Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 1.000 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.542 | |
| 2c6e | HPM | Aurora kinase A | 2.7.11.1 | 0.537 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.527 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.525 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.523 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.522 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.514 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.513 | |
| 2vrx | 447 | Aurora kinase B-A | 2.7.11.1 | 0.512 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.512 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.510 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.509 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.509 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.509 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.508 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.508 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.507 | |
| 3vs0 | VS0 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.505 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.504 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.503 | |
| 3w2o | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.502 | |
| 3w2s | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.502 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.499 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.499 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.498 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.497 | |
| 4hjf | C2E | GGDEF family protein | / | 0.497 | |
| 2ycr | HCW | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.496 | |
| 4jbo | WPH | Aurora kinase A | 2.7.11.1 | 0.495 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.495 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.494 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.493 | |
| 2ba9 | FAD | Putative aminooxidase | / | 0.492 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.492 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.490 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.489 | |
| 4s33 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.488 | |
| 5ap5 | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.488 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.487 | |
| 3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.486 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.486 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.485 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.485 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.484 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.483 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.482 | |
| 3p23 | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.481 | |
| 4crs | AGS | Serine/threonine-protein kinase N2 | 2.7.11.13 | 0.481 | |
| 4lgh | 0JN | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.481 | |
| 4mxy | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.481 | |
| 4mxz | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.481 | |
| 2zyb | KSL | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.480 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.480 | |
| 4c4g | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.480 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.479 | |
| 4an3 | 5Y0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.479 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.478 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.478 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.478 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.478 | |
| 4qms | 1N1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.478 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.477 | |
| 2xcl | ANP | Phosphoribosylamine--glycine ligase | / | 0.477 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.477 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.476 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 3orn | 3OR | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.475 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.475 | |
| 4iak | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.475 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.474 | |
| 3q4z | ANP | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.474 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.474 | |
| 4pd6 | URI | Nucleoside permease | / | 0.474 | |
| 4s34 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.474 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.473 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.473 | |
| 2w7x | D1A | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.473 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.473 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.472 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 3w2r | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.472 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 3gu7 | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.471 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.471 | |
| 2fgi | PD1 | Fibroblast growth factor receptor 1 | / | 0.470 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.470 | |
| 2z7q | ACP | Ribosomal protein S6 kinase alpha-1 | 2.7.11.1 | 0.470 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.470 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.469 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.469 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.468 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.468 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.468 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.468 | |
| 2w4j | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.467 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.467 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.467 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.467 | |
| 1jkk | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.466 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.466 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.466 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.466 | |
| 2r5t | ANP | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.466 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.466 | |
| 3zcw | 4A2 | Kinesin-like protein KIF11 | / | 0.466 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.465 | |
| 2cbs | R13 | Cellular retinoic acid-binding protein 2 | / | 0.465 | |
| 3erk | SB4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.465 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.465 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.465 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.464 | |
| 1osv | CHC | Bile acid receptor | / | 0.464 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 4eoo | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 4fv2 | EK5 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.464 | |
| 1yin | CM3 | Estrogen receptor | / | 0.463 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.463 | |
| 3ml9 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.462 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.462 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.462 | |
| 4at8 | ATP | Interleukin enhancer-binding factor 2 | / | 0.462 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.462 | |
| 2cci | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 2gej | GDD | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.461 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.461 | |
| 3pju | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.461 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.461 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.461 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.460 | |
| 1s9j | BBM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.460 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.460 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.460 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 5c1o | ANP | D-alanine--D-alanine ligase | / | 0.460 | |
| 1uom | PTI | Estrogen receptor | / | 0.459 | |
| 2cjm | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.459 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.459 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.459 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.459 | |
| 4wbb | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 2b9x | FAD | Putative aminooxidase | / | 0.458 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.458 | |
| 4gyi | ADP | Uncharacterized protein | / | 0.458 | |
| 5eg3 | ACP | Fibroblast growth factor receptor 2 | / | 0.458 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.457 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.457 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.457 | |
| 3dk4 | NDP | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.457 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 3vth | APC | Carbamoyltransferase | / | 0.457 | |
| 4joa | 3DK | ALK tyrosine kinase receptor | 2.7.10.1 | 0.457 | |
| 4pl4 | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.457 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.456 | |
| 2cdu | FAD | NADH oxidase | / | 0.456 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.456 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.456 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.456 | |
| 2yw2 | ATP | Phosphoribosylamine--glycine ligase | / | 0.456 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.456 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.456 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.455 | |
| 1lj8 | NAD | Mannitol dehydrogenase | / | 0.455 | |
| 1qmz | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.455 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.455 | |
| 3v04 | V04 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.455 | |
| 1hk1 | T44 | Serum albumin | / | 0.454 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.454 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.454 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.454 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.454 | |
| 3efw | AK8 | Aurora kinase A | 2.7.11.1 | 0.454 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.454 | |
| 4b1f | KRH | Glutamate racemase | / | 0.454 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.454 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.453 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.453 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 3fzt | 4JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.453 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 4c4i | X20 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.453 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.453 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.452 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.452 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 3gcs | BAX | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3ka7 | FAD | Putative oxidoreductase | / | 0.452 | |
| 3pjt | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.452 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.452 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.452 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.452 | |
| 5g3s | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.452 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.451 | |
| 1gd1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 1o1v | TCH | Gastrotropin | / | 0.451 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3dfc | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.451 | |
| 4jbp | YPH | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 5jqb | IBP | Envelope glycoprotein | / | 0.451 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.450 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.450 | |
| 1i44 | ACP | Insulin receptor | 2.7.10.1 | 0.450 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.450 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.450 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.450 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.450 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.450 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3kmw | ATP | Integrin-linked protein kinase | 2.7.11.1 | 0.450 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.450 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.450 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.449 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.449 | |
| 3aox | EMH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.449 | |
| 3nwy | GTP | Uridylate kinase | / | 0.449 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.449 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.449 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.448 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.448 | |
| 2dji | FAD | Pyruvate oxidase | / | 0.448 | |
| 2g9u | G27 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.448 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.448 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.448 | |
| 3cnt | FAD | Polyamine oxidase FMS1 | / | 0.448 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3lov | FAD | Protoporphyrinogen oxidase | / | 0.448 | |
| 3orp | AGS | Serine/threonine protein kinase | / | 0.448 | |
| 4btk | DTQ | Tau-tubulin kinase 1 | 2.7.11.1 | 0.448 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.448 | |
| 5dos | ATP | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 1e94 | ANP | ATP-dependent protease ATPase subunit HslU | / | 0.447 | |
| 1mab | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.447 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1qvn | FRI | Interleukin-2 | / | 0.447 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2v51 | LAB | Actin, alpha skeletal muscle | / | 0.447 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.447 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3h1j | SMA | Cytochrome b | / | 0.447 | |
| 3w2c | N15 | Aurora kinase A | 2.7.11.1 | 0.447 | |
| 3zvv | XAZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.447 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.447 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.447 | |
| 1ad5 | ANP | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.446 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.446 | |
| 1tdk | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.446 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 2y00 | Y01 | Beta-1 adrenergic receptor | / | 0.446 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.446 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.446 | |
| 4k2r | ANP | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.446 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 2c4c | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.445 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.445 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.445 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 3lu6 | IMX | Serum albumin | / | 0.445 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.445 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 3v01 | 3V0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.445 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4anb | YQY | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.445 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4i58 | FAD | Cyclohexylamine Oxidase | / | 0.445 | |
| 5amn | DTQ | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.445 | |
| 5dju | FMN | NPH1-2 | / | 0.445 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.444 | |
| 1e8h | ADP | Vanillyl-alcohol oxidase | 1.1.3.38 | 0.444 | |
| 1ict | T44 | Transthyretin | / | 0.444 | |
| 1j7u | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.444 | |
| 1tdn | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.444 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.444 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2bx8 | AZQ | Serum albumin | / | 0.444 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.444 | |
| 2wmw | ZYW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2wvm | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.444 | |
| 2y02 | Y01 | Beta-1 adrenergic receptor | / | 0.444 | |
| 2y3r | TIR | TamL | / | 0.444 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.444 | |
| 3efl | 706 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 3kvx | FMY | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.444 | |
| 3ncz | 3NC | Rho-associated protein kinase 1 | 2.7.11.1 | 0.444 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.444 | |
| 4nzo | ANP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.444 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.444 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.444 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 1sez | FAD | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.443 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1z6q | 195 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.443 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.443 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3lff | Z83 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3vqx | BLK | Pyrrolysine--tRNA ligase | / | 0.443 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.443 | |
| 4nmj | NAP | Aldehyde dehydrogenase | / | 0.443 | |
| 1a5u | ATP | Pyruvate kinase PKM | 2.7.1.40 | 0.442 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.442 | |
| 1z2p | ACP | Inositol-tetrakisphosphate 1-kinase | 2.7.1.134 | 0.442 | |
| 2c9c | ATP | Psp operon transcriptional activator | / | 0.442 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.442 | |
| 3mwu | BK3 | Calmodulin-domain protein kinase 1, putative | / | 0.442 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4d9t | 0JG | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.442 | |
| 4ej7 | ATP | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.442 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4gt3 | ATP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4iaz | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.442 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.442 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.442 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.441 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.441 | |
| 1wc5 | APC | Adenylate cyclase | / | 0.441 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.441 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
| 3dtw | A96 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3os3 | 3OS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.441 | |
| 3wo1 | ADP | Alanine--anticapsin ligase | / | 0.441 | |
| 4eym | 0RX | Mitogen-activated protein kinase 13 | 2.7.11.24 | 0.441 | |
| 4hse | ADP | Chaperone protein ClpB | / | 0.441 | |
| 4jlo | ADP | Adenylate kinase | / | 0.441 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.441 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4qml | ANP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.441 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1gx1 | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.440 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.440 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.440 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3ieu | GDP | GTPase Era | / | 0.440 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.440 | |
| 3up4 | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 3v0t | ATR | Perakine reductase | 1.1.1.317 | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.440 | |
| 4lgg | VGG | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 4lrj | ANP | Uncharacterized protein | / | 0.440 | |
| 4o8f | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.440 |