sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3p7n | FMN | Light-activated DNA-binding protein EL222 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 1.000 | |
| 2pr5 | FMN | Blue-light photoreceptor | / | 0.549 | |
| 3is2 | FAD | Vivid PAS protein VVD | / | 0.535 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.531 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.527 | |
| 2pd8 | FAD | Vivid PAS protein VVD | / | 0.521 | |
| 5dju | FMN | NPH1-2 | / | 0.509 | |
| 4hia | FMN | LOV protein | / | 0.508 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.504 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.504 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.504 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.504 | |
| 3hji | FAD | Vivid PAS protein VVD | / | 0.499 | |
| 3t50 | FMN | Blue-light-activated histidine kinase | 2.7.13.3 | 0.496 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.496 | |
| 1n9n | FMN | Putative blue light receptor | / | 0.489 | |
| 5djt | FMN | NPH1-2 | / | 0.488 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.483 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.482 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.482 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.482 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.482 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.481 | |
| 3d72 | FAD | Vivid PAS protein VVD | / | 0.481 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.479 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.477 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.477 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.477 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 3ue6 | FMN | Aureochrome1 | / | 0.476 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.476 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.475 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.474 | |
| 4r38 | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.474 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.473 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.472 | |
| 2mwg | FMN | Blue-light photoreceptor | / | 0.471 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.471 | |
| 1n9l | FMN | Putative blue light receptor | / | 0.470 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.470 | |
| 4eeu | FMN | Phototropin-2 | 2.7.11.1 | 0.470 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.469 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.469 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.469 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.468 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.468 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.468 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.467 | |
| 4ees | FMN | Phototropin-2 | 2.7.11.1 | 0.467 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.466 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.466 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.466 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.466 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.465 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.465 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.465 | |
| 4eep | FMN | Phototropin-2 | 2.7.11.1 | 0.465 | |
| 4kuk | RBF | Putative blue-light photoreceptor | / | 0.465 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.464 | |
| 3nbv | ANP | Ketohexokinase | / | 0.464 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.464 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.463 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.463 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.463 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.462 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.462 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.461 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.461 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2xvv | 9DN | Serum albumin | / | 0.461 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.461 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.461 | |
| 2pdt | FAD | Vivid PAS protein VVD | / | 0.460 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.460 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.459 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 1g28 | FMN | PHY3 | / | 0.458 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.458 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.458 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.458 | |
| 4jlo | ADP | Adenylate kinase | / | 0.458 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.457 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.457 | |
| 4hj4 | FMN | LOV protein | / | 0.457 | |
| 4hj6 | FMN | LOV protein | / | 0.457 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.457 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.457 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.457 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 5efw | FMN | NPH1-1 | / | 0.457 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.456 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.456 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.456 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.455 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.455 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.454 | |
| 1yin | CM3 | Estrogen receptor | / | 0.454 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.454 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.454 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.454 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.454 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.453 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.453 | |
| 3u9e | COA | Lmo1369 protein | / | 0.453 | |
| 5dkk | FMN | Predicted protein | / | 0.453 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.452 | |
| 3b9l | AZZ | Serum albumin | / | 0.452 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.452 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.452 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.452 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.452 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.452 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.452 | |
| 4l9k | EHF | Serum albumin | / | 0.452 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.452 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.451 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.451 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.451 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.451 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.450 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.450 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.449 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.449 | |
| 3qa2 | XNA | Ketohexokinase | / | 0.449 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.449 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.449 | |
| 4o1p | ANP | Ribonuclease L | / | 0.449 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.449 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.449 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.449 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.449 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 2v1a | FMN | NPH1-1 | / | 0.448 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.448 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.447 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2y3s | TIR | TamL | / | 0.447 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.447 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.447 | |
| 3so9 | 017 | Pol protein | / | 0.447 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.447 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.447 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.447 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.447 | |
| 4iah | 1DX | Alr2278 protein | / | 0.447 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.447 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.447 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.446 | |
| 2xvw | 9NR | Serum albumin | / | 0.446 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.446 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.446 | |
| 3r0t | FU9 | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.446 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.445 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.445 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.445 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.445 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.445 | |
| 3rnn | RNN | Glutamate receptor 2 | / | 0.445 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.445 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.445 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.444 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.444 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.444 | |
| 2e8h | SAH | Diphthine synthase | / | 0.444 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.444 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.444 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.444 | |
| 3sw1 | FMN | Sensory box protein | / | 0.444 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.444 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.444 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.444 | |
| 4im0 | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.444 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.443 | |
| 1llw | FMN | Ferredoxin-dependent glutamate synthase 2 | 1.4.7.1 | 0.443 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.443 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.443 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.443 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.443 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1ffu | FAD | Carbon monoxide dehydrogenase medium chain | / | 0.442 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.442 | |
| 1mez | GDP | Adenylosuccinate synthetase isozyme 1 | / | 0.442 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.442 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.442 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.442 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.442 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.442 | |
| 4fvq | ATP | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 4lrj | ANP | Uncharacterized protein | / | 0.442 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.442 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.442 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.441 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.441 | |
| 2e08 | SAH | Diphthine synthase | / | 0.441 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 2hw1 | ANP | Ketohexokinase | / | 0.441 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.441 | |
| 3zuy | TCH | Transporter | / | 0.441 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 4w9w | YDJ | BMP-2-inducible protein kinase | 2.7.11.1 | 0.441 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.440 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.440 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2q54 | MU1 | Protease | / | 0.440 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.440 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.440 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.440 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.440 |