Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4rrxLURProstaglandin G/H synthase 21.14.99.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4rrxLURProstaglandin G/H synthase 21.14.99.11.000
1q4gBFLProstaglandin G/H synthase 11.14.99.10.641
4otyLURProstaglandin G/H synthase 21.14.99.10.630
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.617
3mqe416Prostaglandin G/H synthase 21.14.99.10.615
4coxIMNProstaglandin G/H synthase 21.14.99.10.614
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.610
4rrwLURProstaglandin G/H synthase 21.14.99.10.604
4rrzLURProstaglandin G/H synthase 21.14.99.10.604
3ln1CELProstaglandin G/H synthase 21.14.99.10.603
5ikrID8Prostaglandin G/H synthase 21.14.99.10.602
3ntgD72Prostaglandin G/H synthase 21.14.99.10.600
3rr3FLRProstaglandin G/H synthase 21.14.99.10.588
3n8wFLPProstaglandin G/H synthase 11.14.99.10.585
3pghFLPProstaglandin G/H synthase 21.14.99.10.584
2oyuIMSProstaglandin G/H synthase 11.14.99.10.577
5ikqJMSProstaglandin G/H synthase 21.14.99.10.572
3q7dNPXProstaglandin G/H synthase 21.14.99.10.571
3kk6CELProstaglandin G/H synthase 11.14.99.10.560
4ph9IBPProstaglandin G/H synthase 21.14.99.10.558
6coxS58Prostaglandin G/H synthase 21.14.99.10.549
1cx2S58Prostaglandin G/H synthase 21.14.99.10.546
1pxxDIFProstaglandin G/H synthase 21.14.99.10.544
1eqgIBPProstaglandin G/H synthase 11.14.99.10.535
3n8xNIMProstaglandin G/H synthase 11.14.99.10.531
3n8yDIFProstaglandin G/H synthase 11.14.99.10.528
1ht834CProstaglandin G/H synthase 11.14.99.10.524
2aylFLPProstaglandin G/H synthase 11.14.99.10.523
5iktTLFProstaglandin G/H synthase 21.14.99.10.520
1eqhFLPProstaglandin G/H synthase 11.14.99.10.516
1ht5FL2Prostaglandin G/H synthase 11.14.99.10.503
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.501
3n8zFLPProstaglandin G/H synthase 11.14.99.10.500
4ia2BIVVitamin D3 receptor A/0.494
4rupH97Vitamin D3 receptor A/0.494
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.491
4iae1DXAlr2278 protein/0.491
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.484
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.483
3oqkS52Renin3.4.23.150.482
4ryvZEAProtein LlR18A/0.480
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.479
3litE15Protease/0.479
3w0jT08Vitamin D3 receptor/0.479
1wlvCOAPhenylacetic acid degradation protein PaaI/0.478
1opbRETRetinol-binding protein 2/0.476
1zdwFLVPrenyltransferase/0.476
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.476
3wowANPCasein kinase II subunit alpha2.7.11.10.474
2znq401Peroxisome proliferator-activated receptor delta/0.472
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.472
3vtdTKDVitamin D3 receptor/0.472
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
1gqtACPRibokinase/0.470
3mtfA3FActivin receptor type-12.7.11.300.470
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.470
4bb3KKAIsopenicillin N synthase1.21.3.10.470
4jqh1MFAlr2278 protein/0.470
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
1x8lOXRRetinol dehydratase/0.469
2hcdBIVVitamin D3 receptor A/0.469
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.469
3vt7VDXVitamin D3 receptor/0.469
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.468
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.468
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
3oev3OEProteasome subunit beta type-53.4.25.10.467
3oev3OEProteasome subunit beta type-63.4.25.10.467
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1zgaHMKIsoflavone 4'-O-methyltransferase/0.466
3u8hBHPPhospholipase A2, membrane associated/0.466
2om9AJAPeroxisome proliferator-activated receptor gamma/0.465
3ddw055Glycogen phosphorylase, liver form2.4.1.10.465
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.465
1cqp803Integrin alpha-L/0.464
4ia7BIVVitamin D3 receptor A/0.464
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
3m9vTYDFAD-dependent oxidoreductase/0.462
4q73FADBifunctional protein PutA/0.462
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.462
3nbvANPKetohexokinase/0.461
2ywwATPAspartate carbamoyltransferase regulatory chain/0.460
3livE16Protease/0.460
3qlrNDPDihydrofolate reductase1.5.1.30.460
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1rkhVD2Vitamin D3 receptor/0.459
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4uyf73BBromodomain-containing protein 2/0.459
5k2bZMAAdenosine receptor A2a/0.459
1fmlRTLRetinol dehydratase/0.458
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3ln052BProstaglandin G/H synthase 21.14.99.10.458
3lnbCOAN-acetyltransferase family protein/0.458
4ocvANPAminoglycoside phosphotransferase/0.458
4q71FADBifunctional protein PutA/0.458
1fmjRTLRetinol dehydratase/0.457
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.457
3tz3B36Acetyl-CoA carboxylase/0.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3dd125DGlycogen phosphorylase, liver form2.4.1.10.456
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.456
4o701QKBromodomain-containing protein 4/0.456
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.456
1ia1NDPDihydrofolate reductase1.5.1.30.455
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.455
2rkvZBATrichothecene 3-O-acetyltransferase/0.455
3r0tFU9Casein kinase II subunit alpha2.7.11.10.455
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1umlFR4Adenosine deaminase3.5.4.40.454
3pe2E1BCasein kinase II subunit alpha2.7.11.10.454
4g1y0VOVitamin D3 receptor A/0.454
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.454
5uviZMAAdenosine receptor A2a/0.454
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
3b9lAZZSerum albumin/0.453
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.453
3gc9B45Mitogen-activated protein kinase 112.7.11.240.453
3sdi3SDProteasome subunit beta type-53.4.25.10.453
3sdi3SDProteasome subunit beta type-63.4.25.10.453
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4ia3BIVVitamin D3 receptor A/0.453
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.453
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
4l8u9AZSerum albumin/0.453
4m10ICDProstaglandin G/H synthase 21.14.99.10.453
4o71CPBBromodomain-containing protein 4/0.453
4ww4ADPRuvB-like helicase/0.453
1cf3FADGlucose oxidase1.1.3.40.452
1m13HYFNuclear receptor subfamily 1 group I member 2/0.452
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1cjkFOKAdenylate cyclase type 2/0.451
1cjkFOKAdenylate cyclase type 5/0.451
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.451
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.451
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.451
4xwtU5PRibonuclease J/0.451
3dds26BGlycogen phosphorylase, liver form2.4.1.10.450
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.450
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.450
5eccNAPDehydrofolate reductase type I/0.450
5jtbZMAAdenosine receptor A2a/0.450
3sn6P0GBeta-2 adrenergic receptor/0.450
1bv7XV6Gag-Pol polyprotein3.4.23.160.449
1lf2R37Plasmepsin-23.4.23.390.449
2xvv9DNSerum albumin/0.449
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4jq8KJ8Epidermal growth factor receptor2.7.10.10.449
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.449
4z24FADPutative GMC-type oxidoreductase R13510.449
1dhrNADDihydropteridine reductase1.5.1.340.448
1qorNDPQuinone oxidoreductase 1/0.448
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2bxmIMNSerum albumin/0.448
2g226IGRenin3.4.23.150.448
2oxtSAMGenome polyprotein/0.448
2zjmF1MBeta-secretase 13.4.23.460.448
3nmpPYVAbscisic acid receptor PYL2/0.448
3p3zP3ZPutative cytochrome P450/0.448
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.448
1qxlFR8Adenosine deaminase3.5.4.40.447
2iyaZIOOleandomycin glycosyltransferase/0.447
2xgoZKDUncharacterized protein/0.447
3pqbVGPPutative oxidoreductase/0.447
3vtcTK3Vitamin D3 receptor/0.447
3w78CBDFMN-dependent NADH-azoreductase/0.447
4eol1ROCyclin-dependent kinase 22.7.11.220.447
4gk2L66Ephrin type-A receptor 32.7.10.10.447
4tuvCPZCytochrome P450 1191.140.447
1oiyN41Cyclin-dependent kinase 22.7.11.220.446
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.446
2j14GNIPeroxisome proliferator-activated receptor delta/0.446
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.446
4ix4ADPUncharacterized protein/0.446
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.446
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
2npaMMBPeroxisome proliferator-activated receptor alpha/0.445
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.445
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.445
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.445
3zkyWT4Isopenicillin N synthase1.21.3.10.445
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ia1BIVVitamin D3 receptor A/0.445
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.445
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.445
3pwhZMAAdenosine receptor A2a/0.445
1cjtFOKAdenylate cyclase type 2/0.444
1cjtFOKAdenylate cyclase type 5/0.444
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1h1s4SPCyclin-dependent kinase 22.7.11.220.444
2q59240Peroxisome proliferator-activated receptor gamma/0.444
2vn0TDZCytochrome P450 2C8/0.444
2xvw9NRSerum albumin/0.444
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.444
3rp8FADFAD-dependent urate hydroxylase/0.444
3s1dZIRCytokinin dehydrogenase 11.5.99.120.444
3slkNDPPolyketide synthase extender module 2/0.444
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.444
4dymIYZActivin receptor type-12.7.11.300.444
4h9814QUncharacterized protein/0.444
4jazSTLPeroxisome proliferator-activated receptor gamma/0.444
1eyqNARChalcone--flavonone isomerase 15.5.1.60.443
1lf3EH5Plasmepsin-23.4.23.390.443
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.443
3nwq2NCGag-Pol polyprotein3.4.23.160.443
3vt8YI3Vitamin D3 receptor/0.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
1ndzFR5Adenosine deaminase3.5.4.40.442
1o5rFR9Adenosine deaminase3.5.4.40.442
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.442
1v0pPVBCell division control protein 2 homolog2.7.11.220.442
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.442
3gobHXXDdmC/0.442
3keuATPPyridoxal kinase2.7.1.350.442
1bygSTUTyrosine-protein kinase CSK/0.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1tvrTB9Gag-Pol polyprotein2.7.7.490.441
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.441
2wotZZGTGF-beta receptor type-12.7.11.300.441
2ydwWSHBromodomain-containing protein 2/0.441
2zbaZBATrichothecene 3-O-acetyltransferase/0.441
3d7kD7KBenzaldehyde lyase/0.441
3h0aD30Peroxisome proliferator-activated receptor gamma/0.441
3m8qDJZGag-Pol polyprotein2.7.7.490.441
3sdkP3NProteasome subunit beta type-53.4.25.10.441
3sdkP3NProteasome subunit beta type-63.4.25.10.441
3w5p4OAVitamin D3 receptor/0.441
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4en4ATPPyridoxal kinase2.7.1.350.441
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.441
4iteTEYVitamin D3 receptor/0.441
5k2dZMAAdenosine receptor A2a/0.441
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1k6pXN3Gag-Pol polyprotein3.4.23.160.440
1mczRMNBenzoylformate decarboxylase4.1.1.70.440
1r2jFADFkbI/0.440
1tehNADAlcohol dehydrogenase class-31.1.1.10.440
1tl7FOKAdenylate cyclase type 2/0.440
1tl7FOKAdenylate cyclase type 5/0.440
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.440
2tpsTPSThiamine-phosphate synthase/0.440
2zb45OPProstaglandin reductase 21.3.1.480.440
3bw4FMNPutative 2-nitropropane dioxygenase/0.440
3i2834NBifunctional epoxide hydrolase 23.3.2.100.440
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.440
4jlk1NODeoxycytidine kinase2.7.1.740.440
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.440