Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fx360KCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fx360KCyclin-dependent kinase 22.7.11.221.000
1fvv107Cyclin-dependent kinase 22.7.11.220.580
3qxpX64Cyclin-dependent kinase 22.7.11.220.560
3ral04ZCyclin-dependent kinase 22.7.11.220.552
3rak03ZCyclin-dependent kinase 22.7.11.220.551
1gih1PUCyclin-dependent kinase 22.7.11.220.543
2w05FRTCyclin-dependent kinase 22.7.11.220.543
3rmf20ZCyclin-dependent kinase 22.7.11.220.541
4fkw62KCyclin-dependent kinase 22.7.11.220.538
2wxvWXVCyclin-dependent kinase 22.7.11.220.536
3r9dX6BCyclin-dependent kinase 22.7.11.220.535
1pkdUCNCyclin-dependent kinase 22.7.11.220.534
4bgh3I6Cyclin-dependent kinase 22.7.11.220.534
3s1h56ZCyclin-dependent kinase 22.7.11.220.532
3qu0X40Cyclin-dependent kinase 22.7.11.220.525
3sqq99ZCyclin-dependent kinase 22.7.11.220.524
3rk507ZCyclin-dependent kinase 22.7.11.220.523
2w17I19Cyclin-dependent kinase 22.7.11.220.521
1oguST8Cyclin-dependent kinase 22.7.11.220.520
1p2a5BNCyclin-dependent kinase 22.7.11.220.520
3qqkX02Cyclin-dependent kinase 22.7.11.220.520
3rpv26ZCyclin-dependent kinase 22.7.11.220.519
3s2pPMUCyclin-dependent kinase 22.7.11.220.518
2vv9IM9Cyclin-dependent kinase 22.7.11.220.517
4fkr45KCyclin-dependent kinase 22.7.11.220.516
4fkv61KCyclin-dependent kinase 22.7.11.220.516
3rjc06ZCyclin-dependent kinase 22.7.11.220.514
2uzbC75Cyclin-dependent kinase 22.7.11.220.513
3qtzX42Cyclin-dependent kinase 22.7.11.220.513
3r9hZ67Cyclin-dependent kinase 22.7.11.220.513
3rk708ZCyclin-dependent kinase 22.7.11.220.512
4fkt48KCyclin-dependent kinase 22.7.11.220.512
1urwI1PCyclin-dependent kinase 22.7.11.220.511
2wihP48Cyclin-dependent kinase 22.7.11.220.511
2j9mPY8Cyclin-dependent kinase 22.7.11.220.510
3qtxX43Cyclin-dependent kinase 22.7.11.220.510
3rkb12ZCyclin-dependent kinase 22.7.11.220.510
3rni21ZCyclin-dependent kinase 22.7.11.220.510
1oitHDTCyclin-dependent kinase 22.7.11.220.508
1w0xOLOCyclin-dependent kinase 22.7.11.220.508
2i40BLZCyclin-dependent kinase 22.7.11.220.508
2wpa889Cyclin-dependent kinase 22.7.11.220.508
1v1k3FPCyclin-dependent kinase 22.7.11.220.507
2iw84SPCyclin-dependent kinase 22.7.11.220.507
1ke6LS2Cyclin-dependent kinase 22.7.11.220.506
1e9hINRCyclin-dependent kinase 22.7.11.220.505
2btrU73Cyclin-dependent kinase 22.7.11.220.505
2xmyCDKCyclin-dependent kinase 22.7.11.220.505
4bcnT9NCyclin-dependent kinase 22.7.11.220.504
1ke5LS1Cyclin-dependent kinase 22.7.11.220.503
2c6iDT1Cyclin-dependent kinase 22.7.11.220.502
3unk0BYCyclin-dependent kinase 22.7.11.220.502
1vyw292Cyclin-dependent kinase 22.7.11.220.500
1oiyN41Cyclin-dependent kinase 22.7.11.220.499
1pyePM1Cyclin-dependent kinase 22.7.11.220.499
2b52D42Cyclin-dependent kinase 22.7.11.220.499
1ke9LS5Cyclin-dependent kinase 22.7.11.220.498
2uzdC85Cyclin-dependent kinase 22.7.11.220.498
3qxoX65Cyclin-dependent kinase 22.7.11.220.498
3qzgX67Cyclin-dependent kinase 22.7.11.220.498
4erwSTUCyclin-dependent kinase 22.7.11.220.498
1h1r6CPCyclin-dependent kinase 22.7.11.220.497
3uli1N3Cyclin-dependent kinase 22.7.11.220.497
2iw94SPCyclin-dependent kinase 22.7.11.220.496
1g5sI17Cyclin-dependent kinase 22.7.11.220.495
1pxmCK5Cyclin-dependent kinase 22.7.11.220.495
3qtuX44Cyclin-dependent kinase 22.7.11.220.495
2btsU32Cyclin-dependent kinase 22.7.11.220.494
4acm7YGCyclin-dependent kinase 22.7.11.220.494
4eok4SPCyclin-dependent kinase 22.7.11.220.494
3rk909ZCyclin-dependent kinase 22.7.11.220.493
1ke7LS3Cyclin-dependent kinase 22.7.11.220.492
2c5nCK8Cyclin-dependent kinase 22.7.11.220.492
2fvdLIACyclin-dependent kinase 22.7.11.220.492
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.492
3ddqRRCCyclin-dependent kinase 22.7.11.220.492
2c6o4SPCyclin-dependent kinase 22.7.11.220.490
2r3kSCQCyclin-dependent kinase 22.7.11.220.490
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.490
2vu3LZECyclin-dependent kinase 22.7.11.220.490
3my5RFZCyclin-dependent kinase 22.7.11.220.490
3qtrX36Cyclin-dependent kinase 22.7.11.220.490
1oi9N20Cyclin-dependent kinase 22.7.11.220.489
2w06FRVCyclin-dependent kinase 22.7.11.220.489
1fvt106Cyclin-dependent kinase 22.7.11.220.488
2bheBRYCyclin-dependent kinase 22.7.11.220.488
2eufLQQCyclin-dependent kinase 62.7.11.220.488
3ezvEZVCyclin-dependent kinase 22.7.11.220.488
2r3lSCWCyclin-dependent kinase 22.7.11.220.487
2r3p3SCCyclin-dependent kinase 22.7.11.220.487
3r73X87Cyclin-dependent kinase 22.7.11.220.487
1aq1STUCyclin-dependent kinase 22.7.11.220.486
1di8DTQCyclin-dependent kinase 22.7.11.220.486
1h1s4SPCyclin-dependent kinase 22.7.11.220.486
4ek816KCyclin-dependent kinase 22.7.11.220.486
1y91CT9Cyclin-dependent kinase 22.7.11.220.485
4fkpLS5Cyclin-dependent kinase 22.7.11.220.485
3qqfX07Cyclin-dependent kinase 22.7.11.220.484
3sw418KCyclin-dependent kinase 22.7.11.220.482
4qmpDKISerine/threonine-protein kinase 242.7.11.10.482
2a0cCK9Cyclin-dependent kinase 22.7.11.220.481
2r3r6SCCyclin-dependent kinase 22.7.11.220.481
3ig7EFPCyclin-dependent kinase 22.7.11.220.481
3tnwF18Cyclin-dependent kinase 22.7.11.220.481
1ke8LS4Cyclin-dependent kinase 22.7.11.220.480
3roy22ZCyclin-dependent kinase 22.7.11.220.480
2w1hL0FCyclin-dependent kinase 22.7.11.220.479
3lfnA27Cyclin-dependent kinase 22.7.11.220.479
1ckpPVBCyclin-dependent kinase 22.7.11.220.478
3lfsA07Cyclin-dependent kinase 22.7.11.220.478
3rm719ZCyclin-dependent kinase 22.7.11.220.478
3rpy27ZCyclin-dependent kinase 22.7.11.220.478
4bcmT7ZCyclin-dependent kinase 22.7.11.220.478
2x1nX1NCyclin-dependent kinase 22.7.11.220.477
4ek610KCyclin-dependent kinase 22.7.11.220.477
1vyzN5BCyclin-dependent kinase 22.7.11.220.476
3dogNNNCyclin-dependent kinase 22.7.11.220.476
3sw719KCyclin-dependent kinase 22.7.11.220.476
3ti1B49Cyclin-dependent kinase 22.7.11.220.476
4fkg4CKCyclin-dependent kinase 22.7.11.220.476
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.476
1dm2HMDCyclin-dependent kinase 22.7.11.220.475
2vtsLZCCyclin-dependent kinase 22.7.11.220.475
2cchATPCyclin-dependent kinase 22.7.11.220.474
3ddpRC8Cyclin-dependent kinase 22.7.11.220.474
3qtqX35Cyclin-dependent kinase 22.7.11.220.474
3r8zZ63Cyclin-dependent kinase 22.7.11.220.474
4bcpT3CCyclin-dependent kinase 22.7.11.220.474
4fko20KCyclin-dependent kinase 22.7.11.220.474
2b55D31Cyclin-dependent kinase 22.7.11.220.473
3lfqA28Cyclin-dependent kinase 22.7.11.220.473
3qtwX3ACyclin-dependent kinase 22.7.11.220.473
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.473
3r71X86Cyclin-dependent kinase 22.7.11.220.472
3r9oZ71Cyclin-dependent kinase 22.7.11.220.472
1oiqHDUCyclin-dependent kinase 22.7.11.220.471
3qwjX6ACyclin-dependent kinase 22.7.11.220.471
2c6tDT5Cyclin-dependent kinase 22.7.11.220.470
3r7iX9ICyclin-dependent kinase 22.7.11.220.470
1pxkCK3Cyclin-dependent kinase 22.7.11.220.469
2bhhRYUCyclin-dependent kinase 22.7.11.220.469
2uzlC94Cyclin-dependent kinase 22.7.11.220.469
3qzfX66Cyclin-dependent kinase 22.7.11.220.469
2vttLZDCyclin-dependent kinase 22.7.11.220.468
4ez50RSCyclin-dependent kinase 62.7.11.220.468
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.467
4bbfO19Tyrosine-protein kinase JAK2/0.467
4fks46KCyclin-dependent kinase 22.7.11.220.467
2bkzSBCCyclin-dependent kinase 22.7.11.220.466
2uzeC95Cyclin-dependent kinase 22.7.11.220.466
4lyn1YGCyclin-dependent kinase 22.7.11.220.466
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.466
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.465
3r7uX96Cyclin-dependent kinase 22.7.11.220.465
3r7yZ04Cyclin-dependent kinase 22.7.11.220.465
3raiX85Cyclin-dependent kinase 22.7.11.220.465
1pxpCK8Cyclin-dependent kinase 22.7.11.220.464
2c69CT8Cyclin-dependent kinase 22.7.11.220.464
2uznC96Cyclin-dependent kinase 22.7.11.220.464
2xnbY8LCyclin-dependent kinase 22.7.11.220.464
1v0oINRCell division control protein 2 homolog2.7.11.220.463
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
2r64740Cyclin-dependent kinase 22.7.11.220.463
3qzhX69Cyclin-dependent kinase 22.7.11.220.463
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.463
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.463
4qmySTUSerine/threonine-protein kinase 242.7.11.10.463
2r3iSCFCyclin-dependent kinase 22.7.11.220.462
2r3o2SCCyclin-dependent kinase 22.7.11.220.462
3py0SU9Cyclin-dependent kinase 22.7.11.220.462
2r3jSCJCyclin-dependent kinase 22.7.11.220.461
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.461
4eor4SPCyclin-dependent kinase 22.7.11.220.461
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.461
3ezrEZRCyclin-dependent kinase 22.7.11.220.460
2duv371Cyclin-dependent kinase 22.7.11.220.459
2uzoC62Cyclin-dependent kinase 22.7.11.220.459
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.459
3nux3NVCyclin-dependent kinase 62.7.11.220.459
2r3mSCXCyclin-dependent kinase 22.7.11.220.458
3qwkX62Cyclin-dependent kinase 22.7.11.220.458
3zep1NXTyrosine-protein kinase JAK32.7.10.20.458
1ykr628Cyclin-dependent kinase 22.7.11.220.457
2wipP49Cyclin-dependent kinase 22.7.11.220.456
3s0o50ZCyclin-dependent kinase 22.7.11.220.456
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.456
4fkq42KCyclin-dependent kinase 22.7.11.220.456
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.455
4ez30S0Cyclin-dependent kinase 22.7.11.220.455
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.455
1unlRRCCyclin-dependent-like kinase 52.7.11.10.454
3r7vZ02Cyclin-dependent kinase 22.7.11.220.454
3wblPDYCyclin-dependent kinase 22.7.11.220.454
3iggEFQCyclin-dependent kinase 22.7.11.220.453
3pj8404Cyclin-dependent kinase 22.7.11.220.453
3r8lZ30Cyclin-dependent kinase 22.7.11.220.453
4eomATPCyclin-dependent kinase 22.7.11.220.453
4hvh19RTyrosine-protein kinase JAK32.7.10.20.453
3r1yX76Cyclin-dependent kinase 22.7.11.220.452
3rpo24ZCyclin-dependent kinase 22.7.11.220.452
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.452
2c4g514Cyclin-dependent kinase 22.7.11.220.451
4eol1ROCyclin-dependent kinase 22.7.11.220.451
4fki09KCyclin-dependent kinase 22.7.11.220.451
1finATPCyclin-dependent kinase 22.7.11.220.450
3ql8X01Cyclin-dependent kinase 22.7.11.220.450
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.450
4eop1ROCyclin-dependent kinase 22.7.11.220.450
1gii1PUCyclin-dependent kinase 22.7.11.220.449
1h1pCMGCyclin-dependent kinase 22.7.11.220.449
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.449
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.448
3r6xX84Cyclin-dependent kinase 22.7.11.220.448
4bcqTJFCyclin-dependent kinase 22.7.11.220.448
4kd11QKCyclin-dependent kinase 22.7.11.220.448
1pxlCK4Cyclin-dependent kinase 22.7.11.220.447
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.446
1oirHDYCyclin-dependent kinase 22.7.11.220.445
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
3unj0BXCyclin-dependent kinase 22.7.11.220.445
4eon1ROCyclin-dependent kinase 22.7.11.220.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
4gub0Y4Casein kinase II subunit alpha2.7.11.10.445
1oiuN76Cyclin-dependent kinase 22.7.11.220.444
3qruX19Cyclin-dependent kinase 22.7.11.220.444
3rzb02ZCyclin-dependent kinase 22.7.11.220.444
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.444
1gij2PUCyclin-dependent kinase 22.7.11.220.443
2pvnP63Casein kinase II subunit alpha2.7.11.10.443
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.443
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.443
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.442
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.442
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.442
3le62BZCyclin-dependent kinase 22.7.11.220.441
3rm618ZCyclin-dependent kinase 22.7.11.220.441
4eoi1ROCyclin-dependent kinase 22.7.11.220.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.440
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4fv9E71Mitogen-activated protein kinase 12.7.11.240.440
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.440