2.700 Å
X-ray
2013-08-28
Name: | Rap guanine nucleotide exchange factor 4 |
---|---|
ID: | RPGF4_MOUSE |
AC: | Q9EQZ6 |
Organism: | Mus musculus |
Reign: | Eukaryota |
TaxID: | 10090 |
EC Number: | / |
Chain Name: | Percentage of Residues within binding site |
---|---|
E | 100 % |
B-Factor: | 46.201 |
---|---|
Number of residues: | 33 |
Including | |
Standard Amino Acids: | 32 |
Non Standard Amino Acids: | 0 |
Water Molecules: | 1 |
Cofactors: | |
Metals: |
Ligandability | Volume (Å3) |
---|---|
0.991 | 658.125 |
% Hydrophobic | % Polar |
---|---|
47.18 | 52.82 |
According to VolSite |
HET Code: | CMP |
---|---|
Formula: | C10H11N5O6P |
Molecular weight: | 328.198 g/mol |
DrugBank ID: | DB02527 |
Buried Surface Area: | 80.96 % |
Polar Surface area: | 167.48 Å2 |
Number of | |
---|---|
H-Bond Acceptors: | 10 |
H-Bond Donors: | 2 |
Rings: | 4 |
Aromatic rings: | 2 |
Anionic atoms: | 1 |
Cationic atoms: | 0 |
Rule of Five Violation: | 1 |
Rotatable Bonds: | 1 |
X | Y | Z |
---|---|---|
4.93232 | -17.7659 | -60.7307 |
Represent the protein/ligand binding mode, centered on the ligand
Dashed lines represents hydrogen bonds and metal interactions
Green residue labels for amino acids with hydrophobic contacts (green lines) to the ligand
Ligand | Protein | Interaction | |||
---|---|---|---|---|---|
Atom | Atom | Residue | Distance (Å) | Angle (°) | Type |
C5' | CE1 | PHE- 367 | 3.75 | 0 | Hydrophobic |
C4' | CB | PHE- 403 | 4.19 | 0 | Hydrophobic |
C1' | CB | PHE- 403 | 3.82 | 0 | Hydrophobic |
O2' | N | GLY- 404 | 2.97 | 168.92 | H-Bond (Protein Donor) |
C3' | CD2 | LEU- 406 | 3.92 | 0 | Hydrophobic |
O2P | N | ALA- 407 | 3.02 | 157.87 | H-Bond (Protein Donor) |
O2P | NH1 | ARG- 414 | 2.75 | 149.26 | H-Bond (Protein Donor) |
O1P | N | ALA- 415 | 2.95 | 167.93 | H-Bond (Protein Donor) |
C5' | CB | ALA- 416 | 4.02 | 0 | Hydrophobic |
C5' | CG1 | ILE- 418 | 4.48 | 0 | Hydrophobic |
C2' | CD2 | LEU- 449 | 4.4 | 0 | Hydrophobic |
N6 | O | LYS- 450 | 3.05 | 147.66 | H-Bond (Ligand Donor) |
N1 | NZ | LYS- 489 | 3.16 | 172.19 | H-Bond (Protein Donor) |
N7 | O | HOH- 1208 | 2.72 | 145.01 | H-Bond (Protein Donor) |