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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1vyw292Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1vyw292Cyclin-dependent kinase 22.7.11.221.000
2wpa889Cyclin-dependent kinase 22.7.11.220.597
2wihP48Cyclin-dependent kinase 22.7.11.220.578
3ddpRC8Cyclin-dependent kinase 22.7.11.220.555
2bkzSBCCyclin-dependent kinase 22.7.11.220.547
3r73X87Cyclin-dependent kinase 22.7.11.220.546
2wxvWXVCyclin-dependent kinase 22.7.11.220.537
3ddqRRCCyclin-dependent kinase 22.7.11.220.535
4bcpT3CCyclin-dependent kinase 22.7.11.220.535
1e9hINRCyclin-dependent kinase 22.7.11.220.532
1oiyN41Cyclin-dependent kinase 22.7.11.220.530
3bhtMFRCyclin-dependent kinase 22.7.11.220.529
4eor4SPCyclin-dependent kinase 22.7.11.220.528
2r64740Cyclin-dependent kinase 22.7.11.220.526
1h1r6CPCyclin-dependent kinase 22.7.11.220.525
1unlRRCCyclin-dependent-like kinase 52.7.11.10.525
3lfnA27Cyclin-dependent kinase 22.7.11.220.522
3r9dX6BCyclin-dependent kinase 22.7.11.220.522
1oguST8Cyclin-dependent kinase 22.7.11.220.521
1ke6LS2Cyclin-dependent kinase 22.7.11.220.519
3qqfX07Cyclin-dependent kinase 22.7.11.220.519
3qtzX42Cyclin-dependent kinase 22.7.11.220.519
3sqq99ZCyclin-dependent kinase 22.7.11.220.518
1oi9N20Cyclin-dependent kinase 22.7.11.220.517
3ral04ZCyclin-dependent kinase 22.7.11.220.517
3s2pPMUCyclin-dependent kinase 22.7.11.220.517
4fx360KCyclin-dependent kinase 22.7.11.220.516
3r1yX76Cyclin-dependent kinase 22.7.11.220.515
3rpo24ZCyclin-dependent kinase 22.7.11.220.515
3rpv26ZCyclin-dependent kinase 22.7.11.220.515
1gih1PUCyclin-dependent kinase 22.7.11.220.514
2a0cCK9Cyclin-dependent kinase 22.7.11.220.514
3rk507ZCyclin-dependent kinase 22.7.11.220.514
1h1s4SPCyclin-dependent kinase 22.7.11.220.513
2b52D42Cyclin-dependent kinase 22.7.11.220.513
4ek816KCyclin-dependent kinase 22.7.11.220.513
1w0xOLOCyclin-dependent kinase 22.7.11.220.512
3ezrEZRCyclin-dependent kinase 22.7.11.220.512
3qu0X40Cyclin-dependent kinase 22.7.11.220.512
3qzhX69Cyclin-dependent kinase 22.7.11.220.512
4fkq42KCyclin-dependent kinase 22.7.11.220.512
2cchATPCyclin-dependent kinase 22.7.11.220.511
2w06FRVCyclin-dependent kinase 22.7.11.220.511
3roy22ZCyclin-dependent kinase 22.7.11.220.511
3tnwF18Cyclin-dependent kinase 22.7.11.220.511
3qqkX02Cyclin-dependent kinase 22.7.11.220.510
3rk909ZCyclin-dependent kinase 22.7.11.220.510
2btsU32Cyclin-dependent kinase 22.7.11.220.509
3rm618ZCyclin-dependent kinase 22.7.11.220.509
3rni21ZCyclin-dependent kinase 22.7.11.220.509
3qxoX65Cyclin-dependent kinase 22.7.11.220.508
3rmf20ZCyclin-dependent kinase 22.7.11.220.508
1pxoCK7Cyclin-dependent kinase 22.7.11.220.507
2iw84SPCyclin-dependent kinase 22.7.11.220.506
3rjc06ZCyclin-dependent kinase 22.7.11.220.506
4eok4SPCyclin-dependent kinase 22.7.11.220.506
2c6o4SPCyclin-dependent kinase 22.7.11.220.504
1di8DTQCyclin-dependent kinase 22.7.11.220.503
1ke9LS5Cyclin-dependent kinase 22.7.11.220.503
2r3lSCWCyclin-dependent kinase 22.7.11.220.503
3pj8404Cyclin-dependent kinase 22.7.11.220.503
3r7vZ02Cyclin-dependent kinase 22.7.11.220.503
1dm2HMDCyclin-dependent kinase 22.7.11.220.502
2iw94SPCyclin-dependent kinase 22.7.11.220.502
3r7yZ04Cyclin-dependent kinase 22.7.11.220.502
4fkw62KCyclin-dependent kinase 22.7.11.220.502
1v1k3FPCyclin-dependent kinase 22.7.11.220.501
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.501
3ig7EFPCyclin-dependent kinase 22.7.11.220.501
3iggEFQCyclin-dependent kinase 22.7.11.220.501
3rk708ZCyclin-dependent kinase 22.7.11.220.501
4bgh3I6Cyclin-dependent kinase 22.7.11.220.501
4ez30S0Cyclin-dependent kinase 22.7.11.220.501
1g5sI17Cyclin-dependent kinase 22.7.11.220.500
3r6xX84Cyclin-dependent kinase 22.7.11.220.500
3r9hZ67Cyclin-dependent kinase 22.7.11.220.500
2btrU73Cyclin-dependent kinase 22.7.11.220.499
2r3p3SCCyclin-dependent kinase 22.7.11.220.499
3rak03ZCyclin-dependent kinase 22.7.11.220.499
4ek610KCyclin-dependent kinase 22.7.11.220.499
3s0o50ZCyclin-dependent kinase 22.7.11.220.498
1oitHDTCyclin-dependent kinase 22.7.11.220.497
2b55D31Cyclin-dependent kinase 22.7.11.220.497
3r7iX9ICyclin-dependent kinase 22.7.11.220.497
3rm719ZCyclin-dependent kinase 22.7.11.220.497
1h1q2A6Cyclin-dependent kinase 22.7.11.220.496
2c4g514Cyclin-dependent kinase 22.7.11.220.496
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.496
4fkpLS5Cyclin-dependent kinase 22.7.11.220.496
1oiqHDUCyclin-dependent kinase 22.7.11.220.495
3qwkX62Cyclin-dependent kinase 22.7.11.220.495
1p2a5BNCyclin-dependent kinase 22.7.11.220.494
2r3kSCQCyclin-dependent kinase 22.7.11.220.494
3fz1B98Cyclin-dependent kinase 22.7.11.220.494
4lyn1YGCyclin-dependent kinase 22.7.11.220.494
3r7eX88Cyclin-dependent kinase 22.7.11.220.493
3r83Z14Cyclin-dependent kinase 22.7.11.220.493
3lfsA07Cyclin-dependent kinase 22.7.11.220.492
2uzoC62Cyclin-dependent kinase 22.7.11.220.491
3lfqA28Cyclin-dependent kinase 22.7.11.220.491
3qtuX44Cyclin-dependent kinase 22.7.11.220.491
4eol1ROCyclin-dependent kinase 22.7.11.220.491
2fvdLIACyclin-dependent kinase 22.7.11.220.490
4fki09KCyclin-dependent kinase 22.7.11.220.490
3s1h56ZCyclin-dependent kinase 22.7.11.220.489
4qmpDKISerine/threonine-protein kinase 242.7.11.10.489
1ke7LS3Cyclin-dependent kinase 22.7.11.220.488
1vyzN5BCyclin-dependent kinase 22.7.11.220.488
3qwjX6ACyclin-dependent kinase 22.7.11.220.488
4eos1ROCyclin-dependent kinase 22.7.11.220.488
4fkv61KCyclin-dependent kinase 22.7.11.220.488
3r8lZ30Cyclin-dependent kinase 22.7.11.220.487
4bcmT7ZCyclin-dependent kinase 22.7.11.220.487
4fkr45KCyclin-dependent kinase 22.7.11.220.487
3qzgX67Cyclin-dependent kinase 22.7.11.220.486
3unk0BYCyclin-dependent kinase 22.7.11.220.486
1fvt106Cyclin-dependent kinase 22.7.11.220.485
1pxmCK5Cyclin-dependent kinase 22.7.11.220.485
1y91CT9Cyclin-dependent kinase 22.7.11.220.485
2c6iDT1Cyclin-dependent kinase 22.7.11.220.485
2i40BLZCyclin-dependent kinase 22.7.11.220.485
4bcqTJFCyclin-dependent kinase 22.7.11.220.485
1h0w207Cyclin-dependent kinase 22.7.11.220.484
4nj32KDCyclin-dependent kinase 22.7.11.220.484
3r7uX96Cyclin-dependent kinase 22.7.11.220.482
1ckpPVBCyclin-dependent kinase 22.7.11.220.481
3r1qX75Cyclin-dependent kinase 22.7.11.220.481
4acm7YGCyclin-dependent kinase 22.7.11.220.481
4fkj11KCyclin-dependent kinase 22.7.11.220.481
1ke5LS1Cyclin-dependent kinase 22.7.11.220.480
2x1nX1NCyclin-dependent kinase 22.7.11.220.480
3r71X86Cyclin-dependent kinase 22.7.11.220.480
2vttLZDCyclin-dependent kinase 22.7.11.220.479
3dogNNNCyclin-dependent kinase 22.7.11.220.478
3ql8X01Cyclin-dependent kinase 22.7.11.220.478
4erwSTUCyclin-dependent kinase 22.7.11.220.478
3raiX85Cyclin-dependent kinase 22.7.11.220.477
4fklCK2Cyclin-dependent kinase 22.7.11.220.477
1fvv107Cyclin-dependent kinase 22.7.11.220.476
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
1b39ATPCyclin-dependent kinase 22.7.11.220.475
2uzdC85Cyclin-dependent kinase 22.7.11.220.475
3qruX19Cyclin-dependent kinase 22.7.11.220.475
5aniES4Cyclin-dependent kinase 22.7.11.220.475
1h1pCMGCyclin-dependent kinase 22.7.11.220.474
1urwI1PCyclin-dependent kinase 22.7.11.220.474
2c5nCK8Cyclin-dependent kinase 22.7.11.220.474
3r1sX73Cyclin-dependent kinase 22.7.11.220.474
3qziX72Cyclin-dependent kinase 22.7.11.220.473
3r28XA0Cyclin-dependent kinase 22.7.11.220.473
4eon1ROCyclin-dependent kinase 22.7.11.220.473
2r3mSCXCyclin-dependent kinase 22.7.11.220.472
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.472
3my5RFZCyclin-dependent kinase 22.7.11.220.472
4fkt48KCyclin-dependent kinase 22.7.11.220.472
1finATPCyclin-dependent kinase 22.7.11.220.471
2c6tDT5Cyclin-dependent kinase 22.7.11.220.470
2j9mPY8Cyclin-dependent kinase 22.7.11.220.470
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.470
4cfnJYMCyclin-dependent kinase 22.7.11.220.470
3qtxX43Cyclin-dependent kinase 22.7.11.220.469
4fkg4CKCyclin-dependent kinase 22.7.11.220.469
1r78FMDCyclin-dependent kinase 22.7.11.220.468
2r3iSCFCyclin-dependent kinase 22.7.11.220.468
1oiuN76Cyclin-dependent kinase 22.7.11.220.467
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.467
2wotZZGTGF-beta receptor type-12.7.11.300.467
2xmyCDKCyclin-dependent kinase 22.7.11.220.467
3qrtX14Cyclin-dependent kinase 22.7.11.220.467
1ke8LS4Cyclin-dependent kinase 22.7.11.220.466
3qqhX0ACyclin-dependent kinase 22.7.11.220.466
3r8pZ46Cyclin-dependent kinase 22.7.11.220.466
2r3r6SCCyclin-dependent kinase 22.7.11.220.465
3ezvEZVCyclin-dependent kinase 22.7.11.220.465
2duv371Cyclin-dependent kinase 22.7.11.220.464
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.464
3qqlX03Cyclin-dependent kinase 22.7.11.220.464
4bcoT6QCyclin-dependent kinase 22.7.11.220.463
1e1xNW1Cyclin-dependent kinase 22.7.11.220.462
2a4lRRCCyclin-dependent kinase 22.7.11.220.462
3qx2X63Cyclin-dependent kinase 22.7.11.220.462
4bcnT9NCyclin-dependent kinase 22.7.11.220.462
3r9oZ71Cyclin-dependent kinase 22.7.11.220.460
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.460
3sw418KCyclin-dependent kinase 22.7.11.220.459
1pyePM1Cyclin-dependent kinase 22.7.11.220.458
1w8cN69Cyclin-dependent kinase 22.7.11.220.458
1ykr628Cyclin-dependent kinase 22.7.11.220.458
2vthLZ2Cyclin-dependent kinase 22.7.11.220.458
3rahO1ZCyclin-dependent kinase 22.7.11.220.458
4eomATPCyclin-dependent kinase 22.7.11.220.458
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.456
3sheI85MAP kinase-activated protein kinase 32.7.11.10.456
1gz8MBPCyclin-dependent kinase 22.7.11.220.455
1b38ATPCyclin-dependent kinase 22.7.11.220.454
3r8uZ31Cyclin-dependent kinase 22.7.11.220.454
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.453
2r3fSC8Cyclin-dependent kinase 22.7.11.220.453
2r3gSC9Cyclin-dependent kinase 22.7.11.220.453
3qzfX66Cyclin-dependent kinase 22.7.11.220.453
1h0vUN4Cyclin-dependent kinase 22.7.11.220.452
2r3o2SCCyclin-dependent kinase 22.7.11.220.452
2uzeC95Cyclin-dependent kinase 22.7.11.220.452
2w1hL0FCyclin-dependent kinase 22.7.11.220.452
3rkb12ZCyclin-dependent kinase 22.7.11.220.452
2uznC96Cyclin-dependent kinase 22.7.11.220.451
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.450
2bheBRYCyclin-dependent kinase 22.7.11.220.449
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.449
3rpy27ZCyclin-dependent kinase 22.7.11.220.449
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.449
1gij2PUCyclin-dependent kinase 22.7.11.220.448
2vtsLZCCyclin-dependent kinase 22.7.11.220.448
2c6mDT5Cyclin-dependent kinase 22.7.11.220.447
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.447
3r8zZ63Cyclin-dependent kinase 22.7.11.220.447
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
1oirHDYCyclin-dependent kinase 22.7.11.220.446
3ti1B49Cyclin-dependent kinase 22.7.11.220.446
1pxpCK8Cyclin-dependent kinase 22.7.11.220.445
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.445
4ii5ADPCyclin-dependent kinase 22.7.11.220.445
1gy3ATPCyclin-dependent kinase 22.7.11.220.444
1v0oINRCell division control protein 2 homolog2.7.11.220.444
2b53D23Cyclin-dependent kinase 22.7.11.220.444
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.444
4kd11QKCyclin-dependent kinase 22.7.11.220.444
3qtrX36Cyclin-dependent kinase 22.7.11.220.443
4eoi1ROCyclin-dependent kinase 22.7.11.220.443
1pxkCK3Cyclin-dependent kinase 22.7.11.220.442
2exmZIPCyclin-dependent kinase 22.7.11.220.442
3unj0BXCyclin-dependent kinase 22.7.11.220.442
4bgg844Activin receptor type-12.7.11.300.442
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2r3jSCJCyclin-dependent kinase 22.7.11.220.441
2uzbC75Cyclin-dependent kinase 22.7.11.220.441
4eop1ROCyclin-dependent kinase 22.7.11.220.441
4fko20KCyclin-dependent kinase 22.7.11.220.440
4fks46KCyclin-dependent kinase 22.7.11.220.440