sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1iiu | RTL | Retinol-binding protein 4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1iiu | RTL | Retinol-binding protein 4 | / | 1.000 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.737 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.703 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.668 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.657 | |
| 1kt4 | RTL | Retinol-binding protein 4 | / | 0.653 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.627 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.608 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.555 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.516 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.508 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.508 | |
| 4lb2 | DM5 | Serum albumin | / | 0.503 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.500 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.496 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.496 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.494 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.493 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.492 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.491 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.489 | |
| 1osv | CHC | Bile acid receptor | / | 0.489 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.489 | |
| 3ipt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.485 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.485 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.484 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.484 | |
| 4mfb | 29T | Gag-Pol polyprotein | 2.7.7.49 | 0.484 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.484 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.483 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.483 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.483 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.482 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.481 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.480 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.479 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.479 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.479 | |
| 3h1j | SMA | Cytochrome b | / | 0.479 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.478 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.478 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.478 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.477 | |
| 4pd6 | URI | Nucleoside permease | / | 0.477 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.477 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.476 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.476 | |
| 1tys | DHF | Thymidylate synthase | / | 0.475 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.475 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.475 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.474 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.474 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 1kt5 | RTL | Retinol-binding protein 4 | / | 0.473 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.473 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.473 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.473 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 3bhr | THG | Thymidylate synthase | / | 0.472 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.472 | |
| 1nkz | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.471 | |
| 1nkz | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.471 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.471 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.471 | |
| 3l70 | JZV | Cytochrome b | / | 0.471 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.471 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.470 | |
| 3lu8 | IQX | Serum albumin | / | 0.470 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.469 | |
| 1sqp | MYX | Cytochrome b | / | 0.469 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.469 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.469 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.469 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.469 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.468 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.467 | |
| 2qjy | SMA | Cytochrome b | / | 0.467 | |
| 3up3 | XCA | aceDAF-12 | / | 0.467 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.467 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.467 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.466 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.466 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.466 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.465 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.465 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.465 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.465 | |
| 3up0 | D7S | aceDAF-12 | / | 0.465 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.465 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.465 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.465 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.464 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.464 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.464 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.464 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.464 | |
| 4eb4 | D16 | Thymidylate synthase | 2.1.1.45 | 0.464 | |
| 4h4o | 506 | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.464 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.463 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.463 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.463 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.463 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 4o7u | THF | Thymidylate synthase | / | 0.463 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 2uxx | FAJ | Lysine-specific histone demethylase 1A | 1 | 0.462 | |
| 3p9t | TCL | Repressor | / | 0.462 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.462 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.462 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.461 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.461 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.461 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 3t9i | 3T9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.461 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.461 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3nal | DBK | Calcium-transporting ATPase | / | 0.460 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.460 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 2dji | FAD | Pyruvate oxidase | / | 0.459 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.459 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.459 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.459 | |
| 1eio | GCH | Gastrotropin | / | 0.458 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.458 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.458 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.458 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.458 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.458 | |
| 4l9q | 9TP | Serum albumin | / | 0.458 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.457 | |
| 1srj | NAB | Streptavidin | / | 0.457 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 1ysx | 4EB | Serum albumin | / | 0.457 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.457 | |
| 3bej | MUF | Bile acid receptor | / | 0.457 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.457 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.457 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.457 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.457 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.457 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.457 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.456 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.456 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.456 | |
| 2e0i | FAD | DNA photolyase | / | 0.456 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.456 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3cem | AVD | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.456 | |
| 3eq6 | BCO | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.456 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.456 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.456 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.456 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.456 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.455 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.455 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.455 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.455 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.455 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.454 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.454 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.454 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.454 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.454 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.454 | |
| 3cxh | SMA | Cytochrome b | / | 0.454 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.454 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.454 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.454 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.453 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.453 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.453 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3ukr | CKH | Actin-related protein 3 | / | 0.453 | |
| 3ukr | CKH | Actin-related protein 2 | / | 0.453 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.453 | |
| 5doz | NDP | JamJ | / | 0.453 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.452 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1v5e | FAD | Pyruvate oxidase | / | 0.452 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.452 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.452 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.452 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.452 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.452 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.452 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.452 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.452 | |
| 1axw | MTX | Thymidylate synthase | / | 0.451 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.451 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.451 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.451 | |
| 2uyw | BTN | Avd protein | / | 0.451 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3bzu | A21 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.451 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.451 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.451 | |
| 1chw | HXC | Chalcone synthase 2 | 2.3.1.74 | 0.450 | |
| 1kqg | HQO | Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit | / | 0.450 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.450 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.450 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.450 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.450 | |
| 3ang | DCC | Transcriptional repressor, TetR family | / | 0.450 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.450 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.450 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.450 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.450 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.450 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.449 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.449 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.449 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.449 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1sqv | UHD | Cytochrome b | / | 0.448 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.448 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.448 | |
| 3tgu | WF3 | Cytochrome b | / | 0.448 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.448 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.448 | |
| 1fnd | A2P | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.447 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.447 | |
| 2am2 | 2LG | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.447 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.447 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 3gki | CLR | Niemann-Pick C1 protein | / | 0.447 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.447 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.447 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.447 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.446 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 4i58 | FAD | Cyclohexylamine Oxidase | / | 0.446 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.446 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.445 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.445 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.445 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.445 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.445 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.445 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.445 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.445 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.445 | |
| 1kvo | OAP | Phospholipase A2, membrane associated | / | 0.444 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.444 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.444 | |
| 2won | ZZE | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.444 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3l71 | AZO | Cytochrome b | / | 0.444 | |
| 4i42 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.444 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.444 | |
| 5dp2 | NAP | CurF | / | 0.444 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.444 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.443 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.443 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.443 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.443 | |
| 3bhl | THG | Thymidylate synthase | / | 0.443 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.443 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.443 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.443 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.443 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4n4t | 2GV | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.443 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.443 | |
| 1an5 | CB3 | Thymidylate synthase | / | 0.442 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1kb9 | SMA | Cytochrome b | / | 0.442 | |
| 1kyo | SMA | Cytochrome b | / | 0.442 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 2bx8 | AZQ | Serum albumin | / | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.442 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.442 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.442 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3rpn | GTX | Glutathione S-transferase kappa 1 | 2.5.1.18 | 0.442 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.442 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4irn | FAD | AnaB | / | 0.442 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4qoe | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.442 | |
| 5fit | AP2 | Bis(5'-adenosyl)-triphosphatase | 3.6.1.29 | 0.442 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.442 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.441 | |
| 1e1l | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.441 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.441 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.441 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.441 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 1rti | HEF | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.441 | |
| 2hnz | PC0 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.441 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.441 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.441 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.441 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.441 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.441 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.441 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.440 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.440 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.440 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.440 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.440 | |
| 2uz2 | BTN | Avd protein | / | 0.440 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 3apy | FAD | Methylenetetrahydrofolate reductase | / | 0.440 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.440 | |
| 3fnu | 006 | HAP protein | / | 0.440 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.440 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.440 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.440 | |
| 4xvq | GNP | GTPase HRas | / | 0.440 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.440 |