sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.920 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.675 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.620 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.601 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.601 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.601 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.599 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.598 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.590 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.578 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.576 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.568 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.567 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.566 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.564 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.561 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.550 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.545 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.544 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.543 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.540 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.536 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.524 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.520 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.517 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.512 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.509 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.508 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.501 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.499 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.499 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.495 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.487 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.486 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.484 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.484 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.483 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.483 | |
| 3zuy | TCH | Transporter | / | 0.480 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.478 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.478 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.476 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.475 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.473 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.472 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.469 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.468 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.467 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.467 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.465 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.464 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.464 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.463 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.463 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.463 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.461 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.460 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.460 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.459 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.459 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.457 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.457 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.457 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.457 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.456 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.456 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.456 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.455 | |
| 3gob | HXX | DdmC | / | 0.455 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.455 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.454 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.453 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.453 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.453 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.452 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.452 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.452 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.451 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.451 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.451 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.450 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.449 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.449 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.449 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.448 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.448 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.448 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.448 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.448 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.448 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.447 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.447 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.447 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.447 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 1fml | RTL | Retinol dehydratase | / | 0.445 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.445 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.445 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.444 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.444 | |
| 4h6p | FMN | Chromate reductase | / | 0.444 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.443 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.443 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.443 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.443 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.442 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 5a3b | APR | SIR2 family protein | / | 0.442 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.442 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.441 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.441 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.441 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.440 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.440 | |
| 2y3r | TRK | TamL | / | 0.440 | |
| 2y3s | TIR | TamL | / | 0.440 | |
| 2y4g | TIR | TamL | / | 0.440 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.440 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.440 | |
| 4xr9 | NAD | CalS8 | / | 0.440 |