eL0EAurora kinase A2.7.11.10.486
3efwAK8Aurora kinase A2.7.11.10.486
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.485
5ap7SVEDual specificity protein kinase TTK2.7.12.10.485
5dr2ATPAurora kinase A2.7.11.10.485
3oriAGSSerine/threonine protein kinase/0.484
5dn3ATPAurora kinase A2.7.11.10.484
3ttiKBIMitogen-activated protein kinase 102.7.11.240.481
3ttjJBIMitogen-activated protein kinase 102.7.11.240.481
4k33ACPFibroblast growth factor receptor 32.7.10.10.481
4o0wADNAurora kinase A2.7.11.10.481
2v7a627Tyrosine-protein kinase ABL12.7.10.20.479
4c4f7CEDual specificity protein kinase TTK2.7.12.10.479
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.478
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.478
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.478
4ysjADPCalmodulin-like domain protein kinase/0.478
5l8jADPAurora kinase A2.7.11.10.478
1bygSTUTyrosine-protein kinase CSK/0.477
2j0m4STFocal adhesion kinase 12.7.10.20.477
3i60E86Mitogen-activated protein kinase 12.7.11.240.475
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.474
2ijmADPFocal adhesion kinase 12.7.10.20.474
4i4e1BQFocal adhesion kinase 12.7.10.20.474
2x6dX6DAurora kinase A2.7.11.10.473
4j95ACPFibroblast growth factor receptor 2/0.473
4qnyANPMitogen activated protein kinase, putative/0.473
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.473
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.471
1ol7ADPAurora kinase A2.7.11.10.470
4btjADPTau-tubulin kinase 12.7.11.10.469
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.468
1mqbANPEphrin type-A receptor 22.7.10.10.468
4lrjANPUncharacterized protein/0.468
2xngA0HAurora kinase A2.7.11.10.467
3a7hATPSerine/threonine-protein kinase 242.7.11.10.467
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.466
3ztxZTXAurora kinase B-A2.7.11.10.466
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.466
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.466
3cgoJNOMitogen-activated protein kinase 102.7.11.240.465
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.465
3w16P9JAurora kinase A2.7.11.10.465
1ol6ATPAurora kinase A2.7.11.10.464
2izsBRQCasein kinase I isoform gamma-32.7.11.10.464
4xlvACPInsulin receptor2.7.10.10.464
4id71G0Activated CDC42 kinase 1/0.463
5ap57RODual specificity protein kinase TTK2.7.12.10.463
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
5av2KMPDeath-associated protein kinase 12.7.11.10.461
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.460
1dayGNPCasein kinase II subunit alpha2.7.11.10.459
1knuYPAPeroxisome proliferator-activated receptor gamma/0.459
4c57FEFCyclin-G-associated kinase2.7.11.10.459
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.458
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.457
2excJNKMitogen-activated protein kinase 102.7.11.240.457
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.457
3vs1VSATyrosine-protein kinase HCK2.7.10.20.457
3bu5ATPInsulin receptor2.7.10.10.455
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
5l8kADPAurora kinase A2.7.11.10.455
2xs0ANPMitogen-activated protein kinase 82.7.11.240.454
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.454
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.454
3lltANPProtein serine/threonine kinase-1/0.453
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.453
5drdATPAurora kinase A2.7.11.10.453
2b1pAIZMitogen-activated protein kinase 102.7.11.240.452
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.452
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.452
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.451
4deaNHIAurora kinase A2.7.11.10.451
4s33ANPMitogen-activated protein kinase 12.7.11.240.451
3orpAGSSerine/threonine protein kinase/0.450
4btjATPTau-tubulin kinase 12.7.11.10.450
4c4g7RODual specificity protein kinase TTK2.7.12.10.450
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.450
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.450
5av3KMPDeath-associated protein kinase 12.7.11.10.450
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.449
2yaaATPDeath-associated protein kinase 2/0.449
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.449
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.449
5dt4ATPAurora kinase A2.7.11.10.449
4riyADPEpidermal growth factor receptor2.7.10.10.448
4utdACPAurora kinase A2.7.11.10.448
3nbvANPKetohexokinase/0.447
3ormAGSSerine/threonine protein kinase/0.447
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.447
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.446
2qocANPEphrin type-A receptor 32.7.10.10.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
2vwu7X1Ephrin type-B receptor 42.7.10.10.445
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.445
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.445
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.445
2xrwANPMitogen-activated protein kinase 82.7.11.240.445
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.445
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.445
3erkSB4Mitogen-activated protein kinase 12.7.11.240.445
3w2sW2REpidermal growth factor receptor2.7.10.10.445
5eg3ACPFibroblast growth factor receptor 2/0.445
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.444
2ojj82AMitogen-activated protein kinase 12.7.11.240.444
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.444
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.443
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.443
3vthAPCCarbamoyltransferase/0.443
4k8aK8AFocal adhesion kinase 12.7.10.20.443
5kghACOPredicted acetyltransferase/0.443
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.442
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.442
2dwbANPAurora kinase A2.7.11.10.442
2qo9ANPEphrin type-A receptor 32.7.10.10.442
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.441
2j7t274Serine/threonine-protein kinase 102.7.11.10.441
2xneASHAurora kinase A2.7.11.10.441
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.441
4c4h7RODual specificity protein kinase TTK2.7.12.10.441
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.441
4qo9627Serine/threonine-protein kinase 242.7.11.10.441
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.440
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
4b8lA0PAurora kinase B-A2.7.11.10.440
4cd0AWJALK tyrosine kinase receptor2.7.10.10.440