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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l4aCAMCamphor 5-monooxygenase1.14.15.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4l4aCAMCamphor 5-monooxygenase1.14.15.11.000
4l4bCAMCamphor 5-monooxygenase1.14.15.10.867
1iwiCAMCamphor 5-monooxygenase1.14.15.10.796
3cppCAMCamphor 5-monooxygenase1.14.15.10.754
1gebCAMCamphor 5-monooxygenase1.14.15.10.741
1iwjCAMCamphor 5-monooxygenase1.14.15.10.737
2cppCAMCamphor 5-monooxygenase1.14.15.10.723
1t88CAMCamphor 5-monooxygenase1.14.15.10.713
1phgMYTCamphor 5-monooxygenase1.14.15.10.712
4cp4CAMCamphor 5-monooxygenase1.14.15.10.710
1nooCAHCamphor 5-monooxygenase1.14.15.10.701
5cp4CAMCamphor 5-monooxygenase1.14.15.10.696
4ek1CAMCamphor 5-monooxygenase1.14.15.10.695
4l49CAMCamphor 5-monooxygenase1.14.15.10.692
1yrdCAMCamphor 5-monooxygenase1.14.15.10.679
3fwiCAMCamphor 5-monooxygenase1.14.15.10.677
1dz4CAMCamphor 5-monooxygenase1.14.15.10.674
1phePIYCamphor 5-monooxygenase1.14.15.10.671
2zawCAMCamphor 5-monooxygenase1.14.15.10.671
2zaxCAMCamphor 5-monooxygenase1.14.15.10.671
3wrhCAMCamphor 5-monooxygenase1.14.15.10.671
4l4dCAMCamphor 5-monooxygenase1.14.15.10.669
1dz6CAMCamphor 5-monooxygenase1.14.15.10.668
1yrcCAMCamphor 5-monooxygenase1.14.15.10.666
3fwjCAMCamphor 5-monooxygenase1.14.15.10.666
3fwgCAMCamphor 5-monooxygenase1.14.15.10.663
3fwfCAMCamphor 5-monooxygenase1.14.15.10.662
2z97CAMCamphor 5-monooxygenase1.14.15.10.661
4l4cCAMCamphor 5-monooxygenase1.14.15.10.658
1t86CAMCamphor 5-monooxygenase1.14.15.10.657
1t87CAMCamphor 5-monooxygenase1.14.15.10.656
3l63CAMCamphor 5-monooxygenase1.14.15.10.655
1uyuCAMCamphor 5-monooxygenase1.14.15.10.650
3wrlCAMCamphor 5-monooxygenase1.14.15.10.650
4g3rCAMCamphor 5-monooxygenase1.14.15.10.646
2a1mCAMCamphor 5-monooxygenase1.14.15.10.643
2a1nCAMCamphor 5-monooxygenase1.14.15.10.643
1t85CAMCamphor 5-monooxygenase1.14.15.10.642
3wrjCAMCamphor 5-monooxygenase1.14.15.10.641
6cp4CAMCamphor 5-monooxygenase1.14.15.10.641
2qblCAMCamphor 5-monooxygenase1.14.15.10.639
1dz8CAMCamphor 5-monooxygenase1.14.15.10.638
2feuCAMCamphor 5-monooxygenase1.14.15.10.638
2m56CAMCamphor 5-monooxygenase1.14.15.10.638
4kkyCAMCamphor 5-monooxygenase1.14.15.10.638
4c9pCAMCytochrome P450/0.632
1o76CAMCamphor 5-monooxygenase1.14.15.10.631
2qboCAMCamphor 5-monooxygenase1.14.15.10.629
3wrmCAMCamphor 5-monooxygenase1.14.15.10.627
2a1oCAMCamphor 5-monooxygenase1.14.15.10.624
4l4fCAMCamphor 5-monooxygenase1.14.15.10.622
2zuiCAMCamphor 5-monooxygenase1.14.15.10.620
4jx1CAMCamphor 5-monooxygenase1.14.15.10.620
4l4eCAMCamphor 5-monooxygenase1.14.15.10.619
2qbnCAMCamphor 5-monooxygenase1.14.15.10.616
2qbmCAMCamphor 5-monooxygenase1.14.15.10.613
3lxiCAMCytochrome P450/0.603
3ol5SAWCamphor 5-monooxygenase1.14.15.10.593
4jx1CAHCamphor 5-monooxygenase1.14.15.10.569
1rf9DBRCamphor 5-monooxygenase1.14.15.10.566
4c9oCAMCytochrome P450/0.562
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.530
5hs1VORLanosterol 14-alpha demethylase/0.520
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.512
1jipKTN6-deoxyerythronolide B hydroxylase/0.510
4j6cSTRCytochrome P450 monooxygenase/0.508
4tuvCPZCytochrome P450 1191.140.504
3zk5Z18Cytochrome P450 monooxygenase PikC/0.503
4enhFVXCholesterol 24-hydroxylase/0.503
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.503
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.502
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.498
1jioDEB6-deoxyerythronolide B hydroxylase/0.497
4j6bPLOCytochrome P450 monooxygenase/0.497
4ejh0QACytochrome P450 2A131.14.14.10.496
3tk3CPZCytochrome P450 2B41.14.14.10.492
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.488
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.488
1eupASD6-deoxyerythronolide B hydroxylase/0.485
3mdvCL6Cholesterol 24-hydroxylase/0.485
3mdmFJZCholesterol 24-hydroxylase/0.484
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.484
4uymVOR14-alpha sterol demethylase Cyp51B/0.483
3a1l2CCCytochrome P450/0.479
3nr4PYVAbscisic acid receptor PYL2/0.479
2ca0PXICytochrome P450 monooxygenase PikC/0.477
3s79ASDAromatase1.14.14.140.477
1k6cMK1Gag-Pol polyprotein3.4.23.160.476
3t3r9PLCytochrome P450 2A61.14.130.476
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.475
5c7oNADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific1.2.1.120.475
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.474
2vn0TDZCytochrome P450 2C8/0.473
4i8vBHFCytochrome P450 1A11.14.14.10.473
4egnTWOCytochrome P450/0.472
4j6dTESCytochrome P450 monooxygenase/0.471
4r20AERCytochrome P450 family 17 polypeptide 2/0.471
1suoCPZCytochrome P450 2B41.14.14.10.469
3qm4PN0Cytochrome P450 2D6/0.469
1uy7PU4Heat shock protein HSP 90-alpha/0.468
2cig1DGDihydrofolate reductase1.5.1.30.467
2z3uCRRCytochrome P450/0.467
3t3q9PLCytochrome P450 2A61.14.130.467
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.467
4jbtASDCytochrome P450 monooxygenase/0.467
3p99LNPLanosterol 14-alpha-demethylase/0.466
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.464
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.464
3tdaPN0Cytochrome P450 2D6/0.464
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
3nmpPYVAbscisic acid receptor PYL2/0.462
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.462
2rhrEMOPutative ketoacyl reductase1.3.10.461
4ejgNCTCytochrome P450 2A131.14.14.10.461
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.459
1k6tXN1Gag-Pol polyprotein3.4.23.160.458
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
3ns2PYVAbscisic acid receptor PYL2/0.458
1pkfEPDEpothilone C/D epoxidase1.140.457
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.457
3tjsD0RCytochrome P450 3A4/0.457
3pm0BHFCytochrome P450 1B1/0.456
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.456
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.456
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.456
1m9m6NINitric oxide synthase, endothelial1.14.13.390.455
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.455
4nm9FADBifunctional protein PutA/0.455
4g3jVNTLanosterol 14-alpha-demethylase/0.454
4ly91YYGlucokinase regulatory protein/0.454
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.453
3drcMTXDihydrofolate reductase1.5.1.30.453
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.453
3wecAUICytochrome P450/0.453
3sn6P0GBeta-2 adrenergic receptor/0.453
1xddAAYIntegrin alpha-L/0.452
3eej53RUncharacterized protein/0.452
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.451
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
4ia7BIVVitamin D3 receptor A/0.451
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.450
1k6pXN3Gag-Pol polyprotein3.4.23.160.450
1pl8NADSorbitol dehydrogenase1.1.1.140.450
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.450
3d0bSNXHeat shock protein HSP 90-alpha/0.450
3pb3SAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.450
1e7qNAPGDP-L-fucose synthase/0.449
1m9rINENitric oxide synthase, endothelial1.14.13.390.449
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.449
2cx8SAHRibosomal RNA small subunit methyltransferase E/0.449
4ipw1G7Mycocyclosin synthase1.14.21.90.449
2zbaZBATrichothecene 3-O-acetyltransferase/0.448
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3nj0PYVAbscisic acid receptor PYL2/0.448
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
3w0jT08Vitamin D3 receptor/0.448
5ca0ACPTubulin tyrosine ligase/0.448
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.447
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.447
2ph5NADHomospermidine synthase/0.447
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.447
2y37A54Nitric oxide synthase, inducible1.14.13.390.447
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.447
3cv9VDXVitamin D3 dihydroxylase/0.447
4a9mP9MBromodomain-containing protein 2/0.447
4ia3BIVVitamin D3 receptor A/0.447
1tj0FADBifunctional protein PutA1.5.5.20.446
2ft9CHDFatty acid-binding protein 2, liver/0.446
2y3sTIRTamL/0.446
3gw9VNILanosterol 14-alpha-demethylase/0.446
3oafOAGDihydrofolate reductase1.5.1.30.446
4bquCLRJapanin/0.446
4e5yNDPGDP-L-fucose synthase1.1.1.2710.446
5a3cNADSIR2 family protein/0.446
1d2sDHTSex hormone-binding globulin/0.445
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1ouk084Mitogen-activated protein kinase 14/0.445
1uy9PU6Heat shock protein HSP 90-alpha/0.445
2ghlLIBMitogen-activated protein kinase 14/0.445
2hasC3OVitamin D3 receptor/0.445
2hcdBIVVitamin D3 receptor A/0.445
2itqITQEpidermal growth factor receptor2.7.10.10.445
2nnhREACytochrome P450 2C8/0.445
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.445
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
3ibdCPZCytochrome P450 2B61.14.130.445
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4la7A1OAbscisic acid receptor PYL2/0.445
1rb2FOLDihydrofolate reductase1.5.1.30.444
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
3abaFLICytochrome P450/0.444
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.444
4g7gVFVLanosterol 14-alpha-demethylase/0.444
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.444
4rcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.443
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.443
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4h9506UDihydrofolate reductase1.5.1.30.443
4jubTPPBenzoylformate decarboxylase4.1.1.70.443
4k9v6AWCytochrome P450 3A4/0.443
1k6vXN2Gag-Pol polyprotein3.4.23.160.442
1mvsDTMDihydrofolate reductase1.5.1.30.442
1uyePU9Heat shock protein HSP 90-alpha/0.442
2vww7X2Ephrin type-B receptor 42.7.10.10.442
2y3rTIRTamL/0.442
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.442
3gc9B45Mitogen-activated protein kinase 112.7.11.240.442
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.442
3vrwYS5Vitamin D3 receptor/0.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4h6rFDAProline dehydrogenase/0.442
4ia1BIVVitamin D3 receptor A/0.442
4jlj1NMDeoxycytidine kinase2.7.1.740.442
4nmbFADBifunctional protein PutA/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
5bmvVLBTubulin alpha-1B chain/0.442
5bmvVLBTubulin beta chain/0.442
1ci7UMPThymidylate synthase2.1.1.450.441
1dyhDZFDihydrofolate reductase1.5.1.30.441
2fznFADBifunctional protein PutA1.5.5.20.441
2hb7O1CVitamin D3 receptor/0.441
2rkvZBATrichothecene 3-O-acetyltransferase/0.441
3flwFLWMitogen-activated protein kinase 14/0.441
3inxJZCHeat shock protein HSP 90-alpha/0.441
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.441
4g1z0VPVitamin D3 receptor A/0.441
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.441
1x8lOXRRetinol dehydratase/0.440
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.440
2yboSAHMethyltransferase/0.440
3ad9NADSubunit alpha of sarocosine oxidase/0.440
3nxuRITCytochrome P450 3A4/0.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440
4hnc0UTMandelate racemase/0.440
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.440
4z34ON7Lysophosphatidic acid receptor 1/0.440
3pwhZMAAdenosine receptor A2a/0.440