sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ycm | 30A | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic | 2.7.7.60 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2ycm | 30A | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic | 2.7.7.60 | 1.000 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.489 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.485 | |
| 1jeh | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.484 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.484 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.483 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.482 | |
| 4nak | PBQ | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic | 2.7.7.60 | 0.481 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.480 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.479 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.478 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.476 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.476 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.475 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta | / | 0.473 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta' | / | 0.473 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.472 | |
| 4gyi | ADP | Uncharacterized protein | / | 0.472 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
| 3wy0 | COA | Uncharacterized protein | / | 0.471 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.470 | |
| 4i9h | 1E4 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.470 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.469 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.469 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 3fgo | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.469 | |
| 3ha8 | 5JZ | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.468 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.468 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.467 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.467 | |
| 4jaq | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.467 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.467 | |
| 1eio | GCH | Gastrotropin | / | 0.466 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.466 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.466 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.466 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.466 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.466 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.465 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.465 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.465 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 4mgk | CMP | Rap guanine nucleotide exchange factor 4 | / | 0.465 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.465 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.464 | |
| 1sn5 | T3 | Transthyretin | / | 0.463 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.463 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.463 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.463 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.463 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.462 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.462 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.462 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.461 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.461 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.461 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.461 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.460 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.460 | |
| 2jas | DTP | Deoxyguanosine kinase | / | 0.460 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.460 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.460 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.459 | |
| 2g37 | FAD | Proline dehydrogenase | / | 0.459 | |
| 3fr0 | AJB | Glucokinase | 2.7.1.2 | 0.459 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.459 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.459 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.459 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.459 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.459 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.458 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.458 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.458 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.458 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.458 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.458 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.457 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.457 | |
| 3bva | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.457 | |
| 5kje | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.456 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.456 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.456 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.456 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1glb | ADP | Glycerol kinase | / | 0.455 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.455 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.455 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.455 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.455 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.455 | |
| 4h4r | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.455 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.455 | |
| 5cdg | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.455 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.454 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.454 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.454 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.454 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.454 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.454 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.453 | |
| 1kvo | OAP | Phospholipase A2, membrane associated | / | 0.453 | |
| 1xcb | NAD | Redox-sensing transcriptional repressor Rex | / | 0.453 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.453 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.453 | |
| 3q9o | NAD | Cholix toxin | 2.4.2.36 | 0.453 | |
| 3vhk | BPK | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.453 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.453 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.452 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.452 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.451 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.451 | |
| 3gu7 | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.451 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.451 | |
| 4jla | ADP | Adenylate kinase | / | 0.451 | |
| 5kj6 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1x15 | NAD | NAD(P) transhydrogenase subunit alpha | 1.6.1.2 | 0.450 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3cp9 | C19 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.450 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.450 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 4eiq | KCT | Putative FAD-monooxygenase | / | 0.450 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.450 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4pd6 | URI | Nucleoside permease | / | 0.450 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1bwa | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.449 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.449 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.449 | |
| 2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.449 | |
| 2ydx | STL | Methionine adenosyltransferase 2 subunit beta | / | 0.449 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.449 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.449 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3lin | E13 | Protease | / | 0.449 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.449 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4jd3 | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.449 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.449 | |
| 5iw5 | NMN | NADH pyrophosphatase | / | 0.449 | |
| 5kcp | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 5kj1 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1uyr | D1L | Acetyl-CoA carboxylase | / | 0.448 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.448 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.448 | |
| 3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.448 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.448 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.448 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 4l8u | 9AZ | Serum albumin | / | 0.448 | |
| 1gld | ADP | Glycerol kinase | / | 0.447 | |
| 1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.447 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.447 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.447 | |
| 1ybu | APC | Probable lignin peroxidase LipJ | / | 0.447 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.447 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.447 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 2y4g | TIR | TamL | / | 0.447 | |
| 3alm | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.447 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 3qa2 | XNA | Ketohexokinase | / | 0.447 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.447 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.447 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1hih | C20 | Gag-Pol polyprotein | / | 0.446 | |
| 1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 1s9p | DES | Estrogen-related receptor gamma | / | 0.446 | |
| 1zy8 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.446 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.446 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.446 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.446 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.446 | |
| 3h18 | PMS | Esterase/lipase | / | 0.446 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.446 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ppj | SMA | Cytochrome b | / | 0.445 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.445 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3w2c | N15 | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4jap | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.445 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.444 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.444 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.444 | |
| 1uqu | UPG | Trehalose-6-phosphate synthase | 2.4.1.15 | 0.444 | |
| 1v4s | MRK | Glucokinase | 2.7.1.2 | 0.444 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.444 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.444 | |
| 3f47 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.444 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.444 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.444 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.443 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.443 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.443 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.443 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 3hu3 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.443 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.443 | |
| 5cds | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.442 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.442 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.442 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.442 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.442 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.442 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.442 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.442 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.442 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3vey | 0H5 | Glucokinase | 2.7.1.2 | 0.442 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.442 | |
| 4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 4l9q | 9TP | Serum albumin | / | 0.442 | |
| 5kcp | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1eqg | IBP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.441 | |
| 1eqh | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.441 | |
| 1jgt | APC | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.441 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.441 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.441 | |
| 2nmy | ROC | Protease | / | 0.441 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.441 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.441 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.441 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.441 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.441 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.441 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.441 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.441 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.440 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.440 | |
| 2f3k | RO1 | Protease | / | 0.440 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 | |
| 2lf1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2nnk | ROC | Protease | / | 0.440 | |
| 2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.440 | |
| 3ggj | 25H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.440 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.440 | |
| 3okx | SAM | S-adenosyl-L-methionine-binding protein RPA0152 | / | 0.440 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.440 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.440 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 4wlv | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.440 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.440 |