sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 1.000 | |
| 3rqh | B6P | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.646 | |
| 3rqq | BA3 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.616 | |
| 3rq8 | AP5 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.603 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.496 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.494 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.492 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.491 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.486 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.486 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.483 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.483 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.480 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.477 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.474 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.474 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.473 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.473 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.472 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.472 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.471 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.471 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.471 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.471 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 5dp2 | NAP | CurF | / | 0.471 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.470 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.469 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.469 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.469 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.469 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.469 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.468 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.467 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.467 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.466 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.466 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.466 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.465 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.465 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 1zdw | FLV | Prenyltransferase | / | 0.464 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.464 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.464 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.463 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.463 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.462 | |
| 2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.462 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.462 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.462 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.462 | |
| 5a3b | APR | SIR2 family protein | / | 0.462 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.461 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.460 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.460 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.460 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.459 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.459 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.459 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.458 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.458 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2ejz | SAH | Diphthine synthase | / | 0.457 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.457 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.457 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.456 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.456 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.456 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.456 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.456 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.456 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.455 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.455 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.455 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.455 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.455 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.454 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.454 | |
| 4e2b | FMN | Dehydrogenase | / | 0.454 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.454 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.453 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.453 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.453 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.453 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.453 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.452 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2ci0 | 1CM | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.452 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.452 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2y3s | TIR | TamL | / | 0.451 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.451 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.451 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.451 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.450 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.450 | |
| 3zuy | TCH | Transporter | / | 0.450 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.449 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.449 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.449 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.449 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.449 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.449 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.448 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.448 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.448 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.447 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.447 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.447 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.447 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.447 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.447 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 2p6k | SAH | Diphthine synthase | / | 0.446 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.446 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.446 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.446 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.446 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.446 | |
| 4kqw | NAP | Ketol-acid reductoisomerase (NADP(+)) | / | 0.446 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.445 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.445 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1vza | UMP | Thymidylate synthase | / | 0.445 | |
| 2dsi | SAH | Diphthine synthase | / | 0.445 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.445 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.445 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.445 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.445 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.445 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.444 | |
| 2e16 | SAH | Diphthine synthase | / | 0.444 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.443 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4hjf | C2E | GGDEF family protein | / | 0.443 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.442 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.442 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.442 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.442 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.442 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.441 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.441 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.441 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 2bxo | OPB | Serum albumin | / | 0.441 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.441 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.441 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.441 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.441 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.441 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.441 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.441 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1in5 | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.440 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.440 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.440 | |
| 3d2p | COA | Amino-acid acetyltransferase | / | 0.440 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.440 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.440 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.440 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.440 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |