sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3d74 | NBB | Pheromone-binding protein ASP1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 1.000 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.701 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.598 | |
| 3d76 | NBB | Pheromone-binding protein ASP1 | / | 0.558 | |
| 3d77 | NBB | Pheromone-binding protein ASP1 | / | 0.552 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.549 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.519 | |
| 3p9t | TCL | Repressor | / | 0.506 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.501 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.499 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.495 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.492 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.492 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.486 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.483 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.482 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.482 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.480 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.480 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.480 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.480 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.479 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.479 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.478 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.476 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.475 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.474 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.474 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.473 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.473 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.473 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.472 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.472 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.471 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.471 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.470 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 4e70 | N7I | Coniferyl alcohol 9-O-methyltransferase | / | 0.470 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.470 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.469 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.469 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.469 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.469 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 3up0 | D7S | aceDAF-12 | / | 0.468 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.468 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.468 | |
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.468 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.468 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.467 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.467 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.466 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.466 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.466 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.465 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.465 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.464 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.464 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.464 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.464 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.463 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.463 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.463 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.463 | |
| 2xvv | 9DN | Serum albumin | / | 0.463 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.462 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.462 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.462 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.461 | |
| 2bxm | IMN | Serum albumin | / | 0.461 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.461 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.461 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.461 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.460 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.460 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 5doz | NDP | JamJ | / | 0.460 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.460 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.459 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.459 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.459 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.459 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.459 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.458 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.458 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.458 | |
| 3bej | MUF | Bile acid receptor | / | 0.458 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.458 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.458 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.458 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.458 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.458 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.458 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 1err | RAL | Estrogen receptor | / | 0.457 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.457 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.457 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.457 | |
| 3cse | N22 | Uncharacterized protein | / | 0.457 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.457 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.457 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.456 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3fzs | B96 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.456 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.456 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.456 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.456 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.456 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.455 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.455 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.455 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.455 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.455 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.455 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.455 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.454 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ppj | ANY | Cytochrome b | / | 0.453 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.453 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.452 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.452 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.452 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.452 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.452 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.452 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.452 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.451 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.451 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.451 | |
| 2za0 | MGI | Lactoylglutathione lyase | 4.4.1.5 | 0.451 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.451 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.451 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.451 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.451 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.450 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.450 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.450 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 4egn | TWO | Cytochrome P450 | / | 0.450 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.450 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.450 | |
| 4l8u | 9AZ | Serum albumin | / | 0.450 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2bxq | IMN | Serum albumin | / | 0.449 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3h18 | PMS | Esterase/lipase | / | 0.449 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.449 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1osv | CHC | Bile acid receptor | / | 0.448 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3b9l | AZZ | Serum albumin | / | 0.448 | |
| 3up3 | XCA | aceDAF-12 | / | 0.448 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 3v1m | HPK | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.448 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 3aba | FLI | Cytochrome P450 | / | 0.447 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.447 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.447 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3iiu | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.447 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.447 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3qly | 55V | Uncharacterized protein | / | 0.447 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.447 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.447 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.447 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.447 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.447 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.446 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.446 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.446 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.446 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.446 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.446 | |
| 4qrc | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.446 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.445 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.445 | |
| 2esd | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.445 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.445 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.445 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.445 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 2y37 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.444 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.444 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.444 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3nks | ACJ | Protoporphyrinogen oxidase | 1.3.3.4 | 0.444 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.444 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 4gmg | NAP | Yersiniabactin biosynthetic protein YbtU | / | 0.444 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 4xwr | FAD | Cholesterol oxidase | 1.1.3.6 | 0.444 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.443 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.443 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.443 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.443 | |
| 4flp | JQ1 | Bromodomain testis-specific protein | / | 0.443 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.443 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.443 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 5dp2 | NAP | CurF | / | 0.443 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.442 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.441 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.441 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1s9p | DES | Estrogen-related receptor gamma | / | 0.441 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.441 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.441 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.440 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 1w2c | ANP | Inositol-trisphosphate 3-kinase A | 2.7.1.127 | 0.440 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.440 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.440 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.440 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.440 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.440 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.440 |