sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bx7 | B4F | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4bx7 | B4F | Streptavidin | / | 1.000 | |
| 2izh | BTN | Streptavidin | / | 0.665 | |
| 4gda | BTN | Streptavidin | / | 0.649 | |
| 1srg | MHB | Streptavidin | / | 0.645 | |
| 2rtf | BTN | Streptavidin | / | 0.644 | |
| 1i9h | BNI | Streptavidin | / | 0.638 | |
| 2rti | GLL | Streptavidin | / | 0.635 | |
| 1lcw | SHM | Streptavidin | / | 0.631 | |
| 1sre | HAB | Streptavidin | / | 0.628 | |
| 2rtq | IMI | Streptavidin | / | 0.627 | |
| 3ry2 | BTN | Streptavidin | / | 0.626 | |
| 1stp | BTN | Streptavidin | / | 0.624 | |
| 2rtg | BTN | Streptavidin | / | 0.623 | |
| 2rto | IMI | Streptavidin | / | 0.623 | |
| 3wzn | BTN | Streptavidin | / | 0.623 | |
| 1sri | DMB | Streptavidin | / | 0.622 | |
| 4dne | DTB | Streptavidin | / | 0.620 | |
| 2izk | GLL | Streptavidin | / | 0.617 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.614 | |
| 1mk5 | BTN | Streptavidin | / | 0.613 | |
| 1srf | MTB | Streptavidin | / | 0.612 | |
| 2rtd | BTN | Streptavidin | / | 0.612 | |
| 2izg | BTN | Streptavidin | / | 0.610 | |
| 1df8 | BTN | Streptavidin | / | 0.607 | |
| 1srj | NAB | Streptavidin | / | 0.607 | |
| 1srh | MOB | Streptavidin | / | 0.606 | |
| 2rtp | IMI | Streptavidin | / | 0.606 | |
| 2rte | BTN | Streptavidin | / | 0.599 | |
| 2izl | IMI | Streptavidin | / | 0.597 | |
| 1luq | BTN | Streptavidin | / | 0.594 | |
| 1rxh | BNI | Streptavidin | / | 0.594 | |
| 1swt | BTN | Streptavidin | / | 0.591 | |
| 2rtk | GLL | Streptavidin | / | 0.586 | |
| 2rtn | IMI | Streptavidin | / | 0.586 | |
| 2izf | BTN | Streptavidin | / | 0.585 | |
| 2rtr | IMI | Streptavidin | / | 0.584 | |
| 4z28 | BTN | Hoefavidin | / | 0.582 | |
| 2y3f | BTN | Streptavidin | / | 0.579 | |
| 2izi | BTN | Streptavidin | / | 0.576 | |
| 1lcz | BH7 | Streptavidin | / | 0.574 | |
| 3rdq | DTB | Streptavidin | / | 0.571 | |
| 2avi | BTN | Avidin | / | 0.567 | |
| 3wyq | BTN | Streptavidin | / | 0.567 | |
| 2rtm | IMI | Streptavidin | / | 0.565 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.564 | |
| 2izj | BTN | Streptavidin | / | 0.553 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.553 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.551 | |
| 1avd | BTN | Avidin | / | 0.550 | |
| 1swn | BTN | Streptavidin | / | 0.546 | |
| 1swp | BTN | Streptavidin | / | 0.544 | |
| 2uz2 | BTN | Avd protein | / | 0.543 | |
| 1swp | BTQ | Streptavidin | / | 0.542 | |
| 2zsc | BTN | Tamavidin2 | / | 0.538 | |
| 2c4i | BTN | Avidin | / | 0.521 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.519 | |
| 1swe | BTN | Streptavidin | / | 0.518 | |
| 1nc9 | IMI | Streptavidin | / | 0.516 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.513 | |
| 2uyw | BTN | Avd protein | / | 0.510 | |
| 1n9m | BTN | Streptavidin | / | 0.496 | |
| 1ndj | BTN | Streptavidin | / | 0.495 | |
| 1mep | BTN | Streptavidin | / | 0.487 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.487 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.486 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.486 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.485 | |
| 4yvb | BTN | Streptavidin | / | 0.485 | |
| 4bj8 | BTN | Avidin | / | 0.483 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.482 | |
| 1swd | BTN | Streptavidin | / | 0.480 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.479 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.478 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.478 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.477 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.476 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.475 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.474 | |
| 3wyp | BSO | Streptavidin | / | 0.474 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.473 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.472 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.471 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.471 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.469 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.469 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.469 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.468 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.467 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.467 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.466 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.466 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.465 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.465 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.465 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.465 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.465 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.463 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.463 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.463 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.462 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.462 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.461 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.461 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.461 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.461 | |
| 3vgw | NVZ | Avidin | / | 0.461 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.461 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.461 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.460 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.460 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.459 | |
| 2r8o | T5X | Transketolase 1 | / | 0.459 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.459 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.459 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.459 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.459 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.458 | |
| 2jgs | BTN | Avidin | / | 0.458 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 1ngs | TPP | Transketolase 1 | 2.2.1.1 | 0.457 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 2rs1 | W84 | Genome polyprotein | / | 0.457 | |
| 2rtl | IMI | Streptavidin | / | 0.457 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.457 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.457 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.456 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.456 | |
| 3i1y | 33N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.456 | |
| 3vhh | VHH | Avidin | / | 0.456 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.456 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.455 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.455 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.455 | |
| 2hvd | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.455 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.455 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.455 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.455 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4ggz | BTN | Bll1558 protein | / | 0.455 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.455 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.455 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.455 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.453 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.453 | |
| 1lke | DOG | Bilin-binding protein | / | 0.453 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.453 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.453 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.453 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.452 | |
| 1kzi | THG | Thymidylate synthase | / | 0.452 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.452 | |
| 3f0r | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.452 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.452 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.452 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.452 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.452 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.452 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.451 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.451 | |
| 2kce | D16 | Thymidylate synthase | / | 0.451 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.451 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.451 | |
| 4okx | 198 | Androgen receptor | / | 0.451 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.451 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2a5c | 8DA | Avidin | / | 0.450 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.450 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3p9k | CIY | Caffeic acid O-methyltransferase | / | 0.450 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.450 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.450 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.450 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.450 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.449 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.449 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.449 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.449 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.448 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.448 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.448 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.448 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.448 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.448 | |
| 4pd6 | URI | Nucleoside permease | / | 0.448 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.448 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.448 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.448 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.448 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.447 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.447 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.447 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.446 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.446 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.446 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.446 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.446 | |
| 3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3srz | UPG | Toxin A | / | 0.446 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.446 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.446 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.445 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.445 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.445 | |
| 3hav | ATP | Aminoglycoside phosphotransferase | / | 0.445 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.445 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.445 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.445 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.445 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.444 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.444 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 1ppj | ANY | Cytochrome b | / | 0.444 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.444 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3r0t | FU9 | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 3up3 | XCA | aceDAF-12 | / | 0.444 | |
| 4aox | FAD | Steroid monooxygenase | / | 0.444 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.444 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.443 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.443 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.443 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.443 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.443 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4c1f | X8Z | Metallo-beta-lactamase type 2 | / | 0.443 | |
| 4er7 | AW3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.443 | |
| 4h0v | NAD | Iota toxin component Ia | / | 0.443 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1nc1 | MTH | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.442 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.442 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.442 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.442 | |
| 4lwb | QJ8 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.442 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.442 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.441 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.441 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3p9t | TCL | Repressor | / | 0.441 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.441 | |
| 3v3v | MYU | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.441 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.441 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.441 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.441 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.440 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.440 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.440 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 3jq3 | ADP | Lombricine kinase | / | 0.440 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.440 | |
| 3r9h | Z67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.440 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4phl | PIL | Phosphodiesterase | / | 0.440 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.440 |