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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.41

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.411.000
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.629
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.574
4c72TLG3-oxoacyl-ACP synthase/0.574
4c73TLH3-oxoacyl-ACP synthase/0.562
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.561
4c6zTLE3-oxoacyl-ACP synthase/0.557
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.556
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.552
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.549
4jv3N32Beta-ketoacyl synthase/0.538
4c717RD3-oxoacyl-ACP synthase/0.535
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.534
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.531
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.527
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.498
2wgeTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.493
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.492
4c6uTLG3-oxoacyl-ACP synthase/0.491
1xddAAYIntegrin alpha-L/0.486
2fj1CTCTetracycline repressor protein class D/0.483
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.483
3arvSAUChitinase A/0.482
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.478
5dp2NAPCurF/0.478
4h1q0XXMatrix metalloproteinase-93.4.24.350.474
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.472
1ppjANYCytochrome b/0.469
2vceU2FUDP-glycosyltransferase 72B1/0.469
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.469
4bfxZVXPantothenate kinase2.7.1.330.469
2gevCOKPantothenate kinase2.7.1.330.468
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.468
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.467
2igoFADPyranose 2-oxidase/0.467
2zevB71Geranylgeranyl pyrophosphate synthase/0.467
2ym1FADPhenylacetone monooxygenase1.14.13.920.466
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.466
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3oqfS51Renin3.4.23.150.465
3rupADPBiotin carboxylase6.3.4.140.464
4bfwZVWPantothenate kinase2.7.1.330.463
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.463
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3qwbNDPProbable quinone oxidoreductase1.6.5.50.461
4ttiFMCPurine nucleoside phosphorylase DeoD-type/0.461
5irnADPNucleotide binding oligomerization domain containing 2/0.461
1x8lOXRRetinol dehydratase/0.460
2gv8NDPThiol-specific monooxygenase1.14.130.460
1r2jFADFkbI/0.459
2ffqGSPRas-related protein Rab-6B/0.459
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
2g1r3IGRenin3.4.23.150.458
2i4qUA4Renin3.4.23.150.458
2uxoTACHTH-type transcriptional regulator TtgR/0.458
4b1rITCTetracycline repressor protein class D/0.458
1obnASVIsopenicillin N synthase1.21.3.10.457
4bfvZVVPantothenate kinase2.7.1.330.457
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.457
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.456
2xpwOTCTetracycline repressor protein class D/0.455
2g226IGRenin3.4.23.150.454
2gilGTPRas-related protein Rab-6A/0.454
1ja1FADNADPH--cytochrome P450 reductase/0.453
2vkeTACTetracycline repressor protein class D/0.453
4bj9UHBTankyrase-22.4.2.300.453
2ed3SAHDiphthine synthase/0.452
2geuCOKPantothenate kinase2.7.1.330.452
2x7hPFNProstaglandin reductase 310.452
3oqkS52Renin3.4.23.150.452
5c1mCLRMu-type opioid receptor/0.452
1ykdCMPAdenylate cyclase/0.451
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.451
2uxpCLMHTH-type transcriptional regulator TtgR/0.451
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.451
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.451
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.450
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3hl0NADMaleylacetate reductase/0.450
4auxXTCTetracycline repressor protein class D/0.450
1cf3FADGlucose oxidase1.1.3.40.449
3qe2FMNNADPH--cytochrome P450 reductase/0.449
4zj8SUVOrexin receptor type 1/0.449
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.448
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
2ejzSAHDiphthine synthase/0.447
2g247IGRenin3.4.23.150.447
3h3r14HCollagen type IV alpha-3-binding protein/0.447
3h3t16HCollagen type IV alpha-3-binding protein/0.447
3uleC69Actin-related protein 3/0.447
1drhNAPDihydrofolate reductase1.5.1.30.446
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.446
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.446
1cs4FOKAdenylate cyclase type 2/0.445
1cs4FOKAdenylate cyclase type 5/0.445
2ftoCB3Thymidylate synthase/0.445
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.445
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.445
3vqsJT1Genome polyprotein/0.445
3vt9YI4Vitamin D3 receptor/0.445
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4bftZVTPantothenate kinase2.7.1.330.445
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
6stdMS2Scytalone dehydratase4.2.1.940.445
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.444
2hk9NAPShikimate dehydrogenase (NADP(+))/0.444
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.444
3ixp834Ecdysone receptor/0.444
3jzdNADMaleylacetate reductase/0.444
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.444
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.444
4l5b1UXDeoxycytidine kinase2.7.1.740.444
4mihFADPyranose 2-oxidase1.1.3.100.444
7stdCRPScytalone dehydratase4.2.1.940.444
1ewyFADFerredoxin--NADP reductase1.18.1.20.443
3br3ETHTH-type transcriptional regulator QacR/0.443
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
4irnFADAnaB/0.443
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.442
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.442
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.442
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.442
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.442
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3jziJZLBiotin carboxylase6.3.4.140.442
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.442
4df2FMNNADPH dehydrogenase/0.442
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.442
1zgv501Prothrombin3.4.21.50.441
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.441
2uxhQUEHTH-type transcriptional regulator TtgR/0.441
3d4bDZDNAD-dependent protein deacetylase/0.441
3jv7NADSecondary alcohol dehydrogenase/0.441
3pm1ETHTH-type transcriptional regulator QacR/0.441
3r3sNADPutative oxidoreductase/0.441
3ukoNADAlcohol dehydrogenase class-3/0.441
4b4w9L9Bifunctional protein FolD/0.441
4bfuZVUPantothenate kinase2.7.1.330.441
2e07SAHDiphthine synthase/0.440
2vprTDCTetracycline repressor protein class H/0.440
3gwfFADCyclohexanone monooxygenase/0.440
4bio8XQHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.440