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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5i9eATPActin-related protein 4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
5i9eATPActin-related protein 4/1.000
1typFADTrypanothione reductase1.8.1.120.522
2a94AP0L-lactate dehydrogenase1.1.1.270.516
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.490
4dnaFADProbable glutathione reductase/0.489
2j4dFADCryptochrome DASH, chloroplastic/mitochondrial/0.477
1xe55FEPlasmepsin-23.4.23.390.476
3uylTYDProbable NDP-rhamnosyltransferase/0.476
1nhqFADNADH peroxidase1.11.1.10.475
2il2LIXRenin3.4.23.150.475
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.474
2jk6FADTrypanothione reductase/0.474
3wqmB29Diterpene synthase3.1.7.80.473
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.473
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.471
4i1iNADMalate dehydrogenase/0.471
4mhtSAHModification methylase HhaI2.1.1.370.471
3afhGSUGlutamate--tRNA ligase 2/0.470
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.469
4opgFDAConserved Archaeal protein/0.469
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.468
2zbaZBATrichothecene 3-O-acetyltransferase/0.468
4an4DUDPutative glycosyl transferase/0.468
5ahsFADAcyl-CoA dehydrogenase/0.468
2w0hFADTrypanothione reductase/0.467
3lqfNADGalactitol dehydrogenase/0.467
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
1mjbACOHistone acetyltransferase ESA1/0.466
2g247IGRenin3.4.23.150.466
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.465
2wowFADTrypanothione reductase/0.465
4b65FADL-ornithine N(5)-monooxygenase/0.465
1feaFADTrypanothione reductase1.8.1.120.463
3pm9FADPutative oxidoreductase/0.463
5ah5LSSLeucine--tRNA ligase/0.463
1gerFADGlutathione reductase1.8.1.70.462
1tytFADTrypanothione reductase1.8.1.120.462
2ahrNAPPyrroline-5-carboxylate reductase/0.462
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.461
2hqmFADGlutathione reductase1.8.1.70.461
2ylzFADPhenylacetone monooxygenase1.14.13.920.461
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.461
4a6rTA8Probable aminotransferase/0.461
4e32DWNMethyltransferase/0.461
4la1FADThioredoxin glutathione reductase/0.461
5jscFADPutative acyl-CoA dehydrogenase/0.461
1lbcCYZGlutamate receptor 2/0.459
1szgFNSCytochrome b2, mitochondrial1.1.2.30.459
1w4xFADPhenylacetone monooxygenase1.14.13.920.459
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.459
2g1o2IGRenin3.4.23.150.459
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.459
4fsl0VBBeta-secretase 13.4.23.460.459
4opiFDAConserved Archaeal protein/0.459
4ypaSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.459
1u7hNADPutative ornithine cyclodeaminase/0.458
2a92NAIL-lactate dehydrogenase/0.458
2cntCOARibosomal-protein-alanine acetyltransferase/0.458
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.458
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.457
2a4xBLMMitomycin-binding protein/0.457
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3dm5GDPSignal recognition particle 54 kDa protein/0.457
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.457
1x1aSAMC-20 methyltransferase/0.456
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.456
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.456
3ab1FADFerredoxin--NADP reductase1.18.1.20.456
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.456
3grsFADGlutathione reductase, mitochondrial1.8.1.70.456
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.456
3rpeFADPutative modulator of drug activity/0.456
4eb7PLPCysteine desulfurase IscS 2/0.456
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.456
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.456
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.456
1greFADGlutathione reductase, mitochondrial1.8.1.70.455
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.455
4gxs0YSGlutamate receptor 2/0.455
1g1aNADdTDP-glucose 4,6-dehydratase/0.454
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.454
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.454
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.454
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.454
3cb2GDPTubulin gamma-1 chain/0.454
3coz54HPantothenate synthetase6.3.2.10.454
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.454
1t2cNAIL-lactate dehydrogenase1.1.1.270.453
2cv2GSUGlutamate--tRNA ligase6.1.1.170.453
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3cic316Beta-secretase 13.4.23.460.453
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.453
3hlwCE3Beta-lactamase/0.453
3kb1ADPIron-sulfur cluster carrier protein/0.453
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.453
5p2pDHGPhospholipase A2, major isoenzyme3.1.1.40.453
1bv9XV6Gag-Pol polyprotein3.4.23.160.452
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.452
1eveE20Acetylcholinesterase3.1.1.70.452
1knrFADL-aspartate oxidase1.4.3.160.452
1yqzCOACoenzyme A disulfide reductase/0.452
3gnvXNZGenome polyprotein2.7.7.480.452
3iobA4DPantothenate synthetase6.3.2.10.452
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.452
4eb5PLPCysteine desulfurase IscS 2/0.452
1w6hTITPlasmepsin-23.4.23.390.451
2c20NADUDP-glucose 4-epimerase/0.451
2hpvFMNFMN-dependent NADH-azoreductase1.70.451
3kpbSAMUncharacterized protein MJ0100/0.451
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.451
3lpkZ76Beta-secretase 13.4.23.460.451
4lcjNADC-terminal-binding protein 2/0.451
1grgFADGlutathione reductase, mitochondrial1.8.1.70.450
1k6vXN2Gag-Pol polyprotein3.4.23.160.450
2y0mACOHistone acetyltransferase KAT8/0.450
3bgcLJHGag-Pol polyprotein3.4.23.160.450
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3fktSIIBeta-secretase 13.4.23.460.450
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.450
3x2eNAIAdenosylhomocysteinase/0.450
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.450
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.450
4de50JDPantothenate synthetase6.3.2.10.450
4dpwAGSMevalonate diphosphate decarboxylase/0.450
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.450
4k28NADShikimate dehydrogenase family protein/0.450
1gcoNADGlucose 1-dehydrogenase1.1.1.470.449
1np7FADCryptochrome DASH/0.449
1odcA8BAcetylcholinesterase3.1.1.70.449
1vikBAYGag-Pol polyprotein/0.449
2g1r3IGRenin3.4.23.150.449
2xlrFADPutative flavin-containing monooxygenase/0.449
3lzxFADFerredoxin--NADP reductase 21.18.1.20.449
3pndFADFAD:protein FMN transferase/0.449
3vydVYDRenin3.4.23.150.449
4eqwFADCoenzyme A disulfide reductase/0.449
4fse0VABeta-secretase 13.4.23.460.449
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.449
4i8zG08Gag-Pol polyprotein3.4.23.160.449
4oztP1AEcdysone receptor, putative/0.449
1p1hNADInositol-3-phosphate synthase5.5.1.40.448
2fhnBNIAvidin-related protein 4/5/0.448
3em3478Gag-Pol polyprotein3.4.23.160.448
3itjFADThioredoxin reductase 11.8.1.90.448
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.448
4j4nD44Peptidylprolyl isomerase/0.448
4m83ERYOleandomycin glycosyltransferase2.4.10.448
1febFADTrypanothione reductase1.8.1.120.447
1h74ADPHomoserine kinase2.7.1.390.447
1sguMK1Gag-Pol polyprotein3.4.23.160.447
1u33LM2Pancreatic alpha-amylase/0.447
3cow52HPantothenate synthetase6.3.2.10.447
3mj4URMUDP-galactopyranose mutase/0.447
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
4dbzNDPPutative ketoacyl reductase1.3.10.447
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.447
4xguADPPutative pachytene checkpoint protein 2/0.447
4yryFADGlutamate synthase, beta subunit/0.447
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.446
1geeNADGlucose 1-dehydrogenase1.1.1.470.446
1qo8FADFumarate reductase flavoprotein subunit/0.446
2daaDCSD-alanine aminotransferase2.6.1.210.446
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.446
3ag6PAJPantothenate synthetase/0.446
3hy7097A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.446
3k5fAYHBeta-secretase 13.4.23.460.446
4ambDUDPutative glycosyl transferase/0.446
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.446
4jnqFDAThioredoxin reductase/0.446
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.446
5hg0SAMPantothenate synthetase/0.446
2db3ANPATP-dependent RNA helicase vasa, isoform A3.6.4.130.445
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.445
2oegUPGUDP-glucose pyrophosphorylase/0.445
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.445
2yqsUD1UDP-N-acetylglucosamine pyrophosphorylase2.7.7.230.445
3ivxFG6Pantothenate synthetase6.3.2.10.445
3ixk929Beta-secretase 13.4.23.460.445
3nsh957Beta-secretase 13.4.23.460.445
4i0i957Beta-secretase 13.4.23.460.445
1grbFADGlutathione reductase, mitochondrial1.8.1.70.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3eksCY9Actin-5C/0.444
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.444
1fy7COAHistone acetyltransferase ESA1/0.443
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.443
2avvMK1Gag-Pol polyprotein3.4.23.160.443
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.443
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.443
2v13C40Renin3.4.23.150.443
2vbqBSJAminoglycoside N(6')-acetyltransferase type 1/0.443
2wdzNADGalactitol dehydrogenase/0.443
3ndjJHZMethyltransferase/0.443
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.443
3toxNAPPutative oxidoreductase/0.443
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.443
4emtC2EStimulator of interferon genes protein/0.443
4g6hFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.443
5af7FADAcyl-CoA dehydrogenase/0.443
5c1mCLRMu-type opioid receptor/0.443
1bwb146Gag-Pol polyprotein3.4.23.160.442
1k6tXN1Gag-Pol polyprotein3.4.23.160.442
1sb9UPGWbpP/0.442
1y3aGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.442
1yqzFADCoenzyme A disulfide reductase/0.442
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.442
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.442
3wagTYDGlycosyltransferase/0.442
4bftZVTPantothenate kinase2.7.1.330.442
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.442
4z24FADPutative GMC-type oxidoreductase R13510.442
2g1s4IGRenin3.4.23.150.441
2i4qUA4Renin3.4.23.150.441
2rcyNAPPyrroline-5-carboxylate reductase/0.441
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3kmxG00Beta-secretase 13.4.23.460.441
3nu6478Gag-Pol polyprotein3.4.23.160.441
4dfg0JVGag-Pol polyprotein3.4.23.160.441
4k9h1QUBeta-secretase 13.4.23.460.441
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.441
5e7oMGDDMSO reductase family type II enzyme, molybdopterin subunit/0.441
5f8eSAHPossible transcriptional regulatory protein/0.441
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.440
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.440
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.440
1lquNDPNADPH-ferredoxin reductase FprA1.18.1.20.440
1npa3NHGag-Pol polyprotein3.4.23.160.440
1npwLGZGag-Pol polyprotein3.4.23.160.440
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.440
1rwbNADGlucose 1-dehydrogenase1.1.1.470.440
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.440
2f81017Gag-Pol polyprotein3.4.23.160.440
2fonFADAcyl-coenzyme A oxidase/0.440
2p4j23IBeta-secretase 13.4.23.460.440
3ioeA7DPantothenate synthetase6.3.2.10.440
3ivgFG5Pantothenate synthetase6.3.2.10.440
3qfrFMNNADPH--cytochrome P450 reductase/0.440
3s5wNAPL-ornithine N(5)-monooxygenase/0.440
4em4FADCoenzyme A disulfide reductase/0.440
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.440