sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 1.000 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.555 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.534 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.532 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.509 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.502 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.501 | |
| 2hl1 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.496 | |
| 3pd5 | TSB | Threonine--tRNA ligase | 6.1.1.3 | 0.493 | |
| 4rrq | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.492 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.488 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.485 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.483 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.483 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.482 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.481 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.480 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.477 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.476 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.476 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.474 | |
| 4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.474 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.472 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.472 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.472 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.471 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.471 | |
| 3v2u | ATP | Protein GAL3 | / | 0.471 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.470 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.469 | |
| 4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.469 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.468 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.468 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.468 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.468 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.468 | |
| 4rrb | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.468 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.467 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.467 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.467 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.466 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.465 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.465 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.465 | |
| 1zrq | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.464 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.464 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.464 | |
| 2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.464 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.464 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.463 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.463 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.462 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.462 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.462 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.462 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.462 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.461 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.460 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1fml | RTL | Retinol dehydratase | / | 0.460 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.459 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.459 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.459 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.459 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.459 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.458 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.458 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.458 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.456 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.456 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.456 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.456 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.455 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.455 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.455 | |
| 3iod | A6D | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.455 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.455 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.454 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.454 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.454 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.454 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.453 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.453 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.453 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.453 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.453 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.452 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.452 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 3lzx | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.452 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.452 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.452 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.451 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.451 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.451 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.451 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.450 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.450 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.450 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.450 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.450 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.450 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.450 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.450 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 5dp2 | NAP | CurF | / | 0.450 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.449 | |
| 2bbw | GP5 | Adenylate kinase 4, mitochondrial | / | 0.449 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.449 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.449 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.449 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.449 | |
| 4a28 | ADP | Kinesin-like protein KIF11 | / | 0.449 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.449 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.449 | |
| 4yaf | FAD | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.448 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.448 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.448 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.448 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.448 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.448 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.447 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.447 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.447 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.447 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.447 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.447 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.446 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.446 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.446 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 4e2d | FMN | Dehydrogenase | / | 0.446 | |
| 4f97 | VDO | Putative glycosyltransferase | / | 0.446 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.445 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.445 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.445 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.445 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3nz4 | TCA | Phenylalanine aminomutase (L-beta-phenylalanine forming) | / | 0.445 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.445 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.445 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.444 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.444 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.444 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.444 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.444 | |
| 4rrl | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.444 | |
| 5ebu | FMN | Lactate oxidase | / | 0.444 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.444 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.443 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.443 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.443 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.443 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.443 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.443 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.443 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.443 | |
| 4a32 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4y7c | FAD | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.442 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.442 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.442 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.442 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.442 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.442 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.442 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.442 | |
| 3zuy | TCH | Transporter | / | 0.442 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.442 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.442 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.442 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.441 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.441 | |
| 3ov7 | ATP | CCA-adding enzyme | 2.7.7.72 | 0.441 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.441 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.441 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.441 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.440 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.440 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3ie3 | N11 | Glutathione S-transferase P | 2.5.1.18 | 0.440 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.440 | |
| 3ooi | SAM | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific | 2.1.1.43 | 0.440 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.440 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 | |
| 3x2v | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 |