sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2r0c | FAD | Putative FAD-monooxygenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 2r0c | FAD | Putative FAD-monooxygenase | / | 1.226 | |
| 2bra | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.779 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.767 | |
| 1reo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.758 | |
| 2bry | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.743 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.743 | |
| 1tdk | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.741 | |
| 4j34 | FAD | Kynurenine 3-monooxygenase | / | 0.739 | |
| 1tdn | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.738 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.736 | |
| 3uox | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.733 | |
| 2qae | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.731 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.730 | |
| 2q0l | FAD | Thioredoxin reductase | 1.8.1.9 | 0.729 | |
| 2dki | FAD | 3-hydroxybenzoate 4-monooxygenase | 1.14.13.23 | 0.728 | |
| 4rek | FAD | Cholesterol oxidase | 1.1.3.6 | 0.727 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.727 | |
| 4xwr | FAD | Cholesterol oxidase | 1.1.3.6 | 0.726 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.723 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.722 | |
| 2x3n | FAD | Probable FAD-dependent monooxygenase | / | 0.721 | |
| 4hb9 | FAD | Uncharacterized protein | / | 0.718 | |
| 1bwc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.714 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.714 | |
| 1grh | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.713 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.713 | |
| 3kkj | FAD | Renalase | / | 0.713 | |
| 4u2t | FAD | Cholesterol oxidase | 1.1.3.6 | 0.712 | |
| 1ges | FAD | Glutathione reductase | 1.8.1.7 | 0.711 | |
| 3kpf | FAD | Polyamine oxidase | 1.5.3.14 | 0.711 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.709 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.709 | |
| 1ebd | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.707 | |
| 1n4w | FAD | Cholesterol oxidase | 1.1.3.6 | 0.707 | |
| 1b8s | FAD | Cholesterol oxidase | 1.1.3.6 | 0.706 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.706 | |
| 4u2s | FDA | Cholesterol oxidase | 1.1.3.6 | 0.706 | |
| 4xxg | FAD | Cholesterol oxidase | 1.1.3.6 | 0.706 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.705 | |
| 3cox | FAD | Cholesterol oxidase | 1.1.3.6 | 0.705 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.704 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.703 | |
| 3gyj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.700 | |
| 4tm3 | FAD | KtzI | / | 0.700 | |
| 5dbj | FAD | FADH2-dependent halogenase PltA | / | 0.700 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.699 | |
| 1grg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.698 | |
| 1k4q | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.698 | |
| 1n4u | FAE | Cholesterol oxidase | 1.1.3.6 | 0.698 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.698 | |
| 3urh | FAD | Dihydrolipoyl dehydrogenase | / | 0.698 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.698 | |
| 3ics | FAD | Coenzyme A disulfide reductase | / | 0.697 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.696 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.695 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.694 | |
| 1tde | FAD | Thioredoxin reductase | 1.8.1.9 | 0.693 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.692 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.692 | |
| 1n4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.691 | |
| 3nlc | FAD | Uncharacterized protein | / | 0.691 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.690 | |
| 3gyi | FAD | Cholesterol oxidase | 1.1.3.6 | 0.690 | |
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 0.690 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.689 | |
| 3dgz | FAD | Thioredoxin reductase 2, mitochondrial | 1.8.1.9 | 0.689 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.689 | |
| 4jq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.689 | |
| 1zmc | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.688 | |
| 2cdu | ADP | NADH oxidase | / | 0.688 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.688 | |
| 4em4 | FAD | Coenzyme A disulfide reductase | / | 0.687 | |
| 1lvl | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.686 | |
| 4eqx | FAD | Coenzyme A disulfide reductase | / | 0.686 | |
| 4tlx | FDA | KtzI | / | 0.686 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.685 | |
| 1yqz | FAD | Coenzyme A disulfide reductase | / | 0.685 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.685 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.685 | |
| 4jnq | FDA | Thioredoxin reductase | / | 0.685 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.684 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.684 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.684 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.682 | |
| 1cbo | FAD | Cholesterol oxidase | 1.1.3.6 | 0.681 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.681 | |
| 3gwd | FAD | Cyclohexanone monooxygenase | / | 0.681 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.681 | |
| 3kve | FAD | L-amino-acid oxidase | / | 0.681 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.681 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.681 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.680 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.680 | |
| 1gra | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.679 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.679 | |
| 1n1p | FAD | Cholesterol oxidase | 1.1.3.6 | 0.678 | |
| 2gew | FAD | Cholesterol oxidase | 1.1.3.6 | 0.678 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.678 | |
| 4fk1 | FAD | Putative thioredoxin reductase | / | 0.678 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.677 | |
| 2eq7 | FAD | Dihydrolipoyl dehydrogenase | / | 0.677 | |
| 2c3d | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.676 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.676 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.676 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.676 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.676 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.675 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.675 | |
| 2cul | FAD | GidA-related protein | / | 0.674 | |
| 3ute | FAD | UDP-galactopyranose mutase | / | 0.674 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.674 | |
| 3grs | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.673 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.673 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.672 | |
| 4x4j | FAD | Putative oxygenase | / | 0.672 | |
| 2ba9 | FAD | Putative aminooxidase | / | 0.671 | |
| 2iid | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.671 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.671 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.671 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.670 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.670 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.670 | |
| 1o94 | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.669 | |
| 3cgd | FAD | Coenzyme A disulfide reductase | / | 0.669 | |
| 3ish | FAD | Thioredoxin reductase | 1.8.1.9 | 0.669 | |
| 4b69 | FAD | L-ornithine N(5)-monooxygenase | / | 0.669 | |
| 4txi | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.669 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.668 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.668 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.668 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.668 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.668 | |
| 3a3b | RBF | Lumazine protein | / | 0.668 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.668 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.668 | |
| 4nte | FAD | DepH | / | 0.668 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.667 | |
| 4k5r | FAD | Oxygenase | / | 0.667 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.666 | |
| 4gr1 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.666 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.666 | |
| 1wam | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.664 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.664 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.664 | |
| 3ihg | FAD | Aklavinone 12-hydroxylase RdmE | / | 0.664 | |
| 1tdf | FAD | Thioredoxin reductase | 1.8.1.9 | 0.663 | |
| 2ylt | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.663 | |
| 4g73 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.663 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.662 | |
| 2jb2 | FAD | L-amino acid oxidase | / | 0.662 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.662 | |
| 4gcm | FAD | Thioredoxin reductase | 1.8.1.9 | 0.661 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.660 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.660 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.660 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.660 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.660 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.660 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.660 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.659 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.659 | |
| 4b64 | FAD | L-ornithine N(5)-monooxygenase | / | 0.659 | |
| 4em3 | FAD | Coenzyme A disulfide reductase | / | 0.658 | |
| 1feb | FAD | Trypanothione reductase | 1.8.1.12 | 0.657 | |
| 2c3c | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.657 | |
| 3ept | FDA | Putative FAD-monooxygenase | / | 0.657 | |
| 4jn9 | FAD | DepH | / | 0.657 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.657 | |
| 1npx | FAD | NADH peroxidase | 1.11.1.1 | 0.656 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.656 | |
| 1xpq | FAD | Polyamine oxidase FMS1 | / | 0.656 | |
| 2j3n | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.656 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.656 | |
| 3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.656 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.656 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.656 | |
| 1djq | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.655 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.655 | |
| 1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.655 | |
| 1tdo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.655 | |
| 2jk6 | FAD | Trypanothione reductase | / | 0.655 | |
| 3ic9 | FAD | Putative dihydrolipoamide dehydrogenase | / | 0.655 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.655 | |
| 1gal | FAD | Glucose oxidase | 1.1.3.4 | 0.654 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.654 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.654 | |
| 3qj4 | FAD | Renalase | / | 0.654 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.654 | |
| 4guu | FA9 | Lysine-specific histone demethylase 1B | 1 | 0.654 | |
| 4u8m | FDA | UDP-galactopyranose mutase | / | 0.654 | |
| 1gte | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.653 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.653 | |
| 2aqj | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.653 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.653 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.653 | |
| 4up3 | FAD | Thioredoxin reductase | / | 0.653 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.652 | |
| 3hdy | FAD | UDP-galactopyranose mutase | / | 0.652 | |
| 3oz2 | FAD | Digeranylgeranylglycerophospholipid reductase | / | 0.652 | |
| 4tlz | FAD | KtzI | / | 0.652 | |
| 1trb | FAD | Thioredoxin reductase | 1.8.1.9 | 0.651 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.651 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.651 | |
| 3k30 | ADP | Histamine dehydrogenase | / | 0.651 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.651 | |
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.651 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.650 | |
| 2bi8 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.650 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.650 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.650 | |
| 2yqu | FAD | Dihydrolipoyl dehydrogenase | / | 0.650 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.650 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.650 | |
| 4g6h | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.650 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.650 |