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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5drdATPAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5drdATPAurora kinase A2.7.11.11.000
5dosATPAurora kinase A2.7.11.10.645
5dt4ATPAurora kinase A2.7.11.10.598
5dr9SKEAurora kinase A2.7.11.10.597
4jboWPHAurora kinase A2.7.11.10.593
1ol5ADPAurora kinase A2.7.11.10.577
3k5uPFQAurora kinase A2.7.11.10.577
5dpvSKEAurora kinase A2.7.11.10.573
2dwbANPAurora kinase A2.7.11.10.572
5dn3ATPAurora kinase A2.7.11.10.572
5dt3ATPAurora kinase A2.7.11.10.572
5dt0SKEAurora kinase A2.7.11.10.565
4jajXU1Aurora kinase A2.7.11.10.554
4o0sADNAurora kinase A2.7.11.10.553
2np8CC3Aurora kinase A2.7.11.10.547
4c3rACPAurora kinase A2.7.11.10.547
1mq4ADPAurora kinase A2.7.11.10.546
4jbpYPHAurora kinase A2.7.11.10.540
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.540
4o0wADNAurora kinase A2.7.11.10.535
5dr2ATPAurora kinase A2.7.11.10.531
2w1fL0FAurora kinase A2.7.11.10.530
3uo50BXAurora kinase A2.7.11.10.529
1ol7ADPAurora kinase A2.7.11.10.527
4deaNHIAurora kinase A2.7.11.10.524
2xru400Aurora kinase A2.7.11.10.521
5dnrATPAurora kinase A2.7.11.10.519
3efwAK8Aurora kinase A2.7.11.10.518
2x1nX1NCyclin-dependent kinase 22.7.11.220.514
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.512
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.512
3w18N13Aurora kinase A2.7.11.10.511
3c50ADPRhodopsin kinase/0.502
4utdACPAurora kinase A2.7.11.10.499
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.497
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.496
3c4zADPRhodopsin kinase/0.494
5dr6SKEAurora kinase A2.7.11.10.493
4gmy0X5Tyrosine-protein kinase JAK2/0.491
3w2cN15Aurora kinase A2.7.11.10.490
4qmpDKISerine/threonine-protein kinase 242.7.11.10.490
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.489
2w1gL0GAurora kinase A2.7.11.10.488
2x6dX6DAurora kinase A2.7.11.10.488
4k33ACPFibroblast growth factor receptor 32.7.10.10.488
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.486
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.486
4e4m0NHTyrosine-protein kinase JAK2/0.486
2xngA0HAurora kinase A2.7.11.10.484
3t8oATPRhodopsin kinase/0.484
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.484
2xikJ60Serine/threonine-protein kinase 252.7.11.10.483
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.483
1h1s4SPCyclin-dependent kinase 22.7.11.220.482
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.481
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.478
3sheI85MAP kinase-activated protein kinase 32.7.11.10.478
4o0uADNAurora kinase A2.7.11.10.478
1h1r6CPCyclin-dependent kinase 22.7.11.220.477
2xneASHAurora kinase A2.7.11.10.477
4cegADPAurora kinase A2.7.11.10.477
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.475
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.474
4dgmAGICasein kinase II subunit alpha2.7.11.10.474
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.473
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.472
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.472
2c6tDT5Cyclin-dependent kinase 22.7.11.220.471
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.471
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.471
4wsqKSAAP2-associated protein kinase 12.7.11.10.471
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.470
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.470
2ijmATPFocal adhesion kinase 12.7.10.20.468
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.468
4jbqVX6Aurora kinase A2.7.11.10.468
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.468
4nifANPMitogen-activated protein kinase 12.7.11.240.467
4jqeANPCasein kinase II subunit alpha2.7.11.10.466
5e8wSTUTGF-beta receptor type-12.7.11.300.466
3gxlQIGTGF-beta receptor type-12.7.11.300.465
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.465
4hvh19RTyrosine-protein kinase JAK32.7.10.20.465
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.464
2c5nCK8Cyclin-dependent kinase 22.7.11.220.464
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.464
2w05FRTCyclin-dependent kinase 22.7.11.220.464
3a7jADPSerine/threonine-protein kinase 242.7.11.10.464
3ggfGVDSerine/threonine-protein kinase 26/0.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.464
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
3mtfA3FActivin receptor type-12.7.11.300.462
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.462
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.461
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.460
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.460
3ttjJBIMitogen-activated protein kinase 102.7.11.240.460
1lp4ANPCasein kinase II subunit alpha2.7.11.10.459
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.459
1oguST8Cyclin-dependent kinase 22.7.11.220.458
1xjdSTUProtein kinase C theta type2.7.11.130.458
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.458
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.457
2izsBRQCasein kinase I isoform gamma-32.7.11.10.457
3c4wATPRhodopsin kinase/0.457
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.457
4dgo0JWCasein kinase II subunit alpha2.7.11.10.457
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.456
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.456
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.456
4g3rCAMCamphor 5-monooxygenase1.14.15.10.456
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.455
2iw84SPCyclin-dependent kinase 22.7.11.220.455
2p33J07Mitogen-activated protein kinase 102.7.11.240.455
3zep1NXTyrosine-protein kinase JAK32.7.10.20.455
3eljGS7Mitogen-activated protein kinase 82.7.11.240.454
3rmf20ZCyclin-dependent kinase 22.7.11.220.454
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.454
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.454
4oauADP2-5A-dependent ribonuclease3.1.260.454
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2zdt46CMitogen-activated protein kinase 102.7.11.240.453
3kpkFADSulfide-quinone reductase/0.453
4eomATPCyclin-dependent kinase 22.7.11.220.453
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.453
3a62STURibosomal protein S6 kinase beta-12.7.11.10.452
4k8aK8AFocal adhesion kinase 12.7.10.20.452
4qmlANPSerine/threonine-protein kinase 242.7.11.10.452
1oi9N20Cyclin-dependent kinase 22.7.11.220.451
1oiyN41Cyclin-dependent kinase 22.7.11.220.451
2qblCAMCamphor 5-monooxygenase1.14.15.10.451
3iok1P6Tyrosine-protein kinase JAK2/0.451
3r9hZ67Cyclin-dependent kinase 22.7.11.220.451
3rk507ZCyclin-dependent kinase 22.7.11.220.451
4ek816KCyclin-dependent kinase 22.7.11.220.451
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.451
1e9hINRCyclin-dependent kinase 22.7.11.220.450
1m2qMNXCasein kinase II subunit alpha2.7.11.10.450
2b7aIZATyrosine-protein kinase JAK2/0.450
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.450
2w1dL0DAurora kinase A2.7.11.10.450
2hog710Serine/threonine-protein kinase Chk12.7.11.10.449
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
4jia1K3Tyrosine-protein kinase JAK2/0.449
4oavACP2-5A-dependent ribonuclease3.1.260.449
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.448
2h96893Mitogen-activated protein kinase 82.7.11.240.448
2wqeADPAurora kinase A2.7.11.10.448
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3cgoJNOMitogen-activated protein kinase 102.7.11.240.448
4bgg844Activin receptor type-12.7.11.300.448
4fkr45KCyclin-dependent kinase 22.7.11.220.448
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.448
5e92ANPTGF-beta receptor type-22.7.11.300.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1pmn984Mitogen-activated protein kinase 102.7.11.240.447
2v7a627Tyrosine-protein kinase ABL12.7.10.20.447
3cgfJNFMitogen-activated protein kinase 102.7.11.240.447
3ddpRC8Cyclin-dependent kinase 22.7.11.220.447
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.447
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.447
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.447
4fv6E57Mitogen-activated protein kinase 12.7.11.240.447
4hge15VTyrosine-protein kinase JAK2/0.447
4hvi19STyrosine-protein kinase JAK32.7.10.20.447
4lxhC1EAlpha/beta hydrolase fold/0.447
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.446
1gih1PUCyclin-dependent kinase 22.7.11.220.445
1ke6LS2Cyclin-dependent kinase 22.7.11.220.445
2btrU73Cyclin-dependent kinase 22.7.11.220.445
2j0m4STFocal adhesion kinase 12.7.10.20.445
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1dayGNPCasein kinase II subunit alpha2.7.11.10.444
1p4fDRGDeath-associated protein kinase 12.7.11.10.444
1x2hLPALipoate-protein ligase A6.3.1.200.444
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.444
3c4xATPRhodopsin kinase/0.444
3fwjCAMCamphor 5-monooxygenase1.14.15.10.444
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4eor4SPCyclin-dependent kinase 22.7.11.220.444
4hnc0UTMandelate racemase/0.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
2bhhRYUCyclin-dependent kinase 22.7.11.220.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
2uzlC94Cyclin-dependent kinase 22.7.11.220.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.443
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
1udaUFGUDP-glucose 4-epimerase5.1.3.20.442
1y91CT9Cyclin-dependent kinase 22.7.11.220.442
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.442
3rk909ZCyclin-dependent kinase 22.7.11.220.442
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4eon1ROCyclin-dependent kinase 22.7.11.220.442
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.442
4lfiGNPCasein kinase II subunit alpha2.7.11.10.442
1b39ATPCyclin-dependent kinase 22.7.11.220.441
1pxlCK4Cyclin-dependent kinase 22.7.11.220.441
2bpv1INGag-Pol polyprotein3.4.23.160.441
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3qu0X40Cyclin-dependent kinase 22.7.11.220.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
4zohFADPutative oxidoreductase FAD-binding subunit/0.441
1di8DTQCyclin-dependent kinase 22.7.11.220.440
1fvv107Cyclin-dependent kinase 22.7.11.220.440
1ppjANYCytochrome b/0.440
1pxpCK8Cyclin-dependent kinase 22.7.11.220.440
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.440
3oroAGSSerine/threonine protein kinase/0.440
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.440
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.440
4ysjADPCalmodulin-like domain protein kinase/0.440
5auwQUEDeath-associated protein kinase 12.7.11.10.440