sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 1.000 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.573 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.571 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.569 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.569 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.559 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.557 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.557 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.552 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.549 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.546 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.544 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 2exl | GDM | Endoplasmin | / | 0.539 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.538 | |
| 2gfd | RDA | Endoplasmin | / | 0.537 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.536 | |
| 2gqp | PA7 | Endoplasmin | / | 0.535 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.533 | |
| 1qy5 | NEC | Endoplasmin | / | 0.531 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.531 | |
| 1u0z | RDC | Endoplasmin | / | 0.530 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.529 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.529 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 3ied | AN2 | HSP90 | / | 0.526 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.524 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.516 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1qy8 | RDI | Endoplasmin | / | 0.512 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.509 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.503 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.501 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.499 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.497 | |
| 1ysz | NEC | Endoplasmin | / | 0.494 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.492 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.491 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.491 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.491 | |
| 1u0y | PA7 | Endoplasmin | / | 0.490 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.490 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.483 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.478 | |
| 1u2o | NEC | Endoplasmin | / | 0.476 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.475 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.475 | |
| 2fyp | RDE | Endoplasmin | / | 0.474 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 2hch | N5A | Endoplasmin | / | 0.472 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.467 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.465 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.463 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.462 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.462 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2hg1 | N5O | Endoplasmin | / | 0.461 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.461 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.458 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.457 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.456 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.456 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.456 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.456 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.455 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.454 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.453 | |
| 2ccu | 2D9 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.452 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.451 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.451 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.449 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.448 | |
| 1yt0 | ADP | Endoplasmin | / | 0.448 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.446 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 2esa | GDM | Endoplasmin | / | 0.446 | |
| 2o1u | ANP | Endoplasmin | / | 0.446 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.446 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.446 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.446 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.445 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 4jic | FMN | GTN Reductase | / | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.444 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.443 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1i5b | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.442 | |
| 4ihl | 1F5 | 14-3-3 protein zeta/delta | / | 0.442 | |
| 4n9w | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.442 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.442 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.441 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2ohv | NHL | Glutamate racemase | / | 0.441 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |