sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ert | OHT | Estrogen receptor |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ert | OHT | Estrogen receptor | / | 1.000 | |
| 2ouz | C3D | Estrogen receptor | / | 0.695 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.540 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.498 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.497 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.497 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.497 | |
| 1m9j | CLW | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.494 | |
| 2ayr | L4G | Estrogen receptor | / | 0.493 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.492 | |
| 2b1z | 17M | Estrogen receptor | / | 0.491 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.488 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.488 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.488 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.486 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4fvz | 4KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.484 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.484 | |
| 1r35 | I58 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.483 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.482 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.482 | |
| 3e6o | A55 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.482 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.482 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.480 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.479 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.479 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.479 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.479 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.479 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.478 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.477 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.477 | |
| 1yim | CM4 | Estrogen receptor | / | 0.476 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.475 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.475 | |
| 3e7m | AT2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.474 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.474 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.474 | |
| 4n49 | MGT | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | 2.1.1.57 | 0.474 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.473 | |
| 1xpc | AIT | Estrogen receptor | / | 0.473 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.473 | |
| 3dqr | JI2 | Nitric oxide synthase, brain | 1.14.13.39 | 0.472 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 4gqe | 6KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.472 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.471 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.471 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.471 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.471 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.471 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.470 | |
| 3qfr | NAP | NADPH--cytochrome P450 reductase | / | 0.470 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.470 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.470 | |
| 4lwb | QJ8 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.470 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3ufq | HW5 | Nitric oxide synthase, brain | 1.14.13.39 | 0.469 | |
| 4pp6 | STL | Estrogen receptor | / | 0.469 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3b3p | JI7 | Nitric oxide synthase, brain | 1.14.13.39 | 0.468 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2qe6 | SAM | Uncharacterized protein | / | 0.467 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.467 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.467 | |
| 4ug5 | XFK | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.467 | |
| 5hyr | EST | Estrogen receptor | / | 0.467 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.466 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.466 | |
| 1y5v | NE8 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.466 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.466 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.466 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1gwr | EST | Estrogen receptor | / | 0.465 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.465 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.465 | |
| 4ug7 | 1EV | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.465 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.464 | |
| 3ufr | H5W | Nitric oxide synthase, brain | 1.14.13.39 | 0.464 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.464 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.464 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.464 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.464 | |
| 1bve | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.463 | |
| 3e7i | B2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.463 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.463 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.463 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.463 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.463 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.463 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 1m9m | 6NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.462 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.462 | |
| 3sls | 77D | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.462 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.462 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.461 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.461 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.461 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4uqs | INE | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.461 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.460 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.460 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.459 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.459 | |
| 3iqe | F42 | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.459 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.459 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 3e7g | AT2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.458 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.458 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.458 | |
| 3nny | 59R | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4jsj | QJ7 | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 1ci7 | CB3 | Thymidylate synthase | 2.1.1.45 | 0.457 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 1w6y | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.457 | |
| 2jf9 | OHT | Estrogen receptor | / | 0.457 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.457 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 1l2i | ETC | Estrogen receptor | / | 0.456 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4k5e | 1Q7 | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 4tv3 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.456 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 1mer | DMQ | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.455 | |
| 3cse | N22 | Uncharacterized protein | / | 0.455 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.455 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.455 | |
| 3tyl | AXW | Nitric oxide synthase, brain | 1.14.13.39 | 0.455 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.455 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.454 | |
| 1jt6 | DEQ | HTH-type transcriptional regulator QacR | / | 0.454 | |
| 1m9t | INE | Nitric oxide synthase, inducible | 1.14.13.39 | 0.454 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.454 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.454 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.454 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.454 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1wc0 | APC | Adenylate cyclase | / | 0.453 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.453 | |
| 1zzr | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.453 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.453 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.453 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.453 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.453 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.453 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.453 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 4v12 | POG | MaoC like domain protein | / | 0.453 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.452 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.452 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.452 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 3eai | 328 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.452 | |
| 3pnf | 8BX | Nitric oxide synthase, brain | 1.14.13.39 | 0.452 | |
| 3sqq | 99Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.452 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.452 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1r2j | FAD | FkbI | / | 0.451 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.451 | |
| 1x7e | 244 | Estrogen receptor | / | 0.451 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.451 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.451 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.451 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.451 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.451 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 4h03 | LAR | Actin, alpha skeletal muscle | / | 0.451 | |
| 4iv4 | 1GS | Estrogen receptor | / | 0.451 | |
| 4k5f | Q14 | Nitric oxide synthase, brain | 1.14.13.39 | 0.451 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.451 | |
| 6upj | NIU | Gag-Pol polyprotein | / | 0.451 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.450 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.450 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.450 | |
| 3uud | EST | Estrogen receptor | / | 0.450 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.450 | |
| 4beb | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.450 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.450 | |
| 4j24 | EST | Estrogen receptor beta | / | 0.450 | |
| 4pda | CTN | Nucleoside permease | / | 0.450 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1owl | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.449 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.449 | |
| 2pvr | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 2wog | ZZD | Kinesin-like protein KIF11 | / | 0.449 | |
| 2yx1 | SFG | tRNA (guanine(37)-N1)-methyltransferase Trm5b | 2.1.1.228 | 0.449 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3jx3 | JI5 | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.449 | |
| 4jsg | Q10 | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4k5d | 1Q6 | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.449 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.448 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2uw6 | GVO | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3oll | EST | Estrogen receptor beta | / | 0.448 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.448 | |
| 4jsf | QJ4 | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 4qin | SG8 | Smoothened homolog | / | 0.448 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1p6j | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.447 | |
| 2fai | 459 | Estrogen receptor | / | 0.447 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.447 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.447 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.447 | |
| 3nlw | 3XF | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3r7i | X9I | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4bmp | FMN | Protein NrdI | / | 0.447 | |
| 4egn | TWO | Cytochrome P450 | / | 0.447 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.447 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1g50 | EST | Estrogen receptor | / | 0.446 | |
| 1own | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1owo | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.446 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.446 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.446 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.446 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.446 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.446 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.446 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.446 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.446 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.446 | |
| 3e7t | B14 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.446 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4gb2 | 0LQ | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4z07 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.446 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.445 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.445 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.445 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.445 | |
| 3nlv | 3XA | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ufo | HW4 | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.445 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.445 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.444 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1nm1 | ATP | Major actin | / | 0.444 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.444 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.444 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1wbp | ADP | SRSF protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2uyq | SAM | Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 | 2.1.1 | 0.444 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.444 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.444 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 3ufs | HW6 | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3uft | HW7 | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.444 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2eau | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.443 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 2ijm | ADP | Focal adhesion kinase 1 | 2.7.10.2 | 0.443 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.443 | |
| 2p9d | SAH | Diphthine synthase | / | 0.443 | |
| 3anm | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.443 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.443 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.443 | |
| 3n65 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.443 | |
| 4giy | 0WY | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.443 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.443 | |
| 4pd5 | GEO | Nucleoside permease | / | 0.443 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.443 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.442 | |
| 1zky | 689 | Estrogen receptor | / | 0.442 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.442 | |
| 2pwu | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.442 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.442 | |
| 2ybo | SAH | Methyltransferase | / | 0.442 | |
| 3e68 | AT6 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.442 | |
| 3gc7 | B45 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3rqj | Y2B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.442 | |
| 4dma | 0L8 | Estrogen receptor | / | 0.442 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.442 | |
| 4x81 | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1bwb | 146 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1gwq | ZTW | Estrogen receptor | / | 0.441 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1krv | 147 | Galactoside O-acetyltransferase | 2.3.1.18 | 0.441 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.441 | |
| 1rs6 | DP2 | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.441 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3jwu | J11 | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3n5v | XFH | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3rqk | X2C | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.441 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.441 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4zn7 | DES | Estrogen receptor | / | 0.441 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.440 | |
| 1jzq | ILA | Isoleucine--tRNA ligase | 6.1.1.5 | 0.440 | |
| 1oh0 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.440 | |
| 2hx4 | 4HX | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 2oj9 | BMI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.440 | |
| 2qa8 | GEN | Estrogen receptor | / | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 3rqm | X2E | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.440 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 4gkt | 0O1 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 |