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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1eh4IC1Casein kinase I homolog 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1eh4IC1Casein kinase I homolog 12.7.11.11.000
4kbk1QGCasein kinase I isoform delta2.7.11.10.529
3uyt0CKCasein kinase I isoform delta2.7.11.10.527
3zh8C58Protein kinase C iota type2.7.11.130.519
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.512
1g5sI17Cyclin-dependent kinase 22.7.11.220.508
3hmm855TGF-beta receptor type-12.7.11.300.504
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.503
3gubGUBDeath-associated protein kinase 12.7.11.10.500
1u4dDBQActivated CDC42 kinase 1/0.499
1xjdSTUProtein kinase C theta type2.7.11.130.499
3gxlQIGTGF-beta receptor type-12.7.11.300.499
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.499
3sheI85MAP kinase-activated protein kinase 32.7.11.10.499
1h1s4SPCyclin-dependent kinase 22.7.11.220.494
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.493
5cnnANPEpidermal growth factor receptor2.7.10.10.492
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.491
2izrBRKCasein kinase I isoform gamma-32.7.11.10.490
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.490
1oguST8Cyclin-dependent kinase 22.7.11.220.489
2x1nX1NCyclin-dependent kinase 22.7.11.220.489
1csnATPCasein kinase I homolog 12.7.11.10.488
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.488
3lfqA28Cyclin-dependent kinase 22.7.11.220.487
4aqc88ATyrosine-protein kinase JAK2/0.487
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.487
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.487
4bcoT6QCyclin-dependent kinase 22.7.11.220.482
1bygSTUTyrosine-protein kinase CSK/0.481
2b52D42Cyclin-dependent kinase 22.7.11.220.481
2iw94SPCyclin-dependent kinase 22.7.11.220.481
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.481
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.481
3uzp0CKCasein kinase I isoform delta2.7.11.10.481
3r83Z14Cyclin-dependent kinase 22.7.11.220.480
1aq1STUCyclin-dependent kinase 22.7.11.220.479
2c475IDCasein kinase I isoform gamma-2/0.479
4hgs15GCasein kinase I isoform gamma-32.7.11.10.477
5cnoANPEpidermal growth factor receptor2.7.10.10.477
1m2pHNACasein kinase II subunit alpha2.7.11.10.476
1u54ACPActivated CDC42 kinase 1/0.476
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.476
2csnCKICasein kinase I homolog 12.7.11.10.475
4jqeANPCasein kinase II subunit alpha2.7.11.10.475
2izuP01Casein kinase I isoform gamma-32.7.11.10.474
2pvmP29Casein kinase II subunit alpha2.7.11.10.474
2pvnP63Casein kinase II subunit alpha2.7.11.10.474
1pmn984Mitogen-activated protein kinase 102.7.11.240.473
4hge15VTyrosine-protein kinase JAK2/0.473
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.472
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.471
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.470
2pvhP19Casein kinase II subunit alpha2.7.11.10.470
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.470
4g160VMCasein kinase I isoform gamma-32.7.11.10.470
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.469
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.469
3iok1P6Tyrosine-protein kinase JAK2/0.469
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.469
4hnf16WCasein kinase I isoform delta2.7.11.10.469
3be9P04Casein kinase II subunit alpha2.7.11.10.468
2xa4AZ5Tyrosine-protein kinase JAK2/0.467
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.467
1ke6LS2Cyclin-dependent kinase 22.7.11.220.465
1oitHDTCyclin-dependent kinase 22.7.11.220.465
4erwSTUCyclin-dependent kinase 22.7.11.220.465
4fkv61KCyclin-dependent kinase 22.7.11.220.465
4hvh19RTyrosine-protein kinase JAK32.7.10.20.465
4hvi19STyrosine-protein kinase JAK32.7.10.20.465
2b7aIZATyrosine-protein kinase JAK2/0.464
2w05FRTCyclin-dependent kinase 22.7.11.220.464
3le62BZCyclin-dependent kinase 22.7.11.220.464
4e4m0NHTyrosine-protein kinase JAK2/0.464
4ek816KCyclin-dependent kinase 22.7.11.220.464
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.464
1gih1PUCyclin-dependent kinase 22.7.11.220.463
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.463
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.463
3lfnA27Cyclin-dependent kinase 22.7.11.220.463
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.463
4c61LMMTyrosine-protein kinase JAK2/0.463
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.463
4y95746Tyrosine-protein kinase/0.463
1unlRRCCyclin-dependent-like kinase 52.7.11.10.462
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.462
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.462
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2iw84SPCyclin-dependent kinase 22.7.11.220.461
3rni21ZCyclin-dependent kinase 22.7.11.220.461
3s1h56ZCyclin-dependent kinase 22.7.11.220.461
4dymIYZActivin receptor type-12.7.11.300.461
5e8xSTUTGF-beta receptor type-12.7.11.300.461
1r78FMDCyclin-dependent kinase 22.7.11.220.460
4anmWULCasein kinase II subunit alpha2.7.11.10.460
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
4ewhT77Activated CDC42 kinase 1/0.460
4ji91M3Tyrosine-protein kinase JAK2/0.460
4riyADPEpidermal growth factor receptor2.7.10.10.460
2izt23DCasein kinase I isoform gamma-32.7.11.10.459
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.459
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.459
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.459
1dawANPCasein kinase II subunit alpha2.7.11.10.458
1di8DTQCyclin-dependent kinase 22.7.11.220.458
1om1IQACasein kinase II subunit alpha2.7.11.10.458
3mtfA3FActivin receptor type-12.7.11.300.458
4j95ACPFibroblast growth factor receptor 2/0.458
1pxmCK5Cyclin-dependent kinase 22.7.11.220.457
2b53D23Cyclin-dependent kinase 22.7.11.220.457
2h96893Mitogen-activated protein kinase 82.7.11.240.457
2j0m4STFocal adhesion kinase 12.7.10.20.457
2pvlP55Casein kinase II subunit alpha2.7.11.10.457
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.457
3s2pPMUCyclin-dependent kinase 22.7.11.220.457
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.457
4jq8KJ8Epidermal growth factor receptor2.7.10.10.457
4qmpDKISerine/threonine-protein kinase 242.7.11.10.457
2in6839Wee1-like protein kinase2.7.10.20.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.456
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.455
1gii1PUCyclin-dependent kinase 22.7.11.220.455
1oi9N20Cyclin-dependent kinase 22.7.11.220.455
1oiyN41Cyclin-dependent kinase 22.7.11.220.455
3bqr4RBDeath-associated protein kinase 3/0.455
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.455
4ix6ADPUncharacterized protein/0.455
2c6kDT2Cyclin-dependent kinase 22.7.11.220.454
2vv9IM9Cyclin-dependent kinase 22.7.11.220.454
3gu83GUDeath-associated protein kinase 12.7.11.10.454
3rmf20ZCyclin-dependent kinase 22.7.11.220.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
3zewSTUEphrin type-B receptor 42.7.10.10.454
4btjADPTau-tubulin kinase 12.7.11.10.454
4eon1ROCyclin-dependent kinase 22.7.11.220.454
4fod0UVALK tyrosine kinase receptor2.7.10.10.454
4gub0Y4Casein kinase II subunit alpha2.7.11.10.454
4y93746Tyrosine-protein kinase/0.454
2a4lRRCCyclin-dependent kinase 22.7.11.220.453
2bkzSBCCyclin-dependent kinase 22.7.11.220.453
2c6o4SPCyclin-dependent kinase 22.7.11.220.453
4bcpT3CCyclin-dependent kinase 22.7.11.220.453
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.453
1h1r6CPCyclin-dependent kinase 22.7.11.220.452
1ykr628Cyclin-dependent kinase 22.7.11.220.452
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
2izsBRQCasein kinase I isoform gamma-32.7.11.10.452
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.452
3ddpRC8Cyclin-dependent kinase 22.7.11.220.452
3lltANPProtein serine/threonine kinase-1/0.452
3t8oATPRhodopsin kinase/0.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.452
4f081RSTyrosine-protein kinase JAK2/0.452
4jia1K3Tyrosine-protein kinase JAK2/0.452
3lpbNVBTyrosine-protein kinase JAK2/0.451
5e8ySTUTGF-beta receptor type-22.7.11.300.451
1v1k3FPCyclin-dependent kinase 22.7.11.220.450
2eufLQQCyclin-dependent kinase 62.7.11.220.450
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3lq5SLQCyclin-dependent kinase 92.7.11.220.450
3pj8404Cyclin-dependent kinase 22.7.11.220.450
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.450
3sqq99ZCyclin-dependent kinase 22.7.11.220.450
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.450
4fv9E71Mitogen-activated protein kinase 12.7.11.240.450
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
1dayGNPCasein kinase II subunit alpha2.7.11.10.449
1gij2PUCyclin-dependent kinase 22.7.11.220.449
2r3jSCJCyclin-dependent kinase 22.7.11.220.449
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3hx4ANPCalmodulin-domain protein kinase 1/0.449
3nwq2NCGag-Pol polyprotein3.4.23.160.449
3nynSGVG protein-coupled receptor kinase 62.7.11.160.449
4bgh3I6Cyclin-dependent kinase 22.7.11.220.449
4btmF8ETau-tubulin kinase 12.7.11.10.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
3ggfGVDSerine/threonine-protein kinase 26/0.448
3rak03ZCyclin-dependent kinase 22.7.11.220.448
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.448
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.447
4eok4SPCyclin-dependent kinase 22.7.11.220.447
4hgt15GCasein kinase I isoform delta2.7.11.10.447
1oirHDYCyclin-dependent kinase 22.7.11.220.446
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.446
2j0lANPFocal adhesion kinase 12.7.10.20.446
2wxvWXVCyclin-dependent kinase 22.7.11.220.446
3nwxKVSGag-Pol polyprotein3.4.23.160.446
3orkAGSSerine/threonine protein kinase/0.446
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.446
4fv6E57Mitogen-activated protein kinase 12.7.11.240.446
4loqSB4Mitogen-activated protein kinase 14/0.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
5e8wSTUTGF-beta receptor type-12.7.11.300.446
1m2rMNYCasein kinase II subunit alpha2.7.11.10.445
3cgfJNFMitogen-activated protein kinase 102.7.11.240.445
3ormAGSSerine/threonine protein kinase/0.445
3rk909ZCyclin-dependent kinase 22.7.11.220.445
4fmqANPMitogen-activated protein kinase 12.7.11.240.445
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
1k6tXN1Gag-Pol polyprotein3.4.23.160.444
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.444
2uznC96Cyclin-dependent kinase 22.7.11.220.444
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.444
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.444
1h0w207Cyclin-dependent kinase 22.7.11.220.443
2jedLG8Protein kinase C theta type2.7.11.130.443
3a62STURibosomal protein S6 kinase beta-12.7.11.10.443
3rk708ZCyclin-dependent kinase 22.7.11.220.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4qmlANPSerine/threonine-protein kinase 242.7.11.10.443
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.443
1y91CT9Cyclin-dependent kinase 22.7.11.220.442
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.442
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.442
2yn8STUEphrin type-B receptor 42.7.10.10.442
3ezrEZRCyclin-dependent kinase 22.7.11.220.442
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.442
4bgg844Activin receptor type-12.7.11.300.442
4enhFVXCholesterol 24-hydroxylase/0.442
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.442
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.441
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.441
4wboANWRhodopsin kinase/0.441
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
1w8cN69Cyclin-dependent kinase 22.7.11.220.440
3qfvNM7Serine/threonine-protein kinase MRCK beta2.7.11.10.440
3rkb12ZCyclin-dependent kinase 22.7.11.220.440
4lfiGNPCasein kinase II subunit alpha2.7.11.10.440