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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3py0SU9Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3py0SU9Cyclin-dependent kinase 22.7.11.221.000
3unk0BYCyclin-dependent kinase 22.7.11.220.682
3qxpX64Cyclin-dependent kinase 22.7.11.220.617
3rpv26ZCyclin-dependent kinase 22.7.11.220.616
3rak03ZCyclin-dependent kinase 22.7.11.220.611
3r9dX6BCyclin-dependent kinase 22.7.11.220.607
4fko20KCyclin-dependent kinase 22.7.11.220.606
3sw719KCyclin-dependent kinase 22.7.11.220.604
3s1h56ZCyclin-dependent kinase 22.7.11.220.600
3rmf20ZCyclin-dependent kinase 22.7.11.220.597
3ral04ZCyclin-dependent kinase 22.7.11.220.594
2xmyCDKCyclin-dependent kinase 22.7.11.220.593
4fkq42KCyclin-dependent kinase 22.7.11.220.590
3unj0BXCyclin-dependent kinase 22.7.11.220.589
3qtxX43Cyclin-dependent kinase 22.7.11.220.587
3qtzX42Cyclin-dependent kinase 22.7.11.220.586
3rk507ZCyclin-dependent kinase 22.7.11.220.583
3sw418KCyclin-dependent kinase 22.7.11.220.580
4acm7YGCyclin-dependent kinase 22.7.11.220.579
1di8DTQCyclin-dependent kinase 22.7.11.220.573
3rk708ZCyclin-dependent kinase 22.7.11.220.569
3rni21ZCyclin-dependent kinase 22.7.11.220.569
3qu0X40Cyclin-dependent kinase 22.7.11.220.566
1urwI1PCyclin-dependent kinase 22.7.11.220.565
4fks46KCyclin-dependent kinase 22.7.11.220.565
3r1sX73Cyclin-dependent kinase 22.7.11.220.561
3qzgX67Cyclin-dependent kinase 22.7.11.220.559
3qtuX44Cyclin-dependent kinase 22.7.11.220.557
4ek816KCyclin-dependent kinase 22.7.11.220.557
1gih1PUCyclin-dependent kinase 22.7.11.220.555
3qzhX69Cyclin-dependent kinase 22.7.11.220.555
4bgh3I6Cyclin-dependent kinase 22.7.11.220.555
4fkv61KCyclin-dependent kinase 22.7.11.220.555
2w05FRTCyclin-dependent kinase 22.7.11.220.554
3ezvEZVCyclin-dependent kinase 22.7.11.220.553
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.552
1oitHDTCyclin-dependent kinase 22.7.11.220.550
3rpy27ZCyclin-dependent kinase 22.7.11.220.548
4fkr45KCyclin-dependent kinase 22.7.11.220.548
1ke6LS2Cyclin-dependent kinase 22.7.11.220.546
2iw84SPCyclin-dependent kinase 22.7.11.220.546
3rk909ZCyclin-dependent kinase 22.7.11.220.546
3uli1N3Cyclin-dependent kinase 22.7.11.220.545
1ke7LS3Cyclin-dependent kinase 22.7.11.220.543
2w06FRVCyclin-dependent kinase 22.7.11.220.543
4fkw62KCyclin-dependent kinase 22.7.11.220.542
3qtrX36Cyclin-dependent kinase 22.7.11.220.540
3rjc06ZCyclin-dependent kinase 22.7.11.220.540
4fkpLS5Cyclin-dependent kinase 22.7.11.220.540
2w1hL0FCyclin-dependent kinase 22.7.11.220.537
1ke5LS1Cyclin-dependent kinase 22.7.11.220.535
3ti1B49Cyclin-dependent kinase 22.7.11.220.535
4fkt48KCyclin-dependent kinase 22.7.11.220.531
3r9oZ71Cyclin-dependent kinase 22.7.11.220.529
1ke9LS5Cyclin-dependent kinase 22.7.11.220.528
2c6iDT1Cyclin-dependent kinase 22.7.11.220.528
3r8zZ63Cyclin-dependent kinase 22.7.11.220.527
1pxmCK5Cyclin-dependent kinase 22.7.11.220.526
1oiyN41Cyclin-dependent kinase 22.7.11.220.525
1ykr628Cyclin-dependent kinase 22.7.11.220.525
3qqkX02Cyclin-dependent kinase 22.7.11.220.525
1gij2PUCyclin-dependent kinase 22.7.11.220.523
2btsU32Cyclin-dependent kinase 22.7.11.220.523
1oi9N20Cyclin-dependent kinase 22.7.11.220.522
2r3lSCWCyclin-dependent kinase 22.7.11.220.522
3rkb12ZCyclin-dependent kinase 22.7.11.220.522
3r9hZ67Cyclin-dependent kinase 22.7.11.220.521
1p2a5BNCyclin-dependent kinase 22.7.11.220.520
2w17I19Cyclin-dependent kinase 22.7.11.220.520
1ke8LS4Cyclin-dependent kinase 22.7.11.220.518
1pxkCK3Cyclin-dependent kinase 22.7.11.220.517
2iw94SPCyclin-dependent kinase 22.7.11.220.517
1w0xOLOCyclin-dependent kinase 22.7.11.220.516
2vv9IM9Cyclin-dependent kinase 22.7.11.220.515
2bheBRYCyclin-dependent kinase 22.7.11.220.514
3sqq99ZCyclin-dependent kinase 22.7.11.220.514
1pxlCK4Cyclin-dependent kinase 22.7.11.220.513
1y91CT9Cyclin-dependent kinase 22.7.11.220.511
4eok4SPCyclin-dependent kinase 22.7.11.220.511
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.509
2c6o4SPCyclin-dependent kinase 22.7.11.220.508
3r8lZ30Cyclin-dependent kinase 22.7.11.220.508
4ez30S0Cyclin-dependent kinase 22.7.11.220.508
4qmpDKISerine/threonine-protein kinase 242.7.11.10.508
1fvt106Cyclin-dependent kinase 22.7.11.220.506
2uzoC62Cyclin-dependent kinase 22.7.11.220.506
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.506
1h1s4SPCyclin-dependent kinase 22.7.11.220.505
2r64740Cyclin-dependent kinase 22.7.11.220.505
3pxyJWSCyclin-dependent kinase 22.7.11.220.505
2b52D42Cyclin-dependent kinase 22.7.11.220.504
3lfnA27Cyclin-dependent kinase 22.7.11.220.504
1vyzN5BCyclin-dependent kinase 22.7.11.220.503
3rzb02ZCyclin-dependent kinase 22.7.11.220.503
1v1k3FPCyclin-dependent kinase 22.7.11.220.500
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.500
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.499
3ql8X01Cyclin-dependent kinase 22.7.11.220.499
4erwSTUCyclin-dependent kinase 22.7.11.220.499
3qtqX35Cyclin-dependent kinase 22.7.11.220.498
3qxoX65Cyclin-dependent kinase 22.7.11.220.498
1oguST8Cyclin-dependent kinase 22.7.11.220.497
3qwjX6ACyclin-dependent kinase 22.7.11.220.497
3s0o50ZCyclin-dependent kinase 22.7.11.220.497
2fvdLIACyclin-dependent kinase 22.7.11.220.496
3r73X87Cyclin-dependent kinase 22.7.11.220.496
1gii1PUCyclin-dependent kinase 22.7.11.220.495
2vttLZDCyclin-dependent kinase 22.7.11.220.495
1ckpPVBCyclin-dependent kinase 22.7.11.220.493
3r8vZ62Cyclin-dependent kinase 22.7.11.220.493
1pxpCK8Cyclin-dependent kinase 22.7.11.220.492
2j9mPY8Cyclin-dependent kinase 22.7.11.220.492
3pj8404Cyclin-dependent kinase 22.7.11.220.492
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.491
3r28XA0Cyclin-dependent kinase 22.7.11.220.491
3r6xX84Cyclin-dependent kinase 22.7.11.220.490
2btrU73Cyclin-dependent kinase 22.7.11.220.489
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.489
3qqhX0ACyclin-dependent kinase 22.7.11.220.489
3rm618ZCyclin-dependent kinase 22.7.11.220.489
3ddpRC8Cyclin-dependent kinase 22.7.11.220.488
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.488
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.487
3r71X86Cyclin-dependent kinase 22.7.11.220.487
2r3iSCFCyclin-dependent kinase 22.7.11.220.486
3qqfX07Cyclin-dependent kinase 22.7.11.220.486
3iggEFQCyclin-dependent kinase 22.7.11.220.485
1g5sI17Cyclin-dependent kinase 22.7.11.220.484
1pyePM1Cyclin-dependent kinase 22.7.11.220.483
3qwkX62Cyclin-dependent kinase 22.7.11.220.483
3roy22ZCyclin-dependent kinase 22.7.11.220.483
2duv371Cyclin-dependent kinase 22.7.11.220.482
3qtwX3ACyclin-dependent kinase 22.7.11.220.482
1pkdUCNCyclin-dependent kinase 22.7.11.220.480
2xnbY8LCyclin-dependent kinase 22.7.11.220.480
4ek610KCyclin-dependent kinase 22.7.11.220.480
4kd11QKCyclin-dependent kinase 22.7.11.220.480
2uznC96Cyclin-dependent kinase 22.7.11.220.478
3r7uX96Cyclin-dependent kinase 22.7.11.220.478
4bcnT9NCyclin-dependent kinase 22.7.11.220.478
3r7vZ02Cyclin-dependent kinase 22.7.11.220.477
2a0cCK9Cyclin-dependent kinase 22.7.11.220.476
2r3p3SCCyclin-dependent kinase 22.7.11.220.476
1y8yCT7Cyclin-dependent kinase 22.7.11.220.475
1oiuN76Cyclin-dependent kinase 22.7.11.220.474
2b54D05Cyclin-dependent kinase 22.7.11.220.474
2b55D31Cyclin-dependent kinase 22.7.11.220.474
3qruX19Cyclin-dependent kinase 22.7.11.220.474
3r7iX9ICyclin-dependent kinase 22.7.11.220.474
4fx360KCyclin-dependent kinase 22.7.11.220.474
1h1r6CPCyclin-dependent kinase 22.7.11.220.473
3ixj586Beta-secretase 13.4.23.460.473
3lpkZ76Beta-secretase 13.4.23.460.473
3rpo24ZCyclin-dependent kinase 22.7.11.220.473
4eor4SPCyclin-dependent kinase 22.7.11.220.473
3r1qX75Cyclin-dependent kinase 22.7.11.220.472
3t3c017Gag-Pol polyprotein3.4.23.160.472
2eufLQQCyclin-dependent kinase 62.7.11.220.471
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.471
3rm719ZCyclin-dependent kinase 22.7.11.220.471
3dogNNNCyclin-dependent kinase 22.7.11.220.470
3cic316Beta-secretase 13.4.23.460.469
3r7eX88Cyclin-dependent kinase 22.7.11.220.469
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.469
1fvv107Cyclin-dependent kinase 22.7.11.220.468
2wihP48Cyclin-dependent kinase 22.7.11.220.468
3r7yZ04Cyclin-dependent kinase 22.7.11.220.468
2bhhRYUCyclin-dependent kinase 22.7.11.220.467
3cid318Beta-secretase 13.4.23.460.467
3qzfX66Cyclin-dependent kinase 22.7.11.220.467
3s2pPMUCyclin-dependent kinase 22.7.11.220.467
2r3o2SCCyclin-dependent kinase 22.7.11.220.466
3raiX85Cyclin-dependent kinase 22.7.11.220.466
3tiz3TICyclin-dependent kinase 22.7.11.220.466
4fki09KCyclin-dependent kinase 22.7.11.220.466
1oiqHDUCyclin-dependent kinase 22.7.11.220.465
2r3kSCQCyclin-dependent kinase 22.7.11.220.465
2uzlC94Cyclin-dependent kinase 22.7.11.220.465
4fkj11KCyclin-dependent kinase 22.7.11.220.465
1e9hINRCyclin-dependent kinase 22.7.11.220.464
2cchATPCyclin-dependent kinase 22.7.11.220.464
3ddqRRCCyclin-dependent kinase 22.7.11.220.463
3ig7EFPCyclin-dependent kinase 22.7.11.220.463
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
2wxvWXVCyclin-dependent kinase 22.7.11.220.462
2fdpFRPBeta-secretase 13.4.23.460.461
2iqgF2IBeta-secretase 13.4.23.460.461
3rpr25ZCyclin-dependent kinase 22.7.11.220.461
1dm2HMDCyclin-dependent kinase 22.7.11.220.460
2c6tDT5Cyclin-dependent kinase 22.7.11.220.460
2p83MR0Beta-secretase 13.4.23.460.460
2r3jSCJCyclin-dependent kinase 22.7.11.220.460
4lyn1YGCyclin-dependent kinase 22.7.11.220.460
1k6vXN2Gag-Pol polyprotein3.4.23.160.459
2vu3LZECyclin-dependent kinase 22.7.11.220.459
3el9DR7Gag-Pol polyprotein3.4.23.160.459
3qrtX14Cyclin-dependent kinase 22.7.11.220.459
3qziX72Cyclin-dependent kinase 22.7.11.220.459
4dh60KNBeta-secretase 13.4.23.460.459
1c70L75Protease/0.458
1msmJE2Gag-Pol polyprotein3.4.23.160.458
2bpw1INGag-Pol polyprotein3.4.23.160.458
3dk1G05Gag-Pol polyprotein3.4.23.160.458
3r1yX76Cyclin-dependent kinase 22.7.11.220.458
1oirHDYCyclin-dependent kinase 22.7.11.220.457
2r3mSCXCyclin-dependent kinase 22.7.11.220.457
2wezZYEBeta-secretase 13.4.23.460.457
2zjmF1MBeta-secretase 13.4.23.460.457
4y95746Tyrosine-protein kinase/0.457
1k6tXN1Gag-Pol polyprotein3.4.23.160.456
2r3r6SCCyclin-dependent kinase 22.7.11.220.456
3qtsX46Cyclin-dependent kinase 22.7.11.220.456
3wblPDYCyclin-dependent kinase 22.7.11.220.456
1v0pPVBCell division control protein 2 homolog2.7.11.220.454
3r83Z14Cyclin-dependent kinase 22.7.11.220.454
1aq1STUCyclin-dependent kinase 22.7.11.220.453
1h0w207Cyclin-dependent kinase 22.7.11.220.453
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.453
2qnqQN3Gag-Pol polyprotein3.4.23.160.453
3ecg065Gag-Pol polyprotein3.4.23.470.453
4fkg4CKCyclin-dependent kinase 22.7.11.220.453
4lxk1YTBeta-secretase 13.4.23.460.453
1r78FMDCyclin-dependent kinase 22.7.11.220.452
3k5fAYHBeta-secretase 13.4.23.460.452
3le62BZCyclin-dependent kinase 22.7.11.220.452
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.452
4k9h1QUBeta-secretase 13.4.23.460.452
1hpxKNIGag-Pol polyprotein/0.451
2a4lRRCCyclin-dependent kinase 22.7.11.220.451
2wpa889Cyclin-dependent kinase 22.7.11.220.451
3ezrEZRCyclin-dependent kinase 22.7.11.220.451
3ggfGVDSerine/threonine-protein kinase 26/0.451
3lpjZ75Beta-secretase 13.4.23.460.451
3mb714ICasein kinase II subunit alpha2.7.11.10.451
2q3kMUWGag-Pol polyprotein/0.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4eol1ROCyclin-dependent kinase 22.7.11.220.450
1c6yMK1Protease/0.449
1dw60Q4Gag-Pol polyprotein3.4.23.160.449
1h1pCMGCyclin-dependent kinase 22.7.11.220.449
4a6cQG9Gag-Pol polyprotein3.4.23.160.449
4dfg0JVGag-Pol polyprotein3.4.23.160.449
2hs1017Protease/0.448
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.448
3cib314Beta-secretase 13.4.23.460.448
3cyw017Gag-Pol polyprotein3.4.23.160.448
1bv9XV6Gag-Pol polyprotein3.4.23.160.447
2c69CT8Cyclin-dependent kinase 22.7.11.220.447
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.447
2r43G3GGag-Pol polyprotein3.4.23.160.447
3g70A5TRenin3.4.23.150.447
3r8pZ46Cyclin-dependent kinase 22.7.11.220.447
4bcpT3CCyclin-dependent kinase 22.7.11.220.447
4eoi1ROCyclin-dependent kinase 22.7.11.220.447
1bwaXV6Gag-Pol polyprotein3.4.23.160.446
1u3dFADCryptochrome-1/0.446
2c6kDT2Cyclin-dependent kinase 22.7.11.220.446
3i7eDJRGag-Pol polyprotein/0.446
3ixk929Beta-secretase 13.4.23.460.446
3litE15Protease/0.446
5e8wSTUTGF-beta receptor type-12.7.11.300.446
3nbvANPKetohexokinase/0.445
3qx2X63Cyclin-dependent kinase 22.7.11.220.445
3w32W32Epidermal growth factor receptor2.7.10.10.445
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.445
2vnaNAPProstaglandin reductase 21.3.1.480.444
3elySAHMethyltransferase/0.444
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.444
2pvnP63Casein kinase II subunit alpha2.7.11.10.443
2r3q5SCCyclin-dependent kinase 22.7.11.220.443
2viyVG3Beta-secretase 13.4.23.460.443
3lfqA28Cyclin-dependent kinase 22.7.11.220.443
3ogqAB1Pol polyprotein/0.443
3s00Z60Cyclin-dependent kinase 22.7.11.220.443
4bcoT6QCyclin-dependent kinase 22.7.11.220.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4j54G52Gag-Pol polyprotein3.4.23.160.443
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
2c6lDT4Cyclin-dependent kinase 22.7.11.220.442
2r3gSC9Cyclin-dependent kinase 22.7.11.220.442
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.442
3rahO1ZCyclin-dependent kinase 22.7.11.220.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4u0mGTPCyclic GMP-AMP synthase/0.442
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5jjrSAHGenome polyprotein/0.442
1kzkJE2Gag-Pol polyprotein3.4.23.160.441
1t7i017Gag-Pol polyprotein3.4.23.160.441
2pwcG3GGag-Pol polyprotein3.4.23.160.441
2x1nX1NCyclin-dependent kinase 22.7.11.220.441
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
3vrwYS5Vitamin D3 receptor/0.441
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
4lxa1YSBeta-secretase 13.4.23.460.441
4njsG08Protease/0.441
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
2wotZZGTGF-beta receptor type-12.7.11.300.440
3a60STURibosomal protein S6 kinase beta-12.7.11.10.440
3wowANPCasein kinase II subunit alpha2.7.11.10.440