sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 1.000 | |
| 4ajn | 88V | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.674 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.608 | |
| 4al4 | W7E | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.569 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.555 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.534 | |
| 3h3f | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.533 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.528 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.517 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.508 | |
| 4ros | APR | Malate dehydrogenase | / | 0.504 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.496 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.490 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.490 | |
| 1ib6 | NAD | Malate dehydrogenase | / | 0.489 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.488 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.487 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.481 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.481 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.481 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.478 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.478 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.477 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.477 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.474 | |
| 3qw4 | U5P | Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | / | 0.474 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.473 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.472 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.472 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.472 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.472 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.472 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.471 | |
| 4xb2 | NDP | 319aa long hypothetical homoserine dehydrogenase | / | 0.471 | |
| 1u5a | BIK | L-lactate dehydrogenase | 1.1.1.27 | 0.470 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.470 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.469 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.468 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.468 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.468 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.468 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.467 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.467 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.467 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.467 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.467 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.467 | |
| 5a3b | APR | SIR2 family protein | / | 0.467 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.466 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.466 | |
| 2y5s | 78H | Dihydropteroate synthase | / | 0.466 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.465 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.465 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.465 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.464 | |
| 3b9l | AZZ | Serum albumin | / | 0.464 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.464 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.463 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.462 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.462 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.462 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.461 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.461 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.461 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.460 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.459 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.459 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.458 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.458 | |
| 4kwh | NAP | Reductase homolog | / | 0.458 | |
| 4x9m | FAD | Uncharacterized protein MG039 homolog | / | 0.458 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.457 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.457 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.456 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.456 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.456 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.456 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.456 | |
| 4e5m | NAP | Phosphonate dehydrogenase | 1.20.1.1 | 0.456 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.456 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.456 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.455 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.455 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.455 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.455 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.455 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.455 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 4lb2 | DM5 | Serum albumin | / | 0.455 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.455 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.454 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2r9e | SDX | Citrate synthase | 2.3.3.16 | 0.454 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2ylt | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.454 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.454 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.454 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.454 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.453 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.453 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.453 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.452 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.452 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.451 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.451 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.451 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.451 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.450 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2bun | FAD | AppA protein | / | 0.450 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.450 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1ytm | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.449 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.449 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.448 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.448 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.448 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1m2q | MNX | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.447 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.447 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.447 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.447 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.447 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.446 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.446 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 2wpx | ACO | Orf14 | / | 0.446 | |
| 2yyu | C5P | Orotidine 5'-phosphate decarboxylase | / | 0.446 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 4co4 | ATP | Nitrogen regulatory protein P-II 1 | / | 0.446 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.446 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.445 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.445 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.445 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.444 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1sny | NAP | LD36273p | / | 0.444 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.444 | |
| 2gmv | PEP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.444 | |
| 3bm1 | FMN | Putative NAD(P)H nitroreductase YdjA | / | 0.444 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.444 | |
| 1b8u | NAD | Malate dehydrogenase | / | 0.443 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.443 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.443 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.443 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.443 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.443 | |
| 2xvv | 9DN | Serum albumin | / | 0.443 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.443 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3okx | SAM | S-adenosyl-L-methionine-binding protein RPA0152 | / | 0.443 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.443 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4ike | ADP | Adenylate kinase | / | 0.443 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.443 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.443 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.442 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.442 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.442 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 2p5c | SAH | Diphthine synthase | / | 0.442 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.442 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.442 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.442 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.442 | |
| 3ojl | NAD | Cap5O | / | 0.442 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.442 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.442 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.441 | |
| 1qr0 | COA | 4'-phosphopantetheinyl transferase sfp | 2.7.8 | 0.441 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.441 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.441 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.441 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.441 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.441 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.441 | |
| 2ya3 | J7V | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.441 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.441 | |
| 3n0z | 3AT | Adenylate cyclase 2 | / | 0.441 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 4e2b | FMN | Dehydrogenase | / | 0.441 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.441 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.441 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.441 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1oya | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.440 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.440 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.440 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.440 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.440 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 4die | C5P | Cytidylate kinase | / | 0.440 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.440 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.440 | |
| 4jic | FMN | GTN Reductase | / | 0.440 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 5im3 | DTP | Ribonucleoside-diphosphate reductase | / | 0.440 |