sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3p0z | CTN | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3p0z | CTN | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 1.000 | |
| 3k2x | I5A | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.621 | |
| 3iew | CTP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.594 | |
| 4c8g | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.580 | |
| 3t80 | CTN | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.579 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.564 | |
| 3jvh | HHV | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.558 | |
| 4c8e | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.554 | |
| 1h48 | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.552 | |
| 3f0g | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.541 | |
| 1h47 | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.532 | |
| 3ke1 | 829 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.531 | |
| 1iv4 | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.518 | |
| 1iv2 | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.515 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.511 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.509 | |
| 2uzh | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.509 | |
| 3f0f | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.506 | |
| 3elc | F01 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.504 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.504 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.491 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.484 | |
| 5djt | FMN | NPH1-2 | / | 0.484 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.483 | |
| 4hj6 | FMN | LOV protein | / | 0.483 | |
| 4ktc | 1X3 | Genome polyprotein | 3.4.21.98 | 0.483 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.479 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.477 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.477 | |
| 1gx1 | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.476 | |
| 1sxj | ADP | Replication factor C subunit 5 | / | 0.475 | |
| 2amt | 1AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.474 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.474 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.473 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.472 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.472 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.472 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.471 | |
| 1cm8 | ANP | Mitogen-activated protein kinase 12 | / | 0.470 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 2pd8 | FAD | Vivid PAS protein VVD | / | 0.470 | |
| 4ees | FMN | Phototropin-2 | 2.7.11.1 | 0.470 | |
| 4hj4 | FMN | LOV protein | / | 0.470 | |
| 1n9n | FMN | Putative blue light receptor | / | 0.469 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.469 | |
| 3qro | NK9 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.468 | |
| 1n9l | FMN | Putative blue light receptor | / | 0.468 | |
| 3r4b | 74T | Gag-Pol polyprotein | / | 0.468 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.468 | |
| 4hia | FMN | LOV protein | / | 0.468 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 2r3j | SCJ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 3el0 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 3sw1 | FMN | Sensory box protein | / | 0.467 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.467 | |
| 4oa9 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.467 | |
| 4r38 | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.467 | |
| 2pr5 | FMN | Blue-light photoreceptor | / | 0.466 | |
| 3bxr | DRR | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 3u9e | COA | Lmo1369 protein | / | 0.466 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.466 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.465 | |
| 4hnb | FMN | LOV protein | / | 0.465 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.464 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.464 | |
| 3em4 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 4h3y | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.464 | |
| 2r38 | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 3qbf | JHG | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 3t50 | FMN | Blue-light-activated histidine kinase | 2.7.13.3 | 0.463 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.463 | |
| 1jsc | TPP | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.462 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.462 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.462 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.462 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3nie | ANP | Mitogen-activated protein kinase | / | 0.461 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2qi0 | MZ3 | Gag-Pol polyprotein | / | 0.460 | |
| 3gi5 | K62 | Gag-Pol polyprotein | / | 0.460 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 4lvb | 20N | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.460 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.460 | |
| 1wyg | FAD | Xanthine dehydrogenase/oxidase | / | 0.459 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.459 | |
| 2fle | AI | Protease | / | 0.459 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.459 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.459 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.459 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 5dju | FMN | NPH1-2 | / | 0.459 | |
| 1uv5 | BRW | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.458 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 4q1x | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.458 | |
| 1hvk | A79 | Gag-Pol polyprotein | / | 0.457 | |
| 1tcx | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.457 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.457 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.457 | |
| 2jkq | VG8 | Focal adhesion kinase 1 | 2.7.10.2 | 0.456 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3a20 | FMN | FMN-binding protein | / | 0.456 | |
| 3qpj | N4I | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.456 | |
| 4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4xzn | NAP | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.456 | |
| 1gih | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.455 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.455 | |
| 2yr5 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.455 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.455 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.455 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.455 | |
| 4eep | FMN | Phototropin-2 | 2.7.11.1 | 0.455 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.455 | |
| 2bxq | IMN | Serum albumin | / | 0.454 | |
| 2hs2 | 017 | Protease | / | 0.454 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 2qnn | QN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.454 | |
| 2r3t | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3sa3 | 23X | Protease | / | 0.454 | |
| 4lj9 | ACP | Chaperone protein ClpB | / | 0.454 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.454 | |
| 1g28 | FMN | PHY3 | / | 0.453 | |
| 1hck | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1n49 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.453 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2nmy | ROC | Protease | / | 0.453 | |
| 2qhy | MZ1 | Gag-Pol polyprotein | / | 0.453 | |
| 3gi4 | K60 | Gag-Pol polyprotein | / | 0.453 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3nyg | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4dea | NHI | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 5dkk | FMN | Predicted protein | / | 0.453 | |
| 5ijz | NAP | NADP-specific glutamate dehydrogenase | 1.4.1.4 | 0.453 | |
| 2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.452 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.452 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.452 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1nb9 | RBF | Riboflavin kinase | 2.7.1.26 | 0.451 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2qnp | QN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3is2 | FAD | Vivid PAS protein VVD | / | 0.451 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 4rvj | 478 | Protease | / | 0.451 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2qd7 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2qi3 | MZ5 | Gag-Pol polyprotein | / | 0.450 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4heg | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4jld | ADP | Adenylate kinase | / | 0.450 | |
| 4n3e | 2AN | Phenolic oxidative coupling protein | / | 0.450 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.449 | |
| 2gbl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.449 | |
| 2ieo | 017 | Protease | / | 0.449 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.449 | |
| 2pyw | ADP | Methylthioribose kinase | 2.7.1.100 | 0.449 | |
| 2xne | ASH | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3lzv | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3pkp | DTP | Glucose-1-phosphate thymidylyltransferase | 2.7.7.24 | 0.449 | |
| 4hj3 | FMN | LOV protein | / | 0.449 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.448 | |
| 1mrw | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.448 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.448 | |
| 2psu | MUU | Protease | / | 0.448 | |
| 2x3f | APC | Pantothenate synthetase | / | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4q1w | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1ec3 | MS3 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1hxw | RIT | Gag-Pol polyprotein | / | 0.447 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.447 | |
| 1kqc | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.447 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.447 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.447 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.447 | |
| 2p3b | 3TL | V-1 protease | / | 0.447 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3hji | FAD | Vivid PAS protein VVD | / | 0.447 | |
| 3o9f | K2D | Gag-Pol polyprotein | / | 0.447 | |
| 3sa9 | A68 | Protease | / | 0.447 | |
| 3tog | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3uic | 09T | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.447 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.447 | |
| 4kuk | RBF | Putative blue-light photoreceptor | / | 0.447 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 4c59 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.446 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.446 | |
| 4njs | G08 | Protease | / | 0.446 | |
| 4o3m | ADP | Bloom syndrome protein | 3.6.4.12 | 0.446 | |
| 4upj | U04 | Gag-Pol polyprotein | / | 0.446 | |
| 1e79 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 1e79 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.445 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.445 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.445 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.445 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 2x5z | GDD | Mannose-1-phosphate guanylyltransferase | / | 0.445 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 3amf | FMN | FMN-binding protein | / | 0.445 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 3lq5 | SLQ | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.445 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.445 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 1k2b | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1k2c | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1pxp | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.444 | |
| 2i51 | FMN | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding | / | 0.444 | |
| 2qi6 | MZ8 | Gag-Pol polyprotein | / | 0.444 | |
| 3bva | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.444 | |
| 3eky | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3ndx | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3s56 | ROC | Protease | / | 0.444 | |
| 3sac | AF8 | Protease | / | 0.444 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4djo | MK5 | Pol polyprotein | / | 0.444 | |
| 1bdq | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.443 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.443 | |
| 3nuy | JPZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3qts | X46 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.443 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.443 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4fv1 | EK4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4p0g | BLG | Membrane-bound lytic murein transglycosylase F | / | 0.443 | |
| 5dt0 | SKE | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 1dif | A85 | Gag-Pol polyprotein | / | 0.442 | |
| 1flm | FMN | FMN-binding protein | / | 0.442 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.442 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.442 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.442 | |
| 2q54 | MU1 | Protease | / | 0.442 | |
| 3awh | FMN | FMN-binding protein | / | 0.442 | |
| 3b9l | AZZ | Serum albumin | / | 0.442 | |
| 3bem | FMN | Putative NAD(P)H nitroreductase MhqN | 1 | 0.442 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.442 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3gga | GGW | Gag-Pol polyprotein | / | 0.442 | |
| 3kdc | JZP | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3ok9 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3tl9 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.442 | |
| 4kik | KSA | Inhibitor of nuclear factor kappa-B kinase subunit beta | 2.7.11.10 | 0.442 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.442 | |
| 1a94 | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ec0 | BED | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.441 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2huv | SAH | Diphthine synthase | / | 0.441 | |
| 2qi4 | MZ6 | Gag-Pol polyprotein | / | 0.441 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.441 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.441 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.441 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.441 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.441 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.440 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1n07 | FMN | Riboflavin kinase | 2.7.1.26 | 0.440 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.440 | |
| 1pme | SB2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 1zsr | 0ZT | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2f81 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2foi | JPA | Enoyl-acyl carrier reductase | / | 0.440 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 2pwr | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2xvw | 9NR | Serum albumin | / | 0.440 | |
| 3k0f | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.440 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3s1h | 56Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.440 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.440 | |
| 4kb9 | G79 | Protease | / | 0.440 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.440 | |
| 5efw | FMN | NPH1-1 | / | 0.440 |