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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fmqANPMitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fmqANPMitogen-activated protein kinase 12.7.11.241.000
2y9qANPMitogen-activated protein kinase 12.7.11.240.648
4h3qANPMitogen-activated protein kinase 12.7.11.240.619
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.580
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.549
4nifANPMitogen-activated protein kinase 12.7.11.240.547
4fv9E71Mitogen-activated protein kinase 12.7.11.240.544
3nieANPMitogen-activated protein kinase/0.541
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.529
4s34ANPMitogen-activated protein kinase 12.7.11.240.520
4fv6E57Mitogen-activated protein kinase 12.7.11.240.515
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.512
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.508
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.507
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.507
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.506
3i60E86Mitogen-activated protein kinase 12.7.11.240.506
3r83Z14Cyclin-dependent kinase 22.7.11.220.504
1tvoFRZMitogen-activated protein kinase 12.7.11.240.503
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.502
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.499
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.497
2ojj82AMitogen-activated protein kinase 12.7.11.240.496
2oji33AMitogen-activated protein kinase 12.7.11.240.495
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.494
1py5PY1TGF-beta receptor type-12.7.11.300.492
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
4s33ANPMitogen-activated protein kinase 12.7.11.240.491
4fuxE75Mitogen-activated protein kinase 12.7.11.240.490
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.489
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.489
3nynSGVG protein-coupled receptor kinase 62.7.11.160.488
4b99R4LMitogen-activated protein kinase 72.7.11.240.488
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.484
4fv8E63Mitogen-activated protein kinase 12.7.11.240.484
5e8ySTUTGF-beta receptor type-22.7.11.300.484
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.482
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.481
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.481
4ic7ANPMitogen-activated protein kinase 72.7.11.240.481
2vtqLZACyclin-dependent kinase 22.7.11.220.480
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.479
2c4g514Cyclin-dependent kinase 22.7.11.220.476
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.476
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.475
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.474
2ojg19AMitogen-activated protein kinase 12.7.11.240.474
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.474
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.474
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.473
3zh8C58Protein kinase C iota type2.7.11.130.473
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.472
2z7lS91Mitogen-activated protein kinase 12.7.11.240.472
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.472
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.471
3hmm855TGF-beta receptor type-12.7.11.300.471
2btsU32Cyclin-dependent kinase 22.7.11.220.470
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.470
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.470
2btrU73Cyclin-dependent kinase 22.7.11.220.469
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.469
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.469
4g6oE28Mitogen-activated protein kinase 12.7.11.240.468
2j0m4STFocal adhesion kinase 12.7.10.20.467
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.467
4fkj11KCyclin-dependent kinase 22.7.11.220.467
4hge15VTyrosine-protein kinase JAK2/0.467
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.466
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.466
2hog710Serine/threonine-protein kinase Chk12.7.11.10.466
3nwq2NCGag-Pol polyprotein3.4.23.160.466
3sheI85MAP kinase-activated protein kinase 32.7.11.10.466
4dgmAGICasein kinase II subunit alpha2.7.11.10.466
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.466
3qtrX36Cyclin-dependent kinase 22.7.11.220.465
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
5e92ANPTGF-beta receptor type-22.7.11.300.465
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.464
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.464
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.463
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.463
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.463
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.463
3qyw6PBMitogen-activated protein kinase 12.7.11.240.463
3r8lZ30Cyclin-dependent kinase 22.7.11.220.463
3rak03ZCyclin-dependent kinase 22.7.11.220.463
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.462
2wotZZGTGF-beta receptor type-12.7.11.300.462
3qrtX14Cyclin-dependent kinase 22.7.11.220.462
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.461
2vu3LZECyclin-dependent kinase 22.7.11.220.461
3dfcANPDeath-associated protein kinase 12.7.11.10.461
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.461
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.461
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.460
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.460
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
1aq1STUCyclin-dependent kinase 22.7.11.220.459
1e9hINRCyclin-dependent kinase 22.7.11.220.459
1oirHDYCyclin-dependent kinase 22.7.11.220.459
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2xvdAS6Ephrin type-B receptor 42.7.10.10.459
3gu83GUDeath-associated protein kinase 12.7.11.10.459
3mtfA3FActivin receptor type-12.7.11.300.459
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.459
3rm618ZCyclin-dependent kinase 22.7.11.220.459
4aacAAVMitogen-activated protein kinase 14/0.459
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
1eh4IC1Casein kinase I homolog 12.7.11.10.458
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3c4xATPRhodopsin kinase/0.458
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.458
4bgg844Activin receptor type-12.7.11.300.458
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.457
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.457
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.457
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.457
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.457
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.457
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.456
2wouZZFTGF-beta receptor type-12.7.11.300.456
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.456
3gubGUBDeath-associated protein kinase 12.7.11.10.456
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.456
4fob0USALK tyrosine kinase receptor2.7.10.10.456
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.455
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.455
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.455
1pxoCK7Cyclin-dependent kinase 22.7.11.220.454
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.454
1y91CT9Cyclin-dependent kinase 22.7.11.220.454
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.454
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3lfqA28Cyclin-dependent kinase 22.7.11.220.454
3qqlX03Cyclin-dependent kinase 22.7.11.220.454
3qzgX67Cyclin-dependent kinase 22.7.11.220.454
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.454
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.454
4fkv61KCyclin-dependent kinase 22.7.11.220.454
4gk3L87Ephrin type-A receptor 32.7.10.10.454
4s32ANPMitogen-activated protein kinase 12.7.11.240.454
1oiyN41Cyclin-dependent kinase 22.7.11.220.453
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.453
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.453
3lltANPProtein serine/threonine kinase-1/0.453
3nwxKVSGag-Pol polyprotein3.4.23.160.453
4ivb1J5Tyrosine-protein kinase JAK1/0.453
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.452
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.452
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.452
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2a4lRRCCyclin-dependent kinase 22.7.11.220.451
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.451
3bqr4RBDeath-associated protein kinase 3/0.451
3rni21ZCyclin-dependent kinase 22.7.11.220.451
3s2pPMUCyclin-dependent kinase 22.7.11.220.451
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.450
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.450
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3pe2E1BCasein kinase II subunit alpha2.7.11.10.450
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.450
3ql8X01Cyclin-dependent kinase 22.7.11.220.450
3r7yZ04Cyclin-dependent kinase 22.7.11.220.450
3sqq99ZCyclin-dependent kinase 22.7.11.220.450
4f650S9Fibroblast growth factor receptor 1/0.450
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.450
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.450
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
1w0xOLOCyclin-dependent kinase 22.7.11.220.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
3pxkPXKFocal adhesion kinase 12.7.10.20.449
3rjc06ZCyclin-dependent kinase 22.7.11.220.449
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.449
4hjfC2EGGDEF family protein/0.449
1h0w207Cyclin-dependent kinase 22.7.11.220.448
1hckATPCyclin-dependent kinase 22.7.11.220.448
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.448
2ijmADPFocal adhesion kinase 12.7.10.20.448
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.448
2x1nX1NCyclin-dependent kinase 22.7.11.220.448
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.448
3w32W32Epidermal growth factor receptor2.7.10.10.448
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.448
5e8xSTUTGF-beta receptor type-12.7.11.300.448
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3s1h56ZCyclin-dependent kinase 22.7.11.220.447
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.447
1oitHDTCyclin-dependent kinase 22.7.11.220.446
1vyzN5BCyclin-dependent kinase 22.7.11.220.446
1w8cN69Cyclin-dependent kinase 22.7.11.220.446
2j0lANPFocal adhesion kinase 12.7.10.20.446
3qxoX65Cyclin-dependent kinase 22.7.11.220.446
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.446
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.446
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.446
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.446
2x9fX9FEphrin type-B receptor 42.7.10.10.445
2zoq5IDMitogen-activated protein kinase 32.7.11.240.445
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.445
4ek610KCyclin-dependent kinase 22.7.11.220.445
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.445
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.445
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.445
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.445
4i5cC5ITyrosine-protein kinase JAK1/0.445
4jboWPHAurora kinase A2.7.11.10.445
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.445
1bygSTUTyrosine-protein kinase CSK/0.444
1pxlCK4Cyclin-dependent kinase 22.7.11.220.444
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3ddqRRCCyclin-dependent kinase 22.7.11.220.444
3iok1P6Tyrosine-protein kinase JAK2/0.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
4fki09KCyclin-dependent kinase 22.7.11.220.444
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.444
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.444
4n6hEJ4Delta-type opioid receptor/0.444
5av2KMPDeath-associated protein kinase 12.7.11.10.444
1h1r6CPCyclin-dependent kinase 22.7.11.220.443
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2uzbC75Cyclin-dependent kinase 22.7.11.220.443
2w05FRTCyclin-dependent kinase 22.7.11.220.443
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
1oi9N20Cyclin-dependent kinase 22.7.11.220.442
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.442
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.442
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.442
3r8pZ46Cyclin-dependent kinase 22.7.11.220.442
3r9dX6BCyclin-dependent kinase 22.7.11.220.442
3rk708ZCyclin-dependent kinase 22.7.11.220.442
3teiANPMitogen-activated protein kinase 12.7.11.240.442
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.442
1ckpPVBCyclin-dependent kinase 22.7.11.220.441
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.441
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2w06FRVCyclin-dependent kinase 22.7.11.220.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.441
3ddpRC8Cyclin-dependent kinase 22.7.11.220.441
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4c02TAKActivin receptor type-12.7.11.300.441
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.441
4fv7E94Mitogen-activated protein kinase 12.7.11.240.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
5auvAGIDeath-associated protein kinase 12.7.11.10.441
1ke5LS1Cyclin-dependent kinase 22.7.11.220.440
1m2rMNYCasein kinase II subunit alpha2.7.11.10.440
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
2vttLZDCyclin-dependent kinase 22.7.11.220.440
3my5RFZCyclin-dependent kinase 22.7.11.220.440
3r1sX73Cyclin-dependent kinase 22.7.11.220.440
4aguD15Cyclin-dependent kinase-like 1/0.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4g170VNCasein kinase I isoform gamma-32.7.11.10.440
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.440
4ux9ANPMitogen-activated protein kinase 82.7.11.240.440