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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bry FAD [F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.428
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.393
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.189
4a99 FADTetX family tetracycline inactivation enzyme / 0.854
4bk2 FADProbable salicylate monooxygenase / 0.792
2rgj FADFlavin-containing monooxygenase / 0.791
3ihg FADAklavinone 12-hydroxylase RdmE / 0.789
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.775
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.774
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.773
3nlc FADUncharacterized protein / 0.767
2b9y FADPutative aminooxidase / 0.764
3cge FADCoenzyme A disulfide reductase / 0.761
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.760
2xdo FADTetX family tetracycline inactivation enzyme / 0.759
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.759
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.758
2yg5 FADPutrescine oxidase / 0.758
2eq8 FADDihydrolipoyl dehydrogenase / 0.757
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.756
4hb9 FADUncharacterized protein / 0.754
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.752
4bjz FADProbable salicylate monooxygenase / 0.752
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.750
5buk FADFADH2-dependent halogenase / 0.749
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.748
3ish FADThioredoxin reductase 1.8.1.9 0.746
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.744
2bab FADPutative aminooxidase / 0.744
2r0c FADPutative FAD-monooxygenase / 0.743
3rha FDAPutrescine oxidase / 0.743
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.741
4aox FADSteroid monooxygenase / 0.739
2eq6 FADDihydrolipoyl dehydrogenase / 0.738
1k0j FADp-hydroxybenzoate hydroxylase / 0.737
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.737
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.737
2b9x FADPutative aminooxidase / 0.735
2rab FADGlutathione amide reductase / 0.735
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.735
2yqu FADDihydrolipoyl dehydrogenase / 0.735
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.733
5dbj FADFADH2-dependent halogenase PltA / 0.733
4dna FADProbable glutathione reductase / 0.732
2qa2 FADPolyketide oxygenase CabE / 0.729
3cn8 FADPolyamine oxidase FMS1 / 0.729
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.729
1ges FADGlutathione reductase 1.8.1.7 0.728
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.727
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.726
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.726
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.726
4j2w FADKynurenine 3-monooxygenase / 0.725
2gvc FADThiol-specific monooxygenase 1.14.13 0.724
1nhr FADNADH peroxidase 1.11.1.1 0.723
2ba9 FADPutative aminooxidase / 0.722
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.722
2yg3 FADPutrescine oxidase / 0.719
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.718
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.716
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.714
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.713
3fpz AHZThiamine thiazole synthase / 0.713
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.712
4opd FDAConserved Archaeal protein / 0.711
1ger FADGlutathione reductase 1.8.1.7 0.710
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.710
2w0h FADTrypanothione reductase / 0.710
2x3n FADProbable FAD-dependent monooxygenase / 0.710
2x8g FADThioredoxin glutathione reductase / 0.710
2x8h FADThioredoxin glutathione reductase / 0.709
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.709
4yac NAIC alpha-dehydrogenase / 0.709
1fec FADTrypanothione reductase 1.8.1.12 0.708
1feb FADTrypanothione reductase 1.8.1.12 0.707
4j36 FADKynurenine 3-monooxygenase / 0.707
1get FADGlutathione reductase 1.8.1.7 0.706
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.705
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.705
2npx FADNADH peroxidase 1.11.1.1 0.705
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.705
3cnd FADPolyamine oxidase FMS1 / 0.704
3k30 ADPHistamine dehydrogenase / 0.704
3cgb FADCoenzyme A disulfide reductase / 0.703
3gwf FADCyclohexanone monooxygenase / 0.703
4opi FDAConserved Archaeal protein / 0.702
1fea FADTrypanothione reductase 1.8.1.12 0.701
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.700
4gcm FADThioredoxin reductase 1.8.1.9 0.700
4opc FDAConserved Archaeal protein / 0.700
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.700
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.699
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.699
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.699
4la1 FADThioredoxin glutathione reductase / 0.699
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.698
3atq FDAConserved Archaeal protein / 0.698
3urh FADDihydrolipoyl dehydrogenase / 0.698
4nte FADDepH / 0.698
1gal FADGlucose oxidase 1.1.3.4 0.697
4j33 FADKynurenine 3-monooxygenase / 0.696
4mo2 FADUDP-galactopyranose mutase / 0.696
3ad9 NADSubunit alpha of sarocosine oxidase / 0.695
3ada NADSubunit alpha of sarocosine oxidase / 0.695
4bk3 FADProbable salicylate monooxygenase / 0.695
2v6o FADThioredoxin glutathione reductase / 0.694
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.693
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.692
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.691
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.690
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.690
3ict FADCoenzyme A disulfide reductase / 0.690
4nev FADTrypanothione reductase / 0.690
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.689
1typ FADTrypanothione reductase 1.8.1.12 0.689
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.689
2jk6 FADTrypanothione reductase / 0.689
4j31 FADKynurenine 3-monooxygenase / 0.689
1bzl FADTrypanothione reductase 1.8.1.12 0.688
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.687
1gpe FADGlucose oxidase 1.1.3.4 0.686
2wba FADTrypanothione reductase 1.8.1.12 0.686
2xvh FADPutative flavin-containing monooxygenase / 0.686
4j56 FADThioredoxin reductase 2 1.8.1.9 0.686
4j34 FADKynurenine 3-monooxygenase / 0.685
4jq9 FADDihydrolipoyl dehydrogenase / 0.684
1f8r FADL-amino-acid oxidase 1.4.3.2 0.683
4u2s FDACholesterol oxidase 1.1.3.6 0.683
1nhp FADNADH peroxidase 1.11.1.1 0.682
1qo8 FADFumarate reductase flavoprotein subunit / 0.682
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
3qvp FADGlucose oxidase 1.1.3.4 0.682
2eq7 FADDihydrolipoyl dehydrogenase / 0.681
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.681
3f8r NAPNADH oxidase/thioredoxin reductase / 0.680
3lov FADProtoporphyrinogen oxidase / 0.680
4b1b FADThioredoxin reductase 1.8.1.9 0.680
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.679
4u2t FADCholesterol oxidase 1.1.3.6 0.679
1f8w FADNADH peroxidase 1.11.1.1 0.678
1ojt FADDihydrolipoyl dehydrogenase / 0.678
2tpr FADTrypanothione reductase 1.8.1.12 0.678
2xlp FADPutative flavin-containing monooxygenase / 0.678
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.677
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
2wow FADTrypanothione reductase / 0.676
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.676
4eqw FADCoenzyme A disulfide reductase / 0.676
1nhs FADNADH peroxidase 1.11.1.1 0.675
2yvf FADFerredoxin reductase / 0.675
5hxw FADL-amino acid deaminase / 0.675
2b9w FADPutative aminooxidase / 0.674
4gur FADLysine-specific histone demethylase 1B 1 0.674
4x9m FADUncharacterized protein MG039 homolog / 0.674
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.673
1n4u FAECholesterol oxidase 1.1.3.6 0.673
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.673
2vq7 FADPutative flavin-containing monooxygenase / 0.673
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.673
4hj3 FMNLOV protein / 0.673
4xwr FADCholesterol oxidase 1.1.3.6 0.673
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.672
2o06 MTASpermidine synthase 2.5.1.16 0.672
3mj4 FADUDP-galactopyranose mutase / 0.672
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
4b66 FADL-ornithine N(5)-monooxygenase / 0.672
3qvr FADGlucose oxidase 1.1.3.4 0.671
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
4b69 FADL-ornithine N(5)-monooxygenase / 0.671
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.670
3t37 FADPyridoxine 4-oxidase / 0.670
1k0l FADp-hydroxybenzoate hydroxylase / 0.669
3f8p NADNADH oxidase/thioredoxin reductase / 0.669
4aos FADSteroid monooxygenase / 0.669
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.668
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.668
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.668
3icr FADCoenzyme A disulfide reductase / 0.668
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.667
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.667
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.667
4hj4 FMNLOV protein / 0.667
4qi4 FADCellobiose dehydrogenase / 0.667
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.666
2qa1 FADPgaE / 0.666
3bg7 FADPyranose 2-oxidase / 0.666
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.666
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.665
4tm0 FADKtzI / 0.665
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.664
4mok FADPyranose 2-oxidase / 0.664
1geu FADGlutathione reductase 1.8.1.7 0.663
2q7v FADThioredoxin reductase / 0.663
5br7 FADUDP-galactopyranose mutase / 0.663
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.662
2xve FADPutative flavin-containing monooxygenase / 0.662
3fg2 FADPutative rubredoxin reductase / 0.662
3jsk AHZThiamine thiazole synthase / 0.662
4ap3 FADSteroid monooxygenase / 0.662
2hqm FADGlutathione reductase 1.8.1.7 0.661
2vqb FADPutative flavin-containing monooxygenase / 0.661
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.661
2jb2 FADL-amino acid oxidase / 0.660
4em3 FADCoenzyme A disulfide reductase / 0.660
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.659
1zx9 FADMercuric reductase 1.16.1.1 0.659
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.659
2z6i FMN2-nitropropane dioxygenase / 0.659
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.659
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.658
4hsu FADLysine-specific histone demethylase 1B 1 0.658
4up3 FADThioredoxin reductase / 0.658
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.657
2xvf FADPutative flavin-containing monooxygenase / 0.657
3ics ADPCoenzyme A disulfide reductase / 0.657
4ap1 FADSteroid monooxygenase / 0.657
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.656
2eq9 FADDihydrolipoyl dehydrogenase / 0.656
4guv FADTetX family tetracycline inactivation enzyme / 0.656
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.656
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.655
2dw4 FADLysine-specific histone demethylase 1A 1 0.655
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.655
2r9z FADGlutathione amide reductase / 0.654
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.654
3r9u FADThioredoxin reductase / 0.654
4fwe FADLysine-specific histone demethylase 1B 1 0.654
4yry FADGlutamate synthase, beta subunit / 0.654
1f8s FADL-amino-acid oxidase 1.4.3.2 0.653
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.653
3q9t FAYUncharacterized protein / 0.653
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.653
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.653
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.653
1npx FADNADH peroxidase 1.11.1.1 0.652
2yg4 FADPutrescine oxidase / 0.652
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.651
1tyt FADTrypanothione reductase 1.8.1.12 0.650
2ign FADPyranose 2-oxidase / 0.650
2q0l FADThioredoxin reductase 1.8.1.9 0.650
3zdn FADMonoamine oxidase N 1.4.3.4 0.650
4opg FDAConserved Archaeal protein / 0.650