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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.782
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.756
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.755
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.747
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.693
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.688
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.675
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.653
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.640
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.635
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.614
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.608
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.593
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.579
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.568
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.559
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.558
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.558
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.553
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.549
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.536
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.535
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.525
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.512
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.511
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.503
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.502
4ipw1G7Mycocyclosin synthase1.14.21.90.497
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.488
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.487
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.484
3s1dZIRCytokinin dehydrogenase 11.5.99.120.484
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.482
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
4q71FADBifunctional protein PutA/0.478
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.478
2jn3JN3Fatty acid-binding protein, liver/0.476
3lqfNADGalactitol dehydrogenase/0.476
5a9sNAPPutative dehydrogenase/0.476
1jioDEB6-deoxyerythronolide B hydroxylase/0.475
4uymVOR14-alpha sterol demethylase Cyp51B/0.475
4a81DXCMajor pollen allergen Bet v 1-A/0.474
3nr4PYVAbscisic acid receptor PYL2/0.473
2ev9NAPShikimate dehydrogenase (NADP(+))/0.472
4r20AERCytochrome P450 family 17 polypeptide 2/0.472
1nvtNAPShikimate dehydrogenase (NADP(+))/0.471
4ktl1CQCytochrome P450/0.471
4tuvCPZCytochrome P450 1191.140.471
4yaoFMNNADPH--cytochrome P450 reductase/0.471
1bk0ACVIsopenicillin N synthase1.21.3.10.469
1phgMYTCamphor 5-monooxygenase1.14.15.10.469
3lvfNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.469
4q72FADBifunctional protein PutA/0.469
1xddAAYIntegrin alpha-L/0.468
2y3sTIRTamL/0.468
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.468
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.467
2ft9CHDFatty acid-binding protein 2, liver/0.467
2zbaZBATrichothecene 3-O-acetyltransferase/0.467
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.467
4ia7BIVVitamin D3 receptor A/0.467
3vt7VDXVitamin D3 receptor/0.466
4o59NADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.466
4q73FADBifunctional protein PutA/0.466
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.465
2nnhREACytochrome P450 2C8/0.465
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.465
4enhFVXCholesterol 24-hydroxylase/0.465
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.465
4iteTEYVitamin D3 receptor/0.464
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
2cchATPCyclin-dependent kinase 22.7.11.220.463
2he5NDPAldo-keto reductase family 1 member C211.1.10.463
3f8rNAPNADH oxidase/thioredoxin reductase/0.463
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.462
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.462
5hs1VORLanosterol 14-alpha demethylase/0.462
2uxoTACHTH-type transcriptional regulator TtgR/0.461
3vrwYS5Vitamin D3 receptor/0.461
4a83DXCMajor pollen allergen Bet v 1-A/0.461
4qecNAPElxO/0.461
1xe55FEPlasmepsin-23.4.23.390.460
2hk9NAPShikimate dehydrogenase (NADP(+))/0.460
2nq8ZIDEnoyl-ACP reductase/0.460
2vn0TDZCytochrome P450 2C8/0.460
3g5hYTTMycocyclosin synthase1.14.21.90.460
4lxhC1EAlpha/beta hydrolase fold/0.460
1cqp803Integrin alpha-L/0.459
2a1nCAMCamphor 5-monooxygenase1.14.15.10.459
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.459
3zuyTCHTransporter/0.459
5jlaNADPutative short-chain dehydrogenase/reductase/0.459
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1w6hTITPlasmepsin-23.4.23.390.458
2cy0NAPShikimate dehydrogenase (NADP(+))/0.458
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.458
3gwfNAPCyclohexanone monooxygenase/0.458
3h3t16HCollagen type IV alpha-3-binding protein/0.458
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2ds11CDCyclin-dependent kinase 22.7.11.220.457
2ozuACOHistone acetyltransferase KAT6A/0.457
1m13HYFNuclear receptor subfamily 1 group I member 2/0.456
2y4gTIRTamL/0.456
3d84NDPDihydrofolate reductase1.5.1.30.456
4ia3BIVVitamin D3 receptor A/0.456
1eioGCHGastrotropin/0.455
1zeoC01Peroxisome proliferator-activated receptor gamma/0.455
3bc3OPTCathepsin L13.4.22.150.455
3fwjCAMCamphor 5-monooxygenase1.14.15.10.455
3s79ASDAromatase1.14.14.140.455
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4g47TZFMycocyclosin synthase1.14.21.90.455
4xiwAZMCarbonic anhydrase, alpha type/0.455
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.454
3fwfCAMCamphor 5-monooxygenase1.14.15.10.454
3qlrNDPDihydrofolate reductase1.5.1.30.454
3uylTYDProbable NDP-rhamnosyltransferase/0.454
3vt9YI4Vitamin D3 receptor/0.454
1rm4NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.453
1w4zNAPPutative ketoacyl reductase1.3.10.453
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2ph5NADHomospermidine synthase/0.453
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.453
3vt8YI3Vitamin D3 receptor/0.453
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.453
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.453
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1dz4CAMCamphor 5-monooxygenase1.14.15.10.452
1nzdUPGDNA beta-glucosyltransferase/0.452
1osvCHCBile acid receptor/0.452
2ejvNADL-threonine 3-dehydrogenase/0.452
2y3rTRKTamL/0.452
3gobHXXDdmC/0.452
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.452
1dz6CAMCamphor 5-monooxygenase1.14.15.10.451
1t88CAMCamphor 5-monooxygenase1.14.15.10.451
2vbdV10Isopenicillin N synthase1.21.3.10.451
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.451
4cukNAID-lactate dehydrogenase/0.451
4k6mSAHGenome polyprotein/0.451
4ktkKTKCytochrome P450/0.451
1fm4DXCMajor pollen allergen Bet v 1-L/0.450
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1tsxUMPThymidylate synthase/0.450
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
2hasC3OVitamin D3 receptor/0.450
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.450
2qboCAMCamphor 5-monooxygenase1.14.15.10.450
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.450
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.450
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.450
4jx1CAHCamphor 5-monooxygenase1.14.15.10.450
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
2a7r5GPGMP reductase 2/0.449
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
2qbnCAMCamphor 5-monooxygenase1.14.15.10.449
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.449
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.449
4g3rCAMCamphor 5-monooxygenase1.14.15.10.449
4m6jNDPDihydrofolate reductase1.5.1.30.449
1yb5NAPQuinone oxidoreductase1.6.5.50.448
1yw2PGJMitogen-activated protein kinase 14/0.448
2jb4A14Isopenicillin N synthase1.21.3.10.448
2lfoGCHFatty acid-binding protein, liver/0.448
2uxpCLMHTH-type transcriptional regulator TtgR/0.448
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
3dmtNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.448
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.448
3vjoANPEpidermal growth factor receptor2.7.10.10.448
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4dbvNDPGlyceraldehyde-3-phosphate dehydrogenase/0.448
4f6w0SSCyclin-dependent kinase 82.7.11.220.448
4g2gTDHMycocyclosin synthase1.14.21.90.448
1bwsNDPGDP-L-fucose synthase/0.447
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
1zioAP5Adenylate kinase/0.447
2gmjFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.447
2qblCAMCamphor 5-monooxygenase1.14.15.10.447
3mvm39PMitogen-activated protein kinase 14/0.447
3opdHIEHeat shock protein 83/0.447
3r9uFADThioredoxin reductase/0.447
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.447
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.447
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.447
4gavFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.447
4qedNAPElxO/0.447
5eypLOCTubulin beta chain/0.447
1dyhDZFDihydrofolate reductase1.5.1.30.446
1g5sI17Cyclin-dependent kinase 22.7.11.220.446
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.446
3a9wNADNDP-sugar epimerase/0.446
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.446
3ictCOACoenzyme A disulfide reductase/0.446
3mtfA3FActivin receptor type-12.7.11.300.446
3t1tGDPProbable gliding protein mglA/0.446
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.446
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4b14NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4g48PZBMycocyclosin synthase1.14.21.90.446
4jx1CAMCamphor 5-monooxygenase1.14.15.10.446
4nm9FADBifunctional protein PutA/0.446
4r21STRCytochrome P450 family 17 polypeptide 2/0.446
1dyiFOLDihydrofolate reductase1.5.1.30.445
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1rx7FOLDihydrofolate reductase1.5.1.30.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
2ovhAS0Progesterone receptor/0.445
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.445
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.445
3inxJZCHeat shock protein HSP 90-alpha/0.445
3l4sNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.445
3tk3CPZCytochrome P450 2B41.14.14.10.445
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4bb3KKAIsopenicillin N synthase1.21.3.10.445
4ebfNADPhosphonate dehydrogenase1.20.1.10.445
4zowCLMMultidrug transporter MdfA/0.445
1o76CAMCamphor 5-monooxygenase1.14.15.10.444
1rx8FOLDihydrofolate reductase1.5.1.30.444
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
2ohvNHLGlutamate racemase/0.444
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.444
3b6zCO7Enoyl reductase LovC10.444
3dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
3gggNADPrephenate dehydrogenase/0.444
3vt5YI2Vitamin D3 receptor/0.444
4iah1DXAlr2278 protein/0.444
1jipKTN6-deoxyerythronolide B hydroxylase/0.443
2bi4NADLactaldehyde reductase1.1.1.770.443
2uxhQUEHTH-type transcriptional regulator TtgR/0.443
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.443
3pgqGY3Acetyl-CoA carboxylase/0.443
3vtbTKAVitamin D3 receptor/0.443
3wrjCAMCamphor 5-monooxygenase1.14.15.10.443
4h6rFDAProline dehydrogenase/0.443
5a3bAPRSIR2 family protein/0.443
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1hb1OCVIsopenicillin N synthase1.21.3.10.442
1ia3TQ5Dihydrofolate reductase1.5.1.30.442
1t87CAMCamphor 5-monooxygenase1.14.15.10.442
2bl4NADLactaldehyde reductase1.1.1.770.442
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.442
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3och2MXDihydrofolate reductase1.5.1.30.442
3w5rLOAVitamin D3 receptor/0.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
4h9506UDihydrofolate reductase1.5.1.30.442
4ktf1TMCytochrome P450/0.442
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.442
4qi4FADCellobiose dehydrogenase/0.442
4v2gITCTetracycline repressor protein class D/0.442
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1nytNAPShikimate dehydrogenase (NADP(+))/0.441
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.441
1yinCM3Estrogen receptor/0.441
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2feuCAMCamphor 5-monooxygenase1.14.15.10.441
3hx4ANPCalmodulin-domain protein kinase 1/0.441
3kpzZNEVitamin D3 receptor/0.441
3l63CAMCamphor 5-monooxygenase1.14.15.10.441
3le62BZCyclin-dependent kinase 22.7.11.220.441
3qrwNDPPutative ketoacyl reductase1.3.10.441
3wrmCAMCamphor 5-monooxygenase1.14.15.10.441
3zeiAWHO-acetylserine sulfhydrylase/0.441
4a30MYAGlycylpeptide N-tetradecanoyltransferase/0.441
4a6bQG8Gag-Pol polyprotein3.4.23.160.441
4cdmFO1Deoxyribodipyrimidine photolyase/0.441
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.441
4nmdFDABifunctional protein PutA/0.441
4wriOKAOkadaic acid binding protein 2-alpha/0.441
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.441
1fmlRTLRetinol dehydratase/0.440
1ie8KH1Vitamin D3 receptor/0.440
1rkhVD2Vitamin D3 receptor/0.440
2iviACWIsopenicillin N synthase1.21.3.10.440
2qbmCAMCamphor 5-monooxygenase1.14.15.10.440
2vrbNAPTriphenylmethane reductase/0.440
2z97CAMCamphor 5-monooxygenase1.14.15.10.440
3fwgCAMCamphor 5-monooxygenase1.14.15.10.440
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.440
3t3r9PLCytochrome P450 2A61.14.130.440
3vt3VDXVitamin D3 receptor/0.440
3wrhCAMCamphor 5-monooxygenase1.14.15.10.440
3zxsFADDeoxyribodipyrimidine photolyase-related protein/0.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4g1z0VPVitamin D3 receptor A/0.440
4ia2BIVVitamin D3 receptor A/0.440
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.440
4xguADPPutative pachytene checkpoint protein 2/0.440
5e8wSTUTGF-beta receptor type-12.7.11.300.440