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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wbgLGSBeta-glucosidase A3.2.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wbgLGSBeta-glucosidase A3.2.1.211.000
2j7dGI1Beta-glucosidase A3.2.1.210.627
2j7cIDEBeta-glucosidase A3.2.1.210.599
2vrjNCWBeta-glucosidase A3.2.1.210.596
3rnoNAPNAD(P)H-hydrate epimerase5.1.99.60.524
4n3r2GUTankyrase-12.4.2.300.522
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.484
1gky5GPGuanylate kinase2.7.4.80.477
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.477
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.477
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.473
1ex75GPGuanylate kinase2.7.4.80.472
1w76GNTAcetylcholinesterase3.1.1.70.471
3n19FNRXenobiotic reductase/0.471
2g1a5HGClass B acid phosphatase3.1.3.20.470
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.470
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.469
2cekN8TAcetylcholinesterase3.1.1.70.468
2f2hXTGAlpha-xylosidase3.2.1.1770.468
2qimZEAClass 10 plant pathogenesis-related protein/0.466
3mesPT3Putative choline kinase/0.465
1q84TZ4Acetylcholinesterase3.1.1.70.464
2p5uNADUDP-glucose 4-epimerase/0.464
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.464
3ufl508Beta-secretase 13.4.23.460.463
4n9qFMNFMN-dependent NADH-azoreductase 1/0.462
2jf0HBPAcetylcholinesterase3.1.1.70.461
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.461
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.460
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.459
2b82ADNClass B acid phosphatase3.1.3.20.459
3k8o229Purine nucleoside phosphorylase2.4.2.10.459
3zj6VM2Raucaffricine-O-beta-D-glucosidase3.2.1.1250.459
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.459
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.459
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.459
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.458
1u65CP0Acetylcholinesterase3.1.1.70.457
3vilSA0Beta-glucosidase/0.457
2y6fM9FIsopenicillin N synthase1.21.3.10.456
1blzACVIsopenicillin N synthase1.21.3.10.455
2r7nADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.455
1w7gMIUProthrombin3.4.21.50.454
2b8jADNClass B acid phosphatase3.1.3.20.454
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.454
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.453
4ej1FOLDihydrofolate reductase1.5.1.30.453
4lrrCF9Thymidylate synthase/0.452
4ug5XFKNitric oxide synthase oxygenase1.14.13.1650.452
1tllFMNNitric oxide synthase, brain1.14.13.390.451
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.451
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.451
3q1kADPD-alanine--D-alanine ligase A6.3.2.40.451
4a81DXCMajor pollen allergen Bet v 1-A/0.451
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.450
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.450
3rvhHQ2Lysine-specific demethylase 4A1.14.110.450
2flhZEACytokinin-specific binding protein/0.449
3ptqNFGBeta-glucosidase 12/0.449
1s63778Protein farnesyltransferase subunit beta2.5.1.580.448
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.448
1zzrDP9Nitric oxide synthase, brain1.14.13.390.448
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.448
4az29MUProthrombin3.4.21.50.448
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.448
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.448
4rvfTYDD-mycarose 3-C-methyltransferase/0.448
4to4DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.448
1o86LPRAngiotensin-converting enzyme3.2.10.447
1odcA8BAcetylcholinesterase3.1.1.70.447
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3ebf332Nitric oxide synthase, inducible1.14.13.390.447
4to1DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.447
1i7cMGBS-adenosylmethionine decarboxylase proenzyme4.1.1.500.446
2a3bCFFEndochitinase B13.2.1.140.446
2g1r3IGRenin3.4.23.150.446
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.446
2xugTZ4Acetylcholinesterase3.1.1.70.446
2xweAMFGlucosylceramidase3.2.1.450.446
3g72A6TRenin3.4.23.150.446
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.446
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.446
4q4eBB2Aminopeptidase N3.4.11.20.446
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.446
1qtiGNTAcetylcholinesterase3.1.1.70.445
1tkaN3TTransketolase 12.2.1.10.445
2wwjY28Lysine-specific demethylase 4A/0.445
2y1w849Histone-arginine methyltransferase CARM1/0.445
3bj8COADiamine acetyltransferase 1/0.445
3dufR1TPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.445
3dufR1TPyruvate dehydrogenase E1 component subunit beta1.2.4.10.445
3py4TYLLactoperoxidase1.11.1.70.445
3rviRVIBeta-secretase 13.4.23.460.445
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.445
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.444
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.444
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.444
2g8yNADHydroxycarboxylate dehydrogenase B/0.444
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.444
3af3GCPPantothenate kinase2.7.1.330.444
3bgxTMPThymidylate synthase/0.444
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.444
4iarERM5-hydroxytryptamine receptor 1B/0.444
1dx6GNTAcetylcholinesterase3.1.1.70.443
1ry0PG2Aldo-keto reductase family 1 member C3/0.443
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.443
1w1vALJChitinase/0.443
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2g1o2IGRenin3.4.23.150.443
2rd2QSIGlutamine--tRNA ligase6.1.1.180.443
2zevIPEGeranylgeranyl pyrophosphate synthase/0.443
4bftZVTPantothenate kinase2.7.1.330.443
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.443
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.443
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.443
1j36LPRAngiotensin-converting enzyme3.4.15.10.442
1m9nAMZBifunctional purine biosynthesis protein PURH2.1.2.30.442
1yryMSGPurine nucleoside phosphorylase2.4.2.10.442
2v57PRLTetR family transcriptional regulator/0.442
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.70.442
3pdqKC6Lysine-specific demethylase 4A1.14.110.442
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.442
1pqc444Oxysterols receptor LXR-beta/0.441
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.441
2wvmGDDMannosyl-3-phosphogylcerate synthase/0.441
3ai0PNWBeta-glucosidase/0.441
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.441
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.441
4isk1JYThymidylate synthase/0.441
4kl1PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.441
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.440
1w6rGNTAcetylcholinesterase3.1.1.70.440
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.440
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3mtwM3RXaa-Pro dipeptidase, putative/0.440
3upyFOMOxidoreductase, putative/0.440
4bfyZVYPantothenate kinase2.7.1.330.440
4h3j10WBeta-secretase 13.4.23.460.440
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.440
4yklGMPAprataxin-like protein30.440