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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4o0uADNAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4o0uADNAurora kinase A2.7.11.11.000
2wqeADPAurora kinase A2.7.11.10.599
4jboWPHAurora kinase A2.7.11.10.590
4jbpYPHAurora kinase A2.7.11.10.581
4c3pACPAurora kinase A2.7.11.10.550
5l8lADPAurora kinase A2.7.11.10.549
4jbqVX6Aurora kinase A2.7.11.10.547
2ijmATPFocal adhesion kinase 12.7.10.20.544
3k5uPFQAurora kinase A2.7.11.10.544
2w1fL0FAurora kinase A2.7.11.10.539
4o0wADNAurora kinase A2.7.11.10.539
5dnrATPAurora kinase A2.7.11.10.539
4deeADPAurora kinase A2.7.11.10.535
2bmcMPYAurora kinase A2.7.11.10.527
1ol5ADPAurora kinase A2.7.11.10.525
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.519
3w16P9JAurora kinase A2.7.11.10.516
4j99ACPFibroblast growth factor receptor 2/0.515
3uo50BXAurora kinase A2.7.11.10.513
3w18N13Aurora kinase A2.7.11.10.509
5dt3ATPAurora kinase A2.7.11.10.509
5dn3ATPAurora kinase A2.7.11.10.508
1pmn984Mitogen-activated protein kinase 102.7.11.240.507
2j0lANPFocal adhesion kinase 12.7.10.20.505
5dr9SKEAurora kinase A2.7.11.10.505
2w1eL0EAurora kinase A2.7.11.10.504
5dosATPAurora kinase A2.7.11.10.503
3efwAK8Aurora kinase A2.7.11.10.502
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.501
2c6eHPMAurora kinase A2.7.11.10.498
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.498
1ol7ADPAurora kinase A2.7.11.10.494
2x6dX6DAurora kinase A2.7.11.10.494
4deaNHIAurora kinase A2.7.11.10.494
4j95ACPFibroblast growth factor receptor 2/0.494
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.492
1bygSTUTyrosine-protein kinase CSK/0.491
2xru400Aurora kinase A2.7.11.10.490
3ttiKBIMitogen-activated protein kinase 102.7.11.240.490
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.489
4qmlANPSerine/threonine-protein kinase 242.7.11.10.489
2qoqANPEphrin type-A receptor 32.7.10.10.488
3t8oATPRhodopsin kinase/0.488
2qo7ANPEphrin type-A receptor 32.7.10.10.487
2w1gL0GAurora kinase A2.7.11.10.487
2j0m4STFocal adhesion kinase 12.7.10.20.486
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.485
5dr2ATPAurora kinase A2.7.11.10.485
5dr6SKEAurora kinase A2.7.11.10.485
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.484
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.483
3ggfGVDSerine/threonine-protein kinase 26/0.483
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.483
5dt4ATPAurora kinase A2.7.11.10.483
1i44ACPInsulin receptor2.7.10.10.482
3cgfJNFMitogen-activated protein kinase 102.7.11.240.482
5drdATPAurora kinase A2.7.11.10.481
4jia1K3Tyrosine-protein kinase JAK2/0.480
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.479
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.479
4k33ACPFibroblast growth factor receptor 32.7.10.10.479
2xngA0HAurora kinase A2.7.11.10.478
3iok1P6Tyrosine-protein kinase JAK2/0.478
4btjADPTau-tubulin kinase 12.7.11.10.478
4lrjANPUncharacterized protein/0.478
3orpAGSSerine/threonine protein kinase/0.477
2v7a627Tyrosine-protein kinase ABL12.7.10.20.476
4b0gVEKAurora kinase A2.7.11.10.476
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
2xrwANPMitogen-activated protein kinase 82.7.11.240.475
3i60E86Mitogen-activated protein kinase 12.7.11.240.475
4utdACPAurora kinase A2.7.11.10.475
2dwbANPAurora kinase A2.7.11.10.474
2ojj82AMitogen-activated protein kinase 12.7.11.240.474
5av2KMPDeath-associated protein kinase 12.7.11.10.474
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.473
2henADPEphrin type-B receptor 22.7.10.10.473
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.473
4btjATPTau-tubulin kinase 12.7.11.10.473
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.472
4l9i8PRRhodopsin kinase/0.472
2xs0ANPMitogen-activated protein kinase 82.7.11.240.471
2xvdAS6Ephrin type-B receptor 42.7.10.10.471
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.471
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.470
2np8CC3Aurora kinase A2.7.11.10.469
4aguD15Cyclin-dependent kinase-like 1/0.469
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.469
2p33J07Mitogen-activated protein kinase 102.7.11.240.468
3eljGS7Mitogen-activated protein kinase 82.7.11.240.468
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3kvxFMYMitogen-activated protein kinase 102.7.11.240.468
3ttjJBIMitogen-activated protein kinase 102.7.11.240.468
4mb2ATPUncharacterized protein/0.468
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.466
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.466
5dpvSKEAurora kinase A2.7.11.10.466
5l8kADPAurora kinase A2.7.11.10.466
2xneASHAurora kinase A2.7.11.10.465
3oriAGSSerine/threonine protein kinase/0.465
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.465
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.464
4qnyANPMitogen activated protein kinase, putative/0.464
4ux9ANPMitogen-activated protein kinase 82.7.11.240.464
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.464
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.464
3my5RFZCyclin-dependent kinase 22.7.11.220.463
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.463
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.463
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.462
4c3rACPAurora kinase A2.7.11.10.462
4zohFADPutative oxidoreductase FAD-binding subunit/0.462
5awmANPStress-activated protein kinase JNK2.7.11.240.462
2vu3LZECyclin-dependent kinase 22.7.11.220.461
3bu5ATPInsulin receptor2.7.10.10.461
3d7tSTUTyrosine-protein kinase CSK/0.461
4c57FEFCyclin-G-associated kinase2.7.11.10.461
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.461
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.460
4anqVGHALK tyrosine kinase receptor2.7.10.10.460
3ztxZTXAurora kinase B-A2.7.11.10.459
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
5dt0SKEAurora kinase A2.7.11.10.459
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ansVGHALK tyrosine kinase receptor2.7.10.10.458
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.457
3vs1VSATyrosine-protein kinase HCK2.7.10.20.457
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.457
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.457
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.456
4gmy0X5Tyrosine-protein kinase JAK2/0.456
4xlvACPInsulin receptor2.7.10.10.456
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.455
3a7hATPSerine/threonine-protein kinase 242.7.11.10.455
3t3c017Gag-Pol polyprotein3.4.23.160.455
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.455
4hvi19STyrosine-protein kinase JAK32.7.10.20.455
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.455
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.455
4y95746Tyrosine-protein kinase/0.455
5av3KMPDeath-associated protein kinase 12.7.11.10.455
5e8ySTUTGF-beta receptor type-22.7.11.300.455
1mqbANPEphrin type-A receptor 22.7.10.10.454
1ol6ATPAurora kinase A2.7.11.10.454
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
3c4xATPRhodopsin kinase/0.454
3poz03PEpidermal growth factor receptor2.7.10.10.454
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.454
4aotGW8Serine/threonine-protein kinase 102.7.11.10.454
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.454
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.453
2ijmADPFocal adhesion kinase 12.7.10.20.453
3keuATPPyridoxal kinase2.7.1.350.453
3ziaATPATP synthase subunit alpha, mitochondrial/0.453
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.453
4ysjADPCalmodulin-like domain protein kinase/0.453
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
2bfyH1NAurora kinase B-A2.7.11.10.451
2j4z626Aurora kinase A2.7.11.10.451
2o0uC0MMitogen-activated protein kinase 102.7.11.240.451
3qyw6PBMitogen-activated protein kinase 12.7.11.240.451
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.450
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.450
2vwu7X1Ephrin type-B receptor 42.7.10.10.450
3c4wATPRhodopsin kinase/0.450
3fhyATPPyridoxal kinase2.7.1.350.450
3gu7ADPDeath-associated protein kinase 12.7.11.10.450
4bbe3O4Tyrosine-protein kinase JAK2/0.450
4h3qANPMitogen-activated protein kinase 12.7.11.240.450
5l8jADPAurora kinase A2.7.11.10.450
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.449
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.449
4c4f7CEDual specificity protein kinase TTK2.7.12.10.449
4cegADPAurora kinase A2.7.11.10.449
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.449
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3cgoJNOMitogen-activated protein kinase 102.7.11.240.448
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.448
2hog710Serine/threonine-protein kinase Chk12.7.11.10.447
4c58824Cyclin-G-associated kinase2.7.11.10.447
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447
4i4e1BQFocal adhesion kinase 12.7.10.20.447
2excJNKMitogen-activated protein kinase 102.7.11.240.446
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.446
2vv9IM9Cyclin-dependent kinase 22.7.11.220.446
2w4jADPDeath-associated protein kinase 12.7.11.10.446
3c4zADPRhodopsin kinase/0.446
3mtfA3FActivin receptor type-12.7.11.300.446
4b8lA0PAurora kinase B-A2.7.11.10.446
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.446
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.446
4y93746Tyrosine-protein kinase/0.446
1h0w207Cyclin-dependent kinase 22.7.11.220.445
3pxkPXKFocal adhesion kinase 12.7.10.20.445
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.445
1mq4ADPAurora kinase A2.7.11.10.444
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.444
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.443
3nieANPMitogen-activated protein kinase/0.443
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.443
4c4g7RODual specificity protein kinase TTK2.7.12.10.443
4en4ATPPyridoxal kinase2.7.1.350.443
5cnnANPEpidermal growth factor receptor2.7.10.10.443
1u54ACPActivated CDC42 kinase 1/0.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3nbvANPKetohexokinase/0.442
3r9nZ68Cyclin-dependent kinase 22.7.11.220.442
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.442
4cd0AWJALK tyrosine kinase receptor2.7.10.10.442
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
2yfxVGHALK tyrosine kinase receptor2.7.10.10.441
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.441
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.441
3oroAGSSerine/threonine protein kinase/0.441
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.441
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.441
2qo9ANPEphrin type-A receptor 32.7.10.10.440
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.440
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440