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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3p7nFMNLight-activated DNA-binding protein EL222

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3p7nFMNLight-activated DNA-binding protein EL222/1.000
2pr5FMNBlue-light photoreceptor/0.549
3is2FADVivid PAS protein VVD/0.535
4eetFMNPhototropin-22.7.11.10.531
2z6dFMNPhototropin-22.7.11.10.527
2pd8FADVivid PAS protein VVD/0.521
5djuFMNNPH1-2/0.509
4hiaFMNLOV protein/0.508
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.504
2p4yC03Peroxisome proliferator-activated receptor gamma/0.504
2z6cFMNPhototropin-12.7.11.10.504
4fv7E94Mitogen-activated protein kinase 12.7.11.240.504
3hjiFADVivid PAS protein VVD/0.499
3t50FMNBlue-light-activated histidine kinase2.7.13.30.496
4zohFADPutative oxidoreductase FAD-binding subunit/0.496
1n9nFMNPutative blue light receptor/0.489
5djtFMNNPH1-2/0.488
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.483
1xddAAYIntegrin alpha-L/0.482
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.482
2q5p241Peroxisome proliferator-activated receptor gamma/0.482
3lqfNADGalactitol dehydrogenase/0.482
2q59240Peroxisome proliferator-activated receptor gamma/0.481
3d72FADVivid PAS protein VVD/0.481
1zeoC01Peroxisome proliferator-activated receptor gamma/0.479
4hhdFMNPhototropin-12.7.11.10.477
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.477
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.477
2w06FRVCyclin-dependent kinase 22.7.11.220.476
3ue6FMNAureochrome1/0.476
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.476
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.475
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.474
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.474
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.473
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.472
4q72FADBifunctional protein PutA/0.472
2mwgFMNBlue-light photoreceptor/0.471
3d8vUD1Bifunctional protein GlmU/0.471
1n9lFMNPutative blue light receptor/0.470
2zjwREFCasein kinase II subunit alpha2.7.11.10.470
4eeuFMNPhototropin-22.7.11.10.470
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1x2hLPALipoate-protein ligase A6.3.1.200.469
2gjlFMNNitronate monooxygenase1.13.12.160.469
3hyoADPPyridoxal kinase/0.469
2pd7FADVivid PAS protein VVD/0.468
2qo9ANPEphrin type-A receptor 32.7.10.10.468
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.468
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
3pqbVGPPutative oxidoreductase/0.467
4eesFMNPhototropin-22.7.11.10.467
4xumIMNPeroxisome proliferator-activated receptor gamma/0.467
1e3eNAIAlcohol dehydrogenase 41.1.1.10.466
2a94AP0L-lactate dehydrogenase1.1.1.270.466
3ibqATPPyridoxal kinase/0.466
4q73FADBifunctional protein PutA/0.466
1bsvNDPGDP-L-fucose synthase/0.465
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.465
3pe2E1BCasein kinase II subunit alpha2.7.11.10.465
4eepFMNPhototropin-22.7.11.10.465
4kukRBFPutative blue-light photoreceptor/0.465
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.464
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.464
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.464
3nbvANPKetohexokinase/0.464
4c57FEFCyclin-G-associated kinase2.7.11.10.464
1pjkANPCasein kinase II subunit alpha2.7.11.10.463
4ambDUDPutative glycosyl transferase/0.463
4eerFMNPhototropin-22.7.11.10.463
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.462
3a1nNADNDP-sugar epimerase/0.462
3d0bSNXHeat shock protein HSP 90-alpha/0.462
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.461
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.461
1uyhPU0Heat shock protein HSP 90-alpha/0.461
2xvv9DNSerum albumin/0.461
3ad9NADSubunit alpha of sarocosine oxidase/0.461
4ji91M3Tyrosine-protein kinase JAK2/0.461
2pdtFADVivid PAS protein VVD/0.460
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.460
4bb3KKAIsopenicillin N synthase1.21.3.10.460
3b6zCO7Enoyl reductase LovC10.459
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
1g28FMNPHY3/0.458
1u3cFADCryptochrome-1/0.458
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.458
3t2zFADSulfide-quinone reductase/0.458
4bfxZVXPantothenate kinase2.7.1.330.458
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.458
4jloADPAdenylate kinase/0.458
2dvlFADAcyl-CoA dehydrogenase/0.457
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.457
3dds26BGlycogen phosphorylase, liver form2.4.1.10.457
4hj4FMNLOV protein/0.457
4hj6FMNLOV protein/0.457
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.457
4u0mGTPCyclic GMP-AMP synthase/0.457
4yswFADXanthine dehydrogenase/oxidase/0.457
5cnoANPEpidermal growth factor receptor2.7.10.10.457
5efwFMNNPH1-1/0.457
2dwbANPAurora kinase A2.7.11.10.456
2po7CHDFerrochelatase, mitochondrial4.99.1.10.456
4aotGW8Serine/threonine-protein kinase 102.7.11.10.456
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.456
2npaMMBPeroxisome proliferator-activated receptor alpha/0.455
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3hx4ANPCalmodulin-domain protein kinase 1/0.455
3iaeD7KBenzaldehyde lyase/0.455
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.455
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/0.454
1yinCM3Estrogen receptor/0.454
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.454
2zdt46CMitogen-activated protein kinase 102.7.11.240.454
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3opdHIEHeat shock protein 83/0.454
1ykdCMPAdenylate cyclase/0.453
3eljGS7Mitogen-activated protein kinase 82.7.11.240.453
3u9eCOALmo1369 protein/0.453
5dkkFMNPredicted protein/0.453
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.452
3b9lAZZSerum albumin/0.452
3clyACPFibroblast growth factor receptor 2/0.452
3dd125DGlycogen phosphorylase, liver form2.4.1.10.452
3oibFDAPutative acyl-CoA dehydrogenase/0.452
4c58824Cyclin-G-associated kinase2.7.11.10.452
4e5yNDPGDP-L-fucose synthase1.1.1.2710.452
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.452
4l9kEHFSerum albumin/0.452
4lxhC1EAlpha/beta hydrolase fold/0.452
1dhrNADDihydropteridine reductase1.5.1.340.451
1udaUFGUDP-glucose 4-epimerase5.1.3.20.451
2qa2FADPolyketide oxygenase CabE/0.451
2yk2YJWHeat shock protein HSP 90-alpha/0.451
3ixp834Ecdysone receptor/0.451
3mdmFJZCholesterol 24-hydroxylase/0.451
1uy8PU5Heat shock protein HSP 90-alpha/0.450
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.450
3lshFADPyranose 2-oxidase/0.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.449
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.449
2p33J07Mitogen-activated protein kinase 102.7.11.240.449
3gxlQIGTGF-beta receptor type-12.7.11.300.449
3qa2XNAKetohexokinase/0.449
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.449
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.449
4l0qNADAlcohol dehydrogenase class-3/0.449
4o1pANPRibonuclease L/0.449
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.449
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.449
4xgxADPFAD:protein FMN transferase/0.449
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.449
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
5hwsNAP2-dehydropantoate 2-reductase/0.449
1dr3TAPDihydrofolate reductase1.5.1.30.448
1y0s331Peroxisome proliferator-activated receptor delta/0.448
2q5g1FAPeroxisome proliferator-activated receptor delta/0.448
2v1aFMNNPH1-1/0.448
3wfjNAD2-dehydropantoate 2-reductase/0.448
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.448
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.448
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.447
1tqf32PBeta-secretase 13.4.23.460.447
2y3sTIRTamL/0.447
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.447
3ig6438Urokinase-type plasminogen activator3.4.21.730.447
3r9uFADThioredoxin reductase/0.447
3so9017Pol protein/0.447
3tdvGDPGentamicin resistance protein/0.447
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.447
4fxy0W2Neurolysin, mitochondrial3.4.24.160.447
4gk4L90Ephrin type-A receptor 32.7.10.10.447
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.447
4iah1DXAlr2278 protein/0.447
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.447
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.447
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.446
1yb5NAPQuinone oxidoreductase1.6.5.50.446
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2xvw9NRSerum albumin/0.446
3i7eDJRGag-Pol polyprotein/0.446
3kb1ADPIron-sulfur cluster carrier protein/0.446
3r0tFU9Casein kinase II subunit alpha2.7.11.10.446
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.446
5drdATPAurora kinase A2.7.11.10.446
2ejvNADL-threonine 3-dehydrogenase/0.445
2vn0TDZCytochrome P450 2C8/0.445
2vttLZDCyclin-dependent kinase 22.7.11.220.445
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
3f63GTXGlutathione transferase GST1-4/0.445
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.445
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.445
3rnnRNNGlutamate receptor 2/0.445
3wmxNADNAD dependent epimerase/dehydratase/0.445
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.445
4jl6ADPAdenylate kinase/0.445
1bygSTUTyrosine-protein kinase CSK/0.444
1v9aSAHUncharacterized protein/0.444
2dr3ADPUPF0273 protein PH0284/0.444
2e8hSAHDiphthine synthase/0.444
2q61SF1Peroxisome proliferator-activated receptor gamma/0.444
2qak1UNGag-Pol polyprotein3.4.23.160.444
2x7hPFNProstaglandin reductase 310.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3owj1ELCasein kinase II subunit alpha2.7.11.10.444
3sdi3SDProteasome subunit beta type-53.4.25.10.444
3sdi3SDProteasome subunit beta type-63.4.25.10.444
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.444
3sw1FMNSensory box protein/0.444
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.444
3w18N13Aurora kinase A2.7.11.10.444
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.444
4f9fGDPPutative glycosyltransferase/0.444
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.444
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
5cnnANPEpidermal growth factor receptor2.7.10.10.444
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1llwFMNFerredoxin-dependent glutamate synthase 21.4.7.10.443
1nhhANPDNA mismatch repair protein MutL/0.443
1wlvCOAPhenylacetic acid degradation protein PaaI/0.443
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.443
2pmoHMDProtein kinase 7/0.443
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2xa4AZ5Tyrosine-protein kinase JAK2/0.443
3i6oGR6Gag-Pol polyprotein3.4.23.160.443
3mb714ICasein kinase II subunit alpha2.7.11.10.443
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.443
1bwsNDPGDP-L-fucose synthase/0.442
1ffuFADCarbon monoxide dehydrogenase medium chain/0.442
1l8qADPChromosomal replication initiator protein DnaA/0.442
1mezGDPAdenylosuccinate synthetase isozyme 1/0.442
1oiyN41Cyclin-dependent kinase 22.7.11.220.442
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.442
3ajrNADNDP-sugar epimerase/0.442
3frqERYErythromycin resistance repressor protein/0.442
3ijdC2FMethylenetetrahydrofolate reductase/0.442
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
4fvqATPTyrosine-protein kinase JAK2/0.442
4lrjANPUncharacterized protein/0.442
4prvADPDNA gyrase subunit B/0.442
4tuvCPZCytochrome P450 1191.140.442
4zseANPEpidermal growth factor receptor2.7.10.10.442
6cp4CAMCamphor 5-monooxygenase1.14.15.10.442
1ay0TPPTransketolase 12.2.1.10.441
1ma0NADAlcohol dehydrogenase class-31.1.1.10.441
1o9bNAIQuinate/shikimate dehydrogenase/0.441
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
2e08SAHDiphthine synthase/0.441
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.441
2hw1ANPKetohexokinase/0.441
3hllI45Mitogen-activated protein kinase 14/0.441
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.441
3zuyTCHTransporter/0.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.441
4i8zG08Gag-Pol polyprotein3.4.23.160.441
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4r1lADPPhenylacetate-coenzyme A ligase/0.441
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.441
1bw9NADPhenylalanine dehydrogenase/0.440
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1kkq471Peroxisome proliferator-activated receptor alpha/0.440
1sxjAGSReplication factor C subunit 1/0.440
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.440
2b53D23Cyclin-dependent kinase 22.7.11.220.440
2q54MU1Protease/0.440
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
2y0mACOHistone acetyltransferase KAT8/0.440
3fwjCAMCamphor 5-monooxygenase1.14.15.10.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3triNAPPyrroline-5-carboxylate reductase/0.440
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.440
3zep1NXTyrosine-protein kinase JAK32.7.10.20.440
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.440
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.440
4jbiNDPAlcohol dehydrogenase (Zinc)/0.440