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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ce17FKATP-dependent molecular chaperone HSP82

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ce17FKATP-dependent molecular chaperone HSP82/1.000
4ce2BO5ATP-dependent molecular chaperone HSP82/0.664
1am1ADPATP-dependent molecular chaperone HSP82/0.651
2breKJ2ATP-dependent molecular chaperone HSP82/0.628
2qg0A94Heat shock protein HSP 90-alpha/0.612
2bz5AB4Heat shock protein HSP 90-alpha/0.611
2yegXQGHeat shock protein HSP 90-alpha/0.610
3r4pFU7Heat shock protein HSP 90-alpha/0.610
2cgfP2NATP-dependent molecular chaperone HSP82/0.605
1osfKOSHeat shock protein HSP 90-alpha/0.601
1u0zRDCEndoplasmin/0.600
2xd6XD6ATP-dependent molecular chaperone HSP82/0.599
3vhaVHAHeat shock protein HSP 90-alpha/0.594
1yc443PHeat shock protein HSP 90-alpha/0.593
1u2oNECEndoplasmin/0.591
2xk2ADPHeat shock protein HSP 90-alpha/0.590
2iwuNP5ATP-dependent molecular chaperone HSP82/0.589
1yc34BCHeat shock protein HSP 90-alpha/0.587
3ekrPY9Heat shock protein HSP 90-alpha/0.586
1yszNECEndoplasmin/0.582
2iwxM1SATP-dependent molecular chaperone HSP82/0.582
2bt0CT5Heat shock protein HSP 90-alpha/0.579
3hhu819Heat shock protein HSP 90-alpha/0.574
3rlq3RQHeat shock protein HSP 90-alpha/0.573
2brcCT5ATP-dependent molecular chaperone HSP82/0.571
2xabVHDHeat shock protein HSP 90-alpha/0.571
4fcr0TMHeat shock protein HSP 90-alpha/0.570
4bqjXKLHeat shock protein HSP 90-alpha/0.569
4as94QSATP-dependent molecular chaperone HSP82/0.568
4egiB2JHeat shock protein HSP 90-alpha/0.568
4xcjADPHeat shock cognate 90 kDa protein/0.568
1amwADPATP-dependent molecular chaperone HSP82/0.567
3k99PFTHeat shock protein HSP 90-alpha/0.566
3rlr3RRHeat shock protein HSP 90-alpha/0.564
3k981RCHeat shock protein HSP 90-alpha/0.563
3t1kANPHeat shock protein HSP 90-alpha/0.559
4asf62UATP-dependent molecular chaperone HSP82/0.559
2wepADPATP-dependent molecular chaperone HSP82/0.558
4ipeANPTNF receptor-associated protein 1/0.558
2byi2DDHeat shock protein HSP 90-alpha/0.557
3t10ACPHeat shock protein HSP 90-alpha/0.556
3r4nFU5Heat shock protein HSP 90-alpha/0.555
1qy8RDIEndoplasmin/0.554
2werRDCATP-dependent molecular chaperone HSP82/0.554
3r4oFU3Heat shock protein HSP 90-alpha/0.551
1u0yPA7Endoplasmin/0.550
2byh2D7Heat shock protein HSP 90-alpha/0.550
1bgqRDCATP-dependent molecular chaperone HSP82/0.548
3ekoPYUHeat shock protein HSP 90-alpha/0.548
3k974CDHeat shock protein HSP 90-alpha/0.546
2xhrC0PHeat shock protein HSP 90-alpha/0.542
2exlGDMEndoplasmin/0.541
2fxsRDAATP-dependent molecular chaperone HSP82/0.541
1yc14BCHeat shock protein HSP 90-alpha/0.540
3hyz42CHeat shock protein HSP 90-alpha/0.540
4gqtADPHeat shock protein 90/0.540
2xcmADPCytosolic heat shock protein 90/0.538
3t2sAGSHeat shock protein HSP 90-alpha/0.538
2wi6ZZ6Heat shock protein HSP 90-alpha/0.537
1uy7PU4Heat shock protein HSP 90-alpha/0.536
3hekBD0Heat shock protein HSP 90-alpha/0.536
4ce3L4VATP-dependent molecular chaperone HSP82/0.535
2iwsNP4ATP-dependent molecular chaperone HSP82/0.532
3d0bSNXHeat shock protein HSP 90-alpha/0.531
3whaWHAHeat shock protein HSP 90-alpha/0.530
2qfoA13Heat shock protein HSP 90-alpha/0.529
2xx213CATP-dependent molecular chaperone HSP82/0.529
4xdmGDMHeat shock cognate 90 kDa protein/0.529
1uymPU3Heat shock protein HSP 90-beta/0.528
1y4sADPChaperone protein HtpG/0.527
2fypRDEEndoplasmin/0.527
4xc0ACPHeat shock cognate 90 kDa protein/0.526
4jqlVJ6Heat shock protein HSP 90-alpha/0.524
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.524
2fwyH64Heat shock protein HSP 90-alpha/0.522
1yetGDMHeat shock protein HSP 90-alpha/0.521
2gqpPA7Endoplasmin/0.521
1uy8PU5Heat shock protein HSP 90-alpha/0.520
4asg814ATP-dependent molecular chaperone HSP82/0.520
2xhtC0YHeat shock protein HSP 90-alpha/0.516
3iedAN2HSP90/0.515
2wi72KLHeat shock protein HSP 90-alpha/0.514
4b7p9UNHeat shock protein HSP 90-alpha/0.511
1qy5NECEndoplasmin/0.510
1uyePU9Heat shock protein HSP 90-alpha/0.510
3c11GDMATP-dependent molecular chaperone HSP82/0.509
2xjxXJXHeat shock protein HSP 90-alpha/0.506
4egkRDCHeat shock protein HSP 90-alpha/0.506
2yee2ECHeat shock protein HSP 90-alpha/0.505
2hchN5AEndoplasmin/0.504
2yefANPHeat shock protein HSP 90-alpha/0.504
3o0iP54Heat shock protein HSP 90-alpha/0.504
4efuEFUHeat shock protein HSP 90-alpha/0.504
3b28B2XHeat shock protein HSP 90-alpha/0.503
1uy9PU6Heat shock protein HSP 90-alpha/0.501
4xclAGSHeat shock cognate 90 kDa protein/0.500
1byqADPHeat shock protein HSP 90-alpha/0.495
2qfoA51Heat shock protein HSP 90-alpha/0.495
2o1vADPEndoplasmin/0.493
1uydPU8Heat shock protein HSP 90-alpha/0.492
2gfdRDAEndoplasmin/0.492
2xjjL81Heat shock protein HSP 90-alpha/0.492
2xx413IATP-dependent molecular chaperone HSP82/0.492
3hz5Z64Heat shock protein HSP 90-alpha/0.492
3t0zATPHeat shock protein HSP 90-alpha/0.492
2hg1N5OEndoplasmin/0.491
2ykjYKJHeat shock protein HSP 90-alpha/0.491
4ivgANPTNF receptor-associated protein 1/0.491
2yi5YI5Heat shock protein HSP 90-alpha/0.490
1uy6PU3Heat shock protein HSP 90-alpha/0.485
3pehIBDEndoplasmin homolog, putative/0.483
4awq592Heat shock protein HSP 90-alpha/0.480
2iorADPChaperone protein HtpG/0.479
2wi4ZZ4Heat shock protein HSP 90-alpha/0.479
3qdd94MHeat shock protein HSP 90-alpha/0.477
2yjxYJXHeat shock protein HSP 90-alpha/0.475
2esaGDMEndoplasmin/0.471
2wi5ZZ5Heat shock protein HSP 90-alpha/0.471
3hz142CHeat shock protein HSP 90-alpha/0.471
4hy6FJ1Heat shock protein HSP 90-alpha/0.471
2uwd2GGHeat shock protein HSP 90-alpha/0.468
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.465
1yt0ADPEndoplasmin/0.464
2yejZZ3Heat shock protein HSP 90-alpha/0.464
3inxJZCHeat shock protein HSP 90-alpha/0.464
3opdHIEHeat shock protein 83/0.464
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.463
2vcj2EQHeat shock protein HSP 90-alpha/0.463
2yejXQKHeat shock protein HSP 90-alpha/0.463
1uyiPUZHeat shock protein HSP 90-alpha/0.462
3h3t16HCollagen type IV alpha-3-binding protein/0.462
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.460
2yeiXQIHeat shock protein HSP 90-alpha/0.460
3hz137DHeat shock protein HSP 90-alpha/0.460
2o1uANPEndoplasmin/0.459
3pejBC2Endoplasmin homolog, putative/0.459
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.457
4ia3BIVVitamin D3 receptor A/0.457
2vwcBC2ATP-dependent molecular chaperone HSP82/0.456
2wi1ZZ2Heat shock protein HSP 90-alpha/0.456
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.456
4awp99AHeat shock protein HSP 90-alpha/0.455
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.454
3mnrSD1Heat shock protein HSP 90-alpha/0.454
1yrdCAMCamphor 5-monooxygenase1.14.15.10.453
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.453
4a8v2ANMajor pollen allergen Bet v 1-J/0.452
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.451
2w6qOA5Biotin carboxylase6.3.4.140.451
4l49CAMCamphor 5-monooxygenase1.14.15.10.451
4nh82LCHeat shock protein HSP 90-alpha/0.451
4kkyCAMCamphor 5-monooxygenase1.14.15.10.450
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.449
2cchATPCyclin-dependent kinase 22.7.11.220.448
2hcdBIVVitamin D3 receptor A/0.448
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.447
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
3inwJZBHeat shock protein HSP 90-alpha/0.446
1b6kPI5Gag-Pol polyprotein3.4.23.160.445
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2qak1UNGag-Pol polyprotein3.4.23.160.445
3h3r14HCollagen type IV alpha-3-binding protein/0.445
4ekg0QJHistone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.445
4ia7BIVVitamin D3 receptor A/0.445
2yecXQ0Heat shock protein HSP 90-alpha/0.444
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
2itpAEEEpidermal growth factor receptor2.7.10.10.442
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
2ykeYKEHeat shock protein HSP 90-alpha/0.442
3ibdCPZCytochrome P450 2B61.14.130.442
3kb1ADPIron-sulfur cluster carrier protein/0.442
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.442
1i59ANPChemotaxis protein CheA2.7.13.30.441
1proA88Gag-Pol polyprotein/0.441
1xe55FEPlasmepsin-23.4.23.390.441
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2bsmBSMHeat shock protein HSP 90-alpha/0.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.441
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.441
3h3sH15Collagen type IV alpha-3-binding protein/0.441
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.441
4jazSTLPeroxisome proliferator-activated receptor gamma/0.441
4uymVOR14-alpha sterol demethylase Cyp51B/0.441
1pjcNADAlanine dehydrogenase/0.440
2w6zL21Biotin carboxylase6.3.4.140.440
2wi2ZZ3Heat shock protein HSP 90-alpha/0.440
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.440
3a3gDLZLumazine protein/0.440
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.440
4ic7ANPMitogen-activated protein kinase 72.7.11.240.440
4l9q9TPSerum albumin/0.440