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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3il6B833-oxoacyl-[acyl-carrier-protein] synthase 3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3il6B833-oxoacyl-[acyl-carrier-protein] synthase 3/1.000
3il5B823-oxoacyl-[acyl-carrier-protein] synthase 3/0.519
1hnjMLC3-oxoacyl-[acyl-carrier-protein] synthase 3/0.493
5hs1VORLanosterol 14-alpha demethylase/0.489
3qlrNDPDihydrofolate reductase1.5.1.30.488
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.485
1hnhCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.484
1bwsNDPGDP-L-fucose synthase/0.479
3ixp834Ecdysone receptor/0.478
2ylxFADPhenylacetone monooxygenase1.14.13.920.476
3p99LNPLanosterol 14-alpha-demethylase/0.476
4jx1CAMCamphor 5-monooxygenase1.14.15.10.475
5k2dZMAAdenosine receptor A2a/0.474
3q9zTXQCasein kinase II subunit alpha2.7.11.10.472
2xviFADPutative flavin-containing monooxygenase/0.470
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.470
3ddw055Glycogen phosphorylase, liver form2.4.1.10.469
2rqfJH3Hemolymph juvenile hormone binding protein/0.467
3unj0BXCyclin-dependent kinase 22.7.11.220.467
1cqp803Integrin alpha-L/0.466
3h65I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.466
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.466
3pqbVGPPutative oxidoreductase/0.466
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2/0.466
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.465
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.465
4jx1CAHCamphor 5-monooxygenase1.14.15.10.465
4nieNBHNuclear receptor ROR-gamma/0.465
4xwtU5PRibonuclease J/0.465
4cd2FOLDihydrofolate reductase1.5.1.30.464
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.463
3eksCY9Actin-5C/0.463
2vn0TDZCytochrome P450 2C8/0.462
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.462
4z34ON7Lysophosphatidic acid receptor 1/0.462
2npnSAMPutative cobalamin synthesis related protein/0.461
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.461
3lqfNADGalactitol dehydrogenase/0.461
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.461
4a802ANMajor pollen allergen Bet v 1-A/0.461
4z9g1Q5Corticotropin-releasing factor receptor 1/0.461
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.460
3iaeD7KBenzaldehyde lyase/0.460
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.460
4ruoBIVVitamin D3 receptor A/0.460
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.460
5jtbZMAAdenosine receptor A2a/0.460
1dd6MCIMetallo-beta-lactamase type 2/0.459
2kceD16Thymidylate synthase/0.459
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.459
3ijdC2FMethylenetetrahydrofolate reductase/0.459
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.459
3oev3OEProteasome subunit beta type-53.4.25.10.459
3oev3OEProteasome subunit beta type-63.4.25.10.459
4g1y0VOVitamin D3 receptor A/0.459
4m10ICDProstaglandin G/H synthase 21.14.99.10.459
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.459
1cjuFOKAdenylate cyclase type 2/0.458
1cjuFOKAdenylate cyclase type 5/0.458
1kceCB3Thymidylate synthase/0.458
3ha5SFGHydroxymycolate synthase MmaA42.1.10.458
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.457
2w1fL0FAurora kinase A2.7.11.10.457
3csdEMOPutative ketoacyl reductase1.3.10.457
1x8lOXRRetinol dehydratase/0.456
2bxoOPBSerum albumin/0.456
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2qo9ANPEphrin type-A receptor 32.7.10.10.456
2zbaZBATrichothecene 3-O-acetyltransferase/0.456
3b9lAZZSerum albumin/0.456
4awo99BHeat shock protein HSP 90-alpha/0.456
4tvbNADHomospermidine synthase2.5.1.440.456
1fvt106Cyclin-dependent kinase 22.7.11.220.455
2ejvNADL-threonine 3-dehydrogenase/0.455
2imfTOM2-hydroxychromene-2-carboxylate isomerase5.99.1.40.455
2uxoTACHTH-type transcriptional regulator TtgR/0.455
4c58824Cyclin-G-associated kinase2.7.11.10.455
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.455
1dr2TAPDihydrofolate reductase1.5.1.30.454
3gyjFADCholesterol oxidase1.1.3.60.454
3p3zP3ZPutative cytochrome P450/0.454
3sdkP3NProteasome subunit beta type-53.4.25.10.454
3sdkP3NProteasome subunit beta type-63.4.25.10.454
4jlk1NODeoxycytidine kinase2.7.1.740.454
4nmdFDABifunctional protein PutA/0.454
4uymVOR14-alpha sterol demethylase Cyp51B/0.454
1hndCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.453
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.453
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.453
3u9eCOALmo1369 protein/0.453
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.453
5k2bZMAAdenosine receptor A2a/0.453
3emlZMAAdenosine receptor A2a/0.453
1nvtNAPShikimate dehydrogenase (NADP(+))/0.452
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.452
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.452
2hcdBIVVitamin D3 receptor A/0.452
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.452
3vvpBNUUncharacterized protein/0.452
4mihFADPyranose 2-oxidase1.1.3.100.452
1p0hACOMycothiol acetyltransferase2.3.1.1890.451
1xddAAYIntegrin alpha-L/0.451
2o4rVD5Vitamin D3 receptor/0.451
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.451
3qu0X40Cyclin-dependent kinase 22.7.11.220.451
4iah1DXAlr2278 protein/0.451
4nb6444Nuclear receptor ROR-gamma/0.451
1dhrNADDihydropteridine reductase1.5.1.340.450
1dr3TAPDihydrofolate reductase1.5.1.30.450
1hvyD16Thymidylate synthase2.1.1.450.450
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.450
2idkC2FGlycine N-methyltransferase2.1.1.200.450
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.450
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.450
3stxBKAMethylketone synthase I/0.450
4jqh1MFAlr2278 protein/0.450
1eblCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.449
1kzjCB3Thymidylate synthase/0.449
1osvCHCBile acid receptor/0.449
1rd4L08Integrin alpha-L/0.449
2gjlFMNNitronate monooxygenase1.13.12.160.449
2gjnFMNNitronate monooxygenase1.13.12.160.449
2igoFADPyranose 2-oxidase/0.449
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3nglNAPBifunctional protein FolD/0.449
3q44D50M1 family aminopeptidase3.4.110.449
4ez8DHFThymidylate synthase2.1.1.450.449
4j6cSTRCytochrome P450 monooxygenase/0.449
3pwhZMAAdenosine receptor A2a/0.449
1cboFADCholesterol oxidase1.1.3.60.448
1f4fTP3Thymidylate synthase/0.448
1ia1NDPDihydrofolate reductase1.5.1.30.448
1ndzFR5Adenosine deaminase3.5.4.40.448
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.448
2jn3JN3Fatty acid-binding protein, liver/0.448
2w71L23Biotin carboxylase6.3.4.140.448
2znq401Peroxisome proliferator-activated receptor delta/0.448
3adaNADSubunit alpha of sarocosine oxidase/0.448
3ibdCPZCytochrome P450 2B61.14.130.448
3l6jZ90Alr2278 protein/0.448
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.448
4g47TZFMycocyclosin synthase1.14.21.90.448
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.448
4i6gFADCryptochrome-2/0.448
4irnFADAnaB/0.448
4kf1HT5Aryldialkylphosphatase3.1.8.10.448
4o701QKBromodomain-containing protein 4/0.448
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.448
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.448
1ay0TPPTransketolase 12.2.1.10.447
1b8sFADCholesterol oxidase1.1.3.60.447
1m78NDPDihydrofolate reductase1.5.1.30.447
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.447
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3tjzGNPADP-ribosylation factor 1/0.447
3vruYS3Vitamin D3 receptor/0.447
3w6hAZMCarbonic anhydrase 14.2.1.10.447
4bb3KKAIsopenicillin N synthase1.21.3.10.447
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.447
1eioGCHGastrotropin/0.446
1n4uFAECholesterol oxidase1.1.3.60.446
1tj0FADBifunctional protein PutA1.5.5.20.446
3iocA5DPantothenate synthetase6.3.2.10.446
3stv3HOMethylketone synthase I/0.446
4a6bQG8Gag-Pol polyprotein3.4.23.160.446
4ia3BIVVitamin D3 receptor A/0.446
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
5kj1PFBAlcohol dehydrogenase E chain1.1.1.10.446
1ddsMTXDihydrofolate reductase1.5.1.30.445
1fmjRTLRetinol dehydratase/0.445
1fmlRTLRetinol dehydratase/0.445
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1rf7DHFDihydrofolate reductase1.5.1.30.445
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.445
2xvq9DSSerum albumin/0.445
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3fcjFADNitroalkane oxidase1.7.3.10.445
3mdmFJZCholesterol 24-hydroxylase/0.445
3p3e3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.445
3up0D7SaceDAF-12/0.445
4ambDUDPutative glycosyl transferase/0.445
4cdmFO1Deoxyribodipyrimidine photolyase/0.445
5k2aZMAAdenosine receptor A2a/0.445
4k5y1Q5Corticotropin-releasing factor receptor 1/0.445
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1dirNADDihydropteridine reductase1.5.1.340.444
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.444
1nzfUPGDNA beta-glucosyltransferase/0.444
1ohkCOPDihydrofolate reductase1.5.1.30.444
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.444
2cig1DGDihydrofolate reductase1.5.1.30.444
2ij7TPFMycocyclosin synthase1.14.21.90.444
3f47I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.444
3oquA8SAbscisic acid receptor PYL9/0.444
3vspEK8Peroxisome proliferator-activated receptor gamma/0.444
3vt7VDXVitamin D3 receptor/0.444
4h4yNAPBiphenyl dioxygenase ferredoxin reductase subunit/0.444
4iarERM5-hydroxytryptamine receptor 1B/0.444
4o8aFADBifunctional protein PutA1.2.1.880.444
5a3cNADSIR2 family protein/0.444
4xnw2IDP2Y purinoceptor 1/0.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.443
3oafOAGDihydrofolate reductase1.5.1.30.443
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.443
4enhFVXCholesterol 24-hydroxylase/0.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
4o1mNADEnoyl-acyl carrier reductase/0.443
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.443
4tuvCPZCytochrome P450 1191.140.443
4uyf73BBromodomain-containing protein 2/0.443
5hynSAHHistone-lysine N-methyltransferase EZH22.1.1.430.443
1ie9VDXVitamin D3 receptor/0.442
1ijhFADCholesterol oxidase1.1.3.60.442
1mczRMNBenzoylformate decarboxylase4.1.1.70.442
1pq944BOxysterols receptor LXR-beta/0.442
2hasC3OVitamin D3 receptor/0.442
2xvv9DNSerum albumin/0.442
2ylzFADPhenylacetone monooxygenase1.14.13.920.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.442
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.442
4bfzZVZPantothenate kinase2.7.1.330.442
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.442
5uviZMAAdenosine receptor A2a/0.442
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.441
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1u54ACPActivated CDC42 kinase 1/0.441
2iw84SPCyclin-dependent kinase 22.7.11.220.441
3mdvCL6Cholesterol 24-hydroxylase/0.441
3oom507Activin receptor type-12.7.11.300.441
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.441
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4kbyC2EStimulator of interferon genes protein/0.441
4la0198Serum albumin/0.441
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.441
4ly91YYGlucokinase regulatory protein/0.441
4mrtCOA4'-phosphopantetheinyl transferase sfp2.7.80.441
4rekFADCholesterol oxidase1.1.3.60.441
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.441
1g6oADPCag alpha/0.440
1pq6965Oxysterols receptor LXR-beta/0.440
1pqc444Oxysterols receptor LXR-beta/0.440
1r2jFADFkbI/0.440
1sozVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.440
1xe65FPPlasmepsin-23.4.23.390.440
2bxmIMNSerum albumin/0.440
2dvlFADAcyl-CoA dehydrogenase/0.440
2ylrFADPhenylacetone monooxygenase1.14.13.920.440
3d80Q22Dihydrofolate reductase1.5.1.30.440
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.440
3gobHXXDdmC/0.440
3ibqATPPyridoxal kinase/0.440
3kytHC2Nuclear receptor ROR-gamma/0.440
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.440
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.440
4awq592Heat shock protein HSP 90-alpha/0.440
4ia1BIVVitamin D3 receptor A/0.440
4oaeCLMUncharacterized protein/0.440
4rrxLURProstaglandin G/H synthase 21.14.99.10.440
4xwrFADCholesterol oxidase1.1.3.60.440